Longitudinal Study of Frailty in Shanghai Older People
24. november 2020 opdateret af: Shanghai University of Traditional Chinese Medicine
To investigate the prevalence of Frailty in community older residents.
Studieoversigt
Status
Ukendt
Betingelser
Detaljeret beskrivelse
Detailed Description:
Objective:
- To investigate the prevalence of Frailty in community older residents.
- To explore the causes and risk factors of frailty.
Method:
The survey is a Community-based, multicenter prospective cohort study.
1). 6,000 participants are expected to be included.
- Through a questionnaire and physical examination form, carries on the investigation to the more than 65 years old people during the 3-year follow-up period.
- The questionnaires include survey date, participant characteristics and related risk factors, such as comprise demographic characteristics, Chinese ethnic nationality, marital status, education level, family incomes, occupation, pregnancy and parity history, menstrual history, frequency and amount of daily smoking and alcohol drinking, frequency of urination and defecation, dietary habits, hours per day of sleep and sun exposure. Medical history including medication use and disease status for comorbidities, will be obtained from participants' medical records. Syndrome differentiation of deficiency of the five zang-organs in TCM will be analyzed.
- Height and body weight will be measured for body mass index (BMI) calculation. The waist circumference and hip circumference will be recorded, and the ratios calculated. The muscle strengths of both hands will be measured with a hand dynamometer. Each of these measures will be assessed twice and the average score used in analyses.
- Subjects will be asked to walk a distance of 4 meters and record the time at the same time to measure the walking speed.
- Clock Drawing Test (CDT), physical frailty examination, Mini-Mental State Examination (MMSE), Skeletal muscle mass index (SMI) will also be conducted or calculated .
- Each participant will provide a total of 7 mL of venous blood after an overnight fast (10-hour).
After being collected, markers of frailty will be measured, such as Interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1) and estrogen (E). And blood routine, urine routine, liver and kidney function, fasting plasma glucose, serum lipid will be detected.
- Physicians in each community as the backbone, Shanghai Geriatric Institute of Chinese Medicine is responsible for personnel training.
- Shanghai community health service centers are responsible for organization and coordination.
Undersøgelsestype
Observationel
Tilmelding (Forventet)
6000
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Chuan Chen
- Telefonnummer: 86-21-64720010
- E-mail: ch9453@126.com
Studiesteder
-
-
Shanghai
-
Shanghai, Shanghai, Kina, 200000
- Rekruttering
- Shanghai Geriatric Institute of Chinese Medicine
-
Kontakt:
- Chuan Chen
- Telefonnummer: 86-21-64720010
- E-mail: ch9453@126.com
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
65 år til 85 år (Ældre voksen)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
Cluster random sampling was used in urban and rural areas of Shanghai
Beskrivelse
Inclusion Criteria:
- more than 65 years old
- Permanent residence in Shanghai and long-term residence in the community implemented by this project (more than five years)
- Be willing to and be able to join in the study and signed Informed consent.
Exclusion Criteria:
- Excluding the patients whose physical function is affected by diseases or disabilities such as stroke, Parkinson's disease, tumor, fracture, etc.
- Excluding schizophrenia, depression, anxiety and other mental diseases and dependent on drug control.
- If they were unable to complete the study survey.
- Unwilling to join in the study and don't sign Informed consent.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
The level of frailty
Tidsramme: baseline
|
|
baseline
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Clock Drawing Test
Tidsramme: baseline
|
The subjects were scored on a four-point scale by drawing a clock face on a piece of white paper.
|
baseline
|
|
Mini-Mental State Examination (MMSE)
Tidsramme: baseline
|
Two or three points in the drawing clock test were measured using the MMSE.
|
baseline
|
|
Skeletal muscle mass index (SMI)
Tidsramme: baseline
|
The ratio of skeletal muscle weight to height squared was measured by DXA.
|
baseline
|
|
Markers of frailty
Tidsramme: baseline
|
Markers of frailty, such as Interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1) and estrogen (E).
|
baseline
|
|
Routine inspection
Tidsramme: baseline
|
Fasting peripheral blood collected 4ml.
blood routine, urine routine, liver and kidney function, fasting plasma glucose, serum lipid.
|
baseline
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Efterforskere
- Ledende efterforsker: Chuan Chen, Shanghai Geriatric Institute of Chinese Medicine
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. januar 2018
Primær færdiggørelse (Forventet)
31. december 2021
Studieafslutning (Forventet)
31. december 2021
Datoer for studieregistrering
Først indsendt
24. august 2020
Først indsendt, der opfyldte QC-kriterier
24. november 2020
Først opslået (Faktiske)
3. december 2020
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
3. december 2020
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
24. november 2020
Sidst verificeret
1. maj 2020
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- Shanghai Frailty Survey
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
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