Randomiserad, inbäddad, multifaktoriell adaptiv plattformsprövning för gemenskapsförvärvad lunginflammation (REMAP-CAP)
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of hospitalised patients admitted to intensive care with respiratory tract infections.
In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.
REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.
Studieöversikt
Status
Betingelser
Intervention / Behandling
- Läkemedel: Ceftriaxone + Macrolide
- Läkemedel: Moxifloxacin or Levofloxacin
- Läkemedel: Piperacillin-tazobactam + Macrolide
- Läkemedel: Ceftaroline + Macrolide
- Läkemedel: Amoxicillin-clavulanate + Macrolide
- Läkemedel: Standard course macrolide
- Läkemedel: Extended course macrolide
- Övrig: No systemic corticosteroid
- Läkemedel: Fixed-duration Hydrocortisone
- Läkemedel: Shock-dependent hydrocortisone
- Läkemedel: Fixed-duration higher dose Hydrocortisone
- Läkemedel: Fixed-duration dexamethasone
- Övrig: No antiviral agent for influenza
- Läkemedel: Five-days oseltamivir
- Läkemedel: Ten-days oseltamivir
- Läkemedel: Baloxavir Marboxil
- Läkemedel: Five-days oseltamivir + baloxavir marboxil
- Läkemedel: Ten-days oseltamivir + baloxavir marboxil
- Övrig: No antiviral agent for COVID-19
- Läkemedel: Lopinavir / Ritonavir
- Läkemedel: Hydroxychloroquine
- Läkemedel: Hydroxychloroquine + lopinavir/ritonavir
- Läkemedel: Ivermectin
- Övrig: No immune modulation for COVID-19
- Läkemedel: Interferon beta-1a
- Läkemedel: Anakinra
- Läkemedel: Tocilizumab
- Läkemedel: Sarilumab
- Läkemedel: Tocilizumab
- Läkemedel: Local standard venous thromboprophylaxis
- Läkemedel: Therapeutic dose anticoagulation
- Läkemedel: Conventional low dose thromboprophylaxis
- Läkemedel: Intermediate dose thromboprophylaxis
- Läkemedel: Continuation of therapeutic dose anticoagulation
- Övrig: No immunoglobulin
- Biologisk: Convalescent plasma
- Biologisk: Delayed administration of convalescent plasma
- Övrig: No vitamin C
- Läkemedel: Vitamin C
- Övrig: No simvastatin
- Läkemedel: Simvastatin
- Övrig: No antiplatelet
- Läkemedel: Aspirin
- Läkemedel: P2Y12 inhibitor
- Procedur: Clinician-preferred mechanical ventilation strategy
- Procedur: Protocolised mechanical ventilation strategy
- Läkemedel: Eritoran
- Läkemedel: Apremilast
- Övrig: No renin-angiotensin system inhibitor
- Läkemedel: Angiotensin converting enzyme inhibitor
- Läkemedel: Angiotensin Receptor Blockers
- Läkemedel: ARB + DMX-200
- Övrig: No cysteamine
- Läkemedel: Cysteamine
- Övrig: No endothelial modulator
- Läkemedel: Imatinib
- Övrig: No Immune Modulator for Influenza
- Läkemedel: Baricitinib
- Läkemedel: Nirmatrelvir/ritonavir
- Läkemedel: Remdesivir
- Läkemedel: Nirmatrelvir/ritonavir + remdesivir
- Läkemedel: Amoxicillin-clavulanate + Ceftazidime + Macrolide
- Läkemedel: Meropenem + Macrolide
Detaljerad beskrivning
Background: Respiratory tract infections that are of sufficient severity to require admission to hospital are associated with substantial mortality. All hospitalized patients with respiratory tract infections will receive therapy that consists of a combination of multiple different treatments. For many of these treatments, different options are available currently. For example, several antibiotics exist that are active against the microorganisms that commonly cause pneumonia but it is not known if one antibiotic strategy is best, or whether all suitable antibiotic strategies have similar levels of effectiveness. Of all the treatments that clinicians use for patients with respiratory tract infections, only a small minority have been tested in randomized controlled trials to determine their comparative effectiveness. As a consequence, the standard treatments that are administered vary between and within countries. Current conventional clinical trials methods to assess the efficacy of treatments for respiratory tract infections generally compare two treatment options (either two options for the same treatment modality, where both are in common use; or a new treatment against no treatment or placebo, where the effectiveness of the new treatment is not known). Using this approach, in a series of separate and sequential trials, it will take an inordinate length of time to study all the treatment options. Additionally, with conventional trial designs it is not possible to evaluate interactions between treatment options.
Aim: The primary objective of this platform trial is, for patients hospitalized with respiratory tract infection, to identify the effect of a range of interventions to improve patient outcomes.
Methods: The study will enroll hospitalized patients with respiratory tract infection using a trial design known as a REMAP, which is a type of platform trial. Within this platform trial, eligible participants will be randomized to receive one intervention in each of one or more domains. The primary outcome is a composite of 90-day all-cause mortality and, among survivors, a daily ordinal scale analyzed as a trajectory of illness and recovery to 28-days. There will also be both Platform and domain-specific secondary outcome measures.
In a conventional trial enrollment continues until a pre-specified sample size is obtained, at which time enrollment ceases and the trial data are analyzed to obtain a result. The possible results are that a difference is detected, or no that no difference is detected. However, when the conclusion of the statistical test is "no difference", this could reflect that there truly is no meaningful difference or that the result is indeterminate (i.e., it is possible that if more patients had been enrolled a clinically relevant difference may have been detected).
In comparison to a conventional trial this Platform uses an adaptive design that:
- avoids indeterminate results by concluding an answer to a question when sufficient data have accrued (not when a pre-specified sample is reached);
- utilizes already accrued data to increase the likelihood that patients within the trial are more likely to be randomized to treatments that are more likely to be beneficial;
- is intended to be perpetual (or at least open-ended), substituting new questions in series as initial questions are answered; and
- can evaluate the interaction between interventions in different domains, added at different timepoints into the Platform.
Bayesian statistical methods will be used to define Statistical Triggers that reflect thresholds for decision making within a domain. While a limited number of initial treatments and treatment domains were specified at initiation, other interventions and domains have been evaluated over time, and it is planned that this platform trial will continue to evaluate other treatments in the future. Furthermore, in the event of a future epidemic, this Platform is able to adapt to evaluate the most relevant treatment options.
Studietyp
Inskrivning (Beräknad)
Fas
- Fas 3
Kontakter och platser
Studiekontakt
- Namn: Cameron Green, MSc
- E-post: info@remapcap.org
Studera Kontakt Backup
- Namn: Svenja Peters, MSc
- E-post: EU.remapcap@umcutrecht.nl
Studieorter
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Australian Capital Territory
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Canberra, Australian Capital Territory, Australien, 2605
- Rekrytering
- Canberra Hospital
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New South Wales
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Bankstown, New South Wales, Australien, 2200
- Rekrytering
- Bankstown-Lidcombe Hospital
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Blacktown, New South Wales, Australien, 2148
- Rekrytering
- Blacktown Hospital
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Campbelltown, New South Wales, Australien, 2560
- Rekrytering
- Campbelltown Hospital
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Caringbah, New South Wales, Australien, 2229
- Rekrytering
- Sutherland Hospital
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Concord, New South Wales, Australien, 2139
- Rekrytering
- Concord Hospital
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Dubbo, New South Wales, Australien, 2830
- Rekrytering
- Dubbo Base Hospital
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Frenchs Forest, New South Wales, Australien, 2086
- Rekrytering
- Northern Beaches Hospital
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Kingswood, New South Wales, Australien, 2750
- Rekrytering
- Nepean Hospital
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Kogarah, New South Wales, Australien, 2217
- Rekrytering
- St. George Hospital
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Liverpool, New South Wales, Australien, 2170
- Rekrytering
- Liverpool Hospital
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Newcastle, New South Wales, Australien, 2305
- Rekrytering
- John Hunter Hospital
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Orange, New South Wales, Australien, 2800
- Har inte rekryterat ännu
- Orange Health Service
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Sydney, New South Wales, Australien, 2065
- Rekrytering
- Royal North Shore Hospital
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Sydney, New South Wales, Australien, 2010
- Rekrytering
- St Vincent's Hospital Sydney
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Sydney, New South Wales, Australien, 2031
- Rekrytering
- Prince of Wales Hospital
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Sydney, New South Wales, Australien, 2050
- Har inte rekryterat ännu
- Royal Prince Alfred Hospital
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Sydney, New South Wales, Australien, 2500
- Rekrytering
- Wollongong Hospital
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Wagga Wagga, New South Wales, Australien, 2650
- Har inte rekryterat ännu
- Wagga Wagga Base Hospital
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Westmead, New South Wales, Australien, 2145
- Rekrytering
- Westmead Hospital
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Northern Territory
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Darwin, Northern Territory, Australien, 0810
- Har inte rekryterat ännu
- Royal Darwin Hospital,
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Queensland
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Birtinya, Queensland, Australien, 4575
- Har inte rekryterat ännu
- Sunshine Coast University Hospital
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Brisbane, Queensland, Australien, 4102
- Rekrytering
- Princess Alexandra Hospital
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Brisbane, Queensland, Australien, 4032
- Rekrytering
- The Prince Charles Hospital
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Brisbane, Queensland, Australien, 4101
- Rekrytering
- Mater Hospital Brisbane
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Caboolture, Queensland, Australien, 4510
- Rekrytering
- Caboolture Hospital
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Coopers Plains, Queensland, Australien, 4110
- Rekrytering
- Queen Elizabeth II Jubilee Hospital
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Logan City, Queensland, Australien, 4129
- Har inte rekryterat ännu
- Logan Hospital
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Redcliffe, Queensland, Australien, 4020
- Har inte rekryterat ännu
- Redcliffe Hospital
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Rockhampton, Queensland, Australien, 4700
- Har inte rekryterat ännu
- Rockhampton Hospital
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Southport, Queensland, Australien, 4215
- Rekrytering
- Gold Coast University Hospital
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Toowoomba, Queensland, Australien, 4350
- Rekrytering
- Toowoomba Hospital
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Townsville, Queensland, Australien, 4814
- Rekrytering
- Townsville Hospital
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South Australia
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Adelaide, South Australia, Australien, 5000
- Rekrytering
- Royal Adelaide Hospital
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Adelaide, South Australia, Australien, 5011
- Rekrytering
- The Queen Elizabeth Hospital
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Adelaide, South Australia, Australien, 5112
- Rekrytering
- Lyell McEwin Hospital
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Bedford Park, South Australia, Australien, 5042
- Rekrytering
- Flinders Medical Centre
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Tasmania
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Launceston, Tasmania, Australien, 7250
- Rekrytering
- Launceston Hospital
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Victoria
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Ballarat, Victoria, Australien, 3350
- Rekrytering
- Ballarat Base Hospital
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Bendigo, Victoria, Australien, 3550
- Rekrytering
- Bendigo Hospital
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Berwick, Victoria, Australien, 3806
- Rekrytering
- Casey Hospital
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Box Hill, Victoria, Australien, 3128
- Rekrytering
- Box Hill Hospital
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Clayton, Victoria, Australien, 3168
- Rekrytering
- Monash Medical Centre
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Dandenong, Victoria, Australien, 3175
- Rekrytering
- Dandenong Hospital
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Ferntree Gully, Victoria, Australien, 3156
- Har inte rekryterat ännu
- Angliss Hospital
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Footscray, Victoria, Australien, 3011
- Rekrytering
- Footscray Hospital
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Geelong, Victoria, Australien, 3220
- Rekrytering
- University Hosptial Geelong
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Melbourne, Victoria, Australien, 3004
- Rekrytering
- The Alfred Hospital
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Melbourne, Victoria, Australien, 3050
- Rekrytering
- Royal Melbourne Hospital
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Melbourne, Victoria, Australien, 3065
- Rekrytering
- St Vincent's Hospital Melbourne
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Ringwood East, Victoria, Australien, 3135
- Rekrytering
- Maroondah Hospital
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Sunshine, Victoria, Australien, 3021
- Rekrytering
- Sunshine Hospital
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Werribee, Victoria, Australien, 3030
- Rekrytering
- Werribee Mercy Hospital
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Western Australia
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Midland, Western Australia, Australien, 6056
- Rekrytering
- St John of God Hospital Midland
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Murdoch, Western Australia, Australien, 6150
- Har inte rekryterat ännu
- St John of God Hospital Murdoch
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Perth, Western Australia, Australien, 6000
- Rekrytering
- Royal Perth Hospital
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Perth, Western Australia, Australien, 6150
- Rekrytering
- Fiona Stanley Hospital
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Perth, Western Australia, Australien, 6009
- Rekrytering
- Sir Charles Gairdner Hospital
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Subiaco, Western Australia, Australien, 6008
- Rekrytering
- St John of God Subiaco
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Charleroi, Belgien, 6042
- Rekrytering
- CHU de Charleroi - Hôpital Civil Marie Curie
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Kontakt:
- Patrick Biston, MD
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Ghent, Belgien, 9000
- Rekrytering
- Universitair Ziekenhuis Gent
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Kontakt:
- Pieter Depuydt, Prof.
