Studie for å evaluere effekten av Balcinrenone/Dapagliflozin hos pasienter med hjertesvikt og nedsatt nyrefunksjon (BalanceD-HF)
12. oktober 2026 oppdatert av: AstraZeneca
En fase III, randomisert, dobbeltblind studie for å evaluere effekten av balcinrenon/dapagliflozin, sammenlignet med dapagliflozin, på risikoen for hjertesvikthendelser og kardiovaskulær død hos pasienter med hjertesvikt og nedsatt nyrefunksjon
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death and HF events.
Studieoversikt
Status
Rekruttering
Intervensjon / Behandling
Detaljert beskrivelse
The purpose of this study is to investigate the effect of balcinrenone/dapagliflozin compared with dapagliflozin, on the risk of CV death, HF event with and without hospitalisation, in patients with chronic HF, impaired kidney function, and who have had a recent HF event.
Eligible patients will randomly be assigned with a 1:1:1 ratio to receive once daily administration of one capsule and one tablet of one of the following treatments:
- Balcinrenone/dapagliflozin 15 mg/10 mg capsule and matching placebo for dapagliflozin 10 mg tablet
- Balcinrenone/dapagliflozin 40 mg/10 mg capsule and matching placebo for dapagliflozin 10 mg tablet
- Dapagliflozin 10 mg tablet and matching placebo for balcinrenone/dapagliflozin capsule
The study will be conducted at approximately 700 sites in approximately 40 countries globally.
Studietype
Intervensjonell
Registrering (Antatt)
3850
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: AstraZeneca Clinical Study Information Center
- Telefonnummer: 1-877-240-9479
- E-post: information.center@astrazeneca.com
Studiesteder
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Buenos Aires, Argentina, C1056ABJ
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Buenos Aires, Argentina, C1180AAX
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Buenos Aires, Argentina, 1416
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CABA, Argentina, C1425HFA
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Ciudad de Buenos Aires, Argentina, 1425DES
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Ciudad de Buenos Aires, Argentina, C1419AHL
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Corrientes, Argentina, W3400CDS
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Córdoba, Argentina, X5003DCE
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Córdoba, Argentina, X5006CBI
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Esperanza, Argentina, S3080BQU
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Granadero Baigorria, Argentina, S2152BOF
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Mar del Plata, Argentina, B7600GNY
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Rosario, Argentina, 2123
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San Juan Bautista, Argentina, 1888
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San Miguel de Tucumán, Argentina, 4000
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San Miguel de Tucumán, Argentina, 4000
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San Miguel de Tucumán, Argentina, T4000ICL
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Santa Fe, Argentina, S3000FWO
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Blacktown, Australia, 2148
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Cairns, Australia, 4870
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Canberra, Australia, 2605
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Chermside, Australia, 4032
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Clayton, Australia, 3168
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Concord, Australia, 2139
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Frankston, Australia, 3199
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Geelong, Australia, 3220
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Murdoch, Australia, WA6150
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North Tamworth, Australia, 2340
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Westmead, Australia, 2145
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Aracaju, Brasil, 49055-530
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Blumenau, Brasil, 89020-430
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Brasília, Brasil, 70200-730
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Campina Grande do Sul, Brasil, 83.430-000
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Campinas, Brasil, 13060-080
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Curitiba, Brasil, 80730-150
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Goiânia, Brasil, 74605-020
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Niterói, Brasil, 24033-900
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Porto Alegre, Brasil, 90035-903
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Rio Branco, Brasil, 69915-030
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Rio de Janeiro, Brasil, 20241-180
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Rio de Janeiro, Brasil, 22061-080
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Rio de Janeiro, Brasil, 20551-030
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São José dos Campos, Brasil, 12230-001
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São Paulo, Brasil, 05403-000
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São Paulo, Brasil, 04012-180
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Teresina, Brasil, 64049-550
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Uberlândia, Brasil, 38400-500
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Botevgrad, Bulgaria, 2140
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Dupnitsa, Bulgaria, 2600
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Haskovo, Bulgaria, 6300
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Kozloduy, Bulgaria, 3320
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Pleven, Bulgaria, 5800
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Plovdiv, Bulgaria, 4003
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Plovdiv, Bulgaria, 4000
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Sliven, Bulgaria, 8800
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Sliven, Bulgaria, 8800
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Sofia, Bulgaria, 1000
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Sofia, Bulgaria, 1606
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Sofia, Bulgaria, 1756
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Sofia, Bulgaria, 1431
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Sofia, Bulgaria, 1309
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Sofia, Bulgaria, 1618
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Stara Zagora, Bulgaria, 6000
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British Columbia
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New Westminster, British Columbia, Canada, V3L 3W4
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North Vancouver, British Columbia, Canada, V7M 2H4
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Vancouver, British Columbia, Canada, V6Z 1Y6
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Manitoba
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Winnipeg, Manitoba, Canada, R2H 2A6
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Nova Scotia
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Sydney, Nova Scotia, Canada, B1P 1P3
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Ontario
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Cambridge, Ontario, Canada, N1R 7R1
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Cambridge, Ontario, Canada, N1R 6V6
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Hamilton, Ontario, Canada, L8L 5G4
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London, Ontario, Canada, N6A 5A5
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Newmarket, Ontario, Canada, L3Y 2P6
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North York, Ontario, Canada, M6B 3H7
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Oakville, Ontario, Canada, L6K 3W7
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Oshawa, Ontario, Canada, L1J 2K1
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Ottawa, Ontario, Canada, K1Y 4W7
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Peterborough, Ontario, Canada, K9J 0B2
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Thunder Bay, Ontario, Canada, P7B 7C7
