此页面是自动翻译的，不保证翻译的准确性。请参阅英文版对于源文本。

基因检测指导的靶向治疗治疗晚期难治性实体瘤、淋巴瘤或多发性骨髓瘤患者（MATCH 筛选试验）

2026年10月23日更新者：National Cancer Institute (NCI)

治疗选择的分子分析 (MATCH)

This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and does not respond to treatment (refractory). Patients must have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.

研究概览

地位

主动，不招人

条件

干预/治疗

详细说明

PRIMARY OBJECTIVE:

I. To evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers/lymphomas/multiple myeloma.

SECONDARY OBJECTIVES:

I. To evaluate the proportion of patients alive and progression free at 6 months of treatment with targeted study agent in patients with advanced refractory cancers/lymphomas/multiple myeloma.

II. To evaluate time until death or disease progression. III. To identify potential predictive biomarkers beyond the genomic alteration by which treatment is assigned or resistance mechanisms using additional genomic, ribonucleic acid (RNA), protein and imaging-based assessment platforms.

IV. To assess whether radiomic phenotypes obtained from pre-treatment imaging and changes from pre- through post-therapy imaging can predict objective response and progression free survival and to evaluate the association between pre-treatment radiomic phenotypes and targeted gene mutation patterns of tumor biopsy specimens.

OUTLINE:

STEP 0 (Screening): Patients undergo biopsy along with molecular characterization of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. Consenting patients also undergo collection of blood samples for research purposes.

STEPS 1, 3, 5, 7 (Treatment): Patients are assigned to 1 of 38 treatment subprotocols based on molecularly-defined subgroup. (See Arms Section)

STEPS 2, 4, 6 (Screening): Patients experiencing disease progression on the prior Step treatment or who could not tolerate the assigned treatment undergo review of their previous biopsy results to determine if another treatment is available or undergo another biopsy. Patients may have a maximum of 2 screening biopsies and 2 treatments per biopsy.

STEP 8 (Optional Research): Consenting patients undergo end-of-treatment biopsy and collection of blood samples for research purposes.

Additionally, patients may undergo a computed tomography (CT) scan, magnetic resonance imaging, and/or radionuclide imaging throughout the trial.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 1 year.

研究类型

介入性

注册 (估计的)

