Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells
Muhammad Nadeem Aslam, Narasimharao Bhagavathula, Tejaswi Paruchuri, Xin Hu, Subhas Chakrabarty, James Varani, Muhammad Nadeem Aslam, Narasimharao Bhagavathula, Tejaswi Paruchuri, Xin Hu, Subhas Chakrabarty, James Varani
Abstract
Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12% Ca2+, 1% Mg2+, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca2+ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca2+ (1.4mM). However, with cells that are resistant to Ca2+ alone, the extract was still able to reduce proliferation and stimulate differentiation.
Conflict of interest statement
Conflicts of Interest Statement
All named authors of the original research paper entitled “Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca2+-sensitive and Ca2+-resistant human colon carcinoma cells” express that there exist no financial and/or personal relationships with other people and/or organizations that could inappropriately influence their work.
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Source: PubMed