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Toronto, Ontario, Canada, M6G 1M2
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Waterloo, Ontario, Canada, N2T 0C1
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Quebec
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Chicoutimi, Quebec, Canada, G7H 7K9
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Greenfield Park, Quebec, Canada, J4V 2H1
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Montreal, Quebec, Canada, H4J 1C5
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Montreal, Quebec, Canada, H1T 1C8
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Montreal, Quebec, Canada, H2X 0C1
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Montreal, Quebec, Canada, H3G 1A4
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Saint-Jean-sur-Richelieu, Quebec, Canada, J3A 1J2
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Trois-Rivières, Quebec, Canada, G8T 7A1
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Trois-Rivières, Quebec, Canada, G9A 4P3
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Antofagasta, Chile, 1240000
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Concepción, Chile, 4070196
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Independencia, Chile, 8380465
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Punta Arenas, Chile, 6200000
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Region Metropolitana, Chile, 7550000
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San Bernardo, Chile, 8070996
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Santiago, Chile, 8380453
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Santiago, Chile, 8910259
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Santiago, Chile, 7500922
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Santiago, Chile, 7500587
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Santiago, Chile, 7770086
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Santiago, Chile, 8330034
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Talcahuano, Chile, 4270918
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Temuco, Chile, 4810345
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Temuco, Chile, 4781156
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Valdivia, Chile, 5110683
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Victoria, Chile, 4720097
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Armenia, Colombia, 630004
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Barranquilla, Colombia, 80007
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Barranquilla, Colombia, 080020
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Bogotá, Colombia, 111211
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Bogotá, Colombia, 110221
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Cali, Colombia, 760036
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Cali, Colombia, 760032
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Cartagena, Colombia, 130001
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Cartagena, Colombia, 130013
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Manizales, Colombia, 170004
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Medellín, Colombia, 050034
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Medellín, Colombia, 050030
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Piedecuesta, Colombia, 681017
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Rionegro, Colombia, 054047
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Angeles City, Filippinene, 2009
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Cebu City, Filippinene, 6000
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Cebu City, Filippinene, 6000
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City of Taguig, Filippinene, 1634
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Davao City, Filippinene, 8000
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Davao City, Filippinene, PH-8000
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Davao City, Filippinene, PH-8000
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Iloilo City, Filippinene, 5000
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Las Piñas, Filippinene, PH-1704
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Mabalacat, Filippinene, 2023
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Makati, Filippinene, 1209
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Manadaluyong City, Filippinene, 1552
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Manila, Filippinene, 1008
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Marikina City, Filippinene, 1800
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Pasig, Filippinene, 1605
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Quezon City, Filippinene, 1101
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Quezon City, Filippinene, 1112
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Quezon City, Filippinene
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Roxas City, Filippinene, 5800
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West San Juan City, Filippinene, 1502
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Helsinki, Finland, 00290
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Tampere, Finland, 33520
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Turku, Finland, 20520
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Alabama
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Alexander City, Alabama, Forente stater, 35010
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Birmingham, Alabama, Forente stater, 35209
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Fairhope, Alabama, Forente stater, 36532
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Huntsville, Alabama, Forente stater, 35801
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Arizona
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Phoenix, Arizona, Forente stater, 85016
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Phoenix, Arizona, Forente stater, 85044
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Arkansas
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Little Rock, Arkansas, Forente stater, 72205
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California
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Beverly Hills, California, Forente stater, 90211
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Covina, California, Forente stater, 91723
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Encinitas, California, Forente stater, 92024
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Los Angeles, California, Forente stater, 90089
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Los Angeles, California, Forente stater, 90073
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Newport Beach, California, Forente stater, 92663
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Orange, California, Forente stater, 92868
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Redding, California, Forente stater, 96001
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San Diego, California, Forente stater, 92123
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San Francisco, California, Forente stater, 94110
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San Francisco, California, Forente stater, 94121
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Santa Ana, California, Forente stater, 92704
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Thousand Oaks, California, Forente stater, 91360
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Vista, California, Forente stater, 92081
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West Hills, California, Forente stater, 91307
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Colorado
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Aurora, Colorado, Forente stater, 80045
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Wheat Ridge, Colorado, Forente stater, 80033
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Florida
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Altamonte Springs, Florida, Forente stater, 32701
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Boca Raton, Florida, Forente stater, 33486
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Bradenton, Florida, Forente stater, 34209
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Clearwater, Florida, Forente stater, 33756