6452

阶段

阶段2

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

关岛
- - Tamuning、关岛、96913
    - FHP Health Center-Guam
波多黎各
- - Bayamón、波多黎各、00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Manati、波多黎各、00674
    - Doctors Cancer Center
  - San Juan、波多黎各、00917
    - San Juan Community Oncology Group
  - San Juan、波多黎各、00936
    - San Juan City Hospital
美国
- Alabama
  - Birmingham、Alabama、美国、35233
    - University of Alabama at Birmingham Cancer Center
  - Fairhope、Alabama、美国、36532
    - Thomas Hospital
  - Mobile、Alabama、美国、36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile、Alabama、美国、36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage、Alaska、美国、98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage、Alaska、美国、99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage、Alaska、美国、99508
    - Alaska Oncology and Hematology LLC
  - Anchorage、Alaska、美国、99508
    - Alaska Women's Cancer Care
  - Anchorage、Alaska、美国、99508
    - Anchorage Oncology Centre
  - Anchorage、Alaska、美国、99508
    - Katmai Oncology Group
  - Anchorage、Alaska、美国、99508
    - Providence Alaska Medical Center
  - Anchorage、Alaska、美国、99504
    - Anchorage Radiation Therapy Center
  - Anchorage、Alaska、美国、99508
    - Alaska Regional Hospital
  - Fairbanks、Alaska、美国、99701
    - Fairbanks Memorial Hospital
- Arizona
  - Goodyear、Arizona、美国、85338
    - CTCA at Western Regional Medical Center
  - Kingman、Arizona、美国、86401
    - Kingman Regional Medical Center
  - Phoenix、Arizona、美国、85054
    - Mayo Clinic Hospital in Arizona
  - Phoenix、Arizona、美国、85004
    - Cancer Center at Saint Joseph's
  - Phoenix、Arizona、美国、85013
    - Saint Joseph's Hospital and Medical Center
  - Scottsdale、Arizona、美国、85259
    - Mayo Clinic in Arizona
- Arkansas
  - Fort Smith、Arkansas、美国、72903
    - Mercy Hospital Fort Smith
  - Hot Springs、Arkansas、美国、71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro、Arkansas、美国、72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock、Arkansas、美国、72205
    - University of Arkansas for Medical Sciences
- California
  - Anaheim、California、美国、92806
    - Kaiser Permanente-Anaheim
  - Antioch、California、美国、94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande、California、美国、93420
    - PCR Oncology
  - Arroyo Grande、California、美国、93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn、California、美国、95602
    - Sutter Auburn Faith Hospital
  - Auburn、California、美国、95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Bakersfield、California、美国、93301
    - AIS Cancer Center at San Joaquin Community Hospital
  - Baldwin Park、California、美国、91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower、California、美国、90706
    - Kaiser Permanente-Bellflower
  - Berkeley、California、美国、94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank、California、美国、91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame、California、美国、94010
    - Mills-Peninsula Medical Center
  - Cameron Park、California、美国、95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley、California、美国、94546
    - Eden Hospital Medical Center
  - Clovis、California、美国、93611
    - Community Cancer Institute
  - Clovis、California、美国、93611
    - University Oncology Associates
  - Concord、California、美国、94520
    - John Muir Medical Center-Concord
  - Corona、California、美国、92882
    - City of Hope Corona
  - Costa Mesa、California、美国、92627
    - UC Irvine Health Cancer Center-Newport
  - Davis、California、美国、95616
    - Sutter Davis Hospital
  - Duarte、California、美国、91010
    - City of Hope Comprehensive Cancer Center
  - Dublin、California、美国、94568
    - Kaiser Permanente Dublin
  - Dublin、California、美国、94568
    - Epic Care-Dublin
  - Emeryville、California、美国、94608
    - Bay Area Breast Surgeons Inc
  - Emeryville、California、美国、94608
    - Epic Care Partners in Cancer Care
  - Fontana、California、美国、92335
    - Kaiser Permanente-Fontana
  - Fremont、California、美国、94538
    - Kaiser Permanente-Fremont
  - Fremont、California、美国、94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno、California、美国、93720
    - Kaiser Permanente-Fresno
  - Fresno、California、美国、93720
    - Fresno Cancer Center
  - Fullerton、California、美国、92835
    - Saint Jude Medical Center
  - Greenbrae、California、美国、94904
    - Marin Cancer Care Inc
  - Greenbrae、California、美国、94904
    - Marin General Hospital
  - Harbor City、California、美国、90710
    - Kaiser Permanente South Bay
  - Irvine、California、美国、92618
    - Kaiser Permanente-Irvine
  - La Jolla、California、美国、92093
    - UC San Diego Moores Cancer Center
  - Loma Linda、California、美国、92354
    - Loma Linda University Medical Center
  - Los Angeles、California、美国、90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles、California、美国、90048
    - Cedars-Sinai Medical Center
  - Los Angeles、California、美国、90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles、California、美国、90034
    - Kaiser Permanente West Los Angeles
  - Los Angeles、California、美国、90033
    - Los Angeles General Medical Center
  - Martinez、California、美国、94553-3156
    - Contra Costa Regional Medical Center
  - Marysville、California、美国、95901
    - Fremont - Rideout Cancer Center
  - Modesto、California、美国、95355
    - Memorial Medical Center
  - Modesto、California、美国、95356
    - Kaiser Permanente-Modesto
  - Monterey、California、美国、93940
    - Community Hospital of Monterey Peninsula
  - Monterey、California、美国、93940
    - Pacific Cancer Care-Monterey
  - Mountain View、California、美国、94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View、California、美国、94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach、California、美国、92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Novato、California、美国、94945
    - Sutter Cancer Research Consortium
  - Oakland、California、美国、94611
    - Kaiser Permanente-Oakland
  - Oakland、California、美国、94611
    - Kaiser Permanente Oakland-Broadway
  - Oakland、California、美国、94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland、California、美国、94609
    - Bay Area Tumor Institute
  - Ontario、California、美国、91761
    - Kaiser Permanente-Ontario
  - Orange、California、美国、92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange、California、美国、92868
    - Saint Joseph Hospital - Orange
  - Palm Springs、California、美国、92262
    - Desert Regional Medical Center
  - Palo Alto、California、美国、94304
    - VA Palo Alto Health Care System
  - Palo Alto、California、美国、94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto、California、美国、94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City、California、美国、91402
    - Kaiser Permanente - Panorama City
  - Pasadena、California、美国、91105
    - Keck Medical Center of USC Pasadena
  - Rancho Cordova、California、美国、95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
  - Rancho Mirage、California、美国、92270
    - Eisenhower Medical Center
  - Redwood City、California、美国、94063
    - Kaiser Permanente-Redwood City
  - Redwood City、California、美国、94063
    - Kaiser Permanente- Marshall Medical Offices
  - Richmond、California、美国、94801
    - Kaiser Permanente-Richmond
  - Riverside、California、美国、92505
    - Kaiser Permanente-Riverside
  - Rohnert Park、California、美国、94928
    - Rohnert Park Cancer Center
  - Roseville、California、美国、95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville、California、美国、95661
    - Kaiser Permanente-Roseville
  - Roseville、California、美国、95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville、California、美国、95661
    - Sutter Roseville Medical Center
  - Sacramento、California、美国、95816
    - Sutter Medical Center Sacramento
  - Sacramento、California、美国、95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento、California、美国、95814
    - Kaiser Permanente Downtown Commons
  - Sacramento、California、美国、95823
    - Kaiser Permanente-South Sacramento
  - Sacramento、California、美国、95823
    - South Sacramento Cancer Center
  - Sacramento、California、美国、95825
    - Kaiser Permanente Sacramento Medical Center
  - Sacramento、California、美国、95816
    - Mercy Cancer Center - Sacramento
  - San Diego、California、美国、92123
    - Rady Children's Hospital - San Diego
  - San Diego、California、美国、92120
    - Kaiser Permanente-San Diego Zion
  - San Diego、California、美国、92134
    - Naval Medical Center -San Diego
  - San Diego、California、美国、92123
    - Sharp Memorial Hospital
  - San Diego、California、美国、92103
    - UC San Diego Medical Center - Hillcrest
  - San Diego、California、美国、92108
    - Kaiser Permanente-Rio San Diego
  - San Francisco、California、美国、94115
    - Kaiser Permanente-San Francisco
  - San Francisco、California、美国、94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose、California、美国、95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro、California、美国、94577
    - Kaiser Permanente San Leandro
  - San Luis Obispo、California、美国、93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - San Marcos、California、美国、92078
    - Kaiser Permanente-San Marcos
  - San Mateo、California、美国、94401
    - Mills Health Center
  - San Rafael、California、美国、94903
    - Kaiser San Rafael-Gallinas
  - San Rafael、California、美国、94903
    - Kaiser Permanente-San Rafael
  - Santa Clara、California、美国、95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz、California、美国、95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria、California、美国、93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa、California、美国、95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa、California、美国、95403
    - Sutter Pacific Medical Foundation
  - South San Francisco、California、美国、94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco、California、美国、94080
    - Kaiser Permanente-South San Francisco
  - St. Helena、California、美国、94574
    - Saint Helena Hospital
  - Stockton、California、美国、95210
    - Kaiser Permanente-Stockton
  - Stockton、California、美国、95204
    - Saint Joseph's Medical Center
  - Sunnyvale、California、美国、94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Truckee、California、美国、96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Upland、California、美国、91786
    - City of Hope Upland
  - Vacaville、California、美国、95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo、California、美国、94589
    - Kaiser Permanente-Vallejo
  - Vallejo、California、美国、94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek、California、美国、94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek、California、美国、94598
    - John Muir Medical Center-Walnut Creek
  - Walnut Creek、California、美国、94597
    - Epic Care Cyberknife Center
  - West Covina、California、美国、91790
    - City of Hope West Covina
  - Whittier、California、美国、90602
    - Presbyterian Intercommunity Hospital
  - Woodland、California、美国、95695
    - Woodland Memorial Hospital
  - Woodland Hills、California、美国、91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora、Colorado、美国、80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora、Colorado、美国、80012
    - The Medical Center of Aurora
  - Aurora、Colorado、美国、80045
    - UCHealth University of Colorado Hospital
  - Boulder、Colorado、美国、80303
    - Boulder Community Foothills Hospital
  - Boulder、Colorado、美国、80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial、Colorado、美国、80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs、Colorado、美国、80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs、Colorado、美国、80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs、Colorado、美国、80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs、Colorado、美国、80920
    - Memorial Hospital North
  - Colorado Springs、Colorado、美国、80923
    - Saint Francis Cancer Center
  - Denver、Colorado、美国、80205
    - Kaiser Permanente-Franklin
  - Denver、Colorado、美国、80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver、Colorado、美国、80220
    - Rose Medical Center
  - Denver、Colorado、美国、80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver、Colorado、美国、80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver、Colorado、美国、80204
    - Denver Health Medical Center
  - Denver、Colorado、美国、80218
    - Colorado Blood Cancer Institute
  - Denver、Colorado、美国、80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver、Colorado、美国、80209
    - The Women's Imaging Center
  - Denver、Colorado、美国、80206
    - National Jewish Health-Main Campus
  - Denver、Colorado、美国、80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver、Colorado、美国、80210
    - AdventHealth Porter
  - Durango、Colorado、美国、81301
    - Mercy Medical Center
  - Durango、Colorado、美国、81301
    - CommonSpirit Cancer Center Mercy
  - Englewood、Colorado、美国、80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood、Colorado、美国、80113
    - Swedish Medical Center
  - Englewood、Colorado、美国、80113
    - Rocky Mountain Cancer Centers - Swedish
  - Fort Collins、Colorado、美国、80524
    - Poudre Valley Hospital
  - Golden、Colorado、美国、80401
    - Mountain Blue Cancer Care Center
  - Golden、Colorado、美国、80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction、Colorado、美国、81501
    - Saint Mary's Hospital and Regional Medical Center
  - Grand Junction、Colorado、美国、81505
    - Grand Valley Oncology
  - Greeley、Colorado、美国、80631
    - Banner North Colorado Medical Center
  - Greenwood Village、Colorado、美国、80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lafayette、Colorado、美国、80026
    - Kaiser Permanente-Rock Creek
  - Lafayette、Colorado、美国、80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood、Colorado、美国、80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood、Colorado、美国、80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton、Colorado、美国、80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton、Colorado、美国、80122
    - AdventHealth Littleton
  - Lone Tree、Colorado、美国、80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree、Colorado、美国、80124
    - Sky Ridge Medical Center
  - Lone Tree、Colorado、美国、80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont、Colorado、美国、80501
    - Longmont United Hospital
  - Longmont、Colorado、美国、80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland、Colorado、美国、80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker、Colorado、美国、80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker、Colorado、美国、80138
    - AdventHealth Parker
  - Pueblo、Colorado、美国、81004
    - Saint Mary Corwin Medical Center
  - Pueblo、Colorado、美国、81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton、Colorado、美国、80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton、Colorado、美国、80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge、Colorado、美国、80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Derby、Connecticut、美国、06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield、Connecticut、美国、06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury、Connecticut、美国、06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Greenwich、Connecticut、美国、06830
    - Smilow Cancer Hospital Care Center at Greenwich
  - Guilford、Connecticut、美国、06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford、Connecticut、美国、06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - New Haven、Connecticut、美国、06520
    - Yale University
  - New Haven、Connecticut、美国、06510
    - Smilow Cancer Center/Yale-New Haven Hospital
  - North Haven、Connecticut、美国、06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwich、Connecticut、美国、06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Orange、Connecticut、美国、06477
    - Smilow Cancer Hospital-Orange Care Center
  - Stamford、Connecticut、美国、06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington、Connecticut、美国、06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull、Connecticut、美国、06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury、Connecticut、美国、06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford、Connecticut、美国、06385
    - Smilow Cancer Hospital Care Center - Waterford
  - West Haven、Connecticut、美国、06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Lewes、Delaware、美国、19958
    - Beebe Medical Center
  - Millville、Delaware、美国、19967
    - Beebe South Coastal Health Campus
  - Newark、Delaware、美国、19713
    - Helen F Graham Cancer Center
  - Newark、Delaware、美国、19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark、Delaware、美国、19713
    - Medical Oncology Hematology Consultants PA
  - Newark、Delaware、美国、19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach、Delaware、美国、19971
    - Beebe Health Campus
  - Seaford、Delaware、美国、19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington、Delaware、美国、19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C.、District of Columbia、美国、20010
    - MedStar Washington Hospital Center
  - Washington D.C.、District of Columbia、美国、20007
    - MedStar Georgetown University Hospital
  - Washington D.C.、District of Columbia、美国、20016
    - Sibley Memorial Hospital
- Florida
  - Aventura、Florida、美国、33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Coral Gables、Florida、美国、33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Coral Springs、Florida、美国、33065
    - UM Sylvester Comprehensive Cancer Center at Coral Springs
  - Deerfield Beach、Florida、美国、33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Deerfield Beach、Florida、美国、33064
    - Broward Health North
  - Fort Lauderdale、Florida、美国、33316
    - Broward Health Medical Center
  - Fort Lauderdale、Florida、美国、33308
    - Holy Cross Hospital
  - Gainesville、Florida、美国、32610
    - UF Health Cancer Institute - Gainesville
  - Hollywood、Florida、美国、33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Hollywood、Florida、美国、33021
    - UM Sylvester Comprehensive Cancer Center at Hollywood
  - Jacksonville、Florida、美国、32224-9980
    - Mayo Clinic in Florida
  - Lakeland、Florida、美国、33805
    - The Watson Clinic
  - Miami、Florida、美国、33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami、Florida、美国、33176
    - Miami Cancer Institute
  - Miami、Florida、美国、33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach、Florida、美国、33140
    - Mount Sinai Medical Center
  - Ocoee、Florida、美国、34761
    - Health Central
  - Orlando、Florida、美国、32806
    - Orlando Health Cancer Institute
  - Pembroke Pines、Florida、美国、33028
    - Memorial Hospital West
  - Plantation、Florida、美国、33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Tampa、Florida、美国、33612
    - Moffitt Cancer Center
  - Tampa、Florida、美国、33607
    - Saint Joseph's Hospital/Children's Hospital-Tampa
  - Vero Beach、Florida、美国、32960
    - Indian River Medical Center
- Georgia
  - Athens、Georgia、美国、30607
    - University Cancer and Blood Center LLC
  - Atlanta、Georgia、美国、30308
    - Emory University Hospital Midtown
  - Atlanta、Georgia、美国、30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta、Georgia、美国、30342
    - Emory Saint Joseph's Hospital
  - Atlanta、Georgia、美国、30309
    - Piedmont Hospital
  - Atlanta、Georgia、美国、30342
    - Northside Hospital
  - Augusta、Georgia、美国、30912
    - Augusta University Medical Center
  - Braselton、Georgia、美国、30517
    - Northeast Georgia Medical Center Braselton
  - Columbus、Georgia、美国、31904
    - John B Amos Cancer Center
  - Cumming、Georgia、美国、30041
    - Northside Hospital-Forsyth
  - Decatur、Georgia、美国、30033
    - Emory Decatur Hospital
  - Duluth、Georgia、美国、30096
    - Northside Hospital - Duluth
  - Gainesville、Georgia、美国、30501
    - Northeast Georgia Medical Center-Gainesville
  - Gainesville、Georgia、美国、30501
    - The Longstreet Clinic - Gainesville
  - Lawrenceville、Georgia、美国、30046
    - Northside Hospital - Gwinnett
  - Macon、Georgia、美国、31201
    - Central Georgia Gynecologic Oncology
  - Macon、Georgia、美国、31201
    - Atrium Health Navicent
  - Newnan、Georgia、美国、30265
    - CTCA at Southeastern Regional Medical Center
  - Rome、Georgia、美国、30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah、Georgia、美国、31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah、Georgia、美国、31404
    - Memorial Health University Medical Center
  - Savannah、Georgia、美国、31404
    - Summit Cancer Care-Memorial
  - Savannah、Georgia、美国、31405
    - Summit Cancer Care-Candler
  - Savannah、Georgia、美国、31404
    - Low Country Cancer Care
  - Snellville、Georgia、美国、30078
    - Suburban Hematology Oncology Associates - Snellville
  - Thomasville、Georgia、美国、31792
    - Lewis Hall Singletary Oncology Center
  - Valdosta、Georgia、美国、31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - Honolulu、Hawaii、美国、96813
    - Queen's Medical Center
  - Honolulu、Hawaii、美国、96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu、Hawaii、美国、96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu、Hawaii、美国、96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu、Hawaii、美国、96813
    - Straub Clinic and Hospital
  - Honolulu、Hawaii、美国、96813
    - University of Hawaii Cancer Center
  - Honolulu、Hawaii、美国、96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu、Hawaii、美国、96817
    - Kuakini Medical Center
  - Honolulu、Hawaii、美国、96817
    - Queen's Cancer Center - Kuakini
  - Honolulu、Hawaii、美国、96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu、Hawaii、美国、96813
    - Island Urology
  - Honolulu、Hawaii、美国、96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu、Hawaii、美国、96817
    - Hawaii Diagnostic Radiology Services LLC
  - Kahului、Hawaii、美国、96732
    - Straub Medical Center - Kahului Clinic
  - Kailua、Hawaii、美国、96734
    - Castle Medical Center
  - Lihue、Hawaii、美国、96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea、Hawaii、美国、96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea、Hawaii、美国、96701
    - Pali Momi Medical Center
  - ‘Aiea、Hawaii、美国、96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea、Hawaii、美国、96701
    - The Cancer Center of Hawaii-Pali Momi
  - ‘Aiea、Hawaii、美国、96701
    - Straub Pearlridge Clinic
  - ‘Ewa Beach、Hawaii、美国、96706
    - The Queen's Medical Center - West Oahu
- Idaho
  - Boise、Idaho、美国、83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise、Idaho、美国、83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell、Idaho、美国、83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene、Idaho、美国、83814
    - Kootenai Health - Coeur d'Alene
  - Emmett、Idaho、美国、83617
    - Walter Knox Memorial Hospital
  - Fruitland、Idaho、美国、83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian、Idaho、美国、83642
    - Idaho Urologic Institute-Meridian
  - Meridian、Idaho、美国、83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa、Idaho、美国、83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Nampa、Idaho、美国、83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls、Idaho、美国、83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint、Idaho、美国、83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls、Idaho、美国、83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton、Illinois、美国、62002
    - OSF Saint Anthony's Health Center
  - Aurora、Illinois、美国、60504
    - Rush-Copley Medical Center
  - Bloomington、Illinois、美国、61704
    - Illinois CancerCare-Bloomington
  - Bloomington、Illinois、美国、61701
    - OSF Saint Joseph Medical Center
  - Canton、Illinois、美国、61520
    - Illinois CancerCare-Canton
  - Carbondale、Illinois、美国、62902
    - Memorial Hospital of Carbondale
  - Carterville、Illinois、美国、62918
    - SIH Cancer Institute
  - Carthage、Illinois、美国、62321
    - Illinois CancerCare-Carthage
  - Centralia、Illinois、美国、62801
    - Centralia Oncology Clinic
  - Chicago、Illinois、美国、60611
    - Northwestern University
  - Chicago、Illinois、美国、60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago、Illinois、美国、60612
    - University of Illinois
  - Chicago、Illinois、美国、60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago、Illinois、美国、60608
    - Mount Sinai Hospital Medical Center
  - Chicago、Illinois、美国、60625
    - Swedish Covenant Hospital
  - Chicago、Illinois、美国、60657
    - Advocate Illinois Masonic Medical Center
  - Chicago、Illinois、美国、60612
    - Rush MD Anderson Cancer Center
  - Crystal Lake、Illinois、美国、60014
    - AMG Crystal Lake - Oncology
  - Danville、Illinois、美国、61832
    - Carle at The Riverfront
  - DeKalb、Illinois、美国、60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur、Illinois、美国、62526
    - Decatur Memorial Hospital
  - Decatur、Illinois、美国、62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon、Illinois、美国、61021
    - Illinois CancerCare-Dixon
  - Effingham、Illinois、美国、62401
    - Crossroads Cancer Center
  - Effingham、Illinois、美国、62401
    - Carle Physician Group-Effingham
  - Elk Grove Village、Illinois、美国、60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst、Illinois、美国、60126
    - Elmhurst Memorial Hospital
  - Eureka、Illinois、美国、61530
    - Illinois CancerCare-Eureka
  - Evanston、Illinois、美国、60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston、Illinois、美国、60202
    - Saint Francis Hospital
  - Galesburg、Illinois、美国、61401
    - Western Illinois Cancer Treatment Center
  - Galesburg、Illinois、美国、61401
    - Illinois CancerCare-Galesburg
  - Geneva、Illinois、美国、60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview、Illinois、美国、60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey、Illinois、美国、60426
    - Ingalls Memorial Hospital
  - Highland Park、Illinois、美国、60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Joliet、Illinois、美国、60435
    - Duly Health and Care Joliet
  - Kankakee、Illinois、美国、60901
    - Presence Saint Mary's Hospital
  - Kewanee、Illinois、美国、61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest、Illinois、美国、60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville、Illinois、美国、60048