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Namur, Belgien, 5530
- Rekrytering
- CHU Namur site Godinne
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Kontakt:
- Pierre Bulpa, MD
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Cundinamarca
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Chía, Cundinamarca, Colombia
- Rekrytering
- Universidad de La Sabana
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Tartu, Estland, 50406
- Upphängd
- Tartu University Hospital
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Helsinki, Finland, 00290
- Upphängd
- Helsinki University Hospital
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Tampere, Finland, 33520
- Upphängd
- Tampere University Hospital
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-
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-
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Argenteuil, Frankrike, 95107
- Aktiv, inte rekryterande
- CH Argenteuil
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Aurillac, Frankrike, 15000
- Avslutad
- Centre Hospitalier Henri Mondor d'Aurillac
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Beauvais, Frankrike, 60000
- Aktiv, inte rekryterande
- Beauvais General Hospital
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Belfort, Frankrike, 90400
- Upphängd
- Hopital Nord Franche-Comte
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Boulogne-Billancourt, Frankrike, 92100
- Rekrytering
- Ambroise Pare Hospital
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Kontakt:
- Antoine Vieillard Baron, MD
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Béthune, Frankrike, 62660
- Rekrytering
- Centre hospitalier Bethune Beuvry
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Kontakt:
- Christophe Vinsonneau, MD
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Dax, Frankrike, 40100
- Rekrytering
- CH de Dax
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Kontakt:
- Adrien Auvet, MD
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Dieppe, Frankrike, 76202
- Rekrytering
- Centre Hospitalier de Dieppe
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Kontakt:
- Peierre-Louis Declercq, MD
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Dijon, Frankrike, 21000
- Rekrytering
- CHU Dijon Bourgogne
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Kontakt:
- Jean-Pierre Quenot, MD
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Eaubonne, Frankrike, 95600
- Aktiv, inte rekryterande
- Hopital Simone Veil Eaubonne
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Garches, Frankrike, 92380
- Rekrytering
- Hospital Raymond Poincare
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Kontakt:
- Djillali Annane, MD
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La Roche-sur-Yon, Frankrike, 85000
- Rekrytering
- CHD Vendee
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Kontakt:
- Gwenael Colin, MD
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Le Mans, Frankrike, 72027
- Rekrytering
- Centre Hospitalier Le Mans
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Kontakt:
- Christophe Guitton, MD
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Limoges, Frankrike, 87000
- Rekrytering
- CHU Dupuytren
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Kontakt:
- Francois Bruno, MD
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Melun, Frankrike, 77000
- Aktiv, inte rekryterande
- Centre Hospitalier de Melun
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Mont-de-Marsan, Frankrike, 40024
- Rekrytering
- Centre Hospitalier Layne - Mont-de-Marsan
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Kontakt:
- Arnaud Sement, MD
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Morlaix, Frankrike, 29600
- Rekrytering
- Centre Hospitalier des Pays de Morlaix
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Kontakt:
- Pierre Yves Egreteau, MD
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Orléans, Frankrike, 45100
- Aktiv, inte rekryterande
- CHR d'Orleans
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Paris, Frankrike, 75010
- Aktiv, inte rekryterande
- Lariboisiere Hospital
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Paris, Frankrike, 75020
- Aktiv, inte rekryterande
- Hopital Tenon
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Strasbourg, Frankrike, 67200
- Aktiv, inte rekryterande
- Hopital de Hautepierre Strasbourg
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Strasbourg, Frankrike, 67000
- Rekrytering
- Nouvel Hopital Civil Strasbourg
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Kontakt:
- Ferhat Meziani, MD
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Tours, Frankrike, 37000
- Rekrytering
- CHRU Tours Hopital Bretonneau
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Kontakt:
- Emmanuelle Mercier, MD
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Étampes, Frankrike, 91150
- Aktiv, inte rekryterande
- Sud Essonne Hospital Etampes
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Florida
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Jacksonville, Florida, Förenta staterna, 32209
- Rekrytering
- University of Florida
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Kontakt:
- Hadi Hatoum, MD
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Georgia
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Augusta, Georgia, Förenta staterna, 30912
- Har inte rekryterat ännu
- Augusta University
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Kontakt:
- Jose Vazquez, MD
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Illinois
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Chicago, Illinois, Förenta staterna, 60612
- Rekrytering
- University of Illinois Health
-
Kontakt:
- Jeffrey Jacobson, MD
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Louisiana
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New Orleans, Louisiana, Förenta staterna, 70112
- Har inte rekryterat ännu
- Tulane Medical Center
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Kontakt:
- Joshua Denson, MD
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Michigan
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Ann Arbor, Michigan, Förenta staterna, 48109
- Rekrytering
- University of Michigan
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Kontakt:
- Robert Hyzy, MD
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New York
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New York, New York, Förenta staterna, 10065
- Rekrytering
- Memorial Sloan Kettering Cancer Center
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Kontakt:
- Stephen Pastores, MD
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North Carolina
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Winston-Salem, North Carolina, Förenta staterna, 27157-1009
- Har inte rekryterat ännu
- Wake Forest Baptist Health
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Kontakt:
- Ashish Khanna, MD
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Ohio
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Columbus, Ohio, Förenta staterna, 43210
- Rekrytering
- The Ohio State University Wexner Medical Center
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Kontakt:
- Matthew Exline, MD
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Oregon
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Portland, Oregon, Förenta staterna, 97239-3098
- Rekrytering
- Oregon Health and Science University
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Kontakt:
- Akram Khankhana, MD
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Pennsylvania
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Pittsburgh, Pennsylvania, Förenta staterna
- Rekrytering
- University of Pittsburgh Medical Centre
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Kontakt:
- Stephanie Mongomery
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Rhode Island
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Providence, Rhode Island, Förenta staterna, 02903
- Har inte rekryterat ännu
- Brown University - Rhode Island Hospital
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Kontakt:
- Mitchell Levy, MD
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Tamil Nadu
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Chennai, Tamil Nadu, Indien, 600006
- Aktiv, inte rekryterande
- Apollo Main Hospital
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Chennai, Tamil Nadu, Indien, 600010
- Rekrytering
- Apollo First Med Hospital
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Kontakt:
- Meghena Mathew, MD
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Chennai, Tamil Nadu, Indien, 600095
- Aktiv, inte rekryterande
- Apollo Vanagaram Hospital
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Chennai, Tamil Nadu, Indien, 600096
- Rekrytering
- Apollo Speciality Hospital - OMR
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Kontakt:
- Deva Jayakumar, MD
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Cork, Irland, T12 DC4A
- Aktiv, inte rekryterande
- Cork University Hospital
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Dublin, Irland
- Rekrytering
- Beaumont Hospital
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Kontakt:
- Ger Curley, Prof.
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Dublin, Irland
- Rekrytering
- St. Vincent's University Hospital
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Kontakt:
- Alistair Nichol, Prof.
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Galway, Irland
- Rekrytering
- University Hospital Galway
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Kontakt:
- John Laffey, M.D.
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Waterford, Irland, X91 ER8E
- Aktiv, inte rekryterande
- University Hospital Waterford
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Haifa, Israel, 3109601
- Indragen
- Rambam Medical Center
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Petah Tikva, Israel, 4941492
- Upphängd
- Beilinson Hospital, Rabin Medical Center
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Poria – Neve Oved, Israel, 1528001
- Indragen
- The Baruch Padeh Medical Center
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-
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-
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Brescia, Italien, 25123
- Rekrytering
- AO Spedali Civili di Brescia
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Kontakt:
- Simone Piva, MD
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Milan, Italien, 20132
- Rekrytering
- IRCCS Ospedale San Raffaele
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Kontakt:
- Giovanni Landoni, MD
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Milan, Italien, 20089
- Rekrytering
- Humanitas Research Hospital
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Kontakt:
- Maurizio Cecconi, MD
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Milan, Italien, 20122
- Rekrytering
- Ca' Granda Ospedale Maggiore Policlinico
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Kontakt:
- Francesco Blasi, MD
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Palermo, Italien, 90127
- Rekrytering
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
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Kontakt:
- Andrea Cortegiani, MD
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Palermo, Italien, 90127
- Rekrytering
- Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione
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Kontakt:
- Gennaro Martucci, MD
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Reggio Emilia, Italien, 42123
- Rekrytering
- Arcispedale S. Maria Nuova
-
Kontakt:
- Elena Mantovani, MD
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Rimini, Italien, 47923
- Har inte rekryterat ännu
- Ospedale Infermi di Rimini
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Kontakt:
- Jonathan Montomoli, MD
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Kanagawa
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Kawasaki, Kanagawa, Japan, 216-8511
- Rekrytering
- St Marianna University School of Medicine
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Yokohama, Kanagawa, Japan, 236-0004