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Delray Beach, Florida, Forente stater, 33484
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Fort Lauderdale, Florida, Forente stater, 33308
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Gainesville, Florida, Forente stater, 32610
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Jacksonville, Florida, Forente stater, 32209
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Miami, Florida, Forente stater, 33176
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Miami, Florida, Forente stater, 33133
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Miami Lakes, Florida, Forente stater, 33014
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Palm Beach Gardens, Florida, Forente stater, 33410
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Pensacola, Florida, Forente stater, 32503
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Port Charlotte, Florida, Forente stater, 33952
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Safety Harbor, Florida, Forente stater, 34695
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Saint Augustine, Florida, Forente stater, 32086
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St. Petersburg, Florida, Forente stater, 33701
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Tampa, Florida, Forente stater, 33617
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Georgia
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Atlanta, Georgia, Forente stater, 30303
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Atlanta, Georgia, Forente stater, 30309
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Peachtree City, Georgia, Forente stater, 30269
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Thomasville, Georgia, Forente stater, 31792
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Tucker, Georgia, Forente stater, 30084
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Illinois
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Chicago, Illinois, Forente stater, 60637
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Chicago, Illinois, Forente stater, 60612
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Glenview, Illinois, Forente stater, 60026
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Hazel Crest, Illinois, Forente stater, 60429
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North Chicago, Illinois, Forente stater, 60064
- Avsluttet
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Peoria, Illinois, Forente stater, 61614
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Winfield, Illinois, Forente stater, 60190
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Indiana
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Elkhart, Indiana, Forente stater, 46514
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Evansville, Indiana, Forente stater, 47710
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Hammond, Indiana, Forente stater, 46324
- Suspendert
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Indianapolis, Indiana, Forente stater, 46237
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Muncie, Indiana, Forente stater, 47303
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Munster, Indiana, Forente stater, 46321
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Richmond, Indiana, Forente stater, 47374
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Iowa
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Waterloo, Iowa, Forente stater, 50701
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Kansas
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Wichita, Kansas, Forente stater, 67226
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Wichita, Kansas, Forente stater, 67218
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Kentucky
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Louisville, Kentucky, Forente stater, 40202
- Avsluttet
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Louisiana
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Alexandria, Louisiana, Forente stater, 71301
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New Orleans, Louisiana, Forente stater, 70121
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Shreveport, Louisiana, Forente stater, 71105
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West Monroe, Louisiana, Forente stater, 71291
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Maine
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Augusta, Maine, Forente stater, 04330
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Maryland
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Rockville, Maryland, Forente stater, 20850
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Massachusetts
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Boston, Massachusetts, Forente stater, 02114
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Fall River, Massachusetts, Forente stater, 02721
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Worcester, Massachusetts, Forente stater, 01655
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Michigan
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Ann Arbor, Michigan, Forente stater, 48109
- Tilbaketrukket
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Bloomfield Hills, Michigan, Forente stater, 48304
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Dearborn, Michigan, Forente stater, 48126
- Avsluttet
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Farmington Hills, Michigan, Forente stater, 48334
- Tilbaketrukket
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Flint, Michigan, Forente stater, 48504
- Suspendert
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Troy, Michigan, Forente stater, 48098
- Tilbaketrukket
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Ypsilanti, Michigan, Forente stater, 48197
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Minnesota
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Minneapolis, Minnesota, Forente stater, 55455
- Tilbaketrukket
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Saint Paul, Minnesota, Forente stater, 55109
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Mississippi
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Jackson, Mississippi, Forente stater, 39216
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Missouri
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Columbia, Missouri, Forente stater, 65201
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Kansas City, Missouri, Forente stater, 64111
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Kansas City, Missouri, Forente stater, 64128
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Nebraska
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Lincoln, Nebraska, Forente stater, 68510
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Lincoln, Nebraska, Forente stater, 68506
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Nevada
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Henderson, Nevada, Forente stater, 89074
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North Las Vegas, Nevada, Forente stater, 89086
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New Jersey
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Bridgewater, New Jersey, Forente stater, 08807
- Tilbaketrukket
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Jersey City, New Jersey, Forente stater, 07302
- Rekruttering
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Somerset, New Jersey, Forente stater, 08873
- Rekruttering
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New York
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Albany, New York, Forente stater, 12208
- Tilbaketrukket
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Brooklyn, New York, Forente stater, 11219
- Rekruttering
- Research Site
-
Brooklyn, New York, Forente stater, 11220
- Tilbaketrukket
- Research Site
-
Clifton Park, New York, Forente stater, 12065
- Rekruttering
- Research Site
-
Manhasset, New York, Forente stater, 11030
- Tilbaketrukket
- Research Site
-
New Windsor, New York, Forente stater, 12553
- Tilbaketrukket
- Research Site
-
New York, New York, Forente stater, 10029
- Rekruttering
- Research Site
-
Staten Island, New York, Forente stater, 10310
- Rekruttering
- Research Site
-
Stony Brook, New York, Forente stater, 11794
- Tilbaketrukket
- Research Site
-
The Bronx, New York, Forente stater, 10455
- Rekruttering
- Research Site
-