    - AMG Libertyville - Oncology
  - Macomb、Illinois、美国、61455
    - Illinois CancerCare-Macomb
  - Mattoon、Illinois、美国、61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood、Illinois、美国、60153
    - Loyola University Medical Center
  - Melrose Park、Illinois、美国、60160
    - Marjorie Weinberg Cancer Center at Loyola-Gottlieb
  - Moline、Illinois、美国、61265
    - Trinity Medical Center
  - Mount Vernon、Illinois、美国、62864
    - SSM Health Good Samaritan
  - Naperville、Illinois、美国、60540
    - Edward Hospital/Cancer Center
  - New Lenox、Illinois、美国、60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon、Illinois、美国、62269
    - Cancer Care Center of O'Fallon
  - Orland Park、Illinois、美国、60462
    - University of Chicago Medicine-Orland Park
  - Ottawa、Illinois、美国、61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa、Illinois、美国、61350
    - Radiation Oncology of Northern Illinois
  - Pekin、Illinois、美国、61554
    - Illinois CancerCare-Pekin
  - Pekin、Illinois、美国、61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria、Illinois、美国、61636
    - Methodist Medical Center of Illinois
  - Peoria、Illinois、美国、61637
    - OSF Saint Francis Medical Center
  - Peoria、Illinois、美国、61615
    - Illinois CancerCare-Peoria
  - Peoria、Illinois、美国、61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru、Illinois、美国、61354
    - Illinois CancerCare-Peru
  - Peru、Illinois、美国、61354
    - Valley Radiation Oncology
  - Plainfield、Illinois、美国、60585
    - Edward Hospital/Cancer Center?Plainfield
  - Princeton、Illinois、美国、61356
    - Illinois CancerCare-Princeton
  - Skokie、Illinois、美国、60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie、Illinois、美国、60076
    - North Shore Medical Center
  - Springfield、Illinois、美国、62702
    - Southern Illinois University School of Medicine
  - Springfield、Illinois、美国、62702
    - Springfield Clinic
  - Springfield、Illinois、美国、62702
    - Central Illinois Hematology Oncology Center
  - Springfield、Illinois、美国、62781
    - Springfield Memorial Hospital
  - Swansea、Illinois、美国、62226
    - Southwest Illinois Health Services LLP
  - Urbana、Illinois、美国、61801
    - Carle Cancer Center
  - Urbana、Illinois、美国、61801
    - The Carle Foundation Hospital
  - Warrenville、Illinois、美国、60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington、Illinois、美国、61571
    - Illinois CancerCare - Washington
  - Yorkville、Illinois、美国、60560
    - Rush-Copley Healthcare Center
  - Zion、Illinois、美国、60099
    - Midwestern Regional Medical Center
- Indiana
  - Crown Point、Indiana、美国、46307
    - Michiana Hematology Oncology PC-Crown Point
  - Elkhart、Indiana、美国、46514
    - Michiana Hematology Oncology PC-Elkhart
  - Evansville、Indiana、美国、47713
    - Deaconess Clinic Downtown
  - Indianapolis、Indiana、美国、46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis、Indiana、美国、46219
    - Community Cancer Center East
  - Indianapolis、Indiana、美国、46227
    - Community Cancer Center South
  - Indianapolis、Indiana、美国、46256
    - Community Cancer Center North
  - Indianapolis、Indiana、美国、46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis、Indiana、美国、46290
    - Springmill Medical Center
  - Kokomo、Indiana、美国、46904
    - Community Howard Regional Health
  - Lafayette、Indiana、美国、47904
    - IU Health Arnett Cancer Care
  - Michigan City、Indiana、美国、46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City、Indiana、美国、46360
    - Woodland Cancer Care Center
  - Mishawaka、Indiana、美国、46545
    - Memorial Regional Cancer Center Day Road
  - Mishawaka、Indiana、美国、46545
    - Michiana Hematology Oncology PC-Mishawaka
  - New Albany、Indiana、美国、47150
    - Baptist Health Floyd
  - Newburgh、Indiana、美国、47630
    - Chancellor Center for Oncology
  - Plymouth、Indiana、美国、46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond、Indiana、美国、47374
    - Reid Health
  - South Bend、Indiana、美国、46601
    - Memorial Hospital of South Bend
  - Westville、Indiana、美国、46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames、Iowa、美国、50010
    - Mary Greeley Medical Center
  - Ames、Iowa、美国、50010
    - McFarland Clinic - Ames
  - Boone、Iowa、美国、50036
    - McFarland Clinic - Boone
  - Carroll、Iowa、美国、51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids、Iowa、美国、52403
    - Mercy Hospital
  - Cedar Rapids、Iowa、美国、52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids、Iowa、美国、52402
    - Physicians' Clinic of Iowa PC
  - Clive、Iowa、美国、50325
    - Mercy Cancer Center-West Lakes
  - Clive、Iowa、美国、50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs、Iowa、美国、51503
    - Alegent Health Mercy Hospital
  - Council Bluffs、Iowa、美国、51503
    - Heartland Oncology and Hematology LLP
  - Council Bluffs、Iowa、美国、51503
    - Methodist Jennie Edmundson Hospital
  - Creston、Iowa、美国、50801
    - Greater Regional Medical Center
  - Des Moines、Iowa、美国、50309
    - Iowa Methodist Medical Center
  - Des Moines、Iowa、美国、50314
    - Mercy Medical Center - Des Moines
  - Des Moines、Iowa、美国、50314
    - Broadlawns Medical Center
  - Des Moines、Iowa、美国、50316
    - Iowa Lutheran Hospital
  - Des Moines、Iowa、美国、50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines、Iowa、美国、50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fairfield、Iowa、美国、52556
    - JCHC McCreery Cancer Center
  - Fort Dodge、Iowa、美国、50501
    - McFarland Clinic - Trinity Cancer Center
  - Fort Dodge、Iowa、美国、50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Jefferson、Iowa、美国、50129
    - McFarland Clinic - Jefferson
  - Marshalltown、Iowa、美国、50158
    - McFarland Clinic - Marshalltown
  - Ottumwa、Iowa、美国、52501
    - Ottumwa Regional Health Center
  - Sioux City、Iowa、美国、51101
    - Siouxland Regional Cancer Center
  - West Des Moines、Iowa、美国、50266-7700
    - Methodist West Hospital
  - West Des Moines、Iowa、美国、50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Coffeyville、Kansas、美国、67337
    - Coffeyville Regional Medical Center
  - Emporia、Kansas、美国、66801
    - Newman Regional Health
  - Fairway、Kansas、美国、66205
    - University of Kansas Clinical Research Center
  - Garden City、Kansas、美国、67846
    - Central Care Cancer Center - Garden City
  - Garden City、Kansas、美国、67846
    - Saint Catherine Hospital
  - Great Bend、Kansas、美国、67530
    - Central Care Cancer Center - Great Bend
  - Great Bend、Kansas、美国、67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays、Kansas、美国、67601
    - HaysMed
  - Kansas City、Kansas、美国、66160
    - University of Kansas Cancer Center
  - Kansas City、Kansas、美国、66112
    - University of Kansas Cancer Center-West
  - Lawrence、Kansas、美国、66044
    - Lawrence Memorial Hospital
  - Lenexa、Kansas、美国、66219
    - Kansas Institute of Medicine Cancer and Blood Center
  - Lenexa、Kansas、美国、66219
    - Minimally Invasive Surgery Hospital
  - Olathe、Kansas、美国、66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park、Kansas、美国、66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park、Kansas、美国、66209
    - Menorah Medical Center
  - Overland Park、Kansas、美国、66213
    - Saint Luke's South Hospital
  - Pittsburg、Kansas、美国、66762
    - Mercy Hospital Pittsburg
  - Salina、Kansas、美国、67401
    - Salina Regional Health Center
  - Topeka、Kansas、美国、66606
    - University of Kansas Health System Saint Francis Campus
  - Westwood、Kansas、美国、66205
    - University of Kansas Hospital-Westwood Cancer Center
- Kentucky
  - Bardstown、Kentucky、美国、40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin、Kentucky、美国、40701
    - Baptist Health Corbin
  - Corbin、Kentucky、美国、40701
    - Commonwealth Cancer Center-Corbin
  - Crestview Hills、Kentucky、美国、41017
    - Oncology Hematology Care Inc-Crestview
  - Edgewood、Kentucky、美国、41017
    - Saint Elizabeth Healthcare Edgewood
  - Elizabethtown、Kentucky、美国、42701
    - Baptist Health Hardin
  - Fort Thomas、Kentucky、美国、41075
    - Saint Elizabeth Healthcare Fort Thomas
  - Lexington、Kentucky、美国、40536
    - University of Kentucky/Markey Cancer Center
  - Lexington、Kentucky、美国、40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington、Kentucky、美国、40503
    - Baptist Health Lexington
  - Lexington、Kentucky、美国、40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - London、Kentucky、美国、40741
    - CommonSpirit Saint Joseph Hospital London
  - Louisville、Kentucky、美国、40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville、Kentucky、美国、40202
    - Jewish Hospital
  - Louisville、Kentucky、美国、40245
    - UofL Health Medical Center Northeast
  - Louisville、Kentucky、美国、40207
    - Baptist Health Louisville
  - Louisville、Kentucky、美国、40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville、Kentucky、美国、42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah、Kentucky、美国、42003
    - Baptist Health Paducah
  - Shepherdsville、Kentucky、美国、40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge、Louisiana、美国、70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge、Louisiana、美国、70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge、Louisiana、美国、70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge、Louisiana、美国、70809
    - Ochsner Health Center-Summa
  - Baton Rouge、Louisiana、美国、70816
    - Medical Center of Baton Rouge
  - Baton Rouge、Louisiana、美国、70836
    - Ochsner High Grove
  - Baton Rouge、Louisiana、美国、70806
    - Baton Rouge General Medical Center
  - Baton Rouge、Louisiana、美国、70809
    - Hematology/Oncology Clinic PLLC
  - Baton Rouge、Louisiana、美国、70808
    - Our Lady of The Lake
  - Baton Rouge、Louisiana、美国、70817
    - Our Lady of the Lake Medical Oncology
  - Baton Rouge、Louisiana、美国、70810
    - The NeuroMedical Center-Clinic
  - Baton Rouge、Louisiana、美国、70808
    - Our Lady of the Lake Physician Group
  - Covington、Louisiana、美国、70433
    - Mary Bird Perkins Cancer Center - Covington
  - Covington、Louisiana、美国、70433
    - Northshore Oncology Associates-Covington
  - Covington、Louisiana、美国、70433
    - Ochsner Hematology Oncology North Shore - Covington (West Region)
  - Covington、Louisiana、美国、70433
    - Women's Cancer Care-Covington
  - Gretna、Louisiana、美国、70056
    - Ochsner Medical Center West Bank
  - Houma、Louisiana、美国、70360
    - Mary Bird Perkins Cancer Center - Houma
  - Houma、Louisiana、美国、70360
    - Terrebonne General Medical Center
  - Houma、Louisiana、美国、70360
    - Oncology Center of The South Incorporated
  - Kenner、Louisiana、美国、70065
    - Ochsner Medical Center Kenner
  - Marrero、Louisiana、美国、70072
    - West Jefferson Medical Center
  - Metairie、Louisiana、美国、70006
    - East Jefferson General Hospital
  - Metairie、Louisiana、美国、70006
    - Robert Veith MD LLC
  - Monroe、Louisiana、美国、71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans、Louisiana、美国、70112
    - Tulane University School of Medicine
  - New Orleans、Louisiana、美国、70121
    - Ochsner Medical Center Jefferson
  - New Orleans、Louisiana、美国、70112
    - University Medical Center New Orleans
  - New Orleans、Louisiana、美国、70112
    - Louisiana State University Health Science Center
  - Shreveport、Louisiana、美国、71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport、Louisiana、美国、71105
    - CHRISTUS Highland Medical Center
- Maine
  - Augusta、Maine、美国、04330
    - Harold Alfond Center for Cancer Care
  - Bangor、Maine、美国、04401
    - Eastern Maine Medical Center
  - Belfast、Maine、美国、04915
    - MaineHealth Waldo Hospital
  - Biddeford、Maine、美国、04005
    - MaineHealth Maine Medical Center - Biddeford
  - Brewer、Maine、美国、04412
    - Lafayette Family Cancer Center-EMMC
  - Kennebunk、Maine、美国、04043
    - New England Cancer Specialists - Kennebunk
  - Norway、Maine、美国、04268
    - MaineHealth Stephens Hospital
  - Rockport、Maine、美国、04856
    - Penobscot Bay Medical Center
  - Sanford、Maine、美国、04073
    - MaineHealth Cancer Care and IV Therapy - Sanford
  - Scarborough、Maine、美国、04074
    - MaineHealth Maine Medical Center- Scarborough
  - South Portland、Maine、美国、04106
    - MaineHealth Cancer Care and IV Therapy - South Portland
  - Topsham、Maine、美国、04086
    - New England Cancer Specialists - Topsham
  - Westbrook、Maine、美国、04092
    - New England Cancer Specialists
- Maryland
  - Annapolis、Maryland、美国、21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore、Maryland、美国、21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore、Maryland、美国、21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore、Maryland、美国、21215
    - Sinai Hospital of Baltimore
  - Baltimore、Maryland、美国、21204
    - Greater Baltimore Medical Center
  - Baltimore、Maryland、美国、21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore、Maryland、美国、21218
    - MedStar Union Memorial Hospital
  - Baltimore、Maryland、美国、21239
    - MedStar Good Samaritan Hospital
  - Bethesda、Maryland、美国、20892
    - National Institutes of Health Clinical Center
  - Bethesda、Maryland、美国、20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland、Maryland、美国、21502
    - UPMC Western Maryland
  - Easton、Maryland、美国、21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton、Maryland、美国、21921
    - Christiana Care - Union Hospital
  - Frederick、Maryland、美国、21701
    - Frederick Memorial Hospital
  - Frederick、Maryland、美国、21702
    - FMH James M Stockman Cancer Institute
  - Olney、Maryland、美国、20832
    - MedStar Montgomery Medical Center
  - Randallstown、Maryland、美国、21133
    - Northwest Hospital Center
  - Salisbury、Maryland、美国、21801
    - TidalHealth Peninsula Regional
  - Silver Spring、Maryland、美国、20910
    - Holy Cross Hospital
  - Westminster、Maryland、美国、21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Beverly、Massachusetts、美国、01915
    - Beverly Hospital
  - Boston、Massachusetts、美国、02215
    - Beth Israel Deaconess Medical Center
  - Boston、Massachusetts、美国、02215
    - Dana-Farber Cancer Institute
  - Boston、Massachusetts、美国、02111
    - Tufts Medical Center
  - Boston、Massachusetts、美国、02118
    - Boston Medical Center
  - Boston、Massachusetts、美国、02114
    - Massachusetts General Hospital Cancer Center
  - Burlington、Massachusetts、美国、01805
    - Lahey Clinic
  - Fitchburg、Massachusetts、美国、01420
    - Simonds-Sinon Regional Cancer Center
  - Framingham、Massachusetts、美国、01702
    - MetroWest Medical Center-Framingham Union Hospital
  - Gloucester、Massachusetts、美国、01930
    - Addison Gilbert Hospital
  - Lowell、Massachusetts、美国、01854
    - Lowell General Hospital
  - Peabody、Massachusetts、美国、01960
    - Lahey Clinic Peabody
  - Springfield、Massachusetts、美国、01199
    - Baystate Medical Center
  - Springfield、Massachusetts、美国、01104
    - Mercy Medical Center
  - Winchester、Massachusetts、美国、01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester、Massachusetts、美国、01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian、Michigan、美国、49221
    - Hickman Cancer Center
  - Ann Arbor、Michigan、美国、48109
    - C S Mott Children's Hospital
  - Ann Arbor、Michigan、美国、48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor、Michigan、美国、48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek、Michigan、美国、49017
    - Bronson Battle Creek
  - Brighton、Michigan、美国、48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton、Michigan、美国、48114
    - Trinity Health Medical Center - Brighton
  - Brownstown、Michigan、美国、48183
    - Henry Ford Cancer Institute-Downriver
  - Canton、Michigan、美国、48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton、Michigan、美国、48188
    - Trinity Health Medical Center - Canton
  - Caro、Michigan、美国、48723
    - Caro Cancer Center
  - Chelsea、Michigan、美国、48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea、Michigan、美国、48118
    - Chelsea Hospital
  - Clarkston、Michigan、美国、48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston、Michigan、美国、48346
    - Newland Medical Associates-Clarkston
  - Clinton Township、Michigan、美国、48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Clinton Township、Michigan、美国、48038
    - Henry Ford Hematology Oncology - Hayes
  - Dearborn、Michigan、美国、48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn、Michigan、美国、48124
    - Corewell Health Dearborn Hospital
  - Detroit、Michigan、美国、48202
    - Henry Ford Hospital
  - Detroit、Michigan、美国、48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit、Michigan、美国、48236
    - Henry Ford Health Saint John Hospital
  - East China Township、Michigan、美国、48054
    - Henry Ford River District Hospital
  - East Lansing、Michigan、美国、48823
    - Michigan State University
  - Escanaba、Michigan、美国、49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills、Michigan、美国、48336
    - Corewell Health Farmington Hills Hospital
  - Flint、Michigan、美国、48503
    - Hurley Medical Center
  - Flint、Michigan、美国、48503
    - Genesee Hematology Oncology PC
  - Flint、Michigan、美国、48503
    - Genesys Hurley Cancer Institute
  - Flint、Michigan、美国、48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids、Michigan、美国、49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids、Michigan、美国、49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids、Michigan、美国、49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe、Michigan、美国、48230
    - William Beaumont Hospital-Grosse Pointe
  - Grosse Pointe Woods、Michigan、美国、48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods、Michigan、美国、48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods、Michigan、美国、48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Jackson、Michigan、美国、49201
    - Allegiance Health
  - Kalamazoo、Michigan、美国、49007
    - West Michigan Cancer Center
  - Kalamazoo、Michigan、美国、49007
    - Bronson Methodist Hospital
  - Kalamazoo、Michigan、美国、49048
    - Beacon Kalamazoo
  - Lansing、Michigan、美国、48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing、Michigan、美国、48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia、Michigan、美国、48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia、Michigan、美国、48154
    - Hope Cancer Clinic
  - Macomb、Michigan、美国、48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb、Michigan、美国、48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette、Michigan、美国、48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Midland、Michigan、美国、48670
    - MyMichigan Medical Center Midland
  - Monroe、Michigan、美国、48162
    - Toledo Clinic Cancer Centers-Monroe
  - Monroe、Michigan、美国、48162
    - Monroe Cancer Center
  - Muskegon、Michigan、美国、49444
    - Trinity Health Muskegon Hospital
  - Niles、Michigan、美国、49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores、Michigan、美国、49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi、Michigan、美国、48377
    - Henry Ford Medical Center-Columbus
  - Novi、Michigan、美国、48374
    - Henry Ford Health Providence Novi Hospital
  - Pontiac、Michigan、美国、48341
    - Hope Cancer Center
  - Pontiac、Michigan、美国、48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac、Michigan、美国、48341
    - Michigan Healthcare Professionals Pontiac
  - Pontiac、Michigan、美国、48341
    - Trinity Health IHA Medical Group-Alice Gustafson Center
  - Port Huron、Michigan、美国、48060
    - Lake Huron Medical Center
  - Port Huron、Michigan、美国、48060
    - Huron Medical Center PC
  - Reed City、Michigan、美国、49677
    - Corewell Health Reed City Hospital
  - Rochester Hills、Michigan、美国、48309
    - Henry Ford Rochester Hospital
  - Roseville、Michigan、美国、48066
    - Michigan Cancer Specialists
  - Royal Oak、Michigan、美国、48073
    - Cancer Care Associates PC
  - Royal Oak、Michigan、美国、48073
    - Comprehensive Medical Center PLLC
  - Royal Oak、Michigan、美国、48073
    - Oakland Medical Group
  - Royal Oak、Michigan、美国、48067
    - Oakland Colon Rectal Associates
  - Royal Oak、Michigan、美国、48073
    - Hematology Oncology Consultants PC-Royal Oak
  - Royal Oak、Michigan、美国、48073
    - Corewell Health William Beaumont University Hospital
  - Royal Oak、Michigan、美国、48073
    - Corewell Health Children's
  - Saginaw、Michigan、美国、48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw、Michigan、美国、48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph、Michigan、美国、49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph、Michigan、美国、49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Shelby、Michigan、美国、48315
    - Henry Ford Macomb Health Center - Shelby Township
  - Southfield、Michigan、美国、48075
    - Henry Ford Health Providence Southfield Hospital
  - Sterling Heights、Michigan、美国、48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Sterling Heights、Michigan、美国、48312
    - Premier Hematology Oncology Care
  - Sterling Heights、Michigan、美国、48314
    - Mitchell Folbe MD PC
  - Tawas City、Michigan、美国、48764
    - MyMichigan Medical Center Tawas
  - Traverse City、Michigan、美国、49684
    - Munson Medical Center
  - Troy、Michigan、美国、48084
    - Michigan Institute of Urology-Town Center
  - Troy、Michigan、美国、48085
    - Claudia BR Herke MD PC
  - Troy、Michigan、美国、48098
    - Hematology Oncology Consultants PC-Troy
  - Troy、Michigan、美国、48085
    - Corewell Health Beaumont Troy Hospital
  - Warren、Michigan、美国、48088
    - Advanced Breast Care Center PLLC
  - Warren、Michigan、美国、48093
    - Macomb Hematology Oncology PC
  - Warren、Michigan、美国、48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren、Michigan、美国、48093
    - Henry Ford Health Warren Hospital
  - Warren、Michigan、美国、48093
    - Henry Ford Warren Hospital - GLCMS
  - West Bloomfield、Michigan、美国、48322
    - Henry Ford West Bloomfield Hospital
  - West Branch、Michigan、美国、48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyandotte、Michigan、美国、48192
    - Henry Ford Wyandotte Hospital
  - Wyoming、Michigan、美国、49519
    - University of Michigan Health - West
  - Ypsilanti、Michigan、美国、48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti、Michigan、美国、48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin、Minnesota、美国、56431
    - Riverwood Healthcare Center
  - Baxter、Minnesota、美国、56425
    - Essentia Health - Baxter Clinic
  - Bemidji、Minnesota、美国、56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd、Minnesota、美国、56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville、Minnesota、美国、55337
    - Fairview Ridges Hospital
  - Burnsville、Minnesota、美国、55337
    - Minnesota Oncology - Burnsville
  - Cambridge、Minnesota、美国、55008
    - Cambridge Medical Center
  - Coon Rapids、Minnesota、美国、55433
    - Mercy Hospital
  - Deer River、Minnesota、美国、56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes、Minnesota、美国、56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth、Minnesota、美国、55805
    - Essentia Health Cancer Center
  - Duluth、Minnesota、美国、55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth、Minnesota、美国、55805
    - Miller-Dwan Hospital
  - Edina、Minnesota、美国、55435
    - Fairview Southdale Hospital
  - Ely、Minnesota、美国、55731
    - Essentia Health - Ely Clinic
  - Fergus Falls、Minnesota、美国、56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston、Minnesota、美国、56542
    - Essentia Health - Fosston
  - Fridley、Minnesota、美国、55432
    - Unity Hospital
  - Hibbing、Minnesota、美国、55746
    - Essentia Health Hibbing Clinic
  - International Falls、Minnesota、美国、56649
    - Essentia Health - International Falls Clinic
  - Maple Grove、Minnesota、美国、55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood、Minnesota、美国、55109
    - Saint John's Hospital - Healtheast
  - Maplewood、Minnesota、美国、55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis、Minnesota、美国、55415
    - Hennepin County Medical Center
  - Minneapolis、Minnesota、美国、55407
    - Abbott-Northwestern Hospital
  - Minneapolis、Minnesota、美国、55454
    - Health Partners Inc
  - Minneapolis、Minnesota、美国、55455
    - University of Minnesota/Masonic Cancer Center
  - Monticello、Minnesota、美国、55362
    - Monticello Cancer Center
  - Moose Lake、Minnesota、美国、55767
    - Essentia Health - Moose Lake Clinic
  - New Ulm、Minnesota、美国、56073
    - New Ulm Medical Center
  - Park Rapids、Minnesota、美国、56470
    - Essentia Health - Park Rapids
  - Princeton、Minnesota、美国、55371
    - Fairview Northland Medical Center
  - Robbinsdale、Minnesota、美国、55422
    - North Memorial Medical Health Center
  - Rochester、Minnesota、美国、55905
    - Mayo Clinic in Rochester
  - Saint Louis Park、Minnesota、美国、55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul、Minnesota、美国、55101
    - Regions Hospital
  - Saint Paul、Minnesota、美国、55102
    - United Hospital
  - Sandstone、Minnesota、美国、55072
    - Essentia Health Sandstone
  - Shakopee、Minnesota、美国、55379
    - Saint Francis Regional Medical Center
  - Stillwater、Minnesota、美国、55082
    - Lakeview Hospital
  - Virginia、Minnesota、美国、55792
    - Essentia Health Virginia Clinic
  - Waconia、Minnesota、美国、55387
    - Ridgeview Medical Center
  - Willmar、Minnesota、美国、56201
    - Rice Memorial Hospital
  - Woodbury、Minnesota、美国、55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington、Minnesota、美国、56187
    - Sanford Cancer Center Worthington
  - Wyoming、Minnesota、美国、55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus、Mississippi、美国、39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada、Mississippi、美国、38901
    - Baptist Cancer Center-Grenada
  - Hattiesburg、Mississippi、美国、39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg、Mississippi、美国、39404
    - Forrest General Hospital / Cancer Center
  - Jackson、Mississippi、美国、39216
    - University of Mississippi Medical Center
  - New Albany、Mississippi、美国、38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford、Mississippi、美国、38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula、Mississippi、美国、39581