- Rekrytering
- Yokohama City University Hospital
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Yokohama, Kanagawa, Japan, 241-0811
- Rekrytering
- St. Marianna University Yokohama City Seibu Hospital
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Kumamoto
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Minami, Kumamoto, Japan, 861-4193
- Rekrytering
- Saiseikai Kumamoto Hospital
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Osaka
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Osaka, Osaka, Japan, 534-0021
- Rekrytering
- Osaka City General Hospital
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-
Tokyo
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Tokyo, Tokyo, Japan, 130-8575
- Rekrytering
- Nerima Hikarigaoka Hospital
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Tokyo, Tokyo, Japan, 130-8575
- Rekrytering
- Tokyo Metropolitan Bokutoh Hospital
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Tokyo, Tokyo, Japan, 174-0051
- Rekrytering
- Itabashi Chuo Medical Center
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Tokyo, Tokyo, Japan, 279-0001
- Rekrytering
- Tokyo bay Urayasu-Ichikawa Medical Center
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Wakayama
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Wakayama, Wakayama, Japan, 641-8509
- Rekrytering
- Wakayama Medical University
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Alberta
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, inte rekryterande
- Foothills Medical Centre
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, inte rekryterande
- Peter Lougheed Centre
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, inte rekryterande
- Rockyview General Hospital
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, inte rekryterande
- South Health Campus
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Edmonton, Alberta, Kanada, T5H 3V9
- Rekrytering
- Royal Alexandra Hospital, Alberta
-
Kontakt:
- Demetrios Kutsogiannis, MD
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Edmonton, Alberta, Kanada, T6G 2C8
- Rekrytering
- University of Alberta Hospital
-
Kontakt:
- Wendy Sligl, MD
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British Columbia
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Surrey, British Columbia, Kanada, V3V 1Z2
- Har inte rekryterat ännu
- Surrey Memorial Hospital
-
Kontakt:
- Anish Mitra, MD
-
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Manitoba
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Winnipeg, Manitoba, Kanada, R3A 1R9
- Rekrytering
- Health Sciences Centre Winnipeg
-
Kontakt:
- Ryan Zarychanski, MD
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Winnipeg, Manitoba, Kanada, R2H 2A6
- Rekrytering
- St Boniface General Hospital
-
Kontakt:
- Ryan Zarychanski, MD
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Winnipeg, Manitoba, Kanada, R3J 3M7
- Rekrytering
- Grace Hospital
-
Kontakt:
- Gloria Vazquez-Grande, MD
-
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New Brunswick
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Fredericton, New Brunswick, Kanada, E3B 4R3
- Har inte rekryterat ännu
- Dr. Everett Chalmers Regional Hospital
-
Kontakt:
- Zeeshan Aslam, MD
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Fredericton, New Brunswick, Kanada, E3B 4R3
- Har inte rekryterat ännu
- The Moncton Hospital
-
Kontakt:
- Daniel Smyth, MD
-
Fredericton, New Brunswick, Kanada, E3B 4R3
- Har inte rekryterat ännu
- The Saint John General Hospital
-
Kontakt:
- Stephen Robinson, MD
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Ontario
-
Brampton, Ontario, Kanada, L6R 3J7
- Rekrytering
- William Osler Health System
-
Kontakt:
- Alexandra Binnie, MD
-
Brantford, Ontario, Kanada, N3R 1G9
- Rekrytering
- Brantford General Hospital
-
Kontakt:
- Brenda Reeve, MD
-
Hamilton, Ontario, Kanada, L8N 4A6
- Rekrytering
- St. Joseph's Healthcare Hamilton
-
Kontakt:
- Deborah Cook, MD
-
Hamilton, Ontario, Kanada, L8L 8E7
- Rekrytering
- Juravinski Hospital
-
Kontakt:
- Bram Rochwerg, MD
-
Hamilton, Ontario, Kanada, L8L 8E7
- Rekrytering
- Hamilton general Hospital
-
Kontakt:
- Alison Fox-Robichaud, MD
-
Kingston, Ontario, Kanada, K7L 2V7
- Aktiv, inte rekryterande
- Kingston Health Sciences Centre
-
Kitchener, Ontario, Kanada, N2G 4K9
- Rekrytering
- Grand River Hospital
-
Kontakt:
- Theresa Liu, MD
-
Kitchener, Ontario, Kanada, N2M 1B2
- Rekrytering
- St Mary's General Hospital
-
Kontakt:
- Rebecca Kruisselbrink, MD
-
Ottawa, Ontario, Kanada, K1H 8L6
- Rekrytering
- The Ottawa Hospital
-
Kontakt:
- Lauralyn McIntyre, MD
-
Saint Catharines, Ontario, Kanada, L2S 0A9
- Rekrytering
- Niagara Health
-
Kontakt:
- Jennifer Tsang, MD
-
Thunder Bay, Ontario, Kanada, P7B 6V4
- Aktiv, inte rekryterande
- Thunder Bay General Hospital
-
Toronto, Ontario, Kanada, M5G 2C4
- Rekrytering
- Toronto General Hospital
-
Kontakt:
- Lorenzo del Sorbo, MD
-
Toronto, Ontario, Kanada, M4N 3M5
- Rekrytering
- Sunnybrook Health Sciences Centre
-
Kontakt:
- Rob Fowler, MD
-
Toronto, Ontario, Kanada, M5T 2S8
- Rekrytering
- Toronto Western Hospital
-
Kontakt:
- Elizabeth Wilcox, MD
-
Toronto, Ontario, Kanada, M5G 1X5
- Rekrytering
- Mount Sinai Hospital
-
Kontakt:
- Sangeeta Mehta, MD
-
Toronto, Ontario, Kanada, M5B 1W8
- Rekrytering
- St. Michael's Hospital Unity Health Toronto
-
Kontakt:
- John Marshall, MD
-
Toronto, Ontario, Kanada, M6R 1B5
- Aktiv, inte rekryterande
- St Joseph's Health Centre
-
-
Quebec
-
Lévis, Quebec, Kanada, G6V 3Z1
- Har inte rekryterat ännu
- CIUSS Chaudieres-Appalaches (Levis)
-
Kontakt:
- Patrick Archambault, MD
-
Montreal, Quebec, Kanada, H3H 2R9
- Rekrytering
- McGill University Health Centre
-
Kontakt:
- Kosar Khwaja, MD
-
Montreal, Quebec, Kanada, H2X 0A9
- Rekrytering
- Centre Hospitalier de l'Universite de Montreal
-
Kontakt:
- Michael Chasse, MD
-
Montreal, Quebec, Kanada, H1T 2M4
- Aktiv, inte rekryterande
- Hospital Maisonneuve-Rosemont
-
Montreal, Quebec, Kanada, H2B 1K3
- Har inte rekryterat ännu
- Hôpital Fleury
-
Kontakt:
- Thomas Hemmerling, MD
-
Montreal, Quebec, Kanada, H4J 1C5
- Rekrytering
- Hopital du Sacre-Coeur de Montreal
-
Kontakt:
- Martin Albert, MD
-
Québec, Quebec, Kanada, G1V 4G5
- Rekrytering
- IUCPQ-UL
-
Kontakt:
- Francois Lellouche, MD
-
Québec, Quebec, Kanada, G1R 2J6
- Rekrytering
- CHU de Québec - Université Laval
-
Kontakt:
- Alexis Turgeon, MD
-
Sherbrooke, Quebec, Kanada, J1J 3H5
- Rekrytering
- Centre Hospitalier de l'Université de Sherbrooke
-
Kontakt:
- Francois Lamontagne, MD
-
-
Saskatchewan
-
Saskatoon, Saskatchewan, Kanada, S7K 0M7
- Rekrytering
- Regina General Hospital
-
Kontakt:
- Eric Sy, MD
-
-
-
-
-
Požega, Kroatien, 34000
- Rekrytering
- General County Hospital Požega
-
Kontakt:
- Zdravko Andrić, MD
-
Zagreb, Kroatien, 10000
- Rekrytering
- University Hospital Centre Zagreb
-
Kontakt:
- Ana Vujaklija Brajković, MD
-
Zagreb, Kroatien, 10000
- Indragen
- University Hospital for Infectious Diseases
-
-
-
-
-
's-Hertogenbosch, Nederländerna
- Rekrytering
- Jeroen Bosch Ziekenhuis
-
Kontakt:
- Koen Simons, M.D.
-
Almelo, Nederländerna, 7609PP
- Rekrytering
- ZGT Almelo
-
Kontakt:
- Bastiaan Wittekamp, MD
-
Amersfoort, Nederländerna
- Rekrytering
- Meander Medisch Centrum
-
Kontakt:
- Laura van Gulik, M.D.
-
Amsterdam, Nederländerna, 1091AC
- Aktiv, inte rekryterande
- OLVG
-
Arnhem, Nederländerna, 6815AD
- Rekrytering
- Rijnstate Hospital
-
Kontakt:
- Robert-Jan Hassing, MD
-
Deventer, Nederländerna, 7416SE
- Aktiv, inte rekryterande
- Deventer Hospital
-
Ede, Nederländerna, 6716RP
- Aktiv, inte rekryterande
- Ziekenhuis Gelderse Vallei
-
Eindhoven, Nederländerna, 5631BM
- Aktiv, inte rekryterande
- Maxima Medisch Centrum Eindhoven
-
Groningen, Nederländerna
- Indragen
- Martini Hospital Groningen
-
Groningen, Nederländerna
- Aktiv, inte rekryterande
- University Medical Center Groningen
-
Leeuwarden, Nederländerna, 8934AD
- Aktiv, inte rekryterande
- Medisch Centrum Leeuwarden
-
Leiden, Nederländerna
- Rekrytering
- Leiden University Medical Center
-
Kontakt:
- Evert De Jonge, Prof.
-
Nijmegen, Nederländerna
- Rekrytering
- Radboud University Medical Center
-
Kontakt:
- Frank van de Veerdonk, Prof.
-
Nijmegen, Nederländerna
- Rekrytering
- Canisius Wilhelmina Ziekenhuis
-
Kontakt:
- Oscar Hoiting, M.D.
-
Roermond, Nederländerna, 6043CV
- Aktiv, inte rekryterande
- Laurentius Hospital
-
Rotterdam, Nederländerna, 3079DZ
- Rekrytering
- Maasstad Ziekenhuis
-
Kontakt:
- Corstiaan den Uil, MD
-
The Hague, Nederländerna, 2545AA
- Rekrytering
- Hagaziekenhuis
-
Kontakt:
- Thomas Ottens, MD
-
Uden, Nederländerna, 5406PT
- Aktiv, inte rekryterande
- Bernhoven Hospital
-
-
Utrecht
-
Utrecht, Utrecht, Nederländerna, 3584 CX
- Rekrytering
- University Medical Center Utrecht
-
Kontakt:
- Marc Bonten, Prof.
-
Kontakt:
- Lennie Derde, MD
-
-
-
-
-
Bharatpur, Nepal, 44200
- Rekrytering
- Chitwan Medical College
-
Kontakt:
- Basanta Gauli, MD
-
Kathmandu, Nepal, 44600
- Rekrytering
- Grande International Hospital
-
Kontakt:
- Sushil Khanal, MD
-
Kathmandu, Nepal, 44600
- Rekrytering
- Hospital for Advanced Medicine and Surgery (HAMS)
-
Kontakt:
- Hem Paneru, MD
-
Kathmandu, Nepal, 44600
- Rekrytering
- Nepal Mediciti
-
Kontakt:
- Diptesh Aryal, MD
-
-
-
-
-
Auckland, Nya Zeeland, 0620
- Rekrytering
- North Shore Hospital
-
Kontakt:
- Robert Everitt, MD
-
Auckland, Nya Zeeland, 1023
- Rekrytering
- CVICU, Auckland City Hospital
-
Kontakt:
- Shay McGuinness, MD
-
Auckland, Nya Zeeland, 1023
- Rekrytering
- DCCM, Auckland City Hospital
-
Kontakt:
- Colin McArthur, MD
-
Auckland, Nya Zeeland, 2104
- Rekrytering
- Middlemore Hospital
-
Kontakt:
- Tony Williams, MD
-
Christchurch, Nya Zeeland, 8011
- Rekrytering
- Christchurch Hospital
-
Kontakt:
- Jay Ritzema-Carter, MD
-
Hamilton, Nya Zeeland, 3204
- Rekrytering
- Waikato Hospital
-
Kontakt:
- Robert Martynoga, MD
-
New Plymouth, Nya Zeeland, 4310
- Rekrytering
- Taranaki Base Hospital
-
Kontakt:
- Jonathan Albrett, MD
-
Rotorua, Nya Zeeland, 3010
- Rekrytering
- Rotorua Hospital
-
Kontakt:
- Ulrike Buehner, MD
-
Tauranga, Nya Zeeland, 3112
- Rekrytering
- Tauranga Hospital
-
Kontakt:
- Troy Browne, MD
-
Wellington, Nya Zeeland, 6021
- Rekrytering
- Wellington Regional Hospital
-
Kontakt:
- Paul Young, MD
-
Whangarei, Nya Zeeland, 0148
- Rekrytering
- Whangarei Hospital
-
Kontakt:
- Ralph Fuchs, MD
-
-
-
-
Sindh
-
Karachi, Sindh, Pakistan, 75000
- Rekrytering
- Ziauddin University Hospital Clifton Campus
-
Kontakt:
- Madiha Hashmi, MD
-
Karachi, Sindh, Pakistan, 75300
- Rekrytering
- Abbasi Shaheed Hospital
-
Kontakt:
- Aneela Kidwai, MD
-
Karachi, Sindh, Pakistan, 75510
- Rekrytering
- National Institute of Cardiovascular Diseases, Karachi
-
Kontakt:
- Nawal Salahuddin, MD
-
Karachi, Sindh, Pakistan, 75600
- Rekrytering
- South City Hospital, Karachi
-
Kontakt:
- Nasir Khoso, MD
-
Karachi, Sindh, Pakistan
- Rekrytering
- Ziauddin University North Nazimabad Campus
-
Kontakt:
- Quratul Ain, MD
-
-
-
-
-
Abrantes, Portugal
- Rekrytering
- Centro Hospitalar do Medio Tejo
-
Kontakt:
- Nuno Catorze, M.D.
-
Lisbon, Portugal, 1169-050
- Upphängd
- Hospital Ocidental
-
Lisbon, Portugal
- Upphängd
- Hospital Lusíadas Lisbon
-
-
-
-
-
Bucharest, Rumänien, 030303
- Upphängd
- Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"
-
-
-
-
-
Riyadh, Saudiarabien, 14611
- Rekrytering
- King Abdulaziz Medical City
-
Kontakt:
- Yaseen Arabi, MD
-
-
-
-
-
Zurich, Schweiz, 8091
- Upphängd
- University Hospital Zürich
-
-
-
-
-
Belgrade, Serbien, 11000
- Upphängd
- University Hospital Center Dr Dragiša Mišović
-
Belgrade, Serbien, 11000
- Upphängd
- University Clinical Centre of Serbia
-
Niš, Serbien, 18000
- Rekrytering
- Clinical Centre of Niš
-
Kontakt:
- Tanja Pejčić, MD
-
-
-
-
-
Golnik, Slovenien, 4204
- Upphängd
- University Clinic of Respiratory and Allergic Diseases Golnik
-
Maribor, Slovenien, 2000
- Rekrytering
- University Medical Centre Maribor
-
Kontakt:
- Andre Markota, MD
-
-
-
-
-
Barcelona, Spanien
- Rekrytering
- Hospital del Mar
-
Kontakt:
- Rosana Munoz-Bermúdez, M.D.
-
Cadiz, Spanien, 11407
- Rekrytering
- Hospital Universitario de Jerez
-
Kontakt:
- Ángel Estella, MD
-
Córdoba, Spanien, 14004
- Rekrytering
- Reina Sofia University Hospital
-
Kontakt:
- Eduardo Aguilar Alonso, M.D.
