A Study of HDM1002 Tablets on Cardiac Repolarization in Healthy Subjects

Inclusion Criteria:

• The subject has voluntarily signed a written informed consent form.
• Male or female; age between 18 and 45 years (inclusive).
• Subject's weight ≥50 kg, with a body mass index (BMI) between 19.0 and 28.0 kg/m2, inclusive. BMI = weight (kg) / height2 (m2).
• Medical history inquiry, physical examination, laboratory test items, and other trial-related tests at screening are all normal or show mild abnormalities with no clinical significance, and the subject is judged to be eligible by the clinical research physician.
• The subject is able to communicate well with the investigator and comply with the protocol requirements to complete the study.

Exclusion Criteria:

• History of or current neurological/psychiatric, respiratory, cardiovascular, gastrointestinal, hematological and lymphatic, endocrine, or musculoskeletal system diseases, hepatic or renal insufficiency, or any other disease or physiological condition that may affect the study results;
• Subjects with a personal or family history of medullary thyroid cancer (MTC), thyroid C-cell hyperplasia, or multiple endocrine neoplasia type 2 (MEN2);
• History of chronic pancreatitis or an episode of acute pancreatitis within 3 months prior to screening;
• History of a cholecystitis episode within 3 months prior to screening;
• History of allergy to HDM1002, moxifloxacin hydrochloride tablets, other fluoroquinolones or quinolones, or any of the excipients; or history of food allergy, or a specific allergy history (asthma, urticaria, eczema, etc.);
• Clinically significant major illness or undergone major surgery within 3 months prior to the trial;
• Blood donation within 3 months, or plans to donate blood during this study, or transfusion or blood loss ≥200 mL within 4 weeks prior to the trial;
• Has consumed a special diet, engaged in strenuous exercise, or had other factors that affect drug absorption, distribution, metabolism, and excretion within 48 hours prior to dosing;
• Pregnant or lactating, or has a positive blood pregnancy test result;
• The investigator believes that the subject has any other condition that makes them unsuitable for participation in this clinical trial.