    - Singing River Hospital
  - Southhaven、Mississippi、美国、38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Bolivar、Missouri、美国、65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre、Missouri、美国、63628
    - Parkland Health Center-Bonne Terre
  - Branson、Missouri、美国、65616
    - Cox Cancer Center Branson
  - Cape Girardeau、Missouri、美国、63703
    - Saint Francis Medical Center
  - Cape Girardeau、Missouri、美国、63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield、Missouri、美国、63017
    - Saint Luke's Hospital
  - City of Saint Peters、Missouri、美国、63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia、Missouri、美国、65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur、Missouri、美国、63141
    - Siteman Cancer Center at West County Hospital
  - Farmington、Missouri、美国、63640
    - Parkland Health Center - Farmington
  - Independence、Missouri、美国、64057
    - Centerpoint Medical Center LLC
  - Jefferson City、Missouri、美国、65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin、Missouri、美国、64804
    - Freeman Health System
  - Joplin、Missouri、美国、64804
    - Mercy Hospital Joplin
  - Kansas City、Missouri、美国、64154
    - University of Kansas Cancer Center - North
  - Kansas City、Missouri、美国、64131
    - The University of Kansas Cancer Center-South
  - Kansas City、Missouri、美国、64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City、Missouri、美国、64132
    - Research Medical Center
  - Kansas City、Missouri、美国、64108
    - University Health Truman Medical Center
  - Lee's Summit、Missouri、美国、64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit、Missouri、美国、64086
    - Saint Luke's East - Lee's Summit
  - Liberty、Missouri、美国、64068
    - Liberty Hospital
  - North Kansas City、Missouri、美国、64116
    - University of Kansas Cancer Center at North Kansas City Hospital
  - Rolla、Missouri、美国、65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla、Missouri、美国、65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph、Missouri、美国、64506
    - Heartland Regional Medical Center
  - Sainte Genevieve、Missouri、美国、63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield、Missouri、美国、65807
    - CoxHealth South Hospital
  - Springfield、Missouri、美国、65804
    - Mercy Hospital Springfield
  - St Louis、Missouri、美国、63110
    - Washington University School of Medicine
  - St Louis、Missouri、美国、63129
    - Siteman Cancer Center-South County
  - St Louis、Missouri、美国、63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis、Missouri、美国、63131
    - Missouri Baptist Medical Center
  - St Louis、Missouri、美国、63109
    - Mercy Infusion Center - Chippewa
  - St Louis、Missouri、美国、63141
    - Mercy Hospital Saint Louis
  - St Louis、Missouri、美国、63128
    - Mercy Hospital South
  - Sullivan、Missouri、美国、63080
    - Missouri Baptist Sullivan Hospital
- Montana
  - Anaconda、Montana、美国、59711
    - Community Hospital of Anaconda
  - Billings、Montana、美国、59101
    - Billings Clinic Cancer Center
  - Billings、Montana、美国、59101
    - Saint Vincent Healthcare
  - Billings、Montana、美国、59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman、Montana、美国、59715
    - Bozeman Health Deaconess Hospital
  - Butte、Montana、美国、59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls、Montana、美国、59405
    - Benefis Sletten Cancer Institute
  - Helena、Montana、美国、59601
    - Saint Peter's Community Hospital
  - Kalispell、Montana、美国、59901
    - Logan Health Medical Center
  - Missoula、Montana、美国、59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula、Montana、美国、59804
    - Community Medical Center
- Nebraska
  - Bellevue、Nebraska、美国、68123
    - Nebraska Medicine-Bellevue
  - Grand Island、Nebraska、美国、68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney、Nebraska、美国、68847
    - CHI Health Good Samaritan
  - Kearney、Nebraska、美国、68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln、Nebraska、美国、68506
    - Nebraska Hematology and Oncology
  - Lincoln、Nebraska、美国、68510
    - Nebraska Cancer Research Center
  - Lincoln、Nebraska、美国、68510
    - Saint Elizabeth Regional Medical Center
  - Lincoln、Nebraska、美国、68516
    - Cancer Partners of Nebraska
  - Norfolk、Nebraska、美国、68701
    - Faith Regional Health Services Carson Cancer Center
  - North Platte、Nebraska、美国、69101
    - Great Plains Health Callahan Cancer Center
  - Omaha、Nebraska、美国、68114
    - Nebraska Methodist Hospital
  - Omaha、Nebraska、美国、68198
    - University of Nebraska Medical Center
  - Omaha、Nebraska、美国、68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha、Nebraska、美国、68118
    - Nebraska Medicine-Village Pointe
  - Omaha、Nebraska、美国、68122
    - Alegent Health Immanuel Medical Center
  - Omaha、Nebraska、美国、68130
    - Alegent Health Lakeside Hospital
  - Omaha、Nebraska、美国、68124
    - Nebraska Cancer Specialists - Omaha
  - Omaha、Nebraska、美国、68130
    - Oncology Hematology West PC
  - Omaha、Nebraska、美国、68122
    - Hematology and Oncology Consultants PC
  - Omaha、Nebraska、美国、68114
    - Oncology Associates PC
  - Omaha、Nebraska、美国、68114
    - Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
  - Papillion、Nebraska、美国、68046
    - Midlands Community Hospital
  - Scottsbluff、Nebraska、美国、69361
    - Regional West Medical Center Cancer Center
- Nevada
  - Carson City、Nevada、美国、89703
    - Carson Tahoe Regional Medical Center
  - Henderson、Nevada、美国、89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson、Nevada、美国、89052
    - Cancer and Blood Specialists-Henderson
  - Henderson、Nevada、美国、89052
    - Las Vegas Cancer Center-Henderson
  - Henderson、Nevada、美国、89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson、Nevada、美国、89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson、Nevada、美国、89074
    - Las Vegas Urology - Green Valley
  - Henderson、Nevada、美国、89074
    - Las Vegas Urology - Pebble
  - Henderson、Nevada、美国、89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson、Nevada、美国、89074
    - Oncology Las Vegas - Henderson
  - Las Vegas、Nevada、美国、89144
    - Summerlin Hospital Medical Center
  - Las Vegas、Nevada、美国、89109
    - Sunrise Hospital and Medical Center
  - Las Vegas、Nevada、美国、89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas、Nevada、美国、89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas、Nevada、美国、89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas、Nevada、美国、89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas、Nevada、美国、89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas、Nevada、美国、89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas、Nevada、美国、89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas、Nevada、美国、89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas、Nevada、美国、89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas、Nevada、美国、89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas、Nevada、美国、89102
    - University Medical Center of Southern Nevada
  - Las Vegas、Nevada、美国、89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas、Nevada、美国、89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas、Nevada、美国、89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas、Nevada、美国、89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas、Nevada、美国、89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas、Nevada、美国、89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas、Nevada、美国、89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas、Nevada、美国、89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas、Nevada、美国、89128
    - Ann M Wierman MD LTD
  - Las Vegas、Nevada、美国、89074
    - Las Vegas Urology - Pecos
  - Las Vegas、Nevada、美国、89102
    - Desert West Surgery
  - Las Vegas、Nevada、美国、89106
    - Urology Specialists of Nevada - Central
  - Las Vegas、Nevada、美国、89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas、Nevada、美国、89113
    - Las Vegas Urology - Sunset
  - Las Vegas、Nevada、美国、89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas、Nevada、美国、89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas、Nevada、美国、89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas、Nevada、美国、89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas、Nevada、美国、89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas、Nevada、美国、89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump、Nevada、美国、89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno、Nevada、美国、89502
    - Renown Regional Medical Center
  - Reno、Nevada、美国、89503
    - Saint Mary's Regional Medical Center
  - Reno、Nevada、美国、89509
    - Radiation Oncology Associates
  - Reno、Nevada、美国、89502
    - Center of Hope at Renown Medical Center
- New Hampshire
  - Concord、New Hampshire、美国、03301
    - New Hampshire Oncology Hematology PA-Concord
  - Lebanon、New Hampshire、美国、03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester、New Hampshire、美国、03103
    - Solinsky Center for Cancer Care
  - Manchester、New Hampshire、美国、03103
    - Elliot Hospital
  - Manchester、New Hampshire、美国、03104
    - Dartmouth Cancer Center - Manchester/ DCC Manchester
  - Nashua、New Hampshire、美国、03063
    - Dartmouth Cancer Center - Nashua
- New Jersey
  - Brick、New Jersey、美国、08724
    - Ocean University Medical Center
  - Cape May Court House、New Jersey、美国、08210
    - AtlantiCare Health Park-Cape May Court House
  - Egg Harbor、New Jersey、美国、08234
    - AtlantiCare Surgery Center
  - Elizabeth、New Jersey、美国、07207
    - Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
  - Flemington、New Jersey、美国、08822
    - Hunterdon Medical Center
  - Hackensack、New Jersey、美国、07601
    - Hackensack University Medical Center
  - Holmdel、New Jersey、美国、07733
    - Bayshore Community Hospital
  - Lakewood、New Jersey、美国、08701
    - Monmouth Medical Center Southern Campus
  - Livingston、New Jersey、美国、07039
    - Cooperman Barnabas Medical Center
  - Long Branch、New Jersey、美国、07740
    - Monmouth Medical Center
  - Manahawkin、New Jersey、美国、08050
    - Southern Ocean County Medical Center
  - Middletown、New Jersey、美国、07748
    - Memorial Sloan Kettering Monmouth
  - Morristown、New Jersey、美国、07960
    - Morristown Medical Center
  - Mullica Hill、New Jersey、美国、08062
    - Inspira Medical Center Mullica Hill
  - Neptune City、New Jersey、美国、07753
    - Jersey Shore Medical Center
  - New Brunswick、New Jersey、美国、08903
    - Rutgers Cancer Institute of New Jersey
  - Newark、New Jersey、美国、07112
    - Newark Beth Israel Medical Center
  - Pennington、New Jersey、美国、08534
    - Capital Health Medical Center-Hopewell
  - Red Bank、New Jersey、美国、07701
    - Riverview Medical Center/Booker Cancer Center
  - Sewell、New Jersey、美国、08080
    - Sidney Kimmel Cancer Center Washington Township
  - Summit、New Jersey、美国、07902
    - Overlook Hospital
  - Vineland、New Jersey、美国、08360
    - Inspira Medical Center Vineland
- New Mexico
  - Albuquerque、New Mexico、美国、87106
    - Southwest Gynecologic Oncology Associates Inc
  - Albuquerque、New Mexico、美国、87102
    - Lovelace Medical Center-Downtown
  - Albuquerque、New Mexico、美国、87109
    - New Mexico Oncology Hematology Consultants
  - Albuquerque、New Mexico、美国、87106
    - University of New Mexico Cancer Center
  - Albuquerque、New Mexico、美国、87110
    - Presbyterian Kaseman Hospital
  - Las Cruces、New Mexico、美国、88011
    - Memorial Medical Center-Las Cruces
  - Rio Rancho、New Mexico、美国、87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
  - Santa Fe、New Mexico、美国、87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Bay Shore、New York、美国、11706
    - South Shore University Hospital
  - Brooklyn、New York、美国、11203
    - State University of New York Downstate Medical Center
  - Buffalo、New York、美国、14263
    - Roswell Park Cancer Institute
  - Elmira、New York、美国、14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Glens Falls、New York、美国、12801
    - Glens Falls Hospital
  - Harrison、New York、美国、10604
    - Memorial Sloan Kettering Westchester
  - Lake Success、New York、美国、11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset、New York、美国、11030
    - North Shore University Hospital
  - New Hyde Park、New York、美国、11040
    - Long Island Jewish Medical Center
  - New York、New York、美国、10065
    - Memorial Sloan Kettering Cancer Center
  - New York、New York、美国、10029
    - Mount Sinai Hospital
  - New York、New York、美国、10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York、New York、美国、10065
    - NYP/Weill Cornell Medical Center
  - New York、New York、美国、10075
    - Lenox Hill Hospital
  - New York、New York、美国、10065
    - Manhattan Eye Ear and Throat Hospital
  - Rochester、New York、美国、14642
    - University of Rochester
  - Rochester、New York、美国、14621
    - Rochester General Hospital
  - Stony Brook、New York、美国、11794
    - Stony Brook University Medical Center
  - Syracuse、New York、美国、13210
    - State University of New York Upstate Medical University
  - Syracuse、New York、美国、13215
    - SUNY Upstate Medical Center-Community Campus
  - The Bronx、New York、美国、10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx、New York、美国、10467
    - Children's Hospital at Montefiore
  - The Bronx、New York、美国、10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx、New York、美国、10461
    - Montefiore Medical Center-Weiler Hospital
  - White Plains、New York、美国、10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheville、North Carolina、美国、28801
    - Mission Hospital
  - Asheville、North Carolina、美国、28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville、North Carolina、美国、28806
    - Messino Cancer Centers
  - Asheville、North Carolina、美国、28803
    - AdventHealth Infusion Center Asheville
  - Cary、North Carolina、美国、27518
    - Waverly Hematology Oncology
  - Chapel Hill、North Carolina、美国、27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte、North Carolina、美国、28204
    - Novant Health Presbyterian Medical Center
  - Charlotte、North Carolina、美国、28207
    - Oncology Specialists of Charlotte
  - Charlotte、North Carolina、美国、28262
    - Southern Oncology Specialists-Charlotte
  - Charlotte、North Carolina、美国、28207
    - Novant Health Carolina Surgical - Randolph
  - Clinton、North Carolina、美国、28328
    - Southeastern Medical Oncology Center-Clinton
  - Clyde、North Carolina、美国、28721
    - AdventHealth Infusion Center Haywood
  - Durham、North Carolina、美国、27710
    - Duke University Medical Center
  - Durham、North Carolina、美国、27705
    - Durham VA Medical Center
  - Goldsboro、North Carolina、美国、27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro、North Carolina、美国、27534
    - Wayne Memorial Hospital
  - Greensboro、North Carolina、美国、27403
    - Novant Health Breast Surgery - Greensboro
  - Hendersonville、North Carolina、美国、28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville、North Carolina、美国、28792
    - AdventHealth Hendersonville
  - Huntersville、North Carolina、美国、28078
    - Novant Health Cancer Institute - Huntersville
  - Huntersville、North Carolina、美国、28078
    - Southern Oncology Specialists-Huntersville
  - Huntersville、North Carolina、美国、28078
    - Novant Health Presbyterian Medical Center Huntersville
  - Jacksonville、North Carolina、美国、28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville、North Carolina、美国、28546
    - Onslow Memorial Hospital
  - Kernersville、North Carolina、美国、27284
    - Novant Health Cancer Institute - Kernersville
  - Matthews、North Carolina、美国、28105
    - Matthews Radiation Oncology Center
  - Matthews、North Carolina、美国、28105
    - Novant Health Cancer Institute - Matthews
  - Mooresville、North Carolina、美国、28117
    - Novant Health Cancer Institute - Mooresville
  - Mount Airy、North Carolina、美国、27030
    - Novant Health Cancer Institute - Mount Airy
  - North Wilkesboro、North Carolina、美国、28659
    - Novant Health Cancer Institute - Wilkesboro
  - Pinehurst、North Carolina、美国、28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh、North Carolina、美国、27609
    - Duke Cancer Center Raleigh
  - Salisbury、North Carolina、美国、28144
    - Novant Health Cancer Institute - Rowan
  - Salisbury、North Carolina、美国、28144
    - Rowan Regional Medical Center
  - Statesville、North Carolina、美国、28625
    - Novant Health Cancer Institute - Statesville
  - Thomasville、North Carolina、美国、27360
    - Novant Health Cancer Institute - Thomasville
  - Washington、North Carolina、美国、27889
    - Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
  - Weaverville、North Carolina、美国、28787
    - AdventHealth Infusion Center Weaverville
  - Winston-Salem、North Carolina、美国、27157
    - Wake Forest University Health Sciences
  - Winston-Salem、North Carolina、美国、27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem、North Carolina、美国、27103
    - Winston-Salem Health Care
- North Dakota
  - Bismarck、North Dakota、美国、58501
    - Sanford Bismarck Medical Center
  - Fargo、North Dakota、美国、58122
    - Sanford Roger Maris Cancer Center
  - Fargo、North Dakota、美国、58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo、North Dakota、美国、58122
    - Sanford Broadway Medical Center
  - Fargo、North Dakota、美国、58103
    - Sanford South University Medical Center
  - Jamestown、North Dakota、美国、58401
    - Essentia Health - Jamestown Clinic
  - Minot、North Dakota、美国、58701
    - Trinity Cancer Care Center
- Ohio
  - Alliance、Ohio、美国、44601
    - Aultman Alliance Community Hospital
  - Beachwood、Ohio、美国、44122
    - UHHS-Chagrin Highlands Medical Center
  - Beavercreek、Ohio、美国、45431
    - Indu and Raj Soin Medical Center
  - Belpre、Ohio、美国、45714
    - Strecker Cancer Center-Belpre
  - Boardman、Ohio、美国、44512
    - Saint Elizabeth Boardman Hospital
  - Canton、Ohio、美国、44708
    - Cleveland Clinic Mercy Hospital
  - Canton、Ohio、美国、44710
    - Aultman Health Foundation
  - Centerville、Ohio、美国、45459
    - Miami Valley Hospital South
  - Centerville、Ohio、美国、45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon、Ohio、美国、44024
    - Geauga Hospital
  - Chillicothe、Ohio、美国、45601
    - Adena Regional Medical Center
  - Cincinnati、Ohio、美国、45229
    - Cincinnati Children's Hospital Medical Center
  - Cincinnati、Ohio、美国、45219
    - The Christ Hospital
  - Cincinnati、Ohio、美国、45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati、Ohio、美国、45242
    - Bethesda North Hospital
  - Cincinnati、Ohio、美国、45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati、Ohio、美国、45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati、Ohio、美国、45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati、Ohio、美国、45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati、Ohio、美国、45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati、Ohio、美国、45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati、Ohio、美国、45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland、Ohio、美国、44106
    - Case Western Reserve University
  - Cleveland、Ohio、美国、44109
    - MetroHealth Medical Center
  - Cleveland、Ohio、美国、44195
    - Cleveland Clinic Foundation
  - Columbus、Ohio、美国、43214
    - Riverside Methodist Hospital
  - Columbus、Ohio、美国、43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus、Ohio、美国、43219
    - The Mark H Zangmeister Center
  - Columbus、Ohio、美国、43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus、Ohio、美国、43228
    - Doctors Hospital
  - Columbus、Ohio、美国、43213
    - Mount Carmel East Hospital
  - Columbus、Ohio、美国、43215
    - Grant Medical Center
  - Columbus、Ohio、美国、43222
    - Mount Carmel Health Center West
  - Dayton、Ohio、美国、45406
    - Good Samaritan Hospital - Dayton
  - Dayton、Ohio、美国、45409
    - Miami Valley Hospital
  - Dayton、Ohio、美国、45415
    - Miami Valley Hospital North
  - Dayton、Ohio、美国、45415
    - Dayton Physician LLC - Englewood
  - Delaware、Ohio、美国、43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware、Ohio、美国、43015
    - Delaware Radiation Oncology
  - Delaware、Ohio、美国、43015
    - Grady Memorial Hospital
  - Dublin、Ohio、美国、43016
    - Dublin Methodist Hospital
  - Dublin、Ohio、美国、43016
    - Columbus Oncology and Hematology Associates
  - Elyria、Ohio、美国、44035
    - Mercy Cancer Center-Elyria
  - Elyria、Ohio、美国、44035
    - Hematology Oncology Center Incorporated
  - Fairfield、Ohio、美国、45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay、Ohio、美国、45840
    - Blanchard Valley Hospital
  - Findlay、Ohio、美国、45840
    - Armes Family Cancer Center
  - Findlay、Ohio、美国、45840
    - Orion Cancer Care
  - Franklin、Ohio、美国、45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin、Ohio、美国、45005
    - Dayton Physicians LLC-Atrium
  - Greenville、Ohio、美国、45331
    - Wayne Hospital
  - Greenville、Ohio、美国、45331
    - Dayton Physicians LLC-Wayne
  - Grove City、Ohio、美国、43123
    - Mount Carmel Grove City Hospital
  - Kettering、Ohio、美国、45429
    - Kettering Medical Center
  - Kettering、Ohio、美国、45409
    - Greater Dayton Cancer Center
  - Kettering、Ohio、美国、45420
    - First Dayton Cancer Care
  - Lancaster、Ohio、美国、43130
    - Fairfield Medical Center
  - Lima、Ohio、美国、45801
    - Saint Rita's Medical Center
  - Marietta、Ohio、美国、45750
    - Marietta Memorial Hospital
  - Marion、Ohio、美国、43302
    - OhioHealth Marion General Hospital
  - Maumee、Ohio、美国、43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee、Ohio、美国、43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Mayfield Heights、Ohio、美国、44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor、Ohio、美国、44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights、Ohio、美国、44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Middletown、Ohio、美国、45042
    - Dayton Physicians LLC-Signal Point
  - Mount Vernon、Ohio、美国、43050
    - Knox Community Hospital
  - Newark、Ohio、美国、43055
    - Licking Memorial Hospital
  - Newark、Ohio、美国、43055
    - Newark Radiation Oncology
  - Oregon、Ohio、美国、43616
    - Saint Charles Hospital
  - Parma、Ohio、美国、44129
    - University Hospitals Parma Medical Center
  - Perrysburg、Ohio、美国、43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth、Ohio、美国、45662
    - Southern Ohio Medical Center
  - Sandusky、Ohio、美国、44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Sidney、Ohio、美国、45365
    - Dayton Physicians LLC-Wilson
  - Springfield、Ohio、美国、45504
    - Springfield Regional Cancer Center
  - Springfield、Ohio、美国、45504
    - Springfield Regional Medical Center
  - Steubenville、Ohio、美国、43952
    - Trinity's Tony Teramana Cancer Center
  - Sylvania、Ohio、美国、43560
    - ProMedica Flower Hospital
  - Toledo、Ohio、美国、43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo、Ohio、美国、43623
    - Mercy Health - Saint Anne Hospital
  - Toledo、Ohio、美国、43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo、Ohio、美国、43614
    - University of Toledo
  - Toledo、Ohio、美国、43608
    - Mercy Health - Saint Vincent Hospital
  - Troy、Ohio、美国、45373
    - Upper Valley Medical Center
  - Troy、Ohio、美国、45373
    - Dayton Physicians LLC - Troy
  - Wadsworth、Ohio、美国、44281
    - University Hospitals Sharon Health Center
  - Warren、Ohio、美国、44484
    - Saint Joseph Warren Hospital
  - Westerville、Ohio、美国、43081
    - Saint Ann's Hospital
  - Westlake、Ohio、美国、44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Westlake、Ohio、美国、44145
    - UHHS-Westlake Medical Center
  - Youngstown、Ohio、美国、44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville、Ohio、美国、43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton、Oklahoma、美国、73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City、Oklahoma、美国、73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City、Oklahoma、美国、73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City、Oklahoma、美国、73109
    - Integris Southwest Medical Center
  - Oklahoma City、Oklahoma、美国、73142
    - Integris Cancer Institute of Oklahoma
  - Tulsa、Oklahoma、美国、74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
  - Tulsa、Oklahoma、美国、74133
    - Cancer Treatment Centers of America
- Oregon
  - Baker City、Oregon、美国、97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend、Oregon、美国、97701
    - Saint Charles Health System
  - Clackamas、Oregon、美国、97015
    - Clackamas Radiation Oncology Center
  - Clackamas、Oregon、美国、97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay、Oregon、美国、97420
    - Bay Area Hospital
  - Corvallis、Oregon、美国、97330
    - Good Samaritan Hospital
  - Gresham、Oregon、美国、97030
    - Legacy Mount Hood Medical Center
  - Newberg、Oregon、美国、97132
    - Providence Newberg Medical Center
  - Ontario、Oregon、美国、97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Oregon City、Oregon、美国、97045
    - Providence Willamette Falls Medical Center
  - Portland、Oregon、美国、97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland、Oregon、美国、97213
    - Providence Portland Medical Center
  - Portland、Oregon、美国、97225
    - Providence Saint Vincent Medical Center
  - Portland、Oregon、美国、97227
    - Kaiser Permanente Northwest
  - Redmond、Oregon、美国、97756
    - Saint Charles Health System-Redmond
  - Tualatin、Oregon、美国、97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington、Pennsylvania、美国、19001
    - Jefferson Abington Hospital
  - Allentown、Pennsylvania、美国、18103
    - Lehigh Valley Hospital-Cedar Crest
  - Altoona、Pennsylvania、美国、16601
    - UPMC Altoona
  - Beaver、Pennsylvania、美国、15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem、Pennsylvania、美国、18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr、Pennsylvania、美国、19010
    - Bryn Mawr Hospital
  - Butler、Pennsylvania、美国、16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill、Pennsylvania、美国、17011
    - UPMC Camp Hill
  - Carlisle、Pennsylvania、美国、17015
