Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension

Abstract

This study explored the question as to whether hypotension is related to decreased attentional performance and reduced cortical activation. A total of 50 females aged 19-44 years participated in the study. Attentional performance was assessed using three subtests of the Attentional and Cognitive Efficiency (ACE) battery. Contingent negative variation (CNV) as a measure of cortical activation was registered during a constant fore-period reaction time paradigm: two conditions were defined using tones as S1 (80 or 60 dB) and S2 (70 dB). The following results were obtained. Hypotensive patients performed significantly more poorly on one subtest of the ACE, which indicates a reduced speed for switching from a routine to a controlled response (quantifying attentional flexibility). They also had longer reaction times and revealed a significantly smaller amplitude of the early CNV component. In addition, a significant correlation was observed between systolic blood pressure and the amplitude of the early CNV component. The data support previous findings that hypotension can be related to lowered cortical activation and indicate that specific aspects of attentional performance might be negatively affected by hypotension.