The Bronx, New York, Forente stater, 10451
- Suspendert
- Research Site
-
-
North Carolina
-
Asheville, North Carolina, Forente stater, 28801
- Rekruttering
- Research Site
-
Chapel Hill, North Carolina, Forente stater, 27517
- Rekruttering
- Research Site
-
Charlotte, North Carolina, Forente stater, 28204
- Rekruttering
- Research Site
-
Durham, North Carolina, Forente stater, 27710
- Rekruttering
- Research Site
-
Greensboro, North Carolina, Forente stater, 27405
- Tilbaketrukket
- Research Site
-
Pinehurst, North Carolina, Forente stater, 28374
- Rekruttering
- Research Site
-
Statesville, North Carolina, Forente stater, 28625
- Tilbaketrukket
- Research Site
-
Wilmington, North Carolina, Forente stater, 28401
- Rekruttering
- Research Site
-
-
Ohio
-
Cincinnati, Ohio, Forente stater, 45219
- Tilbaketrukket
- Research Site
-
Cincinnati, Ohio, Forente stater, 45267
- Rekruttering
- Research Site
-
Dayton, Ohio, Forente stater, 45414
- Tilbaketrukket
- Research Site
-
Maumee, Ohio, Forente stater, 43537
- Tilbaketrukket
- Research Site
-
Springfield, Ohio, Forente stater, 45504
- Rekruttering
- Research Site
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forente stater, 73102
- Tilbaketrukket
- Research Site
-
-
Oregon
-
Portland, Oregon, Forente stater, 97225
- Rekruttering
- Research Site
-
-
Pennsylvania
-
Abington, Pennsylvania, Forente stater, 19001
- Rekruttering
- Research Site
-
Camp Hill, Pennsylvania, Forente stater, 17011
- Rekruttering
- Research Site
-
Hershey, Pennsylvania, Forente stater, 17033
- Rekruttering
- Research Site
-
Horsham, Pennsylvania, Forente stater, 19044
- Avsluttet
- Research Site
-
Philadelphia, Pennsylvania, Forente stater, 19104
- Rekruttering
- Research Site
-
-
Rhode Island
-
Providence, Rhode Island, Forente stater, 02908
- Rekruttering
- Research Site
-
-
South Carolina
-
Anderson, South Carolina, Forente stater, 29621
- Avsluttet
- Research Site
-
Charleston, South Carolina, Forente stater, 29401
- Rekruttering
- Research Site
-
Charleston, South Carolina, Forente stater, 29425
- Rekruttering
- Research Site
-
Ladson, South Carolina, Forente stater, 29456
- Tilbaketrukket
- Research Site
-
Lancaster, South Carolina, Forente stater, 29720
- Rekruttering
- Research Site
-
-
South Dakota
-
Rapid City, South Dakota, Forente stater, 57701
- Rekruttering
- Research Site
-
-
Tennessee
-
Jackson, Tennessee, Forente stater, 38305
- Rekruttering
- Research Site
-
Knoxville, Tennessee, Forente stater, 37916
- Rekruttering
- Research Site
-
Memphis, Tennessee, Forente stater, 38120
- Rekruttering
- Research Site
-
Memphis, Tennessee, Forente stater, 38128
- Avsluttet
- Research Site
-
Nashville, Tennessee, Forente stater, 37212
- Rekruttering
- Research Site
-
Tullahoma, Tennessee, Forente stater, 37388
- Rekruttering
- Research Site
-
-
Texas
-
Allen, Texas, Forente stater, 75013
- Rekruttering
- Research Site
-
Amarillo, Texas, Forente stater, 79106
- Rekruttering
- Research Site
-
Amarillo, Texas, Forente stater, 79121
- Rekruttering
- Research Site
-
Cypress, Texas, Forente stater, 77429
- Rekruttering
- Research Site
-
Dallas, Texas, Forente stater, 75216
- Rekruttering
- Research Site
-
Dallas, Texas, Forente stater, 75390
- Rekruttering
- Research Site
-
Dallas, Texas, Forente stater, 75204
- Rekruttering
- Research Site
-
El Paso, Texas, Forente stater, 79905
- Rekruttering
- Research Site
-
Houston, Texas, Forente stater, 77025
- Rekruttering
- Research Site
-
Houston, Texas, Forente stater, 77002
- Avsluttet
- Research Site
-
Katy, Texas, Forente stater, 77493
- Avsluttet
- Research Site
-
Mansfield, Texas, Forente stater, 76063
- Avsluttet
- Research Site
-
McKinney, Texas, Forente stater, 75069
- Rekruttering
- Research Site
-
McKinney, Texas, Forente stater, 75071
- Rekruttering
- Research Site
-
Odessa, Texas, Forente stater, 79761
- Rekruttering
- Research Site
-
Pearland, Texas, Forente stater, 77584
- Suspendert
- Research Site
-
San Antonio, Texas, Forente stater, 78229
- Rekruttering
- Research Site
-
Sherman, Texas, Forente stater, 75092
- Avsluttet
- Research Site
-
Temple, Texas, Forente stater, 76508
- Rekruttering
- Research Site
-
Tyler, Texas, Forente stater, 75702
- Rekruttering
- Research Site
-
Tyler, Texas, Forente stater, 75701
- Rekruttering
- Research Site
-
-
Utah
-
Salt Lake City, Utah, Forente stater, 84107
- Tilbaketrukket
- Research Site
-
Salt Lake City, Utah, Forente stater, 84148
- Rekruttering
- Research Site
-
-
Virginia
-
Falls Church, Virginia, Forente stater, 22042
- Rekruttering
- Research Site
-
Newport News, Virginia, Forente stater, 23606
- Rekruttering
- Research Site
-
-
Washington
-
Puyallup, Washington, Forente stater, 98372
- Tilbaketrukket
- Research Site
-
Seattle, Washington, Forente stater, 98101
- Tilbaketrukket
- Research Site
-
Tacoma, Washington, Forente stater, 98405
- Tilbaketrukket
- Research Site
-
-
-
-
-
Bron, Frankrike, 69667
- Tilbaketrukket
- Research Site
-
Béziers, Frankrike, 34500
- Rekruttering
- Research Site
-
Caen, Frankrike, 14033
- Tilbaketrukket
- Research Site
-
Cholet, Frankrike, 49300
- Rekruttering
- Research Site
-
Créteil, Frankrike, 94010
- Rekruttering
- Research Site
-
Dijon, Frankrike, 21079
- Rekruttering
- Research Site
-
La Roche-sur-Yon, Frankrike, 85925
- Rekruttering
- Research Site
-
La Tronche, Frankrike, 38043
- Tilbaketrukket
- Research Site
-
Le Coudray, Frankrike, 28630
- Tilbaketrukket
- Research Site
-
Limoges, Frankrike, 87000
- Rekruttering
- Research Site
-
Meaux, Frankrike, 77104
- Rekruttering
- Research Site
-
Montauban, Frankrike, 82017
- Tilbaketrukket
- Research Site
-
Montpellier, Frankrike, 34000
- Rekruttering
- Research Site
-
Montpellier, Frankrike, 34295
- Rekruttering
- Research Site
-
Nantes, Frankrike, 44093
- Avsluttet
- Research Site
-
Orléans, Frankrike, 45100
- Tilbaketrukket
- Research Site
-
Paris, Frankrike, 75010
- Rekruttering
- Research Site
-
Paris, Frankrike, 75015
- Rekruttering
- Research Site
-
Poitiers, Frankrike, 86021
- Rekruttering
- Research Site
-
Reims, Frankrike, 51092
- Rekruttering
- Research Site
-
Rennes, Frankrike, 35033
- Rekruttering
- Research Site
-
Rouen, Frankrike, 76031
- Rekruttering
- Research Site
-
Saint-Quentin, Frankrike, 02100
- Tilbaketrukket
- Research Site
-
Strasbourg, Frankrike, 67091
- Tilbaketrukket
- Research Site
-
Toulon, Frankrike, 83100
- Rekruttering
- Research Site
-
Toulouse, Frankrike, 31059
- Avsluttet
- Research Site
-
Tours, Frankrike, 37044
- Tilbaketrukket
- Research Site
-
Valenciennes, Frankrike, 59300
- Rekruttering
- Research Site
-
-
-
-
-
Athens, Hellas, 11528
- Rekruttering
- Research Site
-
Athens, Hellas, 12462
- Rekruttering
- Research Site
-
Athens, Hellas, 11527
- Rekruttering
- Research Site
-
Athens, Hellas, 11526
- Rekruttering
- Research Site
-
Athens, Hellas, 11521
- Rekruttering
- Research Site
-
Athens, Hellas, 14233
- Rekruttering
- Research Site
-
Athens, Hellas, 15123
- Rekruttering
- Research Site
-
Dragana, Hellas, 68100
- Rekruttering
- Research Site
-
Heraklio, Hellas, 71110
- Fullført
- Research Site
-
Thessaloniki, Hellas, 54642
- Rekruttering
- Research Site
-
Thessaloniki, Hellas, 54636
- Rekruttering
- Research Site
-
-
-
-
-
Ahmedabad, India, 380054
- Tilbaketrukket
- Research Site
-
Ajmer, India, 305001
- Tilbaketrukket
- Research Site
-
Amritsar, India, 143501
- Tilbaketrukket
- Research Site
-
Bangalore, India, 560099
- Suspendert
- Research Site
-
Belagavi, India, 590010
- Rekruttering
- Research Site
-
Coimbatore, India, 641018
- Rekruttering
- Research Site
-
Dehradun, India, 248001
- Rekruttering
- Research Site
-
Delhi, India, 110029
- Rekruttering
- Research Site
-
Delhi, India, 110062
- Rekruttering
- Research Site
-
Hyderabad, India, 500035
- Rekruttering
- Research Site
-
Hyderabad, India, 500018
- Tilbaketrukket
- Research Site
-
Hyderabad, India, 500034
- Avsluttet
- Research Site
-
Kanpur, India, 208001
- Rekruttering
- Research Site
-
Karamsad, India, 388345
- Tilbaketrukket
- Research Site
-
Kolkata, India, 700014
- Rekruttering
- Research Site
-
Kolkata, India, 700020
- Suspendert
- Research Site
-
Ludhiana, India, 141001
- Rekruttering
- Research Site
-
Manipal, India, 576104
- Avsluttet
- Research Site
-
Meerut, India, 250005
- Rekruttering
- Research Site
-
Mysuru, India, 570015
- Tilbaketrukket
- Research Site
-
Nagpur, India, 441108
- Tilbaketrukket
- Research Site
-
New Delhi, India, 110029
- Rekruttering
- Research Site
-
New Delhi, India, 110017
- Rekruttering
- Research Site
-
New Delhi, India, 110002
- Rekruttering