    - Carlisle Regional Cancer Center
  - Chadds Ford、Pennsylvania、美国、19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg、Pennsylvania、美国、17201
    - Chambersburg Hospital
  - Collegeville、Pennsylvania、美国、19426
    - Main Line Health Center-Collegeville
  - Cranberry Township、Pennsylvania、美国、16066
    - UPMC Hillman Cancer Center - Passavant - Cranberry
  - Danville、Pennsylvania、美国、17822
    - Geisinger Medical Center
  - Doylestown、Pennsylvania、美国、18901
    - Doylestown Hospital
  - East Stroudsburg、Pennsylvania、美国、18301
    - Pocono Medical Center
  - Easton、Pennsylvania、美国、18042
    - Easton Hospital
  - Ephrata、Pennsylvania、美国、17522
    - Ephrata Cancer Center
  - Ephrata、Pennsylvania、美国、17522
    - Ephrata Community Hospital
  - Erie、Pennsylvania、美国、16505
    - UPMC Hillman Cancer Center Erie
  - Erie、Pennsylvania、美国、16550
    - UPMC Hamot
  - Exton、Pennsylvania、美国、19341
    - Main Line Health Center-Exton
  - Farrell、Pennsylvania、美国、16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg、Pennsylvania、美国、17325
    - Adams Cancer Center
  - Greensburg、Pennsylvania、美国、15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Greenville、Pennsylvania、美国、16125
    - UPMC Hillman Cancer Center in Greenville/UPMC Horizon
  - Hanover、Pennsylvania、美国、17331
    - WellSpan Medical Oncology and Hematology
  - Harrisburg、Pennsylvania、美国、17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Harrisburg、Pennsylvania、美国、17101
    - UPMC Pinnacle Harrisburg
  - Hazleton、Pennsylvania、美国、18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton、Pennsylvania、美国、18201
    - Lehigh Valley Hospital-Hazleton
  - Hershey、Pennsylvania、美国、17033-0850
    - Penn State Milton S Hershey Medical Center
  - Indiana、Pennsylvania、美国、15701
    - IRMC Cancer Center
  - Johnstown、Pennsylvania、美国、15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Kittanning、Pennsylvania、美国、16201
    - Armstrong Center for Medicine and Health
  - Lancaster、Pennsylvania、美国、17601
    - Lancaster General Ann B Barshinger Cancer Institute
  - Lancaster、Pennsylvania、美国、17602
    - Lancaster General Hospital
  - Lebanon、Pennsylvania、美国、17042
    - Sechler Family Cancer Center
  - Lewisburg、Pennsylvania、美国、17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown、Pennsylvania、美国、17044
    - Lewistown Hospital
  - McKeesport、Pennsylvania、美国、15132
    - UPMC Cancer Center at UPMC McKeesport
  - Meadowbrook、Pennsylvania、美国、19046
    - Redeemer Health
  - Mechanicsburg、Pennsylvania、美国、17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media、Pennsylvania、美国、19063
    - Riddle Memorial Hospital
  - Monroeville、Pennsylvania、美国、15146
    - Forbes Hospital
  - Monroeville、Pennsylvania、美国、15146
    - UPMC Hillman Cancer Center - Monroeville
  - Moon Township、Pennsylvania、美国、15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Mount Pleasant、Pennsylvania、美国、15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - N. Huntingdon、Pennsylvania、美国、15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Natrona Heights、Pennsylvania、美国、15065
    - Allegheny Valley Hospital
  - Natrona Heights、Pennsylvania、美国、15065
    - UPMC Cancer Center-Natrona Heights
  - New Castle、Pennsylvania、美国、16105
    - UPMC Hillman Cancer Center - New Castle
  - Norristown、Pennsylvania、美国、19401
    - Suburban Community Hospital and Cancer Center
  - Paoli、Pennsylvania、美国、19301
    - Paoli Memorial Hospital
  - Philadelphia、Pennsylvania、美国、19111
    - Fox Chase Cancer Center
  - Philadelphia、Pennsylvania、美国、19107
    - Thomas Jefferson University Hospital
  - Philadelphia、Pennsylvania、美国、19114
    - Jefferson Torresdale Hospital
  - Philadelphia、Pennsylvania、美国、19102
    - Drexel University School of Medicine
  - Philadelphia、Pennsylvania、美国、19124
    - Eastern Regional Medical Center
  - Philadelphia、Pennsylvania、美国、19152
    - Nazareth Hospital
  - Phoenixville、Pennsylvania、美国、19460
    - Reading Hospital McGlinn Cancer Institute at Phoenixville
  - Pittsburgh、Pennsylvania、美国、15212
    - Allegheny General Hospital
  - Pittsburgh、Pennsylvania、美国、15224
    - West Penn Hospital
  - Pittsburgh、Pennsylvania、美国、15232
    - UPMC Hillman Cancer Center
  - Pittsburgh、Pennsylvania、美国、15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh、Pennsylvania、美国、15215
    - UPMC-Saint Margaret
  - Pittsburgh、Pennsylvania、美国、15237
    - UPMC-Passavant Hospital
  - Pittsburgh、Pennsylvania、美国、15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh、Pennsylvania、美国、15215
    - Oncology Hematology Association
  - Pittsburgh、Pennsylvania、美国、15219
    - UPMC-Mercy Hospital
  - Pottsville、Pennsylvania、美国、17901
    - Geisinger Cancer Services-Pottsville
  - Reading、Pennsylvania、美国、19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre、Pennsylvania、美国、18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton、Pennsylvania、美国、18510
    - Community Medical Center
  - Scranton、Pennsylvania、美国、18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Selinsgrove、Pennsylvania、美国、17870
    - Geisinger Medical Oncology-Selinsgrove
  - Seneca、Pennsylvania、美国、16346
    - UPMC Cancer Center at UPMC Northwest
  - State College、Pennsylvania、美国、16801
    - Geisinger Medical Group
  - State College、Pennsylvania、美国、16803
    - Mount Nittany Medical Center
  - Uniontown、Pennsylvania、美国、15401
    - UPMC Cancer Center-Uniontown
  - Washington、Pennsylvania、美国、15301
    - UPMC Cancer Center-Washington
  - West Chester、Pennsylvania、美国、19380
    - Chester County Hospital
  - West Mifflin、Pennsylvania、美国、15122
    - UPMC West Mifflin-Cancer Center Jefferson
  - West Reading、Pennsylvania、美国、19611
    - Reading Hospital
  - Wilkes-Barre、Pennsylvania、美国、18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport、Pennsylvania、美国、17701
    - UPMC Susquehanna
  - Williamsport、Pennsylvania、美国、17754
    - Divine Providence Hospital
  - Willow Grove、Pennsylvania、美国、19090
    - Asplundh Cancer Pavilion
  - Wynnewood、Pennsylvania、美国、19096
    - Lankenau Medical Center
  - York、Pennsylvania、美国、17403
    - WellSpan Health-York Cancer Center
  - York、Pennsylvania、美国、17403
    - WellSpan Health-York Hospital
  - York、Pennsylvania、美国、17403
    - Cancer Care Associates of York
  - York、Pennsylvania、美国、17408
    - UPMC Memorial
- Rhode Island
  - Newport、Rhode Island、美国、02840
    - Newport Hospital
  - Providence、Rhode Island、美国、02903
    - Rhode Island Hospital
  - Providence、Rhode Island、美国、02905
    - Women and Infants Hospital
  - Providence、Rhode Island、美国、02906
    - Miriam Hospital
  - Westerly、Rhode Island、美国、02891
    - Smilow Cancer Hospital Care Center - Westerly
- South Carolina
  - Anderson、South Carolina、美国、29621
    - AnMed Health Cancer Center
  - Beaufort、South Carolina、美国、29902
    - Beaufort Memorial Hospital
  - Boiling Springs、South Carolina、美国、29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston、South Carolina、美国、29425
    - Medical University of South Carolina
  - Charleston、South Carolina、美国、29401
    - Roper Hospital
  - Charleston、South Carolina、美国、29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston、South Carolina、美国、29414
    - Bon Secours Saint Francis Hospital
  - Charleston、South Carolina、美国、29403
    - Charleston Oncology - Roper
  - Charleston、South Carolina、美国、29414
    - Charleston Oncology - Saint Francis
  - Charleston、South Carolina、美国、29414
    - Lowcountry Oncology Associates - West Ashley
  - Easley、South Carolina、美国、29640
    - Prisma Health Cancer Institute - Easley
  - Florence、South Carolina、美国、29506
    - McLeod Regional Medical Center
  - Gaffney、South Carolina、美国、29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown、South Carolina、美国、29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville、South Carolina、美国、29605
    - Prisma Health Cancer Institute - Faris
  - Greenville、South Carolina、美国、29607
    - Saint Francis Cancer Center
  - Greenville、South Carolina、美国、29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville、South Carolina、美国、29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville、South Carolina、美国、29601
    - Saint Francis Hospital
  - Greenville、South Carolina、美国、29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville、South Carolina、美国、29601
    - Greenville Health System Cancer Institute-Andrews
  - Greenwood、South Carolina、美国、29646
    - Self Regional Healthcare
  - Greer、South Carolina、美国、29650
    - Prisma Health Cancer Institute - Greer
  - Greer、South Carolina、美国、29651
    - Gibbs Cancer Center-Pelham
  - Hilton Head Island、South Carolina、美国、29926
    - The Radiation Oncology Center-Hilton Head/Bluffton
  - Hilton Head Island、South Carolina、美国、29926-3827
    - South Carolina Cancer Specialists PC
  - Mt. Pleasant、South Carolina、美国、29464
    - Lowcountry Oncology Associates - Mount Pleasant
  - Seneca、South Carolina、美国、29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg、South Carolina、美国、29303
    - Spartanburg Medical Center
  - Spartanburg、South Carolina、美国、29307
    - Spartanburg Medical Center - Mary Black Campus
  - Spartanburg、South Carolina、美国、29303
    - North Grove Medical Park
  - Union、South Carolina、美国、29379
    - SMC Center for Hematology Oncology Union
- South Dakota
  - Aberdeen、South Dakota、美国、57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City、South Dakota、美国、57701
    - Rapid City Regional Hospital
  - Sioux Falls、South Dakota、美国、57105
    - Avera Cancer Institute
  - Sioux Falls、South Dakota、美国、57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls、South Dakota、美国、57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Chattanooga、Tennessee、美国、37404
    - Memorial Hospital
  - Collierville、Tennessee、美国、38017
    - Integrity Oncology PLLC-Collierville
  - Cookeville、Tennessee、美国、38501
    - Cookeville Regional Medical Center
  - Franklin、Tennessee、美国、37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson、Tennessee、美国、37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Knoxville、Tennessee、美国、37909
    - Tennessee Cancer Specialists-Dowell Springs
  - Knoxville、Tennessee、美国、37916
    - Covenant Health Cancer Centers
  - Knoxville、Tennessee、美国、37932
    - Covenant Health Cancer Centers - West
  - Maryville、Tennessee、美国、37804
    - Covenant Health Oncology Group - Maryville
  - Memphis、Tennessee、美国、38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville、Tennessee、美国、37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville、Tennessee、美国、37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Nashville、Tennessee、美国、37208
    - Meharry Medical College
  - Oak Ridge、Tennessee、美国、37830
    - Covenant Health Oncology Group - Oak Ridge
  - Ooltewah、Tennessee、美国、37363
    - Memorial GYN Plus
- Texas
  - Austin、Texas、美国、78701
    - Dell Seton Medical Center at The University of Texas
  - Bryan、Texas、美国、77802
    - Saint Joseph Regional Cancer Center
  - Conroe、Texas、美国、77384
    - UT MD Anderson - The Woodlands
  - Dallas、Texas、美国、75235
    - Parkland Memorial Hospital
  - Dallas、Texas、美国、75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas、Texas、美国、75246
    - Baylor University Medical Center
  - Fort Worth、Texas、美国、76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Houston、Texas、美国、77030
    - UT MD Anderson Cancer Center
  - Houston、Texas、美国、77030
    - Houston Methodist Hospital
  - Houston、Texas、美国、77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston、Texas、美国、77030
    - Memorial Hermann Texas Medical Center
  - Houston、Texas、美国、77079
    - UT MD Anderson - West Houston
  - Humble、Texas、美国、77338
    - Memorial Hermann Northeast Hospital
  - League City、Texas、美国、77573
    - UT MD Anderson - League City
  - Lubbock、Texas、美国、79410
    - Covenant Medical Center-Lakeside
  - Richardson、Texas、美国、75080
    - UT Southwestern Clinical Center at Richardson/Plano
  - San Antonio、Texas、美国、78229
    - University Hospital
  - San Antonio、Texas、美国、78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio、Texas、美国、78229
    - Methodist Children's Hospital of South Texas
  - Sugar Land、Texas、美国、77478
    - UT MD Anderson - Sugar Land
  - The Woodlands、Texas、美国、77380
    - Memorial Hermann The Woodlands Hospital
- Utah
  - American Fork、Utah、美国、84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City、Utah、美国、84720
    - Sandra L Maxwell Cancer Center
  - Farmington、Utah、美国、84025
    - Farmington Health Center
  - Logan、Utah、美国、84321
    - Logan Regional Hospital
  - Murray、Utah、美国、84107
    - Intermountain Medical Center
  - Ogden、Utah、美国、84403
    - McKay-Dee Hospital Center
  - Provo、Utah、美国、84604
    - Utah Valley Regional Medical Center
  - Riverton、Utah、美国、84065
    - Riverton Hospital
  - Salt Lake City、Utah、美国、84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City、Utah、美国、84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City、Utah、美国、84143
    - LDS Hospital
  - Salt Lake City、Utah、美国、84106
    - University of Utah Sugarhouse Health Center
  - South Jordan、Utah、美国、84009
    - South Jordan Health Center
  - St. George、Utah、美国、84770
    - Saint George Regional Medical Center
- Vermont
  - Berlin Corners、Vermont、美国、05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington、Vermont、美国、05401
    - University of Vermont Medical Center
  - Burlington、Vermont、美国、05405
    - University of Vermont and State Agricultural College
  - Saint Johnsbury、Vermont、美国、05819
    - Dartmouth Cancer Center - North
- Virginia
  - Danville、Virginia、美国、24541
    - Danville Regional Medical Center
  - Fairfax、Virginia、美国、22031
    - Inova Schar Cancer Institute
  - Fairfax、Virginia、美国、22033
    - Inova Fair Oaks Hospital
  - Falls Church、Virginia、美国、22042
    - Inova Fairfax Hospital
  - Fishersville、Virginia、美国、22939
    - Augusta Health Center for Cancer and Blood Disorders
  - Fredericksburg、Virginia、美国、22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg、Virginia、美国、24501
    - Centra Alan B Pearson Regional Cancer Center
  - Martinsville、Virginia、美国、24112
    - Sovah Health Martinsville
  - Mechanicsville、Virginia、美国、23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian、Virginia、美国、23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian、Virginia、美国、23113
    - Bon Secours Westchester Emergency Center
  - Norfolk、Virginia、美国、23507
    - Children's Hospital of The King's Daughters
  - Richmond、Virginia、美国、23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond、Virginia、美国、23229
    - Virginia Cancer Institute
  - Richmond、Virginia、美国、23226
    - Bon Secours Saint Mary's Hospital
  - Richmond、Virginia、美国、23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - Richmond、Virginia、美国、23298
    - VCU Massey Comprehensive Cancer Center
- Washington
  - Aberdeen、Washington、美国、98520
    - Providence Regional Cancer System-Aberdeen
  - Anacortes、Washington、美国、98221
    - Cancer Care Center at Island Hospital
  - Auburn、Washington、美国、98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island、Washington、美国、98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue、Washington、美国、98004
    - Overlake Medical Center
  - Bellingham、Washington、美国、98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien、Washington、美国、98166
    - Saint Anne Hospital
  - Centralia、Washington、美国、98531
    - Providence Regional Cancer System-Centralia
  - Edmonds、Washington、美国、98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw、Washington、美国、98022
    - Saint Elizabeth Hospital
  - Everett、Washington、美国、98201
    - Providence Regional Cancer Partnership
  - Federal Way、Washington、美国、98002
    - Virginia Mason Federal Way Medical Center
  - Federal Way、Washington、美国、98003
    - Saint Francis Hospital
  - Gig Harbor、Washington、美国、98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor、Washington、美国、98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah、Washington、美国、98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick、Washington、美国、99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick、Washington、美国、99336
    - Northwest Cancer Clinic
  - Lacey、Washington、美国、98503
    - Providence Regional Cancer System-Lacey
  - Lakewood、Washington、美国、98499
    - Saint Clare Hospital
  - Longview、Washington、美国、98632
    - PeaceHealth Saint John Medical Center
  - Lynnwood、Washington、美国、98036
    - Virginia Mason Lynnwood Medical Center
  - Mount Vernon、Washington、美国、98274
    - Skagit Valley Hospital
  - Mount Vernon、Washington、美国、98274
    - Skagit Regional Health Cancer Care Center
  - Port Townsend、Washington、美国、98368
    - Jefferson Healthcare
  - Poulsbo、Washington、美国、98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo、Washington、美国、98370
    - Peninsula Cancer Center
  - Puyallup、Washington、美国、98372
    - MultiCare Good Samaritan Hospital
  - Puyallup、Washington、美国、98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Renton、Washington、美国、98055
    - Valley Medical Center
  - Seattle、Washington、美国、98101
    - Virginia Mason Medical Center
  - Seattle、Washington、美国、98107
    - Swedish Medical Center-Ballard Campus
  - Seattle、Washington、美国、98122
    - Swedish Medical Center-First Hill
  - Seattle、Washington、美国、98195
    - University of Washington Medical Center - Montlake
  - Seattle、Washington、美国、98112
    - Kaiser Permanente Washington
  - Seattle、Washington、美国、98104
    - Minor and James Medical PLLC
  - Seattle、Washington、美国、98104
    - Pacific Gynecology Specialists
  - Seattle、Washington、美国、98122-5711
    - Swedish Medical Center-Cherry Hill
  - Seattle、Washington、美国、98109
    - Fred Hutchinson Cancer Center
  - Sedro-Woolley、Washington、美国、98284
    - PeaceHealth United General Medical Center
  - Shelton、Washington、美国、98584
    - Providence Regional Cancer System-Shelton
  - Silverdale、Washington、美国、98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane、Washington、美国、99204
    - Providence Sacred Heart Medical Center and Children's Hospital
  - Spokane、Washington、美国、99218
    - Evergreen Hematology and Oncology PS
  - Spokane、Washington、美国、99208
    - Spokane Valley Cancer Center-Mayfair
  - Spokane、Washington、美国、99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane、Washington、美国、99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane、Washington、美国、99216
    - Spokane Valley Cancer Center-Mission
  - Spokane Valley、Washington、美国、99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma、Washington、美国、98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma、Washington、美国、98405
    - Northwest Medical Specialties PLLC
  - Tacoma、Washington、美国、98405
    - MultiCare Tacoma General Hospital
  - Tacoma、Washington、美国、98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma、Washington、美国、97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma、Washington、美国、98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver、Washington、美国、98686
    - Legacy Salmon Creek Hospital
  - Vancouver、Washington、美国、98664
    - PeaceHealth Southwest Medical Center
  - Vancouver、Washington、美国、98684
    - Legacy Cancer Institute Medical Oncology and Day Treatment
  - Walla Walla、Washington、美国、99362
    - Providence Saint Mary Regional Cancer Center
  - Wenatchee、Washington、美国、98801
    - Wenatchee Valley Hospital and Clinics
  - Yakima、Washington、美国、98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm、Washington、美国、98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport、West Virginia、美国、26330
    - United Hospital Center
  - Charleston、West Virginia、美国、25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington、West Virginia、美国、25701
    - Edwards Comprehensive Cancer Center
  - Martinsburg、West Virginia、美国、25401
    - WVUH-Berkely Medical Center
  - Morgantown、West Virginia、美国、26506
    - West Virginia University Healthcare
  - Morgantown、West Virginia、美国、26505
    - Monongalia Hospital
  - Parkersburg、West Virginia、美国、26101
    - Camden Clark Medical Center
  - Wheeling、West Virginia、美国、26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Antigo、Wisconsin、美国、54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Appleton、Wisconsin、美国、54915
    - Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
  - Ashland、Wisconsin、美国、54806
    - Duluth Clinic Ashland
  - Ashland、Wisconsin、美国、54806
    - Northwest Wisconsin Cancer Center
  - Brookfield、Wisconsin、美国、53045
    - Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
  - Burlington、Wisconsin、美国、53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chilton、Wisconsin、美国、53014
    - Ascension Calumet Hospital-Chilton
  - Chippewa Falls、Wisconsin、美国、54729
    - Marshfield Clinic-Chippewa Center
  - Cudahy、Wisconsin、美国、53110
    - Aurora Saint Luke's South Shore
  - Eau Claire、Wisconsin、美国、54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire、Wisconsin、美国、54701
    - HSHS Sacred Heart Hospital
  - Eau Claire、Wisconsin、美国、54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac、Wisconsin、美国、54937
    - Aurora Health Center-Fond du Lac
  - Franklin、Wisconsin、美国、53132
    - Ascension Southeast Wisconsin Hospital - Franklin
  - Franklin、Wisconsin、美国、53132
    - Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
  - Germantown、Wisconsin、美国、53022
    - Aurora Health Care Germantown Health Center
  - Grafton、Wisconsin、美国、53024
    - Aurora Cancer Care-Grafton
  - Green Bay、Wisconsin、美国、54311
    - Aurora BayCare Medical Center
  - Green Bay、Wisconsin、美国、54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay、Wisconsin、美国、54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Janesville、Wisconsin、美国、53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Kenosha、Wisconsin、美国、53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse、Wisconsin、美国、54601
    - Gundersen Lutheran Medical Center
  - Ladysmith、Wisconsin、美国、54848
    - Marshfield Medical Center - Ladysmith
  - Madison、Wisconsin、美国、53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Manitowoc、Wisconsin、美国、54221
    - Holy Family Memorial Hospital
  - Marinette、Wisconsin、美国、54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield、Wisconsin、美国、54449
    - Marshfield Medical Center-Marshfield
  - Marshfield、Wisconsin、美国、54449
    - Marshfield Medical Center
  - Medford、Wisconsin、美国、54451
    - Aspirus Medford Hospital
  - Mequon、Wisconsin、美国、53097
    - Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
  - Milwaukee、Wisconsin、美国、53226
    - Medical College of Wisconsin
  - Milwaukee、Wisconsin、美国、53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee、Wisconsin、美国、53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee、Wisconsin、美国、53233
    - Aurora Sinai Medical Center
  - Milwaukee、Wisconsin、美国、53210
    - Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
  - Milwaukee、Wisconsin、美国、53211
    - Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
  - Milwaukee、Wisconsin、美国、53215
    - Ascension Saint Francis Hospital-Milwaukee
  - Minocqua、Wisconsin、美国、54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago、Wisconsin、美国、53149
    - ProHealth D N Greenwald Center
  - New Richmond、Wisconsin、美国、54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc、Wisconsin、美国、53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls、Wisconsin、美国、54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh、Wisconsin、美国、54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Oshkosh、Wisconsin、美国、54904
    - Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
  - Racine、Wisconsin、美国、53406
    - Aurora Cancer Care-Racine
  - Racine、Wisconsin、美国、53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander、Wisconsin、美国、54501
    - Saint Mary's Hospital
  - Rhinelander、Wisconsin、美国、54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake、Wisconsin、美国、54868
    - Marshfield Medical Center-Rice Lake
  - Rice Lake、Wisconsin、美国、54868
    - Lakeview Medical Center-Marshfield Clinic
  - Sheboygan、Wisconsin、美国、53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan、Wisconsin、美国、53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point、Wisconsin、美国、54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Stevens Point、Wisconsin、美国、54481
    - Aspirus Cancer Care - Stevens Point
  - Sturgeon Bay、Wisconsin、美国、54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit、Wisconsin、美国、53066
    - Aurora Medical Center in Summit
  - Two Rivers、Wisconsin、美国、54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha、Wisconsin、美国、53188
    - UW Cancer Center at ProHealth Care
  - Waukesha、Wisconsin、美国、53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha、Wisconsin、美国、53188
    - Aurora Cancer Care-Waukesha
  - Wausau、Wisconsin、美国、54401
    - Marshfield Clinic-Wausau Center
  - Wausau、Wisconsin、美国、54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa、Wisconsin、美国、53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa、Wisconsin、美国、53226
    - Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
  - West Allis、Wisconsin、美国、53227
    - Aurora West Allis Medical Center
  - Weston、Wisconsin、美国、54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids、Wisconsin、美国、54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids、Wisconsin、美国、54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne、Wyoming、美国、82001
    - Cheyenne Regional Medical Center-West
  - Cody、Wyoming、美国、82414
    - Big Horn Basin Cancer Center
  - Cody、Wyoming、美国、82414
    - Billings Clinic-Cody
  - Sheridan、Wyoming、美国、82801
    - Welch Cancer Center