-
Madrid, Spanien, 28034
- Rekrytering
- Ramon y Cajal University Hospital
-
Kontakt:
- Cruz Soriano, MD
-
Málaga, Spanien, 29010
- Rekrytering
- Hospital Regional de Málaga
-
Kontakt:
- Manuel Herrera Gutiérrez, MD
-
Ourense, Spanien, 32005
- Rekrytering
- Hospital Universitario de Ourense
-
Kontakt:
- Pablo Vidal, MD
-
Santander, Spanien, 39008
- Rekrytering
- Hospital Marqués de Valdecilla
-
Kontakt:
- Borja Suberviola, MD
-
Tortosa, Spanien, 43500
- Rekrytering
- Hospital Verge de la Cinta
-
Kontakt:
- Ferran Roche Campo, MD
-
Valencia, Spanien, 46026
- Rekrytering
- Hospital La Fe
-
Kontakt:
- Paula Ramírez, MD
-
Valencia, Spanien, 46017
- Rekrytering
- Doctor Peset University Hospital
-
Kontakt:
- Rafael Zaragoza, MD
-
-
-
-
-
Belfast, Storbritannien, BT16 1RH
- Rekrytering
- Ulster Hospital
-
Kontakt:
- Christopher Murray, MD
-
Bristol, Storbritannien, BS2 8BJ
- Rekrytering
- Bristol Royal Childrens Hospital
-
Kontakt:
- Jolanta Bernatoniene, MD
-
Bury, Storbritannien, BL9 7TD
- Rekrytering
- Fairfield General Hospital
-
Kontakt:
- Andrew Claxton, MD
-
Crewe, Storbritannien, CW1 4QJ
- Rekrytering
- Leighton Hospital
-
Kontakt:
- Richard Lowsby, MD
-
Dorchester, Storbritannien, DT1 2JY
- Avslutad
- Dorset County Hospital
-
Gloucester, Storbritannien, GL1 3NN
- Avslutad
- Gloucester Royal Hospital
-
Haywards Heath, Storbritannien, RH16 4EX
- Aktiv, inte rekryterande
- The Princess Royal Hospital Haywards Heath
-
Leeds, Storbritannien, LS9 7TF
- Rekrytering
- St. James University Hospital
-
Kontakt:
- E Paramasivam, MD
-
London, Storbritannien, NW1 2BU
- Rekrytering
- University College London Hospital
-
Kontakt:
- Michael Marks, MD
-
London, Storbritannien, SW10 9NH
- Rekrytering
- Chelsea and Westminster Hospital
-
Kontakt:
- Roger Davies, MD
-
London, Storbritannien, E9 6SR
- Upphängd
- Homerton Hospital
-
Margate, Storbritannien, CT9 4AN
- Upphängd
- Queen Elizabeth and Queen Mother Hospital
-
Newcastle upon Tyne, Storbritannien, NE1 4LP
- Rekrytering
- Newcastle Royal Victoria Infirmary (Paediatrics)
-
Kontakt:
- Marieke Emonts, MD
-
North Shields, Storbritannien, Ne29 8NH
- Upphängd
- North Tyneside General Hospital
-
Warwick, Storbritannien, CV34 5BW
- Aktiv, inte rekryterande
- Warwick Hospital
-
West Bromwich, Storbritannien, B71 4HJ
- Rekrytering
- Sandwell General Hospital
-
Kontakt:
- Jonathan Hulme, MD
-
-
England
-
Basildon, England, Storbritannien, SS16 5NL
- Aktiv, inte rekryterande
- Basildon Hospital
-
Basingstoke, England, Storbritannien, RG24 9NA
- Rekrytering
- Basingstoke and North Hampshire Hospital
-
Kontakt:
- Irena Grecu, MD
-
Bath, England, Storbritannien, BA1 3NG
- Aktiv, inte rekryterande
- Royal United Hospital, Bath
-
Birmingham, England, Storbritannien, B15 2TH
- Rekrytering
- Queen Elizabeth Hospital Birmingham
-
Kontakt:
- Dhruv Parekh
-
Birmingham, England, Storbritannien, B18 7QH
- Rekrytering
- Birmingham City Hospital
-
Kontakt:
- Jonathan Hulme
-
Blackburn, England, Storbritannien, BB2 3HH
- Rekrytering
- Royal Blackburn Teaching Hospital
-
Kontakt:
- Srikanth Chukkambotla, MD
-
Boston, England, Storbritannien, PE21 9QS
- Upphängd
- Pilgrim Hospital ULHT
-
Bournemouth, England, Storbritannien, BH7 7DW
- Aktiv, inte rekryterande
- Royal Bournemouth Hospital
-
Brighton, England, Storbritannien, BN2 5BE
- Upphängd
- Royal Sussex County Hospital
-
Bristol, England, Storbritannien, BS10 5NB
- Upphängd
- Southmead Hospital
-
Bristol, England, Storbritannien, BS2 8EX
- Aktiv, inte rekryterande
- Bristol Royal Infirmary
-
Burton-on-Trent, England, Storbritannien, DE13 0RB
- Aktiv, inte rekryterande
- Queen's Hospital, Burton
-
Cambridge, England, Storbritannien, CB2 0AY
- Aktiv, inte rekryterande
- Royal Papworth Hospital
-
Cambridge, England, Storbritannien, CB2 0QQ
- Aktiv, inte rekryterande
- Addenbrookes Hospital
-
Carlisle, England, Storbritannien, CA2 7HY
- Upphängd
- North Cumberland Infirmary
-
Chertsey, England, Storbritannien, KT16 0P
- Aktiv, inte rekryterande
- St Peter's Hospital
-
Chester, England, Storbritannien, CH2 1UL
- Aktiv, inte rekryterande
- Countess of Chester Hospital
-
Chesterfield, England, Storbritannien, S44 5BL
- Rekrytering
- Chesterfield Royal Hospital
-
Kontakt:
- Euan Mackay
-
Colchester, England, Storbritannien, CO4 5JL
- Rekrytering
- Colchester Hospital
-
Kontakt:
- Mohamed Ramali
-
Coventry, England, Storbritannien, CV2 2DX
- Aktiv, inte rekryterande
- University Hospital Coventry
-
Darlington, England, Storbritannien, DL3 6HX
- Upphängd
- Darlington Memorial Hospital
-
Dartford, England, Storbritannien, DA2 8DA
- Indragen
- Darent Valley Hospital
-
Dudley, England, Storbritannien, DY1 2HQ
- Aktiv, inte rekryterande
- Russells Hall Hospital
-
Exeter, England, Storbritannien, Ex2 5DW
- Upphängd
- Royal Devon and Exeter Hospital
-
Frimley, England, Storbritannien, GU16 7 UJ
- Upphängd
- Frimley Park Hospital
-
Gateshead, England, Storbritannien, NE9 6SX
- Aktiv, inte rekryterande
- Queen Elizabeth Hospital Gateshead
-
Gillingham, England, Storbritannien, ME7 5NY
- Avslutad
- Medway Maritime Hospital
-
Great Yarmouth, England, Storbritannien, NR31 6LA
- Avslutad
- James Paget University Hospital
-
Guildford, England, Storbritannien, GU2 7XX
- Rekrytering
- Royal Surrey County Hospital
-
Kontakt:
- Ben Creagh-Brown
-
Harrow, England, Storbritannien, HA1 3UJ
- Aktiv, inte rekryterande
- Northwick Park Hospital
-
Hereford, England, Storbritannien, HR1 2ER
- Rekrytering
- Hereford County Hospital
-
Kontakt:
- Charlotte Small
-
High Barnet, England, Storbritannien, EN5 3DJ
- Aktiv, inte rekryterande
- Barnet Hospital
-
Huddersfield, England, Storbritannien, HD3 3EA
- Aktiv, inte rekryterande
- Huddersfield Royal Infirmary
-
Ilford, England, Storbritannien, IG3 8YB
- Aktiv, inte rekryterande
- King George Hospital
-
Ipswich, England, Storbritannien, IP4 5PD
- Indragen
- Ipswich Hospital
-
Kettering, England, Storbritannien, NN16 8UZ
- Rekrytering
- Kettering Hospital
-
Kontakt:
- Dhinesh Sundaran
-
Leeds, England, Storbritannien, LS9 7TF
- Aktiv, inte rekryterande
- Leeds General Infirmary
-
Leicester, England, Storbritannien, LE1 5WW
- Upphängd
- Leicester Royal Infirmary
-
Leicester, England, Storbritannien, LE3 9QP
- Upphängd
- Glenfield Hospital
-
Lincoln, England, Storbritannien, LN2 5QY
- Upphängd
- Lincoln County Hospital
-
Liverpool, England, Storbritannien, L7 8XP
- Aktiv, inte rekryterande
- Royal Liverpool University Hospital
-
Liverpool, England, Storbritannien, L14 3PE
- Avslutad
- Liverpool Heart and Chest Hospital
-
Liverpool, England, Storbritannien, L14 5AB
- Avslutad
- Alder Hey Hospital
-
Liverpool, England, Storbritannien, L9 7AL
- Upphängd
- University Hospital Aintree
-
London, England, Storbritannien, SE5 9RS
- Rekrytering
- King's College Hospital
-
Kontakt:
- Phillip Hopkins
-
London, England, Storbritannien, W12 0HS
- Rekrytering
- Hammersmith Hospital
-
Kontakt:
- Stephen Brett
-
London, England, Storbritannien, W2 1NY
- Rekrytering
- St Mary's Hospital
-
Kontakt:
- Anthony Gordon
-
London, England, Storbritannien, W6 8RF
- Rekrytering
- Charing Cross Hospital
-
Kontakt:
- David Antcliffe
-
London, England, Storbritannien, CR7 7YE
- Aktiv, inte rekryterande
- Croydon University Hospital
-
London, England, Storbritannien, E1 1FR
- Aktiv, inte rekryterande
- Royal London Hospital
-
London, England, Storbritannien, E11 1NR
- Aktiv, inte rekryterande
- Whipps Cross Hospital
-
London, England, Storbritannien, E13 8SL
- Aktiv, inte rekryterande
- Newham University Hospital
-
London, England, Storbritannien, EC1A 7BE
- Aktiv, inte rekryterande
- St Bartholomew's Hospital
-
London, England, Storbritannien, N18 1QX
- Aktiv, inte rekryterande
- North Middlesex University Hospital
-
London, England, Storbritannien, NW3 2QG
- Aktiv, inte rekryterande
- Royal Free Hospital
-
London, England, Storbritannien, SE1 7EH
- Rekrytering
- St Thomas Hospital
-
Kontakt:
- Marlies Ostermann
-
London, England, Storbritannien, SE1 9RT
- Aktiv, inte rekryterande
- Guy's Hospital
-
London, England, Storbritannien, SE18 4QH
- Aktiv, inte rekryterande
- Queen Elizabeth Hospital, Woolwich
-
London, England, Storbritannien, SW3 6JJ
- Aktiv, inte rekryterande
- Royal Marsden Hospital
-
London, England, Storbritannien, SW3 6NP
- Aktiv, inte rekryterande
- Royal Brompton Hospital
-
London, England, Storbritannien, SW17 0QT
- Rekrytering
- St George's University Hospital
-
Kontakt:
- Susannah Leaver
-
Luton, England, Storbritannien, LU4 0DZ
- Upphängd
- Luton and Dunstable University Hospital
-
Maidstone, England, Storbritannien, ME16 9QQ
- Rekrytering
- Maidstone Hospital
-
Kontakt:
- David Golden, MD
-
Manchester, England, Storbritannien, M13 9WL
- Upphängd
- Manchester Royal Infirmary
-
Manchester, England, Storbritannien, M20 4BX
- Avslutad
- The Christie Hospital
-
Manchester, England, Storbritannien, M23 9LT
- Upphängd
- Wythenshawe Hospital
-
Manchester, England, Storbritannien, M8 5RB
- Aktiv, inte rekryterande
- North Manchester General Hospital
-
Metropolitan Borough of Wirral, England, Storbritannien, CH49 5PE
- Rekrytering
- Arrowe Park Hospital
-
Kontakt:
- Craig Denmade, MD
-
Middlesbrough, England, Storbritannien, TS4 3BW
- Rekrytering
- The James Cook University Hospital
-
Kontakt:
- Jeremy Henning, MD
-
Milton Keynes, England, Storbritannien, MK6 5LD
- Rekrytering
- Milton Keynes University Hospital
-
Kontakt:
- Richard Stewart, MD
-
Newcastle, England, Storbritannien, NE1 4LP
- Upphängd
- Royal Victoria Infirmary, Newcastle
-
Newcastle, England, Storbritannien, NE7 7DN
- Upphängd
- Newcastle Freeman Hospital
-
Northampton, England, Storbritannien, NN1 5BD
- Upphängd
- Northampton General Hospital
-
Norwich, England, Storbritannien, NR4 7UY
- Avslutad
- Norfolk and Norwich University Hospital
-
Nottingham, England, Storbritannien, NG5 1PB
- Rekrytering
- City Hospital Nottingham
-
Kontakt:
- Daniel Harvey, MD
-
Nottingham, England, Storbritannien, NG7 2UH
- Rekrytering
- Queen's Medical Centre - Nottingham University Hospitals NHS Trust
-
Kontakt:
- Daniel Harvey, MD
-
Nuneaton, England, Storbritannien, CV10 7DJ
- Aktiv, inte rekryterande
- George Eliot Hospital
-
Oldham, England, Storbritannien, Ol1 2JH
- Rekrytering
- Royal Oldham Hospital
-
Kontakt:
- Redmond Tully, MD
-
Orpington, England, Storbritannien, BR6 8ND
- Upphängd
- Princess Royal University Hospital
-
Oxford, England, Storbritannien, OX3 9DU
- Aktiv, inte rekryterande
- John Radcliffe Hospital
-
Plymouth, England, Storbritannien, PL6 8DH
- Rekrytering
- Derriford Hospital
-
Kontakt:
- Nikitas Nikitas, MD
-
Poole, England, Storbritannien, BH15 2JB
- Rekrytering
- Poole Hospital NHS Foundation Trust
-
Kontakt:
- Henrik Reschreiter, MD
-
Portsmouth, England, Storbritannien, PO6 3LY
- Rekrytering
- Queen Alexandra Hospital
-
Kontakt:
- David Pogson, MD
-
Prescot, England, Storbritannien, L35 5DR
- Avslutad
- Whiston Hospital
-
Preston, England, Storbritannien, PR2 9HT
- Upphängd
- Royal Preston Hospital
-
Reading, England, Storbritannien, RG1 5AN
- Rekrytering
- Royal Berkshire Hospital
-
Kontakt:
- Andrew Walden, MD
-
Redditch, England, Storbritannien, B98 7UB
- Aktiv, inte rekryterande
- Alexandra Hospital, Redditch
-
Romford, England, Storbritannien, RM7 0AG
- Aktiv, inte rekryterande
- Queen's Hospital Romford
-
Rotherham, England, Storbritannien, S60 2UD
- Rekrytering
- Rotherham Hospital
-
Kontakt:
- Anil Hormis, MD
-
Royal Tunbridge Wells, England, Storbritannien, TN2 4QJ
- Rekrytering
- Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust
