Exploratory Study to Determine Tissue Alterations of Advanced Hepatocellular Carcinoma Induced by Electromagnetic Waves of Low Energy Amplitude Modulated to Specific Frequencies During Imaging Study by MRI

Inclusion Criteria:

All individuals selected for these studies should be in accordance with the following inclusion criteria:

• Patients must have a diagnosis of HCC.
• Presence of the primary or metastatic tumor at the time of the procedure, at least one (1) measurable lesion by RECIST criteria modified located in the hepatic parenchyma and size> 2 cm.
• Patients with AFP> 400 ng / ml and image feature not need histopathological confirmation. But in patients with active B virus serology, the value of AFP should be greater than 4000 ng / ml. The remaining patients should be histological confirmation of HCC.
• Patients may be in observation or presence of systemic or intra-hepatic treatment.
• Minimum age 18 years.
• be subjected to MRI study without need for sedation.

Exclusion Criteria:

• Individuals selected for this study will be excluded if they are in accordance with the following exclusion criteria:

  • can not suspend anti-hypertensive drugs or beta blockers for at least 48 hours or be pacemaker carriers or other implantable device.
  • Any restriction known to carry out study of magnetic resonance imaging.
  • menstrual delay, pregnant or breastfeeding.
  • Presence of metal artifacts or implants that can alter the reading of the magnetic signal or heat or move during the MRI procedure.
  • Prior allergic Event Knowledge gadolinium or manganese chloride solution.