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年及以上 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

ELIGIBILITY CRITERIA FOR SCREENING BIOPSY (STEP 0)
Patients must be >= 18 years of age. Because no dosing or adverse event data are currently available on the use of study investigational agents in patients < 18 years of age, children are excluded from this study
Patients of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to registration; patients that are pregnant or breast feeding are excluded; a patient of childbearing potential is anyone, regardless of whether they have undergone tubal ligation, who meets the following criteria:
- Has achieved menarche at some point
- Has not undergone a hysterectomy or bilateral oophorectomy; or
- Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse prior to study entry, for the duration of study participation, and for 4 months after completion of study; should a patient or partner of the patient become pregnant or suspect a pregnancy while participating in this study, the treating physician should be informed immediately
Patients must have histologically documented solid tumors or histologically confirmed diagnosis of lymphoma or multiple myeloma requiring therapy and meet one of the following criteria:
- Patients must have progressed following at least one line of standard systemic therapy and there must not be other approval/standard therapy available that has been shown to prolong overall survival (i.e. in a randomized trial against another standard treatment or by comparison to historical controls); patients who cannot receive other standard therapy that has been shown to prolong overall survival due to medical issues will be eligible, if other eligibility criteria are met; if the patient is currently receiving therapy, the clinician must have assessed that the current therapy is no longer benefitting the patient prior to enrolling on MATCH, regardless of whether it is considered standard OR
- Patients for whose disease no standard treatment exists that has been shown to prolong overall survival
- NOTE: No other prior malignancy is allowed except for the following:
- Adequately treated basal cell or squamous cell skin cancer
- In situ cervical cancer
- Adequately treated stage I or II cancer from which the patient is currently in complete remission
- Any other cancer from which the patient has been disease-free for 5 years
Patients must have measurable disease
Patients must meet the criteria below
- Tumor tissue for the confirmation of "rare variant" by the MATCH assay is to be submitted, preferably from the same time of collection as that used to determine patient candidacy for treatment arm assignment
  - Registration to Step 0 must occur after stopping prior systemic anti-cancer therapy. There is no specific duration for which patients must be off treatment prior to registration to Step 0, as long as all eligibility criteria are met
  - Patients may have received other non-targeted, immunotherapy or targeted treatment between the prior genetic testing at the outside lab and registration to Step 0. The decision to stop such treatment in favor of participation in MATCH, if no further clinical benefit is expected, is per the treating physician's discretion. Documentation of a lack of response to the prior treatment is not required in these cases
  - Patients with an applicable "rare variant" must be able to meet the eligibility criteria for the appropriate subprotocols within 4 weeks following notification of treatment assignment
  - Patient meets one of the following criteria:
    - Patient is a candidate for Z1M based on local Clinical Laboratory Improvement Act (CLIA) assessment of mismatch repair deficiency (MMRd) by immunohistochemistry (IHC) or microsatellite instability (MSI) status by polymerase chain reaction (PCR), adequate tumor tissue is available for submission for mandatory central screening IHC and the patient will be able to meet the eligibility criteria for Z1M within 4 weeks following notification of treatment assignment OR
    - The sites have received results from one of the designated outside laboratories indicating a "rare variant" that is an actionable Mutation of Interest (aMOI) for specific select subprotocols
- NOTE: There is no particular window of time after receiving the sequencing report notification of potential eligibility from an outside lab in which the patient must be registered to Step 0, but treatment slots will be assigned on a first come, first serve basis to those who do register to Step 0, and are not held for those notified of potential eligibility who do not register to Step 0
- NOTE: Treatment assignment (and the start of the associated deadline for Step 1 registration) may occur shortly after Step 0 registration. Note that certain "rare variant" arms require submission of archival tissue for central IHC testing to determine treatment assignment. For those arms, adequate tissue for the central IHC is required to be available for submission
- NOTE: Other potential aMOIs that would be eligibility criteria for "NON RARE" arms, as determined by the designated laboratories, are not applicable for this process in MATCH
Patient must not require the use of full dose coumarin-derivative anticoagulants such as warfarin; low molecular weight heparin is permitted for prophylactic or therapeutic use; factor X inhibitors are permitted
- NOTE: Warfarin may not be started while enrolled in the EAY131 study
- Stopping the anticoagulation for biopsy should be per site standard operating procedure (SOP)
Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 1 and a life expectancy of at least 3 months
Patients must not currently be receiving any other investigational agents
Patients must not have any uncontrolled intercurrent illness including, but not limited to:
- Symptomatic congestive heart failure (New York Heart Association [NYHA] classification of III/IV)
- Unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration to Step 0, 2, 4, 6
- Cardiac arrhythmia (ongoing cardiac dysrhythmias of National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version [v]4 grade >= 2)
- Psychiatric illness/social situations that would limit compliance with study requirements
- Intra-cardiac defibrillators
- Known cardiac metastases
- Abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (ECHO) (as clinically indicated); (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis] can be entered on study); subjects with moderate valvular thickening should not be entered on study
- NOTE: To receive an agent, patient must not have any uncontrolled intercurrent illness such as ongoing or active infection; patients with infections unlikely to be resolved within 2 weeks following screening should not be considered for the trial
Patients must be able to swallow tablets or capsules; a patient with any gastrointestinal disease that would impair ability to swallow, retain, or absorb drug is not eligible
Patients who are human immunodeficiency virus (HIV)-positive are eligible if:
- CD4+ cell count greater or equal to 250 cells/mm^3
- If patient is on antiretroviral therapy, there must be minimal interactions or overlapping toxicity of the antiretroviral therapy with the experimental cancer treatment; for experimental cancer therapeutics with CYP3A/4 interactions, protease inhibitor therapy is disallowed; suggested regimens to replace protease inhibitor therapy include dolutegravir given with tenofovir/emtricitabine; raltegravir given with tenofovir and emtricitabine; once daily combinations that use pharmacologic boosters may not be used
- No history of non-malignancy acquired immune deficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts
- Probable long-term survival with HIV if cancer were not present
Any prior therapy, radiotherapy (except palliative radiation therapy of 30 gray [Gy] or less), or major surgery must have been completed >= 4 weeks prior to start of treatment; all adverse events due to prior therapy have resolved to a grade 1 or better (except alopecia and lymphopenia) by start of treatment; palliative radiation therapy must have been completed at least 2 weeks prior to start of treatment; the radiotherapy must not be to a lesion that is included as measurable disease
- NOTE: Prostate cancer patients may continue their luteinizing hormone-releasing hormone (LHRH) agonist
- NOTE: For patients entering the study via the original screening process, patients may receive non-protocol treatment after biopsy (if clinically indicated) until they receive notification of results; however, lack of response must be documented prior to registration to Step 1; new non-protocol treatment will NOT be permitted as intervening therapy after registration to Step 0; the only intervening treatment permitted is prior therapy that the patient already received prior to Step 0 registration; the decision to stop the intervening non-protocol treatment will be left up to the treating physician if patient has an aMOI; however, patients will need to be off such therapy for at least 4 weeks before receiving any MATCH protocol treatment
- NOTE: For patients entering the study via a designated outside laboratory, no intervening systemic non-protocol treatment is permitted after Step 0 registration; all other eligibility requirements still apply to these patients, including the washouts for prior therapy noted above in this section, the time restrictions outlined, and the eligibility criteria for the intended subprotocol
Patients with brain metastases or primary brain tumors must have completed treatment, surgery or radiation therapy >= 4 weeks prior to start of treatment
Patients must have discontinued steroids >= 1 week prior to registration to Step 0 and remain off steroids thereafter, except as permitted; patients with glioblastoma (GBM) must have been on stable dose of steroids, or be off steroids, for one week prior to registration to treatment (Step 1, 3, 5, 7)
- NOTE: The following steroids are permitted (low dose steroid use is defined as prednisone 10 mg daily or less, or bioequivalent dose of other corticosteroid):
  - Temporary steroid use: e.g. for CT imaging in setting of contrast allergy
  - Low dose steroid use for appetite
  - Chronic inhaled steroid use
  - Steroid injections for joint disease
  - Stable dose of replacement steroid for adrenal insufficiency or low doses for non-malignant disease
  - Topical steroid
  - Steroids required to manage toxicity related to study treatment, as described in the subprotocols
  - Steroids required as pre- or post-chemotherapy medication for acceptable intervening chemotherapy
    - NOTE: Steroids must be completed alongside last dose of chemotherapy
Leukocytes >= 3,000/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
Absolute neutrophil count (ANC) >= 1,500/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
Platelets >= 100,000/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
NOTE: Patients with documented bone marrow involvement by lymphoma are not required to meet the above hematologic parameters, but must have a platelet count of at least 75,000/mcL and neutrophil count of at least 1,000/mcL
Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (unless documented Gilbert's syndrome, for which bilirubin =< 3 x institutional ULN is permitted) (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (up to 5 times ULN in presence of liver metastases) (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional ULN
- As defined by the Cockcroft-Gault equation (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration)
Patients must have an electrocardiogram (ECG) within 8 weeks prior to registration to screening step and must meet the following cardiac criteria:
- Resting corrected QT interval (QTc) =< 480 msec
  - NOTE: If the first recorded QTc exceeds 480 msec, two additional, consecutive ECGs are required and must result in a mean resting QTc =< 480 msec; it is recommended that there are 10-minute (+/- 5 minutes) breaks between the ECGs
- The following only need to be assessed if the mean QTc > 480 msec
  - Check potassium and magnesium serum levels
  - Correct any identified hypokalemia and/or hypomagnesemia and may repeat ECG to confirm exclusion of patient due to QTc
  - For patients with heart rate (HR) 60-100 beats per minute (bpm), no manual read of QTc is required
  - For patients with baseline HR < 60 or > 100 bpm, manual read of QT by trained personnel is required, with Fridericia correction applied to determine QTc
  - Patient must not have hypokalemia (value < institutional lower limit of normal)
- No factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age or any concomitant medication known to prolong the QT interval
  - NOTE: Patient must be taken off prohibited medication prior to registration to the screening step (Step 0, 2, 4, 6) and remain off these medications thereafter, unless permitted on a subprotocol for the management of treatment related toxicity; patient must be off the drug for at least 5 half-lives prior to registration to the treatment step (Step 1, 3, 5, 7); the medication half-life can be found in the package insert for Food and Drug Administration (FDA) approved drugs
ELIGIBILITY CRITERIA FOR FIRST TREATMENT (STEP 1)
NOTE: For patients entering step 0 with assay results from outside laboratories, no systemic treatment is allowed after step 0 registration
As MATCH is designed to add additional subprotocols, implement limited expansions of accrual for certain subprotocols, and/or amend existing arm-specific eligibility criteria, some patients entering under the original screening method may be eligible to have their results rerun in MATCHbox, even if they did not match to a treatment initially or did not receive a treatment assignment due to a lack of available assignment slots; patients whose sequence results will be rerun through MATCHbox must also meet the following criteria:
- Samples must have been collected within 5 months of the activation of the addendum, as there is an additional month needed to get the patients on trial
- Patient has not had treatment within the 5 months that resulted in a PR or better after the performance of the screening assessment
- Patient must meet eligibility criteria, including performance status 1 or better and life expectancy of at least 3 months
- Patients must meet the eligibility requirements with the following exceptions:
  - Patients may have received other non-targeted, immunotherapy or targeted treatment, which could be stopped in favor of returning to MATCH, if no response to the interim treatment has occurred and no further benefit is expected from this interim treatment, per the treating physician's discretion; documentation of a lack of response to the interim treatment is not required in these cases; however, the following restrictions apply:
    - Enrollment onto another investigational therapeutic study is not permitted
    - Patient cannot be responding to interim treatment, since the benefit of the MATCH treatment is unknown and may deprive patient of an effective treatment if it were given when a patient is responding to another treatment
- NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their step 0 results will be re-interrogated to determine if another treatment is available
ELIGIBILITY CRITERIA FOR SECOND SCREENING (STEP 2)
Patient's disease has progressed on Step 1 treatment or patient could not tolerate assigned treatment
- NOTE: PATIENTS ENTERING STEP 1 WITH A "RARE VARIANT" FROM AN "OUTSIDE" LAB ARE NOT ELIGIBLE FOR STEP 2
No response and progression (or inability to tolerate further treatment) occurred < 6 months from start of step 1 treatment
- NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their step 0 MATCH assay results will be re-interrogated to determine if another treatment is available upon registration to this study step; it is not necessary to confirm the availability of another potential treatment assignment in advance; only aMOIs detected by the MATCH assay may be used for the determination of eligibility to a relevant subprotocol OR
Progression (or inability to tolerate further treatment) occurred after a (1) response OR (2) after >= 6 months from start of step 1 treatment; patient must have tumor amenable to percutaneous biopsy and be willing and able to undergo a tumor biopsy or bone marrow aspirate for collection and submission of tumor tissue OR patient will be undergoing a procedure due to medical necessity during which the tissue may be collected for the central determination of the presence of one or more of the specific "actionable" mutations/amplifications of interest (aMOI); archived specimens cannot be accepted
Patients must meet eligibility criteria as defined in step 0
Patient must not have been assigned to step 1 treatment based on a "rare variant" determined by a designated outside laboratory
ELIGIBILITY CRITERIA FOR SECOND TREATMENT (STEP 3)
NOTE: If screening biopsy samples were submitted during step 2, patients may receive non-protocol treatment after biopsy (if clinically indicated) until they receive notification of results however, lack of response must be documented prior to registration to step 3; new non-protocol treatment will NOT be permitted as intervening therapy after registration to step 2; the decision to stop the intervening nonprotocol treatment will be left up to the treating physician if patient has an aMOI; waiting periods as described will apply
ELIGIBILITY CRITERIA FOR THIRD SCREENING (STEP 4)
Patient's disease has progressed on step 3 treatment or patient could not tolerate assigned treatment
- Patient must meet one of the following criteria:
  - No response and progression (or inability to tolerate further treatment) occurred < 6 months from start of step 3 (second) treatment AND a biopsy was performed at step 2 screening
    - NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their latest MATCH assay results will be re-interrogated to determine if another treatment is available upon registration to this study step; it is not necessary to confirm the availability of another potential treatment assignment in advance OR
  - Progression (or inability to tolerate further treatment) occurred on step 3 treatment and a biopsy was not performed at step 2 screening (due to presence of a