-
Kontakt:
- David Golden, MD
-
Salford, England, Storbritannien, M6 8HD
- Rekrytering
- Salford Royal Hospital
-
Kontakt:
- Paul Dark, MD
-
Salisbury, England, Storbritannien, SP2 8BJ
- Rekrytering
- Salisbury District Hospital
-
Kontakt:
- Phil Donnison, MD
-
Sheffield, England, Storbritannien, S10 2JF
- Rekrytering
- Royal Hallamshire Hospital
-
Kontakt:
- Gary Mills, MD
-
Sheffield, England, Storbritannien, S5 7AU
- Rekrytering
- Northern General Hospital
-
Kontakt:
- Gary Mills, MD
-
Slough, England, Storbritannien, SL2 4HL
- Aktiv, inte rekryterande
- Wexham Park Hospital
-
South Shields, England, Storbritannien, NE34 0PL
- Rekrytering
- South Tyneside District Hospital
-
Kontakt:
- Alistair Roy, MD
-
Southampton, England, Storbritannien, SO16 6YD
- Rekrytering
- Southampton General Hospital
-
Kontakt:
- Ahilanandan Dushianthan, MD
-
Stockport, England, Storbritannien, SK2 7JE
- Rekrytering
- Stepping Hill Hospital
-
Kontakt:
- Hywel Garrard, MD
-
Stockton-on-Tees, England, Storbritannien, TS19 8PE
- Rekrytering
- University Hospital of North Tees
-
Kontakt:
- Farooq Brohi, MD
-
Stoke-on-Trent, England, Storbritannien, ST4 6QG
- Rekrytering
- Royal Stoke University Hospital
-
Kontakt:
- Ramprasad Matsa, MD
-
Sunderland, England, Storbritannien, SR4 7TP
- Rekrytering
- Sunderland Royal Hospital
-
Kontakt:
- Alistair Roy, MD
-
Sutton in Ashfield, England, Storbritannien, NG17 4JL
- Rekrytering
- King's Mill Hospital
-
Kontakt:
- Sandaruwan Herath, MD
-
Swindon, England, Storbritannien, SN3 6BB
- Rekrytering
- Western General Hospital
-
Kontakt:
- Jonathan Rhodes, MD
-
Swindon, England, Storbritannien, SN3 6BB
- Aktiv, inte rekryterande
- Great Western Hospital
-
Taunton, England, Storbritannien, TA1 5DA
- Rekrytering
- Musgrove Park Hospital
-
Kontakt:
- Richard Innes, MD
-
Torquay, England, Storbritannien, TQ2 7AA
- Rekrytering
- Torbay Hospital
-
Kontakt:
- Adam Revill, MD
-
Truro, England, Storbritannien, TR1 3LJ
- Rekrytering
- Royal Cornwall Hospital
-
Kontakt:
- Michael Spivey, MD
-
Uxbridge, England, Storbritannien, UB9 6JH
- Avslutad
- Harefield Hospital
-
Watford, England, Storbritannien, WD18 0HB
- Rekrytering
- Watford General Hospital
-
Kontakt:
- Valarie Page, MD
-
Westcliff-on-Sea, England, Storbritannien, ISS0 0RY
- Aktiv, inte rekryterande
- Southend Hospital
-
Whitehaven, England, Storbritannien, CA28 8JG
- Indragen
- West Cumberland Hospital
-
Wigan, England, Storbritannien, WN1 2NN
- Aktiv, inte rekryterande
- Royal Albert Edward Infirmary
-
Winchester, England, Storbritannien, SO22 5DG
- Rekrytering
- Royal Hampshire County Hospital
-
Kontakt:
- Irina Grecu, MD
-
Wolverhampton, England, Storbritannien, WV10 0QP
- Aktiv, inte rekryterande
- New Cross Hospital Wolverhampton
-
Worcester, England, Storbritannien, WR5 1DD
- Aktiv, inte rekryterande
- Worcestershire Royal Hospital
-
York, England, Storbritannien, Y031 8HE
- Rekrytering
- York Teaching Hospital
-
Kontakt:
- Joseph Carter, MD
-
-
Northern Ireland
-
Antrim, Northern Ireland, Storbritannien, BT41 2RL
- Rekrytering
- Antrim Area Hospital
-
Kontakt:
- Paul Johnston, MD
-
Belfast, Northern Ireland, Storbritannien, BT14 6AB
- Rekrytering
- Mater Hospital
-
Kontakt:
- Michael McGinlay, MD
-
Belfast, Northern Ireland, Storbritannien, BT9 7AB
- Rekrytering
- Belfast City Hospital
-
Kontakt:
- Michael McGinlay, MD
-
Belfast, Northern Ireland, Storbritannien, BT12 6BA
- Rekrytering
- Royal Victoria Hospital Belfast
-
Kontakt:
- Michael McGinlay, MD
-
Londonderry, Northern Ireland, Storbritannien, BT47 6SB
- Rekrytering
- Altnagelvin Hospital
-
Kontakt:
- Adrian Donnelly, MD
-
-
Scotland
-
Aberdeen, Scotland, Storbritannien, AB25 2ZN
- Avslutad
- Aberdeen Royal Infirmary
-
Dundee, Scotland, Storbritannien, DD1 9SY
- Rekrytering
- Ninewells Hospital
-
Kontakt:
- James Chambers, MD
-
Edinburgh, Scotland, Storbritannien, EH16 4SA
- Rekrytering
- Royal Infirmary of Edinburgh
-
Kontakt:
- Thomas Craven, MD
-
Glasgow, Scotland, Storbritannien, G4 0SF
- Rekrytering
- Glasgow Royal Infirmary
-
Kontakt:
- Kathryn Puxty, MD
-
Glasgow, Scotland, Storbritannien, G51 4TF
- Rekrytering
- Queen Elizabeth University Hospital, Glasgow
-
Kontakt:
- Malcolm Sim, MD
-
Paisley, Scotland, Storbritannien, PA2 9PN
- Rekrytering
- Royal Alexandra Hospital
-
Kontakt:
- Kevin Rooney, MD
-
-
Wales
-
Abergavenny, Wales, Storbritannien, NP7 7EG
- Aktiv, inte rekryterande
- Neville Hall Hospital
-
Bodelwyddan, Wales, Storbritannien, LL18 5UJ
- Aktiv, inte rekryterande
- Glan Clwyd Hospital
-
Bridgend, Wales, Storbritannien, CF31 1RQ
- Aktiv, inte rekryterande
- Princess of Wales Hospital
-
Cardiff, Wales, Storbritannien, CF14 4XW
- Aktiv, inte rekryterande
- Cardiff and Vale University Hospital Wales
-
Carmarthen, Wales, Storbritannien, SA31 2AF
- Upphängd
- Glangwilli Hospital
-
Cwmbran, Wales, Storbritannien, NP44 8YN
- Aktiv, inte rekryterande
- Grange University Hospital
-
Newport, Wales, Storbritannien, NP20 2UB
- Upphängd
- Royal Gwent Hospital
-
Pont-y-clun, Wales, Storbritannien, CF72 8XR
- Aktiv, inte rekryterande
- Royal Glamorgan Hospital
-
Swansea, Wales, Storbritannien, SA6 6NL
- Aktiv, inte rekryterande
- Morriston Hospital
-
Wrexham, Wales, Storbritannien, LL13 7TD
- Rekrytering
- Wrexham Maelor Hospital
-
Kontakt:
- David Southern, MD
-
-
-
-
-
Prague, Tjeckien, 10000
- Rekrytering
- Fakultní nemocnice Královské Vinohrady
-
Kontakt:
- František Duška, MD
-
Teplice, Tjeckien, 41501
- Upphängd
- Teplice Hospital
-
-
-
-
-
Berlin, Tyskland, 10117
- Indragen
- Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
-
Berlin, Tyskland, 12351
- Avslutad
- Vivantes Klinikum Neukölln
-
Berlin, Tyskland, 13509
- Indragen
- Vivantes Humboldt-Klinikum
-
Berlin, Tyskland, 13353
- Upphängd
- Charite Universitätsmedizin Berlin
-
Cologne, Tyskland, 50937
- Indragen
- University Hospital of Cologne
-
Cottbus, Tyskland, 03058
- Avslutad
- Carl-Thiem-Klinikum Cottbus
-
Dortmund, Tyskland, 44137
- Avslutad
- Klinikum Dortmund
-
Essen, Tyskland, 45138
- Avslutad
- Elisabeth Hospital Essen
-
Frankfurt, Tyskland, 60590
- Indragen
- Universitätsklinikum Frankfurt
-
Hamburg, Tyskland, 20251
- Upphängd
- University Medical Center Hamburg-Eppendorf (UKE)
-
Jena, Tyskland, 07747
- Upphängd
- Universitätsklinikum Jena
-
Leipzig, Tyskland, 04103
- Upphängd
- University Hospital Leipzig
-
Leipzig, Tyskland, 04103
- Upphängd
- Universitätsklinikum Leipzig
-
München, Tyskland, 81675
- Upphängd
- Klinikum rechts der Isar der TU München
-
Münster, Tyskland, 48149
- Upphängd
- Universitätsklinikum Münster
-
Tübingen, Tyskland, 72076
- Avslutad
- Universitäts Klinikum Tübingen
-
Würzburg, Tyskland, 97080
- Upphängd
- Universitätsklinikum Würzburg
-
-
-
-
-
Nyíregyháza, Ungern, 4400
- Avslutad
- Jósa András County Hospital
-
Ózd, Ungern, 3600
- Avslutad
- Almási Balogh Pál Kórház
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
The eligibility criteria for the Platform are applied at multiple levels. One level is that there are inclusion and exclusion criteria that determine eligibility for randomization within the Platform. Another level is that, once eligible for inclusion within the Platform, additional criteria (typically exclusion criteria) are applied that are specific to each domain. Finally, intervention-level eligibility criteria may be applied for interventions within a domain. A patient is eligible for inclusion within a domain when:
- All Platform inclusion criteria are met
- None of the Platform exclusion criteria are met
- Domain-specific eligibility criteria are met
- The patient is eligible for at least two interventions within a domain
As such, the key "inclusion criteria" for being eligible for a domain are that the patient is eligible for the Platform.
--
PLATFORM INCLUSION CRITERIA:
- Hospitalised patient
- Acute respiratory tract infection
- Aged 28 days or older
PLATFORM EXCLUSION CRITERIA:
- Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- Patient is expected to be discharged from hospital within the next 24 hours
- Previous participation in this REMAP within the last 90 days
DOMAIN-SPECIFIC ELIGIBILITY CRITERIA:
Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Faktoriell uppgift
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Övrig: Antibiotic Domain
Patients with community-acquired pneumonia and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment. |
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. Note: this intervention is now closed. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. |
|
Övrig: Macrolide Duration Domain
Patients with community-acquired pneumonia who have been allocated to receive a beta-lactam + macrolide intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy |
Standard course of macrolide therapy, discontinued between study day 3 and the end of study day 5. The dosing of and route of administration is not protocolised, the following guidance is provided:
Extended course of macrolide therapy discontinued at the end of study day 14 or hospital discharge (whichever occurs first). The dosing of and route of administration is not protocolised, the following guidance is provided:
|
|
Övrig: Corticosteroid Domain
Patients with severe lower-respiratory tract infection will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment |
Patients are not to receive any systemic corticosteroids, including hydrocortisone, to study day 28 or hospital discharge (whichever occurs first). 50mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days. Note: this intervention is now closed. 50mg IV hydrocortisone every 6 hours while the patient is in septic shock 100mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days. Note: this intervention was only available to patients with suspected or proven COVID-19 and is now closed. 6 mg of IV or enteral dexamethasone will be administered daily for up to 10 days while in hospital. |
|
Övrig: Influenza Antiviral Domain
Patients with microbiological testing confirmed influenza infection will be randomised to one of six interventions. |
No antiviral agent intended to be active against influenza infection is to be administered Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first) Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first) Baloxavir marboxil administered on days 1 and 4 post-randomisation. Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation. Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation. |
|
Övrig: COVID-19 Antiviral Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed. |
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU. Note: this intervention is now closed. Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first). Note: this intervention is now closed. Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU. Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first). Note: this intervention is now closed. Ivermectin administered enterally at a dose of 0.2 mg/kg once daily with a maximum daily dose of 24mg/day. Note: this intervention is now closed. |
|
Övrig: COVID-19 Immune Modulation Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed. |
No immune modulating agent intended to be active against COVID-19 is to be administered. Note: this intervention is now closed. IFN-β1a 10 μg will be administered as an intravenous bolus injection via a central or peripheral line. IFN-β1a will be administered once daily for 6 days or until ICU discharge, whichever occurs first. Note: this intervention is now closed.
