Energy Expenditure and Substrate Utilization During Acute Under- and Over-feeding
29. november 2012 oppdatert av: University of North Carolina, Chapel Hill
This study will determine the impact of 24, 48 and 72 hours of over and underfeeding on energy expenditure as measured in the metabolic chamber at the UNC Chapel Hill Nutrition Research Institute (UNC NRI).
Studieoversikt
Detaljert beskrivelse
Subjects will complete a baseline eucaloric study day.
Following this, subjects will be randomized to complete 3 days of overfeeding (150% of baseline eucaloric energy requirements) or 3 days of underfeeding (50% of baseline eucaloric energy requirements).
After completing one of these study arms, subjects will cross-over and complete the second arm.
All study arms will be separated by two weeks.
24-hour energy expenditure will be measured 3 times during each of 3 day periods.
We hypothesize that the impact of over or underfeeding on EE will be evident after 24-hours and will be comparable to 72 hour EE.
Studietype
Intervensjonell
Registrering (Faktiske)
7
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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North Carolina
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Kannapolis, North Carolina, Forente stater, 28081
- UNC Chapel Hill Nutrition Research Institute
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
50 år til 65 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Ja
Kjønn som er kvalifisert for studier
Hunn
Beskrivelse
Inclusion Criteria:
- Woman
- Postmenopausal
- Aged 50-65 years
- BMI 25-35kg/m2
- Not taking blood pressure or anti-inflammatory medications or any other medications that may impact the results
- Thyroid hormone profile within the normal reference range
- No medical condition which may impact the results (e.g. diabetes)
- Accustomed to eating regular meals including breakfast
Exclusion Criteria:
- Smoker
- Heavy exerciser (defined as >150 minutes/week for more than 3 months)
- Abuses alcohol or drugs
- Vegetarian
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Randomisert
- Intervensjonsmodell: Crossover-oppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Eucaloric Feeding
Subjects will complete an initial eucaloric feeding study day.
During this study day, subjects will receive 100% of their calorie requirements.
24-hour energy expenditure will be measured.
|
To assess 24-hour energy expenditure and substrate utilization subjects will spend 23 hours and 15 minutes each day in the metabolic chamber at the UNC NRI.
Subjects will be requested to arrive at the study center each morning following a 10hour overnight fast.
During each study day, subjects remained sedentary.
All meals were provided and were tailored to each subject's specific energy requirements and the study protocol (i.e.
50% or 150% of calorie requirements).
|
|
Eksperimentell: Underfeeding
Following the eucaloric feeding study day, subjects will undergo the underfeeding and overfeeding arms in random order.
During the underfeeding study arm, subjects will receive 50% of their calorie requirements (as determined during the initial eucaloric study day) for 3 days.
24-hour energy expenditure will be measured.
|
To assess 24-hour energy expenditure and substrate utilization subjects will spend 23 hours and 15 minutes each day in the metabolic chamber at the UNC NRI.
Subjects will be requested to arrive at the study center each morning following a 10hour overnight fast.
During each study day, subjects remained sedentary.
All meals were provided and were tailored to each subject's specific energy requirements and the study protocol (i.e.
50% or 150% of calorie requirements).
|
|
Eksperimentell: Overfeeding
Following the eucaloric feeding study day, subjects will undergo the underfeeding and overfeeding arms in random order.
During the overfeeding study arm, subjects will receive 150% of their calorie requirements (as determined during the initial eucaloric study day) for 3 days.
24-hour energy expenditure will be measured.
|
To assess 24-hour energy expenditure and substrate utilization subjects will spend 23 hours and 15 minutes each day in the metabolic chamber at the UNC NRI.
Subjects will be requested to arrive at the study center each morning following a 10hour overnight fast.
During each study day, subjects remained sedentary.
All meals were provided and were tailored to each subject's specific energy requirements and the study protocol (i.e.
50% or 150% of calorie requirements).
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Energy Expenditure
Tidsramme: 24-hour energy expenditure will be assessed
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24-hour energy expenditure will be assessed using the metabolic chamber at UNC NRI.
Energy expenditure will be measured during eucaloric feeding (subjects will receive 100% of calorie requirements), as well as during 24, 48 and 72 hours of under and overfeeding.
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24-hour energy expenditure will be assessed
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Whole blood transcriptomics
Tidsramme: Fasting a.m. sample, before lunch, and at 0.5, 2, and 4.5 hours post lunch
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RNA will be extracted from whole blood.
Transcriptomic profile will be assessed by microarray
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Fasting a.m. sample, before lunch, and at 0.5, 2, and 4.5 hours post lunch
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Plasma metabolomics
Tidsramme: Fasting a.m. sample, before lunch, and at 0.5, 2, and 4.5 hours post lunch
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Plasma metabolomic profile will be assessed using GC/MS and LC/MS platforms.
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Fasting a.m. sample, before lunch, and at 0.5, 2, and 4.5 hours post lunch
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Etterforskere
- Hovedetterforsker: Andrew G Swick, PhD, UNC Chapel Hill Nutrition Research Institute
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. mai 2012
Primær fullføring (Faktiske)
1. oktober 2012
Studiet fullført (Faktiske)
1. oktober 2012
Datoer for studieregistrering
Først innsendt
18. november 2012
Først innsendt som oppfylte QC-kriteriene
29. november 2012
Først lagt ut (Anslag)
4. desember 2012
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
4. desember 2012
Siste oppdatering sendt inn som oppfylte QC-kriteriene
29. november 2012
Sist bekreftet
1. november 2012
Mer informasjon
Begreper knyttet til denne studien
Andre studie-ID-numre
- 12-0681
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
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