Chinese pediatric Tuina on children with acute diarrhea: a randomized sham-controlled trial

Taoying Lu, Lingjia Yin, Ruoqing Chen, Huiyan Zhang, Jianxiong Cai, Meiling Li, Lin Dai, Conghao Zhu, Yongping Zhang, Feng Xiang, Li Wang, Lu Li, Lixin Wang, Darong Wu, Taoying Lu, Lingjia Yin, Ruoqing Chen, Huiyan Zhang, Jianxiong Cai, Meiling Li, Lin Dai, Conghao Zhu, Yongping Zhang, Feng Xiang, Li Wang, Lu Li, Lixin Wang, Darong Wu

Abstract

Background: Pediatric Tuina has been widely used in children with acute diarrhea in China. However, due to the lack of high-quality clinical evidence, the benefit of Tuina as a therapy is not clear. We aimed to assess the effect of pediatric Tuina compared with sham Tuina as an add-on therapy in addition to usual care for 0-6-year-old children with acute diarrhea.

Methods: Eighty-six participants aged 0-6 years with acute diarrhea were randomized to receive pediatric Tuina plus usual care (n = 43) or sham Tuina plus usual care (n = 43). The primary outcomes were days of diarrhea from baseline and times of diarrhea on day 3. Secondary outcomes included a global change rating (GCR) and the number of days when the stool characteristics returned to normal. Adverse events were assessed.

Results: Pediatric Tuina was associated with a reduction in times of diarrhea on day 3 compared with sham Tuina in both ITT (crude RR, 0.73 [95% CI, 0.59-0.91]) and PP analyses (crude RR, 0.66 [95% CI, 0.53-0.83]). However, the results were not significant when we adjusted for social demographic and clinical characteristics. No significant difference was found between groups in days of diarrhea, global change rating, or number of days when the stool characteristics returned to normal.

Conclusions: In children aged 0-6 years with acute diarrhea, pediatric Tuina showed significant effects in terms of reducing times of diarrhea compared with sham Tuina. Studies with larger sample sizes and adjusted trial designs are warranted to further evaluate the effect of pediatric Tuina therapy.

Trial registration: Clinicaltrials.gov, Identifier: NCT03005821 , Data of registration: 2016-12-29.

Keywords: Acute diarrhea; Children; Pediatric Tuina; Sham Tuina.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pediatric Tuina manipulation methods for Tuina group (a) and for Sham Tuina group (b)
Fig. 2
Fig. 2
Consolidated Standards of Reporting Trials (CONSORT) Diagram for a Trial of pediatric Tuina on children with acute diarrhea

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Source: PubMed

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