A higher incidence of intermittent hypoxemic episodes is associated with severe retinopathy of prematurity

Juliann M Di Fiore, Jeffrey N Bloom, Faruk Orge, Alison Schutt, Mark Schluchter, Vinay K Cheruvu, Michele Walsh, Neil Finer, Richard J Martin, Juliann M Di Fiore, Jeffrey N Bloom, Faruk Orge, Alison Schutt, Mark Schluchter, Vinay K Cheruvu, Michele Walsh, Neil Finer, Richard J Martin

Abstract

Objective: Retinopathy of prematurity (ROP), a vasoproliferative disorder of the retina in preterm infants, is associated with multiple factors, including oxygenation level. We explored whether the common intermittent hypoxemic events in preterm infants are associated with the development of ROP.

Study design: Oxygen desaturation events were quantified in 79 preterm infants (gestational age, 24 to 27-6/7 weeks) during the first 8 weeks of life. Infants were classified as requiring laser treatment for ROP versus having less severe or no ROP. A linear mixed model was used to study the association between the incidence of intermittent hypoxia and laser treatment of ROP, controlling for gestational age, sex, race, multiple births, and initial severity of illness.

Results: For all infants, hypoxemic events increased with postnatal age (P<.001). Controlling for all covariates, a higher incidence of oxygen desaturation events was found in the infants undergoing laser therapy for ROP (P<.001), males (P<.02), and infants of younger gestational age (P<.003).

Conclusions: The incidence of hypoxemic events was higher in infants with ROP requiring laser therapy. Therapeutic strategies to optimize oxygenation in preterm infants should include minimization of desaturation episodes, which may in turn decrease serious morbidity in this high-risk population.

Copyright (c) 2010. Published by Mosby, Inc.

Figures

Figure 1
Figure 1
The model-based estimate of intermittent hypoxemic events for all infants. There was a change in the incidence of hypoxemic events with increasing postnatal age (p

Figure 2

The model-based estimate of intermittent…

Figure 2

The model-based estimate of intermittent hypoxemic events in infants requiring laser treatment for…

Figure 2
The model-based estimate of intermittent hypoxemic events in infants requiring laser treatment for ROP (LaserROP) and those with either no ROP or ROP not severe enough to require laser therapy (NoLaserROP) controlling for gestational age, race, gender, multiple births and SNAPPE-II score. There was an overall higher incidence of hypoxemic events in LaserROP infants (p

Figure 3

The model based estimate for…

Figure 3

The model based estimate for hyperoxemic (>95%) events in infants requiring laser…

Figure 3
The model based estimate for hyperoxemic (>95%) events in infants requiring laser treatment for ROP (LaserROP) and those with either no ROP or ROP not severe enough to require laser therapy (NoLaserROP). There was a higher incidence of hyperoxemic events in the NoLaserROP group (p=0.005) with significant differences at 2 and 4 through 8 weeks of age (p
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Figure 2
Figure 2
The model-based estimate of intermittent hypoxemic events in infants requiring laser treatment for ROP (LaserROP) and those with either no ROP or ROP not severe enough to require laser therapy (NoLaserROP) controlling for gestational age, race, gender, multiple births and SNAPPE-II score. There was an overall higher incidence of hypoxemic events in LaserROP infants (p

Figure 3

The model based estimate for…

Figure 3

The model based estimate for hyperoxemic (>95%) events in infants requiring laser…

Figure 3
The model based estimate for hyperoxemic (>95%) events in infants requiring laser treatment for ROP (LaserROP) and those with either no ROP or ROP not severe enough to require laser therapy (NoLaserROP). There was a higher incidence of hyperoxemic events in the NoLaserROP group (p=0.005) with significant differences at 2 and 4 through 8 weeks of age (p
Comment in
Similar articles
Cited by
Publication types
MeSH terms
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Figure 3
Figure 3
The model based estimate for hyperoxemic (>95%) events in infants requiring laser treatment for ROP (LaserROP) and those with either no ROP or ROP not severe enough to require laser therapy (NoLaserROP). There was a higher incidence of hyperoxemic events in the NoLaserROP group (p=0.005) with significant differences at 2 and 4 through 8 weeks of age (p

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