Andra namn:
A loading dose of 300mg anakinra will be administered as a bolus via central or peripheral line. This is followed by maintenance doses of 100mg of anakinra administered every 6 hours. In patients with renal impairment, anakinra will be administered on alternate days. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. Note: this intervention is now closed. Sarilumab will be administered as a single dose of 400mg, via IV infusion through peripheral or central line over a one-hour period. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. In children weighing less than 30kg, tocilizumab dose will be 12mg/kg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. |
|
Övrig: Anticoagulation Domain
Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed. |
Standard venous thromboprophylaxis that complies with local guidelines or usual practice will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Note: this intervention is now closed. Patients will be administered either low molecular weight heparin (LMWH) or unfractionated heparin (UFH) to achieve systemic anticoagulation. Either agent may be used and the same patient may be switched between UFH and LMWH at the discretion of the treating clinician. Note: this intervention is now closed. Low dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain. Intermediate dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain. Patients already receiving therapeutic dose anticoagulation at the time of randomisation to this intervention will be administered either unfractionated heparin by IV infusion or low-molecular weight heparin to achieve systemic anticoagulation according to local practice for acute VTE treatment for 14 days following randomisation or until hospital discharge, whichever occurs first. Note: this intervention is now closed. |
|
Övrig: Immunoglobulin Domain
Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients. |
No immunoglobulin intended to be active against SARS-CoV-2 infection is to be administered. Patients will receive at least one and no more than two units of ABO compatible convalescent plasma within 48 hours of randomisation. Note: this intervention is now closed. |
|
Övrig: Vitamin C Domain
Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C. Note: this domain is now closed. |
No high dose intravenous vitamin C is to be administered Note: this intervention is now closed. Intravenous Vitamin C 50mg/kg administered every 6 hours for 16 doses Note: this intervention is now closed. |
|
Övrig: Simvastatin Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin. Note: this domain is now closed. |
No simvastatin intended to be active against COVID-19 is to be administered Note: this intervention is now closed. Simvastatin 80mg administered once daily via enteral route, while the patient remains in hospital up to 28 days after randomisation Note: this intervention is now closed. |
|
Övrig: Antiplatelet Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor. Note: this domain is now closed. |
No antiplatelet agent or NSAID to be administered. Note: this intervention is now closed. Aspirin administered at either 75mg or 100mg once per day for 14 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andra namn:
Site-selected P2Y12 inhibitor:
Note: this intervention is now closed.
Andra namn:
|
|
Övrig: Mechanical Ventilation Domain
Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy |
Clinician-preferred ventilation strategy, including mode of ventilation and all ventilatory parameters Invasive mechanical ventilation strategy delivered as outlined in relevant protocol documents for this domain. |
|
Övrig: COVID-19 Immune Modulation (2) Domain
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed. |
No immune modulating agent intended to be active against COVID-19 is to be administered. Note: this intervention is now closed. Eritoran initiated with a 26.24 mg loading dose (6.56 mg/h IV for 4 hours), followed by a second 13.12 mg loading dose (6.56 mg/h IV for 2 hours) at 12 hours after initiation. Patients will then receive twenty-six 6.56 mg maintenance doses (3.28 mg/h IV for 2 hours) every 12 hours thereafter (total of 14 days). Dosing will be stopped if the patient is discharged from hospital Note: this intervention is now closed. Apremilast administered 30mg twice daily for 14 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed. |
|
Övrig: ACE2 RAS Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed. |
No RAS inhibitor (i.e. no ACEi or ARB) is to be administered up to the end of study day 10. Note: this intervention is now closed. Site-preferred ACEi agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andra namn:
Site-preferred ARB agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andra namn:
Site-preferred ARB agent administered in combination with DMX-200 for 10 days or until hospital discharge, whichever occurs first. ARB administered as directed by the treating clinician. DMX-200 administered enterally at a dose of 120mg twice daily. Note: this intervention is now closed. |
|
Övrig: Cysteamine Domain
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine. Note: this domain is now closed. |
No cysteamine to be administered until the end of study day 10 or hospital discharge, whichever occurs first. Note: this intervention is now closed. Cysteamine administered every 8 hours at a dose of 5 mg/kg estimated or measured body weight (maximum dose of 500mg), for ten days or until ICU discharge, whichever occurs first. Note: this intervention is now closed. |
|
Övrig: Endothelial Domain
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib. |
No endothelial modulator (imatinib or another tyrosine kinase inhibitor targeting the same pathway as imatinib) is to be administered. Enteral imatinib will be administered as a single 800mg loading dose (study day 1) followed by 400mg daily until study day 14 or discharge. |
|
Övrig: Influenza Immune Modulation
Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of three interventions. |
Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. In children weighing less than 30kg, tocilizumab dose will be 12mg/kg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. No immune modulating agent intended to be active against influenza is to be administered. Baricitinib will be administered at a dose that is determined by age and renal function, for up to 10 days or hospital discharge (whichever occurs first). |
|
Övrig: COVID-19 Antiviral (II) Domain
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions. |
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days.
Andra namn:
Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first. Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days. Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first. |
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Övrig: Tropical Antibiotic Domain
Patients with community-acquired pneumonia in regions at locations where or when empiric cover for melioidosis is appropriate, and requiring empiric antibiotic therapy including cover for melioidosis, will be randomised one of two antibiotic interventions |
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. |
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Survival and Recovery Trajectory up to day 90
Tidsram: Day 90
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The primary endpoint, named Survival and Recovery Trajectory, is a composite of: 90-day all-cause mortality and, among survivors, the number of days on which the patient was not receiving organ failure support during the index hospitalisation, up to the end of study day 28; and, among survivors who never receive organ failure support, hospital free days for the index hospitalisation up to the end of study day 28. For the purposes of this endpoint, organ failure support is defined as:
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Day 90
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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All-cause mortality
Tidsram: Day 90
|
All-cause mortality to day 90 post-randomisation |
Day 90
|
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Days alive and free from organ-failure support
Tidsram: Day 28
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Days alive and free from organ failure support during the index hospitalisation to day 28 |
Day 28
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Days alive and out of hospital
Tidsram: Day 28
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Days alive and out of hospital for the index hospitalisation, to day 28 |
Day 28
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Health-related Quality of life assessment
Tidsram: 6 months
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EQ5D-5L and WHODAS 2.0 (not completed in all regions) |
6 months
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Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Domain-Specific Secondary Outcome
Tidsram: During the index hospitalisation to Day 90 post-randomisation, unless otherwise specified
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Each domain may specify domain-specific secondary outcomes. Please see relevant Domain-Specific Protocol Documents for details. |
During the index hospitalisation to Day 90 post-randomisation, unless otherwise specified
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Samarbetspartners och utredare
Sponsor
Samarbetspartners
Utredare
- Studiestol: Steve Webb, Prof, Monash University, Study Chair REMAP-CAP Australia
- Studiestol: Colin McArthur, Dr, Medical Research Institute of New Zealand, Study Chair REMAP-CAP New Zealand
- Studiestol: Marc Bonten, Prof, UMC Utrecht, Study Chair REMAP-CAP Europe
- Studiestol: Lennie Derde, MD, UMC Utrecht, Coordinating Investigator REMAP-CAP Europe
- Studiestol: John Marshall, Prof, Unity Health Toronto, Study Chair REMAP-CAP Canada
- Studiestol: Derek Angus, Prof, University of Pittsburgh Medical Center, Study Chair REMAP-CAP USA
- Studiestol: Luis Felipe Reyes, MD, MSc, PhD, Clínica Universidad de la Sabana, Study Chair REMAP-CAP Colombia
Publikationer och användbara länkar
Allmänna publikationer
- Kreuzberger N, Hirsch C, Chai KL, Tomlinson E, Khosravi Z, Popp M, Neidhardt M, Piechotta V, Salomon S, Valk SJ, Monsef I, Schmaderer C, Wood EM, So-Osman C, Roberts DJ, McQuilten Z, Estcourt LJ, Skoetz N. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database Syst Rev. 2021 Sep 2;9(9):CD013825. doi: 10.1002/14651858.CD013825.pub2.
- Tume LN, Menzies JC, Ray S, Scholefield BR; UK Paediatric Intensive Care Society Study Group. Research Priorities for U.K. Pediatric Critical Care in 2019: Healthcare Professionals' and Parents' Perspectives. Pediatr Crit Care Med. 2021 May 1;22(5):e294-e301. doi: 10.1097/PCC.0000000000002647.
- Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc. 2020 Jul;17(7):879-891. doi: 10.1513/AnnalsATS.202003-192SD.
- REMAP-CAP Investigators; Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettila V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Apr 22;384(16):1491-1502. doi: 10.1056/NEJMoa2100433. Epub 2021 Feb 25.
- Fischer AL, Messer S, Riera R, Martimbianco ALC, Stegemann M, Estcourt LJ, Weibel S, Monsef I, Andreas M, Pacheco RL, Skoetz N. Antiplatelet agents for the treatment of adults with COVID-19. Cochrane Database Syst Rev. 2023 Jul 25;7(7):CD015078. doi: 10.1002/14651858.CD015078.
- REMAP-CAP Investigators; Angus DC. Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial. Intensive Care Med. 2025 Apr;51(4):665-680. doi: 10.1007/s00134-025-07861-w. Epub 2025 Apr 22.
- Derde L, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, Beasley R, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Buxton M, Cheng AC, Cooper N, Cove M, Cremer OL, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Galea J, Goossens H, Haniffa R, Hills TE, Huang DT, Ichihara N, King A, Lamontagne F, Lawler PR, Leavis HL, Lewis RJ, Litton E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Morpeth SC, Murthy S, Netea MG, Ogungbenro K, Orr K, Parke RL, Parker JC, Patanwala AE, Pettila V, Reyes LF, Saito H, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, Tong SYC, Vaara S, Youngstein T, Zarychanski R, Green C, Higgins AM, McArthur CJ, Berry LR, Lorenzi E, Berry S, Webb SA, Angus DC, van de Veerdonk FL. Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial. Thorax. 2025 Jul 15;80(8):530-539. doi: 10.1136/thorax-2024-222488.
- LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Menard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Horvat C, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023 Nov 14;330(18):1745-1759. doi: 10.1001/jama.2023.21407.
- REMAP-CAP Investigators; Hills TE, Lorenzi E, Berry LR, Shyamsundar M, Al-Beidh F, Annane D, Arabi Y, Aryal D, Au C, Beane A, Bhimani Z, Bonten M, Bradbury CA, Brunkhorst FM, Burrell A, Buxton M, Calfee CS, Cecconi M, Cheng AC, Cove ME, Detry MA, Estcourt LJ, Fitzgerald M, Goligher EC, Goossens H, Green C, Haniffa R, Harrison DA, Hashmi M, Higgins AM, Horvat C, Huang DT, Ichihara N, Jayakumar D, Kruger PS, Lamontagne F, Lampro L, Lawler PR, Marshall JC, Mason AJ, McGlothlin A, McGuinness S, McQuilten ZK, McVerry BJ, Mouncey PR, Murthy S, Neal MD, Nichol AD, O'Kane CM, Parke RL, Parker JC, Rabindrarajan E, Reyes LF, Rowan KM, Saito H, Santos M, Saunders CT, Seymour CW, Shankar-Hari M, Sinha P, Thompson BT, Turgeon AF, Turner AM, van de Veerdonk F, Weis S, Young IS, Zarychanski R, Lewis RJ, McArthur CJ, Angus DC, Berry SM, Derde LPG, Webb SA, Gordon AC, McAuley DF. Simvastatin in Critically Ill Patients with Covid-19. N Engl J Med. 2023 Dec 21;389(25):2341-2354. doi: 10.1056/NEJMoa2309995. Epub 2023 Oct 25.
- Bradbury CA, Lawler PR, McVerry BJ, Zarychanski R; REMAP-C. A. P. Investigators. Continuation of therapeutic dose heparin for critically ill patients with COVID-19. Intensive Care Med. 2023 Jul;49(7):873-875. doi: 10.1007/s00134-023-07095-8. Epub 2023 May 31. No abstract available.
- Writing Committee for the REMAP-CAP Investigators; Lawler PR, Derde LPG, van de Veerdonk FL, McVerry BJ, Huang DT, Berry LR, Lorenzi E, van Kimmenade R, Gommans F, Vaduganathan M, Leaf DE, Baron RM, Kim EY, Frankfurter C, Epelman S, Kwan Y, Grieve R, O'Neill S, Sadique Z, Puskarich M, Marshall JC, Higgins AM, Mouncey PR, Rowan KM, Al-Beidh F, Annane D, Arabi YM, Au C, Beane A, van Bentum-Puijk W, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Cecconi M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Ezekowitz J, Fitzgerald M, Gattas D, Godoy LC, Goossens H, Haniffa R, Harrison DA, Hills T, Horvat CM, Ichihara N, Lamontagne F, Linstrum KM, McAuley DF, McGlothlin A, McGuinness SP, McQuilten Z, Murthy S, Nichol AD, Owen DRJ, Parke RL, Parker JC, Pollock KM, Reyes LF, Saito H, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Singh V, Turgeon AF, Turner AM, Zarychanski R, Green C, Lewis RJ, Angus DC, Berry S, Gordon AC, McArthur CJ, Webb SA. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023 Apr 11;329(14):1183-1196. doi: 10.1001/jama.2023.4480.
- Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023 Jan 3;329(1):39-51. doi: 10.1001/jama.2022.23257.
- REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910.
- Writing Committee for the REMAP-CAP Investigators; Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Begin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chasse M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178.
- REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Dzavik V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4.
- ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Dzavik V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, Garcia-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Perez Gonzalez YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4.
- Arabi YM, Gordon AC, Derde LPG, Nichol AD, Murthy S, Beidh FA, Annane D, Swaidan LA, Beane A, Beasley R, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Buzgau A, Cheng A, De Jong M, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Fowler R, Girard TD, Goligher EC, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Huang DT, King AJ, Lamontagne F, Lawler PR, Lewis R, Linstrum K, Litton E, Lorenzi E, Malakouti S, McAuley DF, McGlothlin A, Mcguinness S, McVerry BJ, Montgomery SK, Morpeth SC, Mouncey PR, Orr K, Parke R, Parker JC, Patanwala AE, Rowan KM, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tong SYC, Turgeon AF, Turner AM, Van de Veerdonk FL, Zarychanski R, Green C, Berry S, Marshall JC, McArthur C, Angus DC, Webb SA; REMAP-CAP Investigators. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021 Aug;47(8):867-886. doi: 10.1007/s00134-021-06448-5. Epub 2021 Jul 12.
- Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, Fitzgerald M, Goossens H, Green C, Haniffa R, Higgins AM, Horvat C, Hullegie SJ, Kruger P, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, Marshall J, McAuley D, McGlothin A, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Rowan K, Sanil A, Santos M, Saunders C, Seymour C, Turner A, van de Veerdonk F, Venkatesh B, Zarychanski R, Berry S, Lewis RJ, McArthur C, Webb SA, Gordon AC; Writing Committee for the REMAP-CAP Investigators; Al-Beidh F, Angus D, Annane D, Arabi Y, van Bentum-Puijk W, Berry S, Beane A, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Cheng A, De Jong M, Derde L, Estcourt L, Goossens H, Gordon A, Green C, Haniffa R, Lamontagne F, Lawler P, Litton E, Marshall J, McArthur C, McAuley D, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Rowan K, Seymour C, Turner A, van de Veerdonk F, Webb S, Zarychanski R, Campbell L, Forbes A, Gattas D, Heritier S, Higgins L, Kruger P, Peake S, Presneill J, Seppelt I, Trapani T, Young P, Bagshaw S, Daneman N, Ferguson N, Misak C, Santos M, Hullegie S, Pletz M, Rohde G, Rowan K, Alexander B, Basile K, Girard T, Horvat C, Huang D, Linstrum K, Vates J, Beasley R, Fowler R, McGloughlin S, Morpeth S, Paterson D, Venkatesh B, Uyeki T, Baillie K, Duffy E, Fowler R, Hills T, Orr K, Patanwala A, Tong S, Netea M, Bihari S, Carrier M, Fergusson D, Goligher E, Haidar G, Hunt B, Kumar A, Laffan M, Lawless P, Lother S, McCallum P, Middeldopr S, McQuilten Z, Neal M, Pasi J, Schutgens R, Stanworth S, Turgeon A, Weissman A, Adhikari N, Anstey M, Brant E, de Man A, Lamonagne F, Masse MH, Udy A, Arnold D, Begin P, Charlewood R, Chasse M, Coyne M, Cooper J, Daly J, Gosbell I, Harvala-Simmonds H, Hills T, MacLennan S, Menon D, McDyer J, Pridee N, Roberts D, Shankar-Hari M, Thomas H, Tinmouth A, Triulzi D, Walsh T, Wood E, Calfee C, O'Kane C, Shyamsundar M, Sinha P, Thompson T, Young I, Bihari S, Hodgson C, Laffey J, McAuley D, Orford N, Neto A, Detry M, Fitzgerald M, Lewis R, McGlothlin A, Sanil A, Saunders C, Berry L, Lorenzi E, Miller E, Singh V, Zammit C, van Bentum Puijk W, Bouwman W, Mangindaan Y, Parker L, Peters S, Rietveld I, Raymakers K, Ganpat R, Brillinger N, Markgraf R, Ainscough K, Brickell K, Anjum A, Lane JB, Richards-Belle A, Saull M, Wiley D, Bion J, Connor J, Gates S, Manax V, van der Poll T, Reynolds J, van Beurden M, Effelaar E, Schotsman J, Boyd C, Harland C, Shearer A, Wren J, Clermont G, Garrard W, Kalchthaler K, King A, Ricketts D, Malakoutis S, Marroquin O, Music E, Quinn K, Cate H, Pearson K, Collins J, Hanson J, Williams P, Jackson S, Asghar A, Dyas S, Sutu M, Murphy S, Williamson D, Mguni N, Potter A, Porter D, Goodwin J, Rook C, Harrison S, Williams H, Campbell H, Lomme K, Williamson J, Sheffield J, van't Hoff W, McCracken P, Young M, Board J, Mart E, Knott C, Smith J, Boschert C, Affleck J, Ramanan M, D'Souza R, Pateman K, Shakih A, Cheung W, Kol M, Wong H, Shah A, Wagh A, Simpson J, Duke G, Chan P, Cartner B, Hunter S, Laver R, Shrestha T, Regli A, Pellicano A, McCullough J, Tallott M, Kumar N, Panwar R, Brinkerhoff G, Koppen C, Cazzola F, Brain M, Mineall S, Fischer R, Biradar V, Soar N, White H, Estensen K, Morrison L, Smith J, Cooper M, Health M, Shehabi Y, Al-Bassam W, Hulley A, Whitehead C, Lowrey J, Gresha R, Walsham J, Meyer J, Harward M, Venz E, Williams P, Kurenda C, Smith K, Smith M, Garcia R, Barge D, Byrne D, Byrne K, Driscoll A, Fortune L, Janin P, Yarad E, Hammond N, Bass F, Ashelford A, Waterson S, Wedd S, McNamara R, Buhr H, Coles J, Schweikert S, Wibrow B, Rauniyar R, Myers E, Fysh E, Dawda A, Mevavala B, Litton E, Ferrier J, Nair P, Buscher H, Reynolds C, Santamaria J, Barbazza L, Homes J, Smith R, Murray L, Brailsford J, Forbes L, Maguire T, Mariappa V, Smith J, Simpson S, Maiden M, Bone A, Horton M, Salerno T, Sterba M, Geng W, Depuydt P, De Waele J, De Bus L, Fierens J, Bracke S, Reeve B, Dechert W, Chasse M, Carrier FM, Boumahni D, Benettaib F, Ghamraoui A, Bellemare D, Cloutier E, Francoeur C, Lamontagne F, D'Aragon F, Carbonneau E, Leblond J, Vazquez-Grande G, Marten N, Wilson M, Albert M, Serri K, Cavayas A, Duplaix M, Williams V, Rochwerg B, Karachi T, Oczkowski S, Centofanti J, Millen T, Duan E, Tsang J, Patterson L, English S, Watpool I, Porteous R, Miezitis S, McIntyre L, Brochard L, Burns K, Sandhu G, Khalid I, Binnie A, Powell E, McMillan A, Luk T, Aref N, Andric Z, Cviljevic S, Dimoti R, Zapalac M, Mirkovic G, Barsic B, Kutlesa M, Kotarski V, Vujaklija Brajkovic A, Babel J, Sever H, Dragija L, Kusan I, Vaara S, Pettila L, Heinonen J, Kuitunen A, Karlsson S, Vahtera A, Kiiski H, Ristimaki S, Azaiz A, Charron C, Godement M, Geri G, Vieillard-Baron A, Pourcine F, Monchi M, Luis D, Mercier R, Sagnier A, Verrier N, Caplin C, Siami S, Aparicio C, Vautier S, Jeblaoui A, Fartoukh M, Courtin L, Labbe V, Leparco C, Muller G, Nay MA, Kamel T, Benzekri D, Jacquier S, Mercier E, Chartier D, Salmon C, Dequin P, Schneider F, Morel G, L'Hotellier S, Badie J, Berdaguer FD, Malfroy S, Mezher C, Bourgoin C, Megarbane B, Voicu S, Deye N, Malissin I, Sutterlin L, Guitton C, Darreau C, Landais M, Chudeau N, Robert A, Moine P, Heming N, Maxime V, Bossard I, Nicholier TB, Colin G, Zinzoni V, Maquigneau N, Finn A, Kress G, Hoff U, Friedrich Hinrichs C, Nee J, Pletz M, Hagel S, Ankert J, Kolanos S, Bloos F, Petros S, Pasieka B, Kunz K, Appelt P, Schutze B, Kluge S, Nierhaus A, Jarczak D, Roedl K, Weismann D, Frey A, Klinikum Neukolln V, Reill L, Distler M, Maselli A, Belteczki J, Magyar I, Fazekas A, Kovacs S, Szoke V, Szigligeti G, Leszkoven J, Collins D, Breen P, Frohlich S, Whelan R, McNicholas B, Scully M, Casey S, Kernan M, Doran P, O'Dywer M, Smyth M, Hayes L, Hoiting O, Peters M, Rengers E, Evers M, Prinssen A, Bosch Ziekenhuis J, Simons K, Rozendaal W, Polderman F, de Jager P, Moviat M, Paling A, Salet A, Rademaker E, Peters AL, de Jonge E, Wigbers J, Guilder E, Butler M, Cowdrey KA, Newby L, Chen Y, Simmonds C, McConnochie R, Ritzema Carter J, Henderson S, Van Der Heyden K, Mehrtens J, Williams T, Kazemi A, Song R, Lai V, Girijadevi D, Everitt R, Russell R, Hacking D, Buehner U, Williams E, Browne T, Grimwade K, Goodson J, Keet O, Callender O, Martynoga R, Trask K, Butler A, Schischka L, Young C, Lesona E, Olatunji S, Robertson Y, Jose N, Amaro dos Santos Catorze T, de Lima Pereira TNA, Neves Pessoa LM, Castro Ferreira RM, Pereira Sousa Bastos JM, Aysel Florescu S, Stanciu D, Zaharia MF, Kosa AG, Codreanu D, Marabi Y, Al Qasim E, Moneer Hagazy M, Al Swaidan L, Arishi H, Munoz-Bermudez R, Marin-Corral J, Salazar Degracia A, Parrilla Gomez F, Mateo Lopez MI, Rodriguez Fernandez J, Carcel Fernandez S, Carmona Flores R, Leon Lopez R, de la Fuente Martos C, Allan A, Polgarova P, Farahi N, McWilliam S, Hawcutt D, Rad L, O'Malley L, Whitbread J, Kelsall O, Wild L, Thrush J, Wood H, Austin K, Donnelly A, Kelly M, O'Kane S, McClintock D, Warnock M, Johnston P, Gallagher LJ, Mc Goldrick C, Mc Master M, Strzelecka A, Jha R, Kalogirou M, Ellis C, Krishnamurthy V, Deelchand V, Silversides J, McGuigan P, Ward K, O'Neill A, Finn S, Phillips B, Mullan D, Oritz-Ruiz de Gordoa L, Thomas M, Sweet K, Grimmer L, Johnson R, Pinnell J, Robinson M, Gledhill L, Wood T, Morgan M, Cole J, Hill H, Davies M, Antcliffe D, Templeton M, Rojo R, Coghlan P, Smee J, Mackay E, Cort J, Whileman A, Spencer T, Spittle N, Kasipandian V, Patel A, Allibone S, Genetu RM, Ramali M, Ghosh A, Bamford P, London E, Cawley K, Faulkner M, Jeffrey H, Smith T, Brewer C, Gregory J, Limb J, Cowton A, O'Brien J, Nikitas N, Wells C, Lankester L, Pulletz M, Williams P, Birch J, Wiseman S, Horton S, Alegria A, Turki S, Elsefi T, Crisp N, Allen L, McCullagh I, Robinson P, Hays C, Babio-Galan M, Stevenson H, Khare D, Pinder M, Selvamoni S, Gopinath A, Pugh R, Menzies D, Mackay C, Allan E, Davies G, Puxty K, McCue C, Cathcart S, Hickey N, Ireland J, Yusuff H, Isgro G, Brightling C, Bourne M, Craner M, Watters M, Prout R, Davies L, Pegler S, Kyeremeh L, Arbane G, Wilson K, Gomm L, Francia F, Brett S, Sousa Arias S, Elin Hall R, Budd J, Small C, Birch J, Collins E, Henning J, Bonner S, Hugill