Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R Kamya, Shunmay Yeung, Sarah G Staedke, Teun Bousema, Chris Drakeley, Alice C Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R Kamya, Shunmay Yeung, Sarah G Staedke, Teun Bousema, Chris Drakeley

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

Copyright © 2014, Eziefula et al.

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