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：放映
分配：非随机化
介入模型：并行分配
屏蔽：无（打开标签）

武器和干预

参与者组/臂参与者组/臂根据试验方案，接受特定干预/治疗或不接受干预的临床试验参与者组或亚组。	干预/治疗干预/治疗作为临床研究重点的过程或行动。干预措施包括药物、医疗设备、程序、疫苗和其他处于研究阶段或已经可用的产品。干预措施还可以包括非侵入性方法，例如教育或调整饮食和锻炼。
实验性的：Subprotocol A (EGFR activating mutation) Patients with EGFR activating mutation receive afatinib orally (PO) once daily (QD) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients may also undergo ECHO or nuclear study throughout the trial as clinically necessary. Patients undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集药品：Afatinib Given PO 其他名称：书目 2992 BIBW2992 BIBW-2992 药品：Afatinib Dimaleate Given PO 其他名称： (2E)-N-(4-((3-氯-4-氟苯基)氨基)-7-(((3S)-四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基) but-2-enamide bis(hydrogen (2Z)-but-2-enedioate) 书刊 2992MA2 BIBW2992 MA2 阿霉素程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描
实验性的：Subprotocol B (HER2 activating mutation) Patients with HER2 activating mutation receive afatinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Afatinib Given PO 其他名称：书目 2992 BIBW2992 BIBW-2992 药品：Afatinib Dimaleate Given PO 其他名称： (2E)-N-(4-((3-氯-4-氟苯基)氨基)-7-(((3S)-四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基) but-2-enamide bis(hydrogen (2Z)-but-2-enedioate) 书刊 2992MA2 BIBW2992 MA2 阿霉素其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol C1 (MET amplification) Patients with MET amplification receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation and collection of blood samples throughout the study. Patients may undergo biopsy at screening, on study, and/or at end of treatment.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol C2 (MET exon 14 deletion/mutation) Patients with MET exon 14 deletion or other mutations that disrupt exon 14 receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo tumor biopsy on study and undergo radiologic evaluation and blood sample collection throughout the study.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol E (EGFR T790M or rare activating mutation) Patients with EGFR T790M or rare activating mutation receive osimertinib (AZD9291) PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation throughout the trial, ECHO or multigated acquisition scan (MUGA) during screening, and biopsy and collection of blood samples on trial and at end of treatment.	程序：Multigated Acquisition Scan Undergo MUGA 其他名称：血池扫描平衡放射性核素血管造影门控血池成像穆加放射性核素脑室造影导航导航仪司马扫描同步多门采集扫描穆加扫描多门控采集扫描放射性核素脑室造影扫描门控心池扫描 RNV扫描程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查药品：Osimertinib Given PO 其他名称： AZD-9291 AZD9291 美来替尼 AZD 9291
实验性的：Subprotocol F (ALK translocation) Patients with ALK translocation receive crizotinib PO twice daily (BID) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol G (ROS1 translocation or inversion) Patients with ROS1 translocation or inversion receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol H (BRAF V600E/R/K/D mutation) Patients with BRAF V600E/R/K/D mutation receive dabrafenib PO BID and trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 药品：Dabrafenib Mesylate Given PO 其他名称：达拉非尼甲磺酸盐 GSK2118436 甲磺酸盐 GSK2118436B 塔菲拉其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Dabrafenib Given PO 其他名称： GSK2118436 BRAF 抑制剂 GSK2118436 GSK-2118436 GSK-2118436A 葛兰素史克 2118436 葛兰素史克 2118436A GSK2118436A
实验性的：Subprotocol I (PIK3CA mutation) Patients with PIK3CA mutation without RAS mutation or PTEN loss receive taselisib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Taselisib Given PO 其他名称： GDC-0032 RO5537381
实验性的：Subprotocol J (HER2 amplification >= 7 copy numbers) Patients receive pertuzumab IV over 30-60 minutes and trastuzumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation throughout the trial, ECHO at screening and end of treatment, and biopsy and collection of blood samples on trial and at end of treatment.	生物：Trastuzumab Given IV 其他名称：赫赛汀总部基地 980 ALT02 赫赛汀生物类似药 PF-05280014 赫赛汀曲妥珠单抗生物仿制药 PF-05280014 赫祖玛奥吉夫里闯入者 PF-05280014 大黄单抗HER2 RO0452317 SB3 曲妥珠单抗生物类似药 ABP 980 曲妥珠单抗生物类似药 ALT02 曲妥珠单抗生物类似药 EG12014 曲妥珠单抗生物类似药 HLX02 曲妥珠单抗生物仿制药 PF-05280014 曲妥珠单抗生物仿制药 SB3 曲妥珠单抗-dkst 曲妥珠单抗-dttb 曲妥珠单抗-pkrb 特拉齐梅拉坎金蒂曲妥珠单抗生物仿制药 SIBP-01 曲妥珠单抗曲妥珠单抗-qyyp 赫克隆泽西帕克昆仑1701 QL-1701 QL1701 曲妥珠单抗生物仿制药 QL1701 CT-P06 CT-P6 曲妥珠单抗生物仿制药 CT-P6 比塞尔蒂斯康单抗赫特拉兹赫尔塞西曲妥珠单抗-strf 赫文达曲妥珠单抗-herw 曲妥珠单抗-zerc HLX 02 HLX-02 HLX02 PF 05280014 PF05280014 Trastuzumab-tuzn Tuznue 生物：Pertuzumab Given IV 其他名称：佩捷塔 2C4 2C4抗体 EG1206A HLX11 HS627 单抗2C4 单克隆抗体2C4 Omnitarg 帕妥珠单抗生物类似药 EG1206A 帕妥珠单抗生物类似药 HLX11 帕妥珠单抗生物仿制药 HS627 rhuMAb2C4 RO4368451 BCD-178 帕妥珠单抗生物仿制药 BCD-178 大黄单抗2C4 帕妥珠单抗生物仿制药 TQB2440 TQB 2440 TQB-2440 TQB2440 帕妥珠单抗-dpzb 波赫迪程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol K1 (FGFR amplification) Patients with FGFR amplification receive erdafitinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and MRI throughout study. Patients may also undergo blood sample collection and tumor biopsy throughout the trial.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Erdafitinib Given PO 其他名称：巴尔维萨 JNJ-42756493 江宁 42756493 JNJ42756493
实验性的：Subprotocol K2 (FGFR mutation or fusion) Patients with FGFR mutation or fusion receive erdafitinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo blood sample collection, CT or MRI, and tumor biopsy throughout the study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Erdafitinib Given PO 其他名称：巴尔维萨 JNJ-42756493 江宁 42756493 JNJ42756493
实验性的：Subprotocol L (mTOR mutation) Patients with mTOR mutation receive sapanisertib PO daily on days 1-28. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Sapanisertib Given PO 其他名称： INK-128 INK128 MLN-0128 MLN0128 TAK-228
实验性的：Subprotocol M (TSC1 or TSC2 mutation) Patients with TSC1 or TSC2 mutation receive sapanisertib PO daily on days 1-28. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Sapanisertib Given PO 其他名称： INK-128 INK128 MLN-0128 MLN0128 TAK-228
实验性的：Subprotocol N (PTEN mutation or deletion and PTEN expression) Patients with PTEN mutation or deletion and PTEN expression receive PI3K-beta inhibitor GSK2636771 PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：PI3K-beta Inhibitor GSK2636771 Given PO 其他名称： GSK-2636771 GSK2636771
实验性的：Subprotocol P (PTEN loss) Patients with PTEN loss receive PI3K-beta inhibitor GSK2636771 PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：PI3K-beta Inhibitor GSK2636771 Given PO 其他名称： GSK-2636771 GSK2636771
实验性的：Subprotocol Q (HER2 amplification) Patients with HER2 amplification receive trastuzumab emtansine intravenously (IV) over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	生物：Trastuzumab Given IV 其他名称：赫赛汀总部基地 980 ALT02 赫赛汀生物类似药 PF-05280014 赫赛汀曲妥珠单抗生物仿制药 PF-05280014 赫祖玛奥吉夫里闯入者 PF-05280014 大黄单抗HER2 RO0452317 SB3 曲妥珠单抗生物类似药 ABP 980 曲妥珠单抗生物类似药 ALT02 曲妥珠单抗生物类似药 EG12014 曲妥珠单抗生物类似药 HLX02 曲妥珠单抗生物仿制药 PF-05280014 曲妥珠单抗生物仿制药 SB3 曲妥珠单抗-dkst 曲妥珠单抗-dttb 曲妥珠单抗-pkrb 特拉齐梅拉坎金蒂曲妥珠单抗生物仿制药 SIBP-01 曲妥珠单抗曲妥珠单抗-qyyp 赫克隆泽西帕克昆仑1701 QL-1701 QL1701 曲妥珠单抗生物仿制药 QL1701 CT-P06 CT-P6 曲妥珠单抗生物仿制药 CT-P6 比塞尔蒂斯康单抗赫特拉兹赫尔塞西曲妥珠单抗-strf 赫文达曲妥珠单抗-herw 曲妥珠单抗-zerc HLX 02 HLX-02 HLX02 PF 05280014 PF05280014 Trastuzumab-tuzn Tuznue 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 生物：Trastuzumab Emtansine Given IV 其他名称： RO5304020 卡德奇拉阿多曲妥珠单抗 Emtansine ADO-曲妥珠单抗 Emtansine PRO132365 T-DM1 曲妥珠单抗-DM1 曲妥珠单抗-MCC-DM1 曲妥珠单抗-MCC-DM1 抗体-药物偶联物曲妥珠单抗-MCC-DM1 免疫偶联物时分多路复用1 专业132365 PRO-132365
实验性的：Subprotocol R (BRAF fusion or BRAF non-V600 mutation) Patients with BRAF fusion or BRAF non-V600 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol S1 (NF1 mutation) Patients with NF1 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol S2 (GNAQ or GNA11 mutation) Patients with GNAQ or GNA11 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol T (SMO or PTCH1 mutation) Patients with SMO or PTCH1 mutation receive vismodegib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or nuclear study during screening, tumor biopsy on study and CT scan, MRI and blood sample collection throughout the study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描药品：Vismodegib Given PO 其他名称：埃里维奇 GDC-0449 刺猬拮抗剂 GDC-0449 GDC0449 游戏开发公司 0449
实验性的：Subprotocol U (NF2 inactivating mutation) Patients with NF2 inactivating mutation receive defactinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Defactinib Given PO 其他名称： PF-04554878 VS-6063 药品：Defactinib Hydrochloride Given PO
实验性的：Subprotocol V (cKIT exon 9, 11, 13, or 14 mutation) Patients with cKIT exon 9, 11, 13, or 14 mutation receive sunitinib PO QD on days 1-28 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo ECHO or nuclear study throughout the trial as clinically necessary. Patients undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描药品：Sunitinib Malate Given PO 其他名称：索坦 SU011248 SU11248 舒尼替尼苏11248 苏011248 SU-011248 SU-11248
实验性的：Subprotocol W (FGFR pathway aberrations) Patients with FGFR1-3 mutation or translocation receive FGFR Inhibitor AZD4547 PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Fexagratinib Given PO 其他名称： ABSK-091 ABSK091 AZD4547 KB-74810 FGFR 抑制剂 AZD4547
实验性的：Subprotocol X (DDR2 S768R, I638F, or L239R mutation) Patients with DDR2 S768R, I638F, or L239R mutation receive dasatinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Dasatinib Given PO 其他名称： BMS-354825 达沙替尼水合物达沙替尼一水合物赛赛尔建筑管理系统 354825 BMS354825 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol Y (Akt mutation) Patients with Akt mutation receive capivasertib PO BID on days 1-4, 8-11, 15-18, and 22-25. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Capivasertib Given PO 其他名称： AZD5363 特鲁卡普 AZD 5363 AZD-5363
实验性的：Subprotocol Z1A (NRAS mutation in codon 12, 13, or 61) Patients with NRAS mutation in codon 12, 13, or 61 receive binimetinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Binimetinib Given PO 其他名称：阿里-162 ARRY-438162 MEK162 梅克托维艾瑞 438162 阿里162 ARRY438162 丁酮162 MEK-162
实验性的：Subprotocol Z1B (CCND1, 2, or 3 amplification with Rb by IHC) Patients with CCND1, 2, or 3 amplification that have tumor Rb expression by IHC receive palbociclib PO QD for 21 days. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Palbociclib Given PO 其他名称：布兰斯 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one PD 0332991 PD 332991 PD 991 PD-0332991 PD0332991
实验性的：Subprotocol Z1C (CDK4 or CDK6 amplification and Rb protein) Patients with CDK4 or CDK6 amplification and tumor Rb protein receive palbociclib PO QD on days 1-21. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Palbociclib Given PO 其他名称：布兰斯 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one PD 0332991 PD 332991 PD 991 PD-0332991 PD0332991
实验性的：Subprotocol Z1D (Loss of MLH1 or MSH2 by IHC) Patients with mismatch repair deficiency (loss of MLH1 or MSH2 by IHC) receive nivolumab IV over 30 minutes on days 1 and 15 for 4 cycles and then on day 1 every 28 days. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	生物：Nivolumab Given IV 其他名称： BMS-936558 MDX-1106 尼沃 ONO-4538 欧狄沃 CMAB819 Nivolumab 生物类似药 CMAB819 MDX 1106 MDX1106 电池管理系统 936558 总部血压206 纳武单抗生物仿制药 ABP 206 BCD-263 纳武单抗生物仿制药 BCD-263 BMS936558 小野4538 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol Z1E (NTRK1, NTRK2 or NTRK3 gene fusion) Patients with NTRK1, NTRK2, or NTRK3 gene fusion receive larotrectinib (LOXO-101) PO BID on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Larotrectinib Given PO 其他名称：艾瑞470 洛克索101 LOXO-101 药品：Larotrectinib Sulfate Given PO 其他名称： ARRY 470 硫酸盐 LOXO 101 硫酸盐 LOXO-101 硫酸盐维特拉克维
实验性的：Subprotocol Z1F (PIK3CA mutation) Patients receive copanlisib IV over 1 hour on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo tumor biopsies at screening and end of treatment as well as CT or MRI at baseline and repeated every 2 cycles for the first 26 cycles then every 3 cycles thereafter until progressive disease or start of another MATCH treatment step.	程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1G (PTEN loss) Patients with PTEN loss receive copanlisib IV over 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1H (PTEN mutation) Patients with PTEN mutation receive copanlisib IV over 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1I (BRCA1 or BRCA2 gene mutation) Patients with BRCA1 or BRCA2 gene mutation receive adavosertib PO QD for 5 days for 2 weeks. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Adavosertib Given PO 其他名称： AZD-1775 AZD1775 MK-1775 MK1775 新西兰元 1775 MK 1775
实验性的：Subprotocol Z1K (AKT mutation) Patients receive ipatasertib PO QD. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Ipatasertib Given PO 其他名称： GDC-0068 RG7440 RG-7440 游戏开发者大会 0068 GDC0068 RG 7440
实验性的：Subprotocol Z1L (BRAF fusion, aberration or non-V600 mutation) Patients with a BRAF non-V600 mutation or BRAF fusion, or another BRAF aberration receive ulixertinib (BVD-523FB) PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Ulixertinib Give PO 其他名称： BVD-523 VRT752271
实验性的：Subprotocol Z1M (LAG-3 expression >= 1%) Patients receive nivolumab IV over 30 minutes and relatlimab IV over 30 minutes on day 1.Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	生物：Nivolumab Given IV 其他名称： BMS-936558 MDX-1106 尼沃 ONO-4538 欧狄沃 CMAB819 Nivolumab 生物类似药 CMAB819 MDX 1106 MDX1106 电池管理系统 936558 总部血压206 纳武单抗生物仿制药 ABP 206 BCD-263 纳武单抗生物仿制药 BCD-263 BMS936558 小野4538 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 生物：Relatlimab Given IV 其他名称： BMS-986016 BMS986016 免疫球蛋白 G4、抗（人淋巴细胞激活基因 3 蛋白）（人重链）、人轻链二硫键、二聚体电池管理系统 986016

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Objective response rate (ORR) 大体时间：Up to 3 years	ORR is defined as the percentage of patients whose tumors have a complete or partial response to treatment among analyzable patients. Objective response is defined consistent with Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. 90% two-sided confidence interval is calculated for ORR. For the purposes of this study, patients should be re-evaluated for response: For treatments given in 21 day (3 week) cycles: every 3 cycles (9 weeks) for the first 33 cycles, and every 4 cycles thereafter (12 weeks) For treatments given in 28 day (4 week) cycles: every 2 cycles (8 weeks) for the first 26 cycles, and every three cycles thereafter (12 weeks) For treatments given in 42 day (6 week) cycles: every 2 cycles (12 weeks)	Up to 3 years

次要结果测量

结果测量	措施说明	大体时间
Overall survival (OS) 大体时间：From start of treatment on that step until death, or censored at the date of last contact, assessed up to 3 years	Will be evaluated specifically for each drug (or step). OS will be estimated using the Kaplan-Meier method.	From start of treatment on that step until death, or censored at the date of last contact, assessed up to 3 years
6-month progression free survival (PFS) rate 大体时间：From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed at 6 months	Progression free survival is defined as time from treatment start date to date of progression or death from any cause, whichever occurs first. Disease progression was evaluated using the Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. Please refer to the protocol for detailed definitions of disease progression. 6 month PFS rate was estimated using the Kaplan-Meier method, which can provide a point estimate for any specific time point.	From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed at 6 months
Progression free survival 大体时间：From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed up to 3 years	PFS was defined as time from treatment start date to date of disease progression or death from any causes, whichever occurred first. Median PFS was estimated using the Kaplan-Meier method. Disease progression was evaluated using the Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. Please refer to the protocol for detailed definitions of disease progression.	From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed up to 3 years

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

National Cancer Institute (NCI)

调查人员

首席研究员：Keith T Flaherty、ECOG-ACRIN Cancer Research Group

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

有用的网址

<p>Related Info</p>

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2015年8月17日

初级完成 (估计的)

2027年12月31日

研究完成 (估计的)

2027年12月31日

研究注册日期

首次提交

2015年6月3日

首先提交符合 QC 标准的

2015年6月3日

首次发布 (估计的)

2015年6月8日

研究记录更新

最后更新发布 (实际的)