K, Cirstea E, Wilkinson D, Karlikowski M, Sutherland H, Wilhelmsen E, Woods J, North J, Sundaran D, Hollos L, Coburn S, Walsh J, Turns M, Hopkins P, Smith J, Noble H, Depante MT, Clarey E, Laha S, Verlander M, Williams A, Huckle A, Hall A, Cooke J, Gardiner-Hill C, Maloney C, Qureshi H, Flint N, Nicholson S, Southin S, Nicholson A, Borgatta B, Turner-Bone I, Reddy A, Wilding L, Chamara Warnapura L, Agno Sathianathan R, Golden D, Hart C, Jones J, Bannard-Smith J, Henry J, Birchall K, Pomeroy F, Quayle R, Makowski A, Misztal B, Ahmed I, KyereDiabour T, Naiker K, Stewart R, Mwaura E, Mew L, Wren L, Willams F, Innes R, Doble P, Hutter J, Shovelton C, Plumb B, Szakmany T, Hamlyn V, Hawkins N, Lewis S, Dell A, Gopal S, Ganguly S, Smallwood A, Harris N, Metherell S, Lazaro JM, Newman T, Fletcher S, Nortje J, Fottrell-Gould D, Randell G, Zaman M, Elmahi E, Jones A, Hall K, Mills G, Ryalls K, Bowler H, Sall J, Bourne R, Borrill Z, Duncan T, Lamb T, Shaw J, Fox C, Moreno Cuesta J, Xavier K, Purohit D, Elhassan M, Bakthavatsalam D, Rowland M, Hutton P, Bashyal A, Davidson N, Hird C, Chhablani M, Phalod G, Kirkby A, Archer S, Netherton K, Reschreiter H, Camsooksai J, Patch S, Jenkins S, Pogson D, Rose S, Daly Z, Brimfield L, Claridge H, Parekh D, Bergin C, Bates M, Dasgin J, McGhee C, Sim M, Hay SK, Henderson S, Phull MK, Zaidi A, Pogreban T, Rosaroso LP, Harvey D, Lowe B, Meredith M, Ryan L, Hormis A, Walker R, Collier D, Kimpton S, Oakley S, Rooney K, Rodden N, Hughes E, Thomson N, McGlynn D, Walden A, Jacques N, Coles H, Tilney E, Vowell E, Schuster-Bruce M, Pitts S, Miln R, Purandare L, Vamplew L, Spivey M, Bean S, Burt K, Moore L, Day C, Gibson C, Gordon E, Zitter L, Keenan S, Baker E, Cherian S, Cutler S, Roynon-Reed A, Harrington K, Raithatha A, Bauchmuller K, Ahmad N, Grecu I, Trodd D, Martin J, Wrey Brown C, Arias AM, Craven T, Hope D, Singleton J, Clark S, Rae N, Welters I, Hamilton DO, Williams K, Waugh V, Shaw D, Puthucheary Z, Martin T, Santos F, Uddin R, Somerville A, Tatham KC, Jhanji S, Black E, Dela Rosa A, Howle R, Tully R, Drummond A, Dearden J, Philbin J, Munt S, Vuylsteke A, Chan C, Victor S, Matsa R, Gellamucho M, Creagh-Brown B, Tooley J, Montague L, De Beaux F, Bullman L, Kersiake I, Demetriou C, Mitchard S, Ramos L, White K, Donnison P, Johns M, Casey R, Mattocks L, Salisbury S, Dark P, Claxton A, McLachlan D, Slevin K, Lee S, Hulme J, Joseph S, Kinney F, Senya HJ, Oborska A, Kayani A, Hadebe B, Orath Prabakaran R, Nichols L, Thomas M, Worner R, Faulkner B, Gendall E, Hayes K, Hamilton-Davies C, Chan C, Mfuko C, Abbass H, Mandadapu V, Leaver S, Forton D, Patel K, Paramasivam E, Powell M, Gould R, Wilby E, Howcroft C, Banach D, Fernandez de Pinedo Artaraz Z, Cabreros L, White I, Croft M, Holland N, Pereira R, Zaki A, Johnson D, Jackson M, Garrard H, Juhaz V, Roy A, Rostron A, Woods L, Cornell S, Pillai S, Harford R, Rees T, Ivatt H, Sundara Raman A, Davey M, Lee K, Barber R, Chablani M, Brohi F, Jagannathan V, Clark M, Purvis S, Wetherill B, Dushianthan A, Cusack R, de Courcy-Golder K, Smith S, Jackson S, Attwood B, Parsons P, Page V, Zhao XB, Oza D, Rhodes J, Anderson T, Morris S, Xia Le Tai C, Thomas A, Keen A, Digby S, Cowley N, Wild L, Southern D, Reddy H, Campbell A, Watkins C, Smuts S, Touma O, Barnes N, Alexander P, Felton T, Ferguson S, Sellers K, Bradley-Potts J, Yates D, Birkinshaw I, Kell K, Marshall N, Carr-Knott L, Summers C. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA. 2020 Oct 6;324(13):1317-1329. doi: 10.1001/jama.2020.17022.
- Boyle AJ, Ryan EG, Berry LR, Berry S, Derde L, Lawler PR, Lorenzi E, O'Kane CM, Shankar-Hari M, Veerdonk FV, Gordon AC, McAuley DF; REMAP-CAP Immune Modulation Domain Investigators. Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial. Crit Care. 2026 Oct 1;30(1):506. doi: 10.1186/s13054-026-06311-3.
- Nurmi V, Knight C, Estcourt L, Hepojoki J, Lamikanra AA, Tsang HP, Roberts DJ, Polack FP, Simmonds P, Hedman K, Alvarez-Paggi D, Harvala H. The Relationship Between SARS-CoV-2 Neutralizing Antibody Titers and Avidity in Plasma Collected From Convalescent Nonvaccinated and Vaccinated Blood Donors. J Infect Dis. 2023 Aug 11;228(3):245-250. doi: 10.1093/infdis/jiad070.
- Goligher EC, Lawler PR, Jensen TP, Talisa V, Berry LR, Lorenzi E, McVerry BJ, Chang CH, Leifer E, Bradbury C, Berger J, Hunt BJ, Castellucci LA, Kornblith LZ, Gordon AC, McArthur C, Webb S, Hochman J, Neal MD, Zarychanski R, Berry S, Angus DC; REMAP-CAP, ATTACC, and ACTIV-4a Investigators. Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. JAMA. 2023 Apr 4;329(13):1066-1077. doi: 10.1001/jama.2023.3651.
- UPMC REMAP-COVID Group, on behalf of the REMAP-CAP Investigators. Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system-lessons learned and recommendations. Trials. 2021 Jan 28;22(1):100. doi: 10.1186/s13063-020-04997-6.
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Termer relaterade till denna studie
Nyckelord
- SARS-CoV-2
- Luftvägssjukdomar
- Anti-infektionsmedel
- Lunginflammation
- Ceftarolin
- Influensa
- Covid-19
- Antibiotika
- Tocilizumab
- Intensivvård
- Apremilast
- Lungsjukdomar
- Levofloxacin
- C-vitamin
- Statin
- Luftvägsinfektioner
- Imatinib
- Invasiv mekanisk ventilation
- Hydrokortison
- Moxifloxacin
- Intensivvård
- Ceftriaxon
- Ivermektin
- Konvalescent plasma
- Baricitinib
- Kortikosteroider
- Oseltamivir
- Baloxavir
- Antibakteriella medel
- Piperacillin-tazobactam
- Amoxicillin-klavulanat
- Terapeutisk antikoagulering
- Eritoran
- DMX-200
Ytterligare relevanta MeSH-villkor
- Infektioner
- Orthomyxoviridae-infektioner
- RNA-virusinfektioner
- Virussjukdomar
- Lunginflammation, Viral
- Coronavirusinfektioner
- Coronaviridae-infektioner
- Nidovirales infektioner
- Samhällsförvärvade infektioner
- Covid-19
- Influensa, människa
- Lungsjukdomar
- Lunginflammation
- Luftvägsinfektioner
- Luftvägssjukdomar
- Samhällsförvärvad lunginflammation
- Molekylära mekanismer för farmakologisk verkan
- Hormoner
- Hormoner, hormonsubstitut och hormonantagonister
- Proteashämmare
- Enzyminhibitorer
- Peptider
- Aminosyror, peptider och proteiner
- Oligopeptider
- Proteiner
- Svavelföreningar
- Organiska kemikalier
- Pyridiner
- Heterocykliska föreningar, 1-ring
- Heterocykliska föreningar
- Bensimidazol
- Heterocykliska föreningar, 2-ring
- Heterocykliska föreningar, smältring
- Farmaceutiska förberedelser
- Tiazoler
- Azoler
- Nukleinsyror, nukleotider och nukleosider
- Farmakologiska åtgärder
- Kemiska åtgärder och användningar
- Kolväten
- Cyklohexener
- Cyklohexaner
- Cykloparaffiner
- Kolväten, alicyklisk
- Kolväten, cykliska
- Biologiska faktorer
- Kolhydrater
- Sockersyror
- Syror, acykliska
- Karboxylsyror
- Hydroxisyror
- Naftalar
- Polycykliska aromatiska kolväten
- Kolväten, aromatisk
- Polycykliska föreningar
- Imidazoler
- Amider
- Aminer
- Förenad
- Puriner
- Aminosyror
- Pyrimidiner
- Graviditet
- Steroider
- Fusion-ringföreningar
- Fenoler
- Bensiverivat
- Organisationer
- Hälsovårdsekonomi och organisationer
- Laktoner
- Nukleosider
- Ribonukleosider
- Pyrimidinoner
- Intercellulära signalpeptider och proteiner
- Etylaminer
- Graviditet
- Gravid
- Makrocykliska föreningar
- Aminosyror, väsentliga
- Biologiska produkter
- Komplexa blandningar
- Aminosyror, cykliska
- 11-hydroxikortikosteroider
- Hydroxikortikosteroider
- Binjurhormoner
- 17-hydroxikortikosteroider
- Narkotikakombinationer
- Syror, karbocyklisk
- Penicillin g
- beta-laktamer
- Laktam
- Klavelsyra
- Klavulinsyror
- Cephalosporiner
- Tiaziner
- Fluorokinoloner
- 4-kinoloner
- Kinoloner
- Kinoliner
- Ofloxacin
- Acetamider
- Sulfoner
- Cephaloridin
- Karbapenem
- Thienamycins
- Tazobaktam
- Penicillansyra
- Pipracillin
- Tiofener
- Aminkikinoliner
- Bensoat
- Salicylater
- Hydroxibensoat
- Cytokiner
- Interferon typ I
- Interferoner
- Polyketider
- Vacciner
- Bensamider
- Adenosin
- Purin nukleosider
- Tetrazoler
- Ampicillin
- Penicilliner
- Pipuraziner
- Sulfhydrylföreningar
- Virala vacciner
- Tiklopidin
- Tienopyridiner
- Klorokin
- Bifenylföreningar
- Cefotaxime
- Gris-
- Lovastatin
- Dipeptider
- Interferon-beta
- Spiroföreningar
- Valr
- Aminosyror, grenad kedja
- Amoxicillin
- Merkaptoetylaminer
- Proline
- Iminosyror
- Ticagrelor
- Clopidogrel
- Interferon beta-1a
- Moxifloxacin
- Valsartan
- Imatinib Mesylate
- Prasugrel hydroklorid
- Meropenem
- Telmisartan
- Irbesartan
- Piperacillin, Tazobactam Läkemedelskombination
- Ceftarolin
- Aspirin
- Hydroxiklorokin
- Ceftriaxon
- Hydrokortison
- Ritonavir
- Ivermektin
- Askorbinsyra
- Interleukin 1-receptorantagonistprotein
- Cysteamin
- Amoxicillin-Kaliumklavulanat kombination
- Ramipril
- Levofloxacin
- Losartan
- Oseltamivir
- Simvastatin
- Angiotensin-konverterande enzymhämmare
- Angiotensinreceptorantagonister
- Enalapril
- Lopinavir
- Ceftazidim
- Lisinopril
- Captopril
- Perindopril
- Kongresser som ämne
- tocilizumab
- baricitinib
- remdesivir
- sarilumab
- Influensavacciner
- apremilast
- nirmatrelvir och ritonavir drogkombination
- nirmatrelvir
- baloxavir
- olmesartan
- Makrolider
- candesartan
- trandolapril
- eritoran
Andra studie-ID-nummer
- U1111-1189-1653
- 2015-002340-14 (EudraCT-nummer)
- 602525 (Annat bidrag/finansieringsnummer: European Union, FP7-HEALTH-2013-INNOVATION-1, PREPARE)
- 16/631 (Annat bidrag/finansieringsnummer: Health Research Council of New Zealand)
- APP1101719 (Annat bidrag/finansieringsnummer: National Health and Medical Research Council, Australia)
- 158584 (Annat bidrag/finansieringsnummer: Canadian Institute of Health Research)
- 2023-507889-89-00 (Ctis)
- 2023 (U.S.S. NIH-anslag/kontrakt)
- 2015 (U.S.S. NIH-anslag/kontrakt)
- 965313 (Annat bidrag/finansieringsnummer: European Union, Horizon 2020 research and innovation programme, ECRAID-Base)
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