- Research Site
-
Pune, India, 411001
- Tilbaketrukket
- Research Site
-
Rudrapur, India, 263153
- Suspendert
- Research Site
-
Srinagar, India, 190015
- Tilbaketrukket
- Research Site
-
Vadodara, India, 390022
- Rekruttering
- Research Site
-
Vijayawada, India, 520 008
- Avsluttet
- Research Site
-
-
-
-
-
Afula, Israel, 1834111
- Rekruttering
- Research Site
-
Ashkelon, Israel, 78278
- Rekruttering
- Research Site
-
Beersheba, Israel, 8410101
- Rekruttering
- Research Site
-
Be’er Ya‘aqov, Israel, 70300
- Rekruttering
- Research Site
-
Haifa, Israel, 3109601
- Rekruttering
- Research Site
-
Holon, Israel, 5840608
- Rekruttering
- Research Site
-
Jerusalem, Israel, 00000
- Rekruttering
- Research Site
-
Kfar Saba, Israel, 4428164
- Rekruttering
- Research Site
-
Nahariya, Israel, 22100
- Rekruttering
- Research Site
-
Petah Tikva, Israel, 49372
- Rekruttering
- Research Site
-
Tel Aviv, Israel, 6423906
- Rekruttering
- Research Site
-
Tiberias, Israel, 15208
- Rekruttering
- Research Site
-
-
-
-
-
Acquaviva delle Fonti, Italia, 70021
- Tilbaketrukket
- Research Site
-
Bari, Italia, 70124
- Rekruttering
- Research Site
-
Bergamo, Italia, 24127
- Rekruttering
- Research Site
-
Brescia, Italia, 25100
- Rekruttering
- Research Site
-
Catania, Italia, 95100
- Rekruttering
- Research Site
-
Catanzaro, Italia, 88100
- Rekruttering
- Research Site
-
Cona, Italia, 44124
- Rekruttering
- Research Site
-
Cortona, Italia, 52044
- Rekruttering
- Research Site
-
Florence, Italia, 50134
- Tilbaketrukket
- Research Site
-
Milan, Italia, 20138
- Rekruttering
- Research Site
-
Novara, Italia, 28100
- Tilbaketrukket
- Research Site
-
Pavia, Italia, 27100
- Rekruttering
- Research Site
-
San Giovanni Rotondo, Italia, 71013
- Tilbaketrukket
- Research Site
-
-
-
-
-
Beppu-shi, Japan, 874-0011
- Rekruttering
- Research Site
-
Bunkyō City, Japan, 113-8431
- Rekruttering
- Research Site
-
Fujisawa-shi, Japan, 251-8550
- Rekruttering
- Research Site
-
Fukui-shi, Japan, 910-8526
- Rekruttering
- Research Site
-
Fukuoka, Japan, 812-8582
- Rekruttering
- Research Site
-
Fukuoka, Japan, 810-8563
- Rekruttering
- Research Site
-
Fukuoka, Japan, 815-8555
- Rekruttering
- Research Site
-
Fukutsu-shi, Japan, 811-3298
- Rekruttering
- Research Site
-
Hakusan-shi, Japan, 924-8588
- Rekruttering
- Research Site
-
Higashiibaraki-gun, Japan, 311-3193
- Rekruttering
- Research Site
-
Himeji, Japan, 670-8560
- Rekruttering
- Research Site
-
Iwakuni-shi, Japan, 740-8510
- Rekruttering
- Research Site
-
Kanazawa, Japan, 920-8530
- Rekruttering
- Research Site
-
Kanazawa, Japan, 920-8650
- Tilbaketrukket
- Research Site
-
Kanonji-shi, Japan, 769-1695
- Rekruttering
- Research Site
-
Kasuga-shi, Japan, 816-0864
- Tilbaketrukket
- Research Site
-
Kasugai-shi, Japan, 486-8510
- Rekruttering
- Research Site
-
Kawaguchi, Japan, 333-0842
- Rekruttering
- Research Site
-
Kawanishi-shi, Japan, 666-0125
- Rekruttering
- Research Site
-
Kishiwada-shi, Japan, 596-8522
- Rekruttering
- Research Site
-
Kitakyusyu-shi, Japan, 806-8501
- Tilbaketrukket
- Research Site
-
Kobe, Japan, 654-0155
- Rekruttering
- Research Site
-
Kochi, Japan, 780-8535
- Rekruttering
- Research Site
-
Kure-shi, Japan, 737-8505
- Rekruttering
- Research Site
-
Maebashi, Japan, 371-8511
- Rekruttering
- Research Site
-
Matsumoto-shi, Japan, 390-8621
- Rekruttering
- Research Site
-
Meguro-ku, Japan, 152-8902
- Rekruttering
- Research Site
-
Mito, Japan, 311-4198
- Rekruttering
- Research Site
-
Moriyama-shi, Japan, 524-8524
- Rekruttering
- Research Site
-
Nagoya, Japan, 460-0001
- Tilbaketrukket
- Research Site
-
Osaka, Japan, 540-0006
- Rekruttering
- Research Site
-
Osaka, Japan, 543-0035
- Rekruttering
- Research Site
-
Sagamihara-shi, Japan, 252-5188
- Rekruttering
- Research Site
-
Saitama Shi, Japan, 336 8522
- Rekruttering
- Research Site
-
Saitama-shi, Japan, 339-0033
- Tilbaketrukket
- Research Site
-
Sakaishi, Japan, 599-8247
- Rekruttering
- Research Site
-
Sakata, Japan, 998-8501
- Tilbaketrukket
- Research Site
-
Sanyoonoda-shi, Japan, 756-0095
- Rekruttering
- Research Site
-
Toshima-ku, Japan, 171-0014
- Rekruttering
- Research Site
-
Toyota, Japan, 470-0396
- Rekruttering
- Research Site
-
Tsuchiura-shi, Japan, 300-0028
- Avsluttet
- Research Site
-
Ueda-shi, Japan, 386-8610
- Rekruttering
- Research Site
-
Uji-shi, Japan, 611-0041
- Rekruttering
- Research Site
-
Uwajima-shi, Japan, 798-8510
- Rekruttering
- Research Site
-
Yanagawa-shi, Japan, 832-0077
- Rekruttering
- Research Site
-
Yokohama, Japan, 221-0855
- Rekruttering
- Research Site
-
Yokohama, Japan, 227-8501
- Tilbaketrukket
- Research Site
-
Yokohama, Japan, 245-8575
- Tilbaketrukket
- Research Site
-
Ōita, Japan, 870-8511
- Rekruttering
- Research Site
-
-
-
-
-
Baotou, Kina, 14010
- Rekruttering
- Research Site
-
Beijing, Kina, 100029
- Tilbaketrukket
- Research Site
-
Beijing, Kina, 100730
- Rekruttering
- Research Site
-
Beijing, Kina, 100034
- Rekruttering
- Research Site
-
Beijing, Kina, 100037
- Rekruttering
- Research Site
-
Beijing, Kina, 100029
- Avsluttet
- Research Site
-
Changchun, Kina, 130033
- Rekruttering
- Research Site
-
Changsha, Kina, 430033
- Rekruttering
- Research Site
-
Changsha, Kina, 410015
- Rekruttering
- Research Site
-
Chengdu, Kina, 610041
- Rekruttering
- Research Site
-
Chengdu, Kina, 610072
- Rekruttering
- Research Site
-
Chifeng, Kina, 024000
- Rekruttering
- Research Site
-
Chongqing, Kina, 404197
- Rekruttering
- Research Site
-
Guangzhou, Kina, 510630
- Rekruttering
- Research Site
-
Guangzhou, Kina, 510515
- Rekruttering
- Research Site
-
Guangzhou, Kina, 510100
- Rekruttering
- Research Site
-
Hangzhou, Kina, 310014
- Rekruttering
- Research Site
-
Harbin, Kina, 150001
- Rekruttering
- Research Site
-
Hengyang, Kina, 421001
- Rekruttering
- Research Site
-
Heze, Kina, 274099
- Rekruttering
- Research Site
-
Hohhot, Kina, 010017
- Tilbaketrukket
- Research Site
-
Jinan, Kina, 250013
- Rekruttering
- Research Site
-
Jining, Kina, 272029
- Rekruttering
- Research Site
-
Lanzhou, Kina, 730030
- Rekruttering
- Research Site
-
Liaocheng, Kina, 252000
- Rekruttering
- Research Site
-
Linhai, Kina, 317000
- Rekruttering
- Research Site
-
Nanchang, Kina, 330009
- Rekruttering
- Research Site
-
Nanchong, Kina, 637900
- Fullført
- Research Site
-
Nanjing, Kina, 210009
- Rekruttering
- Research Site
-
Nanjing, Kina, 2100008
- Rekruttering
- Research Site
-
Nanjing, Kina, 210029
- Rekruttering
- Research Site
-
Nanjing, Kina, 210011
- Rekruttering
- Research Site
-
Ningbo, Kina, 315040
- Rekruttering
- Research Site
-
Pingxiang, Kina, 337055
- Rekruttering
- Research Site
-
Quzhou, Kina, 342000
- Rekruttering
- Research Site
-
Sanya, Kina, 572000
- Rekruttering
- Research Site
-
Shanghai, Kina, 200025
- Rekruttering
- Research Site
-
Shanghai, Kina, 200062
- Rekruttering
- Research Site
-
Shenyang, Kina, 110004
- Rekruttering
- Research Site
-
Shenzhen, Kina, 518053
- Rekruttering
- Research Site
-
Wuhan, Kina, 430030
- Tilbaketrukket
- Research Site
-
Wuhan, Kina, 430022
- Tilbaketrukket
- Research Site
-
Xi'an, Kina, 710061
- Rekruttering
- Research Site
-
Xi'an, Kina, 710068
- Rekruttering
- Research Site
-
Xianyang, Kina, 750004
- Tilbaketrukket
- Research Site
-
Xuzhou, Kina, 221000
- Rekruttering
- Research Site
-
Xuzhou, Kina, 221009
- Rekruttering
- Research Site
-
Yangzhou, Kina, 225001
- Rekruttering
- Research Site
-
Zhangjiakou, Kina, 075061
- Rekruttering
- Research Site
-
Zunyi, Kina, 563100
- Rekruttering
- Research Site
-
Ürümqi, Kina, CN-830004
- Rekruttering
- Research Site
-
-
-
-
-
Kajang, Malaysia, 43000
- Rekruttering
- Research Site
-
Kota Kinabalu, Malaysia, 88300
- Rekruttering
- Research Site
-
Kota Samarahan, Malaysia, 94300
- Rekruttering
- Research Site
-
Kuala Lumpur, Malaysia, 50400
- Rekruttering
- Research Site
-
Kuala Terengganu, Malaysia, 20400
- Rekruttering
- Research Site
-
Kuantan, Malaysia, 25200
- Rekruttering
- Research Site
-
Sungai Buloh, Malaysia, 47000
- Rekruttering
- Research Site
-
-
-
-
-
Aguascalientes, Mexico, 20230
- Rekruttering
- Research Site
-
Aguascalientes, Mexico, 20230
- Tilbaketrukket
- Research Site
-
Chihuahua City, Mexico, 31203
- Rekruttering
- Research Site
-
Cuauhtémoc, Mexico, 06700
- Rekruttering
- Research Site
-
Cuauhtémoc, Mexico, 6720
- Tilbaketrukket
- Research Site
-
Culiacán, Mexico, 80230
- Rekruttering
- Research Site
-
Culiacán, Mexico, 80200
- Rekruttering
- Research Site
-
Guadalajara, Mexico, 44670
- Rekruttering
- Research Site
-
Mazatlán, Mexico, 82110