2026年10月26日

上次提交的符合 QC 标准的更新

2026年10月23日

最后验证

2026年9月1日

参与者组/臂参与者组/臂根据试验方案，接受特定干预/治疗或不接受干预的临床试验参与者组或亚组。	干预/治疗干预/治疗作为临床研究重点的过程或行动。干预措施包括药物、医疗设备、程序、疫苗和其他处于研究阶段或已经可用的产品。干预措施还可以包括非侵入性方法，例如教育或调整饮食和锻炼。
实验性的：Subprotocol A (EGFR activating mutation) Patients with EGFR activating mutation receive afatinib orally (PO) once daily (QD) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients may also undergo ECHO or nuclear study throughout the trial as clinically necessary. Patients undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集药品：Afatinib Given PO 其他名称：书目 2992 BIBW2992 BIBW-2992 药品：Afatinib Dimaleate Given PO 其他名称： (2E)-N-(4-((3-氯-4-氟苯基)氨基)-7-(((3S)-四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基) but-2-enamide bis(hydrogen (2Z)-but-2-enedioate) 书刊 2992MA2 BIBW2992 MA2 阿霉素程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描
实验性的：Subprotocol B (HER2 activating mutation) Patients with HER2 activating mutation receive afatinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Afatinib Given PO 其他名称：书目 2992 BIBW2992 BIBW-2992 药品：Afatinib Dimaleate Given PO 其他名称： (2E)-N-(4-((3-氯-4-氟苯基)氨基)-7-(((3S)-四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基) but-2-enamide bis(hydrogen (2Z)-but-2-enedioate) 书刊 2992MA2 BIBW2992 MA2 阿霉素其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol C1 (MET amplification) Patients with MET amplification receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation and collection of blood samples throughout the study. Patients may undergo biopsy at screening, on study, and/or at end of treatment.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol C2 (MET exon 14 deletion/mutation) Patients with MET exon 14 deletion or other mutations that disrupt exon 14 receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo tumor biopsy on study and undergo radiologic evaluation and blood sample collection throughout the study.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol E (EGFR T790M or rare activating mutation) Patients with EGFR T790M or rare activating mutation receive osimertinib (AZD9291) PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation throughout the trial, ECHO or multigated acquisition scan (MUGA) during screening, and biopsy and collection of blood samples on trial and at end of treatment.	程序：Multigated Acquisition Scan Undergo MUGA 其他名称：血池扫描平衡放射性核素血管造影门控血池成像穆加放射性核素脑室造影导航导航仪司马扫描同步多门采集扫描穆加扫描多门控采集扫描放射性核素脑室造影扫描门控心池扫描 RNV扫描程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查药品：Osimertinib Given PO 其他名称： AZD-9291 AZD9291 美来替尼 AZD 9291
实验性的：Subprotocol F (ALK translocation) Patients with ALK translocation receive crizotinib PO twice daily (BID) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol G (ROS1 translocation or inversion) Patients with ROS1 translocation or inversion receive crizotinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Crizotinib Given PO 其他名称： MET 酪氨酸激酶抑制剂 PF-02341066 PF-02341066 PF-2341066 沙科里 PF02341066 PF 02341066 阿尔克森克里佐森特其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol H (BRAF V600E/R/K/D mutation) Patients with BRAF V600E/R/K/D mutation receive dabrafenib PO BID and trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 药品：Dabrafenib Mesylate Given PO 其他名称：达拉非尼甲磺酸盐 GSK2118436 甲磺酸盐 GSK2118436B 塔菲拉其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Dabrafenib Given PO 其他名称： GSK2118436 BRAF 抑制剂 GSK2118436 GSK-2118436 GSK-2118436A 葛兰素史克 2118436 葛兰素史克 2118436A GSK2118436A
实验性的：Subprotocol I (PIK3CA mutation) Patients with PIK3CA mutation without RAS mutation or PTEN loss receive taselisib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Taselisib Given PO 其他名称： GDC-0032 RO5537381
实验性的：Subprotocol J (HER2 amplification >= 7 copy numbers) Patients receive pertuzumab IV over 30-60 minutes and trastuzumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Patients also undergo radiologic evaluation throughout the trial, ECHO at screening and end of treatment, and biopsy and collection of blood samples on trial and at end of treatment.	生物：Trastuzumab Given IV 其他名称：赫赛汀总部基地 980 ALT02 赫赛汀生物类似药 PF-05280014 赫赛汀曲妥珠单抗生物仿制药 PF-05280014 赫祖玛奥吉夫里闯入者 PF-05280014 大黄单抗HER2 RO0452317 SB3 曲妥珠单抗生物类似药 ABP 980 曲妥珠单抗生物类似药 ALT02 曲妥珠单抗生物类似药 EG12014 曲妥珠单抗生物类似药 HLX02 曲妥珠单抗生物仿制药 PF-05280014 曲妥珠单抗生物仿制药 SB3 曲妥珠单抗-dkst 曲妥珠单抗-dttb 曲妥珠单抗-pkrb 特拉齐梅拉坎金蒂曲妥珠单抗生物仿制药 SIBP-01 曲妥珠单抗曲妥珠单抗-qyyp 赫克隆泽西帕克昆仑1701 QL-1701 QL1701 曲妥珠单抗生物仿制药 QL1701 CT-P06 CT-P6 曲妥珠单抗生物仿制药 CT-P6 比塞尔蒂斯康单抗赫特拉兹赫尔塞西曲妥珠单抗-strf 赫文达曲妥珠单抗-herw 曲妥珠单抗-zerc HLX 02 HLX-02 HLX02 PF 05280014 PF05280014 Trastuzumab-tuzn Tuznue 生物：Pertuzumab Given IV 其他名称：佩捷塔 2C4 2C4抗体 EG1206A HLX11 HS627 单抗2C4 单克隆抗体2C4 Omnitarg 帕妥珠单抗生物类似药 EG1206A 帕妥珠单抗生物类似药 HLX11 帕妥珠单抗生物仿制药 HS627 rhuMAb2C4 RO4368451 BCD-178 帕妥珠单抗生物仿制药 BCD-178 大黄单抗2C4 帕妥珠单抗生物仿制药 TQB2440 TQB 2440 TQB-2440 TQB2440 帕妥珠单抗-dpzb 波赫迪程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Radiologic Examination Undergo radiologic evaluation 其他名称：放射学评估放射学检查
实验性的：Subprotocol K1 (FGFR amplification) Patients with FGFR amplification receive erdafitinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and MRI throughout study. Patients may also undergo blood sample collection and tumor biopsy throughout the trial.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Erdafitinib Given PO 其他名称：巴尔维萨 JNJ-42756493 江宁 42756493 JNJ42756493
实验性的：Subprotocol K2 (FGFR mutation or fusion) Patients with FGFR mutation or fusion receive erdafitinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo blood sample collection, CT or MRI, and tumor biopsy throughout the study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Erdafitinib Given PO 其他名称：巴尔维萨 JNJ-42756493 江宁 42756493 JNJ42756493
实验性的：Subprotocol L (mTOR mutation) Patients with mTOR mutation receive sapanisertib PO daily on days 1-28. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Sapanisertib Given PO 其他名称： INK-128 INK128 MLN-0128 MLN0128 TAK-228
实验性的：Subprotocol M (TSC1 or TSC2 mutation) Patients with TSC1 or TSC2 mutation receive sapanisertib PO daily on days 1-28. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Sapanisertib Given PO 其他名称： INK-128 INK128 MLN-0128 MLN0128 TAK-228
实验性的：Subprotocol N (PTEN mutation or deletion and PTEN expression) Patients with PTEN mutation or deletion and PTEN expression receive PI3K-beta inhibitor GSK2636771 PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：PI3K-beta Inhibitor GSK2636771 Given PO 其他名称： GSK-2636771 GSK2636771
实验性的：Subprotocol P (PTEN loss) Patients with PTEN loss receive PI3K-beta inhibitor GSK2636771 PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：PI3K-beta Inhibitor GSK2636771 Given PO 其他名称： GSK-2636771 GSK2636771
实验性的：Subprotocol Q (HER2 amplification) Patients with HER2 amplification receive trastuzumab emtansine intravenously (IV) over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	生物：Trastuzumab Given IV 其他名称：赫赛汀总部基地 980 ALT02 赫赛汀生物类似药 PF-05280014 赫赛汀曲妥珠单抗生物仿制药 PF-05280014 赫祖玛奥吉夫里闯入者 PF-05280014 大黄单抗HER2 RO0452317 SB3 曲妥珠单抗生物类似药 ABP 980 曲妥珠单抗生物类似药 ALT02 曲妥珠单抗生物类似药 EG12014 曲妥珠单抗生物类似药 HLX02 曲妥珠单抗生物仿制药 PF-05280014 曲妥珠单抗生物仿制药 SB3 曲妥珠单抗-dkst 曲妥珠单抗-dttb 曲妥珠单抗-pkrb 特拉齐梅拉坎金蒂曲妥珠单抗生物仿制药 SIBP-01 曲妥珠单抗曲妥珠单抗-qyyp 赫克隆泽西帕克昆仑1701 QL-1701 QL1701 曲妥珠单抗生物仿制药 QL1701 CT-P06 CT-P6 曲妥珠单抗生物仿制药 CT-P6 比塞尔蒂斯康单抗赫特拉兹赫尔塞西曲妥珠单抗-strf 赫文达曲妥珠单抗-herw 曲妥珠单抗-zerc HLX 02 HLX-02 HLX02 PF 05280014 PF05280014 Trastuzumab-tuzn Tuznue 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 生物：Trastuzumab Emtansine Given IV 其他名称： RO5304020 卡德奇拉阿多曲妥珠单抗 Emtansine ADO-曲妥珠单抗 Emtansine PRO132365 T-DM1 曲妥珠单抗-DM1 曲妥珠单抗-MCC-DM1 曲妥珠单抗-MCC-DM1 抗体-药物偶联物曲妥珠单抗-MCC-DM1 免疫偶联物时分多路复用1 专业132365 PRO-132365
实验性的：Subprotocol R (BRAF fusion or BRAF non-V600 mutation) Patients with BRAF fusion or BRAF non-V600 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol S1 (NF1 mutation) Patients with NF1 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol S2 (GNAQ or GNA11 mutation) Patients with GNAQ or GNA11 mutation receive trametinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Trametinib Given PO 其他名称： GSK1120212 JTP-74057 MEK 抑制剂 GSK1120212 葛兰素史克 1120212 GSK-1120212 葛兰素史克212 葛兰素史克-212 JTP 74057 JTP74057 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol T (SMO or PTCH1 mutation) Patients with SMO or PTCH1 mutation receive vismodegib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or nuclear study during screening, tumor biopsy on study and CT scan, MRI and blood sample collection throughout the study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描药品：Vismodegib Given PO 其他名称：埃里维奇 GDC-0449 刺猬拮抗剂 GDC-0449 GDC0449 游戏开发公司 0449
实验性的：Subprotocol U (NF2 inactivating mutation) Patients with NF2 inactivating mutation receive defactinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Defactinib Given PO 其他名称： PF-04554878 VS-6063 药品：Defactinib Hydrochloride Given PO
实验性的：Subprotocol V (cKIT exon 9, 11, 13, or 14 mutation) Patients with cKIT exon 9, 11, 13, or 14 mutation receive sunitinib PO QD on days 1-28 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo ECHO or nuclear study throughout the trial as clinically necessary. Patients undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Echocardiography Test Undergo echocardiography (ECHO) 其他名称：超声心动图欧共体其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振程序：Radionuclide Imaging Undergo nuclear study 其他名称：纳米核医学核医学扫描放射成像放射性核素扫描扫描闪烁显像伽马扫描药品：Sunitinib Malate Given PO 其他名称：索坦 SU011248 SU11248 舒尼替尼苏11248 苏011248 SU-011248 SU-11248
实验性的：Subprotocol W (FGFR pathway aberrations) Patients with FGFR1-3 mutation or translocation receive FGFR Inhibitor AZD4547 PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Fexagratinib Given PO 其他名称： ABSK-091 ABSK091 AZD4547 KB-74810 FGFR 抑制剂 AZD4547
实验性的：Subprotocol X (DDR2 S768R, I638F, or L239R mutation) Patients with DDR2 S768R, I638F, or L239R mutation receive dasatinib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	药品：Dasatinib Given PO 其他名称： BMS-354825 达沙替尼水合物达沙替尼一水合物赛赛尔建筑管理系统 354825 BMS354825 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol Y (Akt mutation) Patients with Akt mutation receive capivasertib PO BID on days 1-4, 8-11, 15-18, and 22-25. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Capivasertib Given PO 其他名称： AZD5363 特鲁卡普 AZD 5363 AZD-5363
实验性的：Subprotocol Z1A (NRAS mutation in codon 12, 13, or 61) Patients with NRAS mutation in codon 12, 13, or 61 receive binimetinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Binimetinib Given PO 其他名称：阿里-162 ARRY-438162 MEK162 梅克托维艾瑞 438162 阿里162 ARRY438162 丁酮162 MEK-162
实验性的：Subprotocol Z1B (CCND1, 2, or 3 amplification with Rb by IHC) Patients with CCND1, 2, or 3 amplification that have tumor Rb expression by IHC receive palbociclib PO QD for 21 days. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Palbociclib Given PO 其他名称：布兰斯 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one PD 0332991 PD 332991 PD 991 PD-0332991 PD0332991
实验性的：Subprotocol Z1C (CDK4 or CDK6 amplification and Rb protein) Patients with CDK4 or CDK6 amplification and tumor Rb protein receive palbociclib PO QD on days 1-21. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Palbociclib Given PO 其他名称：布兰斯 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one PD 0332991 PD 332991 PD 991 PD-0332991 PD0332991
实验性的：Subprotocol Z1D (Loss of MLH1 or MSH2 by IHC) Patients with mismatch repair deficiency (loss of MLH1 or MSH2 by IHC) receive nivolumab IV over 30 minutes on days 1 and 15 for 4 cycles and then on day 1 every 28 days. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	生物：Nivolumab Given IV 其他名称： BMS-936558 MDX-1106 尼沃 ONO-4538 欧狄沃 CMAB819 Nivolumab 生物类似药 CMAB819 MDX 1106 MDX1106 电池管理系统 936558 总部血压206 纳武单抗生物仿制药 ABP 206 BCD-263 纳武单抗生物仿制药 BCD-263 BMS936558 小野4538 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis
实验性的：Subprotocol Z1E (NTRK1, NTRK2 or NTRK3 gene fusion) Patients with NTRK1, NTRK2, or NTRK3 gene fusion receive larotrectinib (LOXO-101) PO BID on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients also undergo biopsies and blood sample collection on study.	程序：Biospecimen Collection Undergo collection of blood samples 其他名称：生物样本采集收集的生物样本标本采集样本收集程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Larotrectinib Given PO 其他名称：艾瑞470 洛克索101 LOXO-101 药品：Larotrectinib Sulfate Given PO 其他名称： ARRY 470 硫酸盐 LOXO 101 硫酸盐 LOXO-101 硫酸盐维特拉克维
实验性的：Subprotocol Z1F (PIK3CA mutation) Patients receive copanlisib IV over 1 hour on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo tumor biopsies at screening and end of treatment as well as CT or MRI at baseline and repeated every 2 cycles for the first 26 cycles then every 3 cycles thereafter until progressive disease or start of another MATCH treatment step.	程序：Biopsy Procedure Undergo tumor biopsy 其他名称： Bx 活组织检查类型活检程序：Computed Tomography Undergo computed tomography (CT) 其他名称： CT 猫电脑扫描计算机轴向断层扫描计算机断层扫描 CT扫描断层扫描计算机轴向断层扫描（程序）计算机断层扫描 (CT) 扫描诊断猫扫描诊断猫扫描服务类型其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样程序：Magnetic Resonance Imaging Undergo magnetic resonance imaging (MRI) 其他名称：核磁共振磁共振磁共振成像扫描医学影像、磁共振/核磁共振先生磁共振成像核磁共振成像扫描核磁共振成像磁共振成像 (MRI) 磁共振成像（程序）结构核磁共振药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1G (PTEN loss) Patients with PTEN loss receive copanlisib IV over 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1H (PTEN mutation) Patients with PTEN mutation receive copanlisib IV over 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Copanlisib Given IV 其他名称：海湾 80-6946 PI3K 抑制剂 BAY 80-6946 湾 80 6946 湾806946 BAY-80-6946 BAY806946 药品：Copanlisib Hydrochloride Given IV 其他名称： 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, 盐酸盐(1:2) 阿里高巴 BAY 80-6946 二盐酸盐 BAY-80-6946 二盐酸盐 Copanlisib二盐酸盐
实验性的：Subprotocol Z1I (BRCA1 or BRCA2 gene mutation) Patients with BRCA1 or BRCA2 gene mutation receive adavosertib PO QD for 5 days for 2 weeks. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Adavosertib Given PO 其他名称： AZD-1775 AZD1775 MK-1775 MK1775 新西兰元 1775 MK 1775
实验性的：Subprotocol Z1K (AKT mutation) Patients receive ipatasertib PO QD. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Ipatasertib Given PO 其他名称： GDC-0068 RG7440 RG-7440 游戏开发者大会 0068 GDC0068 RG 7440
实验性的：Subprotocol Z1L (BRAF fusion, aberration or non-V600 mutation) Patients with a BRAF non-V600 mutation or BRAF fusion, or another BRAF aberration receive ulixertinib (BVD-523FB) PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 药品：Ulixertinib Give PO 其他名称： BVD-523 VRT752271
实验性的：Subprotocol Z1M (LAG-3 expression >= 1%) Patients receive nivolumab IV over 30 minutes and relatlimab IV over 30 minutes on day 1.Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	生物：Nivolumab Given IV 其他名称： BMS-936558 MDX-1106 尼沃 ONO-4538 欧狄沃 CMAB819 Nivolumab 生物类似药 CMAB819 MDX 1106 MDX1106 电池管理系统 936558 总部血压206 纳武单抗生物仿制药 ABP 206 BCD-263 纳武单抗生物仿制药 BCD-263 BMS936558 小野4538 其他：Cytology Specimen Collection Procedure Optional correlative studies 其他名称：细胞学取样其他：Laboratory Biomarker Analysis Undergo molecular analysis 生物：Relatlimab Given IV 其他名称： BMS-986016 BMS986016 免疫球蛋白 G4、抗（人淋巴细胞激活基因 3 蛋白）（人重链）、人轻链二硫键、二聚体电池管理系统 986016

基因检测指导的靶向治疗治疗晚期难治性实体瘤、淋巴瘤或多发性骨髓瘤患者（MATCH 筛选试验）

治疗选择的分子分析 (MATCH)

研究概览

地位

条件

干预/治疗

详细说明

研究类型

注册 (估计的)

阶段

联系人和位置

学习地点

参与标准

资格标准

适合学习的年龄

接受健康志愿者

有资格学习的性别

描述

学习计划

研究是如何设计的？

设计细节

手臂数量

武器和干预

参与者组/臂

干预/治疗

研究衡量的是什么？

主要结果指标

结果测量

措施说明

大体时间

次要结果测量

结果测量

措施说明

大体时间

合作者和调查者

赞助

调查人员

出版物和有用的链接

一般刊物

有用的网址

研究记录日期

研究主要日期

学习开始 (实际的)

初级完成 (估计的)

研究完成 (估计的)

研究注册日期

首次提交

首先提交符合 QC 标准的

首次发布 (估计的)

研究记录更新

最后更新发布 (实际的)

上次提交的符合 QC 标准的更新

最后验证

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

药物和器械信息、研究文件

研究美国 FDA 监管的药品

研究美国 FDA 监管的设备产品

在美国制造并从美国出口的产品