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Longitudinal Study of Frailty in Shanghai Older People

24. november 2020 oppdatert av: Shanghai University of Traditional Chinese Medicine
To investigate the prevalence of Frailty in community older residents.

Studieoversikt

Status

Ukjent

Forhold

Detaljert beskrivelse

Detailed Description:

  1. Objective:

    • To investigate the prevalence of Frailty in community older residents.
    • To explore the causes and risk factors of frailty.

  2. Method:

    • The survey is a Community-based, multicenter prospective cohort study.

      1). 6,000 participants are expected to be included.

    • Through a questionnaire and physical examination form, carries on the investigation to the more than 65 years old people during the 3-year follow-up period.
    • The questionnaires include survey date, participant characteristics and related risk factors, such as comprise demographic characteristics, Chinese ethnic nationality, marital status, education level, family incomes, occupation, pregnancy and parity history, menstrual history, frequency and amount of daily smoking and alcohol drinking, frequency of urination and defecation, dietary habits, hours per day of sleep and sun exposure. Medical history including medication use and disease status for comorbidities, will be obtained from participants' medical records. Syndrome differentiation of deficiency of the five zang-organs in TCM will be analyzed.
    • Height and body weight will be measured for body mass index (BMI) calculation. The waist circumference and hip circumference will be recorded, and the ratios calculated. The muscle strengths of both hands will be measured with a hand dynamometer. Each of these measures will be assessed twice and the average score used in analyses.
    • Subjects will be asked to walk a distance of 4 meters and record the time at the same time to measure the walking speed.
    • Clock Drawing Test (CDT), physical frailty examination, Mini-Mental State Examination (MMSE), Skeletal muscle mass index (SMI) will also be conducted or calculated .
    • Each participant will provide a total of 7 mL of venous blood after an overnight fast (10-hour).

After being collected, markers of frailty will be measured, such as Interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1) and estrogen (E). And blood routine, urine routine, liver and kidney function, fasting plasma glucose, serum lipid will be detected.

  • Physicians in each community as the backbone, Shanghai Geriatric Institute of Chinese Medicine is responsible for personnel training.
  • Shanghai community health service centers are responsible for organization and coordination.

Studietype

Observasjonsmessig

Registrering (Forventet)

6000

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Kina
    • Shanghai
      • Shanghai, Shanghai, Kina, 200000
        • Rekruttering
        • Shanghai Geriatric Institute of Chinese Medicine
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

65 år til 85 år (Eldre voksen)

Tar imot friske frivillige

Ja

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Sannsynlighetsprøve

Studiepopulasjon

Cluster random sampling was used in urban and rural areas of Shanghai

Beskrivelse

Inclusion Criteria:

  • more than 65 years old
  • Permanent residence in Shanghai and long-term residence in the community implemented by this project (more than five years)
  • Be willing to and be able to join in the study and signed Informed consent.

Exclusion Criteria:

  • Excluding the patients whose physical function is affected by diseases or disabilities such as stroke, Parkinson's disease, tumor, fracture, etc.
  • Excluding schizophrenia, depression, anxiety and other mental diseases and dependent on drug control.
  • If they were unable to complete the study survey.
  • Unwilling to join in the study and don't sign Informed consent.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
The level of frailty
Tidsramme: baseline
  1. Unexpected significant weight loss（>5%).
  2. Decreased strength: male grip strength ≤25 kg and female grip strength ≤18 kg
  3. Reduced physical activity in the last month.
  4. Slow walking speed is less than or equal to 0.8 m/s.
  5. How tired you feel for the last month? The frailty period was defined as ≥3 items, early frailty was defined as 1-2 items, and non-frailty was defined as 0 items.
baseline

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Clock Drawing Test
Tidsramme: baseline
The subjects were scored on a four-point scale by drawing a clock face on a piece of white paper.
baseline
Mini-Mental State Examination (MMSE)
Tidsramme: baseline
Two or three points in the drawing clock test were measured using the MMSE.
baseline
Skeletal muscle mass index (SMI)
Tidsramme: baseline
The ratio of skeletal muscle weight to height squared was measured by DXA.
baseline
Markers of frailty
Tidsramme: baseline
Markers of frailty, such as Interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1) and estrogen (E).
baseline
Routine inspection
Tidsramme: baseline
Fasting peripheral blood collected 4ml. blood routine, urine routine, liver and kidney function, fasting plasma glucose, serum lipid.
baseline

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Shanghai University of Traditional Chinese Medicine

Etterforskere

  • Hovedetterforsker: Chuan Chen, Shanghai Geriatric Institute of Chinese Medicine

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. januar 2018

Primær fullføring (Forventet)

31. desember 2021

Studiet fullført (Forventet)

31. desember 2021

Datoer for studieregistrering

Først innsendt

24. august 2020

Først innsendt som oppfylte QC-kriteriene

24. november 2020

Først lagt ut (Faktiske)

3. desember 2020

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

3. desember 2020

Siste oppdatering sendt inn som oppfylte QC-kriteriene

24. november 2020

Sist bekreftet

1. mai 2020

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • Shanghai Frailty Survey

Plan for individuelle deltakerdata (IPD)

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