- Tilbaketrukket
- Research Site
-
Metepec, Mexico, 52170
- Rekruttering
- Research Site
-
Mexico City, Mexico, 03310
- Tilbaketrukket
- Research Site
-
Mexico City, Mexico, 07300
- Tilbaketrukket
- Research Site
-
Monterrey, Mexico, 64460
- Tilbaketrukket
- Research Site
-
Monterrey, Mexico, 64060
- Tilbaketrukket
- Research Site
-
Morelia, Mexico, 58260
- Tilbaketrukket
- Research Site
-
México, Mexico, 14080
- Tilbaketrukket
- Research Site
-
México, Mexico, 07020
- Rekruttering
- Research Site
-
México, Mexico, 11650
- Tilbaketrukket
- Research Site
-
Querétaro, Mexico, 76000
- Rekruttering
- Research Site
-
San Luis Potosí City, Mexico, 78250
- Tilbaketrukket
- Research Site
-
Tijuana, Mexico, 22150
- Rekruttering
- Research Site
-
Torreón, Mexico, 27000
- Rekruttering
- Research Site
-
Veracruz, Mexico, 91910
- Tilbaketrukket
- Research Site
-
Xalapa, Mexico, 91193
- Rekruttering
- Research Site
-
-
-
-
-
Amsterdam, Nederland, 1091 AC
- Rekruttering
- Research Site
-
Arnhem, Nederland, 6815 AD
- Rekruttering
- Research Site
-
Emmen, Nederland, 7824 AA
- Rekruttering
- Research Site
-
Goes, Nederland, 4462 RA
- Rekruttering
- Research Site
-
Hardenberg, Nederland, 7772 SE
- Rekruttering
- Research Site
-
Leeuwarden, Nederland, 8934 AD
- Rekruttering
- Research Site
-
-
-
-
-
Bellavista, Peru, CALLAO 2
- Rekruttering
- Research Site
-
Cusco, Peru, CUSCO 01
- Tilbaketrukket
- Research Site
-
Lima, Peru, 15088
- Rekruttering
- Research Site
-
Lima, Peru, 15046
- Rekruttering
- Research Site
-
Lima, Peru, 15038
- Tilbaketrukket
- Research Site
-
Lima, Peru, LIMA 27
- Rekruttering
- Research Site
-
Lima, Peru, 15046
- Tilbaketrukket
- Research Site
-
Lima, Peru, L18
- Tilbaketrukket
- Research Site
-
Lima, Peru, 15131
- Tilbaketrukket
- Research Site
-
Lima, Peru, LIMA 41
- Rekruttering
- Research Site
-
Lima, Peru, 15024
- Rekruttering
- Research Site
-
Lima, Peru, LIMA 11
- Rekruttering
- Research Site
-
Lima, Peru, 15102
- Tilbaketrukket
- Research Site
-
Lima, Peru, 15072
- Tilbaketrukket
- Research Site
-
Piura, Peru, 20001
- Rekruttering
- Research Site
-
-
-
-
-
Biała Podlaska, Polen, 21-500
- Rekruttering
- Research Site
-
Bielsko-Biala, Polen, 43-316
- Tilbaketrukket
- Research Site
-
Bydgoszcz, Polen, 85-605
- Tilbaketrukket
- Research Site
-
Bydgoszcz, Polen, 85-794
- Avsluttet
- Research Site
-
Chrzanów, Polen, 32-500
- Rekruttering
- Research Site
-
Gdansk, Polen, 80-214
- Rekruttering
- Research Site
-
Gdansk, Polen, 80-462
- Rekruttering
- Research Site
-
Gdynia, Polen, 81-157
- Tilbaketrukket
- Research Site
-
Katowice, Polen, 40-600
- Rekruttering
- Research Site
-
Kazimierza Wielka, Polen, 28-500
- Rekruttering
- Research Site
-
Krakow, Polen, 31-121
- Rekruttering
- Research Site
-
Krakow, Polen, 30-082
- Rekruttering
- Research Site
-
Krakow, Polen, 30-688
- Rekruttering
- Research Site
-
Krakow, Polen, 31-322
- Rekruttering
- Research Site
-
Krakow, Polen, 31-513
- Tilbaketrukket
- Research Site
-
Kędzierzyn-Koźle, Polen, 47-200
- Rekruttering
- Research Site
-
Lodz, Polen, 93-513
- Rekruttering
- Research Site
-
Lodz, Polen, 90-549
- Rekruttering
- Research Site
-
Lodz, Polen, 91-053
- Tilbaketrukket
- Research Site
-
Lodz, Polen, 94-046
- Suspendert
- Research Site
-
Lublin, Polen, 20-857
- Rekruttering
- Research Site
-
Lublin, Polen, 20-068
- Rekruttering
- Research Site
-
Lublin, Polen, 20-044
- Fullført
- Research Site
-
Olsztyn, Polen, 10-165
- Rekruttering
- Research Site
-
Ostrów Mazowiecka, Polen, 07-300
- Rekruttering
- Research Site
-
Piekary Śląskie, Polen, 41-940
- Rekruttering
- Research Site
-
Poznan, Polen, 61- 848
- Rekruttering
- Research Site
-
Poznan, Polen, 60-266
- Suspendert
- Research Site
-
Rzeszów, Polen, 35-205
- Rekruttering
- Research Site
-
Rzeszów, Polen, 35-055
- Tilbaketrukket
- Research Site
-
Szczecin, Polen, 71-526
- Rekruttering
- Research Site
-
Tarnów, Polen, 33-100
- Rekruttering
- Research Site
-
Torun, Polen, 87-100
- Rekruttering
- Research Site
-
Tychy, Polen, 43-100
- Rekruttering
- Research Site
-
Warsaw, Polen, 00-124
- Rekruttering
- Research Site
-
Warsaw, Polen, 00-416
- Tilbaketrukket
- Research Site
-
Warsaw, Polen, 04-501
- Tilbaketrukket
- Research Site
-
Wroclaw, Polen, 53-602
- Tilbaketrukket
- Research Site
-
Wroclaw, Polen, 53-605
- Rekruttering
- Research Site
-
Zabrze, Polen, 41-800
- Rekruttering
- Research Site
-
-
-
-
-
Afumaţi, Romania, 077010
- Rekruttering
- Research Site
-
Arad, Romania, 310037
- Rekruttering
- Research Site
-
Baia Mare, Romania, 430222
- Rekruttering
- Research Site
-
Brasov, Romania, 500102
- Rekruttering
- Research Site
-
Brasov, Romania, 500388
- Rekruttering
- Research Site
-
Bucharest, Romania, 014461
- Rekruttering
- Research Site
-
Bucharest, Romania, 022328
- Rekruttering
- Research Site
-
Bucharest, Romania, 040883
- Tilbaketrukket
- Research Site
-
Bucharest, Romania, 010825
- Tilbaketrukket
- Research Site
-
Bucharest, Romania, 014461
- Avsluttet
- Research Site
-
Cluj-Napoca, Romania, 400437
- Avsluttet
- Research Site
-
Iași, Romania, 700503
- Rekruttering
- Research Site
-
Iași, Romania, 700010
- Tilbaketrukket
- Research Site
-
Satu Mare, Romania, 440055
- Rekruttering
- Research Site
-
Timișoara, Romania, 300254
- Rekruttering
- Research Site
-
Timișoara, Romania, 300310
- Avsluttet
- Research Site
-
Târgu Mureş, Romania, 540099
- Rekruttering
- Research Site
-
Târgu Mureş, Romania, 540136
- Rekruttering
- Research Site
-
-
-
-
-
Dammam, Saudi-Arabia, 31463
- Rekruttering
- Research Site
-
Jeddah, Saudi-Arabia, 22384
- Rekruttering
- Research Site
-
Riyadh, Saudi-Arabia, 11426
- Rekruttering
- Research Site
-
Riyadh, Saudi-Arabia, 11525
- Rekruttering
- Research Site
-
Riyadh, Saudi-Arabia, 12713
- Rekruttering
- Research Site
-
Riyadh, Saudi-Arabia, 11462
- Rekruttering
- Research Site
-
Riyadh, Saudi-Arabia, 11481
- Tilbaketrukket
- Research Site
-
-
-
-
-
Banská Bystrica, Slovakia, 974 01
- Rekruttering
- Research Site
-
Bratislava, Slovakia, 831 01
- Rekruttering
- Research Site
-
Bratislava, Slovakia, 841 08
- Rekruttering
- Research Site
-
Brezno, Slovakia, 977 01
- Rekruttering
- Research Site
-
Košice, Slovakia, 04022
- Rekruttering
- Research Site
-
Košice, Slovakia, 040 01
- Rekruttering
- Research Site
-
Martin, Slovakia, 036 01
- Rekruttering
- Research Site
-
Myjava, Slovakia, 90701
- Rekruttering
- Research Site
-
Nitra, Slovakia, 949 01
- Rekruttering
- Research Site
-
Nové Zámky, Slovakia, 940 01
- Tilbaketrukket
- Research Site
-
Považská Bystrica, Slovakia, 017 01
- Rekruttering
- Research Site
-
Prešov, Slovakia, 080 01
- Tilbaketrukket
- Research Site
-
Rimavská Sobota, Slovakia, 979 01
- Suspendert
- Research Site
-
Svidník, Slovakia, 08901
- Rekruttering
- Research Site
-
-
-
-
-
A Coruña, Spania, 15006
- Rekruttering
- Research Site
-
Barcelona, Spania, 08035
- Rekruttering
- Research Site
-
Barcelona, Spania, 08036
- Rekruttering
- Research Site
-
Barcelona, Spania, 08025
- Rekruttering
- Research Site
-
Lugo, Spania, 27004
- Rekruttering
- Research Site
-
Madrid, Spania, 28007
- Rekruttering
- Research Site
-
Madrid, Spania, 28027
- Rekruttering
- Research Site
-
Majadahonda, Spania, 28222
- Rekruttering
- Research Site
-
Seville, Spania, 41013
- Rekruttering
- Research Site
-
Seville, Spania, 41004
- Rekruttering
- Research Site
-
Seville, Spania, 41071
- Rekruttering
- Research Site
-
Valencia, Spania, 46010
- Rekruttering
- Research Site
-
-
-
-
-
Airdrie, Storbritannia, ML6 0JS
- Rekruttering
- Research Site
-
Barnet, Storbritannia, EN5 3DJ
- Rekruttering
- Research Site
-
Cambridge, Storbritannia, CB2 0AY
- Tilbaketrukket
- Research Site
-
Clydebank, Storbritannia, G81 4DY
- Rekruttering
- Research Site
-
Exeter, Storbritannia, EX2 5DW
- Rekruttering
- Research Site
-
Harefield, Storbritannia, UB9 6JH
- Rekruttering
- Research Site
-
Hastings, Storbritannia, TN37 7RD
- Rekruttering
- Research Site
-
High Wycombe, Storbritannia, HP11 2TT
- Tilbaketrukket
- Research Site
-
Kent, Storbritannia, BR6 8ND
- Rekruttering
- Research Site
-
Kings Lynn, Storbritannia, PE30 4ET
- Rekruttering
- Research Site
-
Lincoln, Storbritannia, LN2 5QY
- Tilbaketrukket
- Research Site
-
London, Storbritannia, SE5 9RS
- Tilbaketrukket
- Research Site
-
London, Storbritannia, EC1M 6BQ
- Fullført
- Research Site
-
Middlesbrough, Storbritannia, TS4 3BW
- Rekruttering
- Research Site
-
Portsmouth, Storbritannia, PO6 3LY
- Rekruttering
- Research Site
-
Sheffield, Storbritannia, S5 7AU
- Tilbaketrukket
- Research Site
-
Sunderland, Storbritannia, SR4 7TP
