Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut (MASTGUT)

Inclusion Criteria group 1 (resection tissue from surgery patients = healthy volunteers):

1. Voluntary written informed consent of the participant has been obtained prior to any screening procedures
2. At least 18 years of age at the time of signing the Informed Consent Form (ICF)
3. Undergoing surgery for colorectal cancer
4. No preoperative radiotherapy or chemotherapy

Exclusion Criteria group 1 (resection tissue from surgery patients = healthy volunteers):

1. Using antihistamines such as ebastine, cetirizine, desloratadine, … (non-exhautive list) at the moment of surgery
2. Inflammatory bowel disease (IBD) or diverticulitis
3. Diabetes or BMI ≥ 30 kg/m²
4. Subject is legally incapacitated

Inclusion Criteria group 2 (rectal biopsies from IBS patients):

1. Voluntary written informed consent of the subject has been obtained prior to any screening procedures
2. At least 18 years of age and maximum age of 65 years of age at the time of signing the Informed Consent Form (ICF)
3. Diagnosed with IBS

Exclusion Criteria group 2 (rectal biopsies from IBS patients):

1. Subject has internal/external hemorrhoids at the moment of biopsy sampling.
2. Using bloodthinners such as Acenocoumarol, Aspirine (acetylsalicylzuur), Apixaban (Eliquis), Clopidogrel (Plavix), Dabigatran (Pradaxa), Edoxaban (Lixiana), Rivaroxaban (Xarelto), warfarine (Marevan®) and Enoxaparine (Clexane), … (non-exhausative list).
3. Using antihistamines such as ebastine, cetirizine, desloratadine, … (non-exhausative list) at the moment of biopsy sampling. These should be stopped 2 weeks prior to the biopsy sampling.
4. Subject is legally incapacitated