A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration
Hyun-Keun Kim, Min Jung Bae, Seonung Lim, Wonwoo Lee, Sunyoung Kim, Hyun-Keun Kim, Min Jung Bae, Seonung Lim, Wonwoo Lee, Sunyoung Kim
Abstract
Psoriasis is a chronic inflammatory disease with complex etiology involving multiple factors. Current treatment methods are highly limited and there is a strong need for the development of safer and efficacious agents. We have previously shown that a water-soluble extract derived from hardy kiwifruit Actinidia arguta, called PG102, shows potent anti-inflammatory effects. Based on its reported biological activities, the effects of PG102 were examined on imiquimod-induced psoriasis-like skin inflammation. Our results showed that topical application of PG102 ameliorates clinical symptoms of psoriasis, reducing skin thickness and Interleukin (IL)-17A level in draining lymph nodes without causing any adverse effects. Treatment with PG102 on cytokine-stimulated HaCaT cells suppressed hyperproliferation and downregulated the expression of various chemokines and antimicrobial peptides known to induce neutrophil infiltration. These anti-inflammatory activities of PG102 were mediated via inhibition of NF-κB and signal transducer of activation (STAT) signaling. We also found decreased neutrophil chemotaxis both in vitro and in vivo. Taken together, PG102 has potential as a safe and effective reagent for the treatment of psoriasis.
Keywords: Actinidia arguta; PG102; keratinocyte; neutrophil; psoriasis.
Conflict of interest statement
M.J.B., W.L. and S.K. are the employees of ViroMed Co.Ltd. S.K. owns stocks of this company. Other authors have no conflict of interest.
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References
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Source: PubMed