- Rekruttering
- Research Site
-
Wakefield, Storbritannia, WF1 4DG
- Rekruttering
- Research Site
-
-
-
-
-
Alingsås, Sverige, 441 83
- Tilbaketrukket
- Research Site
-
Gothenburg, Sverige, 413 46
- Rekruttering
- Research Site
-
Jönköping, Sverige, 55305
- Rekruttering
- Research Site
-
Karlstad, Sverige, 651 85
- Rekruttering
- Research Site
-
Mölndal, Sverige, SE431 80
- Rekruttering
- Research Site
-
Stockholm, Sverige, 112 81
- Rekruttering
- Research Site
-
Stockholm, Sverige, 118 83
- Rekruttering
- Research Site
-
Stockholm, Sverige, 18288
- Rekruttering
- Research Site
-
Stockholm, Sverige, 171 64
- Rekruttering
- Research Site
-
Uppsala, Sverige, 751 85
- Rekruttering
- Research Site
-
Västerås, Sverige, 721 89
- Rekruttering
- Research Site
-
-
-
-
-
Anyang-si, Sør -Korea, 14068
- Rekruttering
- Research Site
-
Bucheon-si, Sør -Korea, 14754
- Rekruttering
- Research Site
-
Busan, Sør -Korea, 47392
- Rekruttering
- Research Site
-
Busan, Sør -Korea, 49201
- Rekruttering
- Research Site
-
Busan, Sør -Korea, 49241
- Rekruttering
- Research Site
-
Busan, Sør -Korea, 49267
- Rekruttering
- Research Site
-
Cheongju-si, Sør -Korea, 28644
- Rekruttering
- Research Site
-
Daegu, Sør -Korea, 42601
- Rekruttering
- Research Site
-
Daejeon, Sør -Korea, 35015
- Rekruttering
- Research Site
-
Gwangju, Sør -Korea, 61469
- Rekruttering
- Research Site
-
Gwangmyeong, Sør -Korea, 14353
- Rekruttering
- Research Site
-
Incheon, Sør -Korea, 21565
- Rekruttering
- Research Site
-
Junggu, Sør -Korea, 22332
- Rekruttering
- Research Site
-
Seongnam-si, Sør -Korea, 13620
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 03080
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 05505
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 03722
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 06591
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 08308
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 02841
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 04763
- Rekruttering
- Research Site
-
Seoul, Sør -Korea, 06351
- Tilbaketrukket
- Research Site
-
Uijeongbu-si, Sør -Korea, 11765
- Rekruttering
- Research Site
-
Wŏnju, Sør -Korea, 26426
- Avsluttet
- Research Site
-
Yangsan, Sør -Korea, 50612
- Rekruttering
- Research Site
-
-
-
-
-
Bloemfontein, Sør-Afrika, 9301
- Rekruttering
- Research Site
-
Centurion, Sør-Afrika, 0157
- Rekruttering
- Research Site
-
Durban, Sør-Afrika, 4052
- Rekruttering
- Research Site
-
Johannesburg, Sør-Afrika, 2193
- Rekruttering
- Research Site
-
KwaDukuza, Sør-Afrika, 4449
- Rekruttering
- Research Site
-
Panorama, Sør-Afrika, 7500
- Rekruttering
- Research Site
-
Parow, Sør-Afrika, 7505
- Rekruttering
- Research Site
-
Pietermaritzburg, Sør-Afrika, 3201
- Rekruttering
- Research Site
-
Somerset West, Sør-Afrika, 7130
- Rekruttering
- Research Site
-
Soweto, Sør-Afrika, 2013
- Rekruttering
- Research Site
-
Worcester, Sør-Afrika, 6850
- Tilbaketrukket
- Research Site
-
-
-
-
-
Changhua, Taiwan, 500
- Rekruttering
- Research Site
-
Kaohsiung City, Taiwan, 80756
- Rekruttering
- Research Site
-
Kaohsiung City, Taiwan, 81362
- Rekruttering
- Research Site
-
New Taipei City, Taiwan, 220
- Rekruttering
- Research Site
-
New Taipei City, Taiwan, 25160
- Rekruttering
- Research Site
-
New Taipei City, Taiwan, 231
- Rekruttering
- Research Site
-
Taichung, Taiwan, 40447
- Rekruttering
- Research Site
-
Taichung, Taiwan, 40705
- Rekruttering
- Research Site
-
Taichung, Taiwan, 433004
- Rekruttering
- Research Site
-
Taipei, Taiwan, TAIWAN
- Rekruttering
- Research Site
-
Taipei, Taiwan, 10002
- Rekruttering
- Research Site
-
Taipei, Taiwan, 11217
- Rekruttering
- Research Site
-
Taipei, Taiwan, 10449
- Rekruttering
- Research Site
-
Taipei, Taiwan, 0116
- Rekruttering
- Research Site
-
Taipei, Taiwan, 11101
- Rekruttering
- Research Site
-
Taipei, Taiwan, 110
- Rekruttering
- Research Site
-
Taoyuan, Taiwan, 333
- Rekruttering
- Research Site
-
Yilan, Taiwan, 260
- Rekruttering
- Research Site
-
Yung Kang City, Taiwan, 71044
- Rekruttering
- Research Site
-
-
-
-
-
Bangkok, Thailand, 10400
- Rekruttering
- Research Site
-
Bangkok, Thailand, 10330
- Rekruttering
- Research Site
-
Bangkok, Thailand, 10700
- Rekruttering
- Research Site
-
Chiang Mai, Thailand, 50200
- Rekruttering
- Research Site
-
Hat Yai, Thailand, 90110
- Rekruttering
- Research Site
-
Khon Kaen, Thailand, 40002
- Rekruttering
- Research Site
-
Naimuang, Thailand, 30000
- Rekruttering
- Research Site
-
Pathum Thani, Thailand, 12120
- Rekruttering
- Research Site
-
-
-
-
-
Brno, Tsjekkia, 60200
- Rekruttering
- Research Site
-
Brno, Tsjekkia, 639 00
- Avsluttet
- Research Site
-
Broumov, Tsjekkia, 55001
- Rekruttering
- Research Site
-
Jaroměř, Tsjekkia, 551 01
- Rekruttering
- Research Site
-
Louny, Tsjekkia, 440 01
- Rekruttering
- Research Site
-
Ostrava, Tsjekkia, 702 00
- Rekruttering
- Research Site
-
Ostrava, Tsjekkia, 702 00
- Suspendert
- Research Site
-
Pilsen, Tsjekkia, 31001
- Tilbaketrukket
- Research Site
-
Plzen - Bory, Tsjekkia, 305 99
- Rekruttering
- Research Site
-
Prague, Tsjekkia, 120 00
- Avsluttet
- Research Site
-
Přerov, Tsjekkia, 75152
- Fullført
- Research Site
-
Slaný, Tsjekkia, 274 01
- Rekruttering
- Research Site
-
Svitavy, Tsjekkia, 568 02
- Rekruttering
- Research Site
-
Ustí Nad Labem, Tsjekkia, 40011
- Tilbaketrukket
- Research Site
-
Zlín, Tsjekkia, 760 01
- Rekruttering
- Research Site
-
Ústí nad Labem, Tsjekkia, 400 01
- Rekruttering
- Research Site
-
Česká Lípa, Tsjekkia, 470 77
- Rekruttering
- Research Site
-
-
-
-
-
Adana, Tyrkia (Türkiye), 01060
- Rekruttering
- Research Site
-
Ankara, Tyrkia (Türkiye), 06
- Rekruttering
- Research Site
-
Antalya, Tyrkia (Türkiye), 07059
- Rekruttering
- Research Site
-
Antalya, Tyrkia (Türkiye), 07100
- Rekruttering
- Research Site
-
Bursa, Tyrkia (Türkiye), 16059
- Fullført
- Research Site
-
Center, Tyrkia (Türkiye), 78200
- Rekruttering
- Research Site
-
Dinar, Tyrkia (Türkiye), 03400
- Rekruttering
- Research Site
-
Eskişehir, Tyrkia (Türkiye), 26480
- Rekruttering
- Research Site
-
Istanbul, Tyrkia (Türkiye), 34668
- Tilbaketrukket
- Research Site
-
Izmir, Tyrkia (Türkiye), 35340
- Rekruttering
- Research Site
-
Kocaeli, Tyrkia (Türkiye), 41380
- Rekruttering
- Research Site
-
Kütahya, Tyrkia (Türkiye), 43100
- Rekruttering
- Research Site
-
Muğla, Tyrkia (Türkiye), 48000
- Fullført
- Research Site
-
Sivas, Tyrkia (Türkiye), 58140
- Rekruttering
- Research Site
-
-
-
-
-
Bad Nauheim, Tyskland, 61231
- Avsluttet
- Research Site
-
Bechhofen, Tyskland, 66894
- Tilbaketrukket
- Research Site
-
Berlin, Tyskland, 12203
- Rekruttering
- Research Site
-
Berlin, Tyskland, 13405
- Rekruttering
- Research Site
-
Bernau bei Berlin, Tyskland, 16321
- Suspendert
- Research Site
-
Chemnitz, Tyskland, 9113
- Tilbaketrukket
- Research Site
-
Coburg, Tyskland, 96450
- Rekruttering
- Research Site
-
Dresden, Tyskland, 1307
- Rekruttering
- Research Site
-
Dresden, Tyskland, 01099
- Tilbaketrukket
- Research Site
-
Elsterwerda, Tyskland, 04910
- Suspendert
- Research Site
-
Frankfurt, Tyskland, 60590
- Tilbaketrukket
- Research Site
-
Freiburg im Breisgau, Tyskland, 79106
- Rekruttering
- Research Site
-
Goslar, Tyskland, 38642
- Rekruttering
- Research Site
-
Göttingen, Tyskland, 37075
- Rekruttering
- Research Site
-
Hagen, Tyskland, 58135
- Rekruttering
- Research Site
-
Hamburg, Tyskland, 20246
- Rekruttering
- Research Site
-
Hamburg, Tyskland, 22457
- Tilbaketrukket
- Research Site
-
Hamburg, Tyskland, 22459
- Tilbaketrukket
- Research Site
-
Heidelberg, Tyskland, 69120
- Rekruttering
- Research Site
-
Kaiserslautern, Tyskland, 67655
- Tilbaketrukket
- Research Site
-
Langen, Tyskland, 63225
- Tilbaketrukket
- Research Site
-
Leipzig, Tyskland, 04103
- Suspendert
- Research Site
-
Leverkusen, Tyskland, 51375
- Tilbaketrukket
- Research Site
-
Mainz, Tyskland, 55131
- Tilbaketrukket
- Research Site
-
Mainz, Tyskland, 55122
- Rekruttering
- Research Site
-
Mönchengladbach, Tyskland, 41063
- Suspendert
- Research Site
-
Münster, Tyskland, 48149
- Tilbaketrukket
- Research Site
-
Paderborn, Tyskland, 33098
- Tilbaketrukket
- Research Site
-
Papenburg, Tyskland, 26871
- Rekruttering
- Research Site
-
Regensburg, Tyskland, 93053
- Rekruttering
- Research Site
-
Rostock, Tyskland, 18059
- Tilbaketrukket
- Research Site
-
Völklingen, Tyskland, 66333
- Tilbaketrukket
- Research Site
-
Wermsdorf, Tyskland, 04779
- Avsluttet
- Research Site
-
Witten, Tyskland, 58455
- Tilbaketrukket
- Research Site
-
-
-
-
-
Chernivtsі, Ukraina, 58002
- Rekruttering
- Research Site
-
Ivano-Frankivsk, Ukraina, 76018
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 04050
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 01601
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 02081
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 03037
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 03680
- Rekruttering
- Research Site
-
Kyiv, Ukraina, 03151
- Rekruttering
- Research Site
-
Ternopil, Ukraina, 46000
- Rekruttering
- Research Site
-
Ternopil, Ukraina, 46002
- Rekruttering
- Research Site
-
Uzhhorod, Ukraina, 88014
- Rekruttering
- Research Site
-
Vinnytsia, Ukraina, 21001
- Rekruttering
- Research Site
-
Vinnytsia, Ukraina, 21029
- Rekruttering
- Research Site
-
Zhytomyr, Ukraina, 100002
- Rekruttering
- Research Site
-
-
-
-
-
Balatonfüred, Ungarn, 8230
- Rekruttering
- Research Site
-
Budapest, Ungarn, 1033
- Rekruttering
- Research Site
-
Budapest, Ungarn, 1036
- Rekruttering
- Research Site
-
Budapest, Ungarn, 1122
- Rekruttering
- Research Site
-
Budapest, Ungarn, 1145
- Tilbaketrukket
- Research Site
-
Békéscsaba, Ungarn, 5600
- Rekruttering
- Research Site
-
Gyula, Ungarn, 5700
- Tilbaketrukket
- Research Site
-
Hódmezővásárhely, Ungarn, 6800
- Tilbaketrukket
- Research Site
-
Kecskemét, Ungarn, 6000
- Rekruttering
- Research Site
-
Orosháza, Ungarn, 5900
- Tilbaketrukket
- Research Site
-
Pécs, Ungarn, 7635
- Rekruttering
- Research Site
-
Pécs, Ungarn, 7623
- Rekruttering
- Research Site
-
Székesfehérvár, Ungarn, 8000
- Rekruttering
- Research Site
-
-
-
-
-
Can Tho, Vietnam, 900000
- Rekruttering
- Research Site
-
Da Nang, Vietnam, 550000
- Rekruttering
- Research Site
-
Haiphong, Vietnam, 180000
- Rekruttering
- Research Site
-
Hanoi, Vietnam, 100000
- Rekruttering
- Research Site
-
Ho Chi Minh City, Vietnam, 70000
- Rekruttering
- Research Site
-
Ho Chi Minh City, Vietnam, 700000
- Rekruttering
- Research Site
-
Hochiminh, Vietnam, 70000
- Rekruttering
- Research Site
-
Hochiminh City, Vietnam, 700000
- Rekruttering
- Research Site
-
Huế, Vietnam, 530000
- Rekruttering
- Research Site
-
Hà Nội, Vietnam, 100000
- Rekruttering
- Research Site
-
Hồ Chí Minh, Vietnam, 700000
- Rekruttering
- Research Site
-
-
-
-
-
Bad Ischl, Østerrike, 4820
- Rekruttering
- Research Site
-
Braunau am Inn, Østerrike, 5280
- Rekruttering
- Research Site
-
Graz, Østerrike, 8036
- Rekruttering
- Research Site
-
Linz, Østerrike, 4020
- Rekruttering
- Research Site
-
Saint Stefan/Stainz, Østerrike, 8511
- Rekruttering
- Research Site
-
Salzburg, Østerrike, 5020
- Rekruttering
- Research Site
-
Sankt Pölten, Østerrike, 3100
- Rekruttering
- Research Site
-
Vienna, Østerrike, 1090
- Rekruttering
- Research Site
-
Vienna, Østerrike, 1100
- Rekruttering
- Research Site
-
Vienna, Østerrike, 1160
- Rekruttering
- Research Site
-
Vöcklabruck, Østerrike, 4840
- Rekruttering
- Research Site
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år til 130 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
- Age ≥ 18 years
- Documented diagnosis of symptomatic HF (NYHA functional class II-IV)
- Having had a recent HF event within 6 months (hospitalization or urgent visit)
- Have a LVEF value from an assessment within the last 12 months
- Managed with SoC therapy for HF and renal impairment according to local guidelines
- NT-proBNP must be >300 pg/mL (>600 pg/mL if concomitant atrial fibrillation or atrial flutter)
- Not taking an MRA
- An eGFR ≥ 20 to < 60 mL/min/1.73 m2
- Serum/plasma potassium ≤ 5.0 mmol/L
Exclusion Criteria:
- Acute coronary syndrome (unstable angina or myocardial infarction), stroke or transient ischaemic attack within the previous 3 months prior to enrolment or during the screening period
- Major cardiac surgery, coronary revascularisation or valvular repair or replacement, or implantation of a Cardiac resynchronisation therapy device within 3 months prior to enrolment or during the screening period, or planned to undergo any of these operations
- History of hypertrophic obstructive cardiomyopathy
- Complex congenital heart disease or severe uncorrected primary valvular disease
- Symptomatic bradycardia or second- or third-degree heart block without a pacemaker
- Systolic BP < 90 mmHg, or symptomatic hypotension within the past 24 hours
- Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD or exacerbation of COPD requiring invasive mechanical ventilation assistance within 12 months prior to enrolment
- Type 1 diabetes mellitus
- Kidney replacement therapy in the past 4 weeks, currently requiring kidney replacement or imminent plan to start kidney replacement therapy
- Acute or chronic liver disease with severe impairment of liver function, eg, ascites, oesophageal varices, coagulopathy, and encephalopathy
- Suspected or confirmed COVID-19 infection within the last 4 weeks or hospitalisation for COVID-19 within the last 12 weeks
- Treatment with strong or moderate CYP3A4 inhibitor or inducer
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Firemannsrom
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: balcinrenone/dapagliflozin 15 mg/10 mg
Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin |
1 capsule of balcinrenone/dapagliflozin 15 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use |
|
Eksperimentell: balcinrenone/dapagliflozin 40 mg/10 mg
Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin |
1 capsule of balcinrenone/dapagliflozin 40 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use |
|
Aktiv komparator: dapagliflozin 10 mg
Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin |
1 tablet of dapagliflozin 10 mg and 1 capsule of matching placebo for balcinrenone/dapagliflozin once daily, oral use |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Time to first occurrence of any of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation
Tidsramme: Approximately 36 months
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of CV death and HF events with and without hospitalisation |
Approximately 36 months
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Total occurrences (first and recurrent) of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation
Tidsramme: Approximately 36 months
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the rate of total occurrences of CV death, and HF events with and without hospitalisation |
Approximately 36 months
|
|
Total occurrences (first and recurrent) of HF hospitalisations
Tidsramme: Approximately 36 months
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the rate of total HF hospitalisations |
Approximately 36 months
|
|
Time to CV death
Tidsramme: Approximately 36 months
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of CV death |
Approximately 36 months
|
|
Time to death from any cause
Tidsramme: Approximately 36 months
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of death from any cause |
Approximately 36 months
|
|
Change in KCCQ total symptom score from baseline to 24 weeks post-randomisation
Tidsramme: Approximately 24 weeks
|
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in improving patient reported symptoms of HF |
Approximately 24 weeks
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
12. april 2024
Primær fullføring (Antatt)
16. april 2027
Studiet fullført (Antatt)
16. april 2027
Datoer for studieregistrering
Først innsendt
6. februar 2024
Først innsendt som oppfylte QC-kriteriene
6. mars 2024
Først lagt ut (Faktiske)
13. mars 2024
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
13. oktober 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
12. oktober 2026
Sist bekreftet
1. oktober 2026
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- D6402C00012
- 2023-508162-15-00 (Registeridentifikator: EU CT number)
- 2023 (U.S. NIH-stipend/kontrakt)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
JA
IPD-planbeskrivelse
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
"Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.
IPD-delingstidsramme
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA/PhRMA Data-Sharing Principles. For details of our timelines, please refer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Tilgangskriterier for IPD-deling
When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. A Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information.
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- SEVJE
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Ja
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .