1,5-AG as a Marker of Postprandial Hyperglycemia and Glucose Variability in Well-controlled Type 2 Diabetes Mellitus
Correlation Between 1,5-anhydroglucitol and Postprandial Hyperglycemia by Continuous Glucose Monitoring System and Clinical Usefulness of 1,5-anhydroglucitol in Well-controlled Diabetic Patients
研究概览
地位
条件
详细说明
1,5-Anhydroglucitol (AG) is a glucose analogue present in the plasma of healthy subjects. Physiologically, the plasma levels of 1,5-AG are very stable and only a small quantity is excreted in the urine. It is competitively reabsorbed with glucose in the renal tubules. Therefore, in the hyperglycemic state where glycosuria is present, glucose competitively inhibits renal tubular reabsorption of 1,5-AG and consequently the plasma 1,5-AG levels decrease. When glycemia is normalized and glycosuria is resolved, 1,5-AG levels increase.
The usefulness of 1, 5-AG in reflecting glycemic excursions have been demonstrated in moderately controlled patients to some extent, although some studies reveal controversial results.
Therefore, the aim of this study was to evaluate the association of 1,5-AG and postprandial hyperglycemia determined using the Continuous Glucose Monitoring System (CGMS) in DM patients with HbA1C<7% and evaluate the usefulness of 1,5-AG as a marker of glycemic control compared to HbA1C and fructosamine.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Seoul、大韩民国、130-702
- Kyunghee University Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- HbA1C < 7%
- HbA1c modification <0.5% in the previous 3 months
- no recent addition of oral hypoglycemic medications or change in insulin dose >10% previous 3 months
Exclusion Criteria:
- pregnancy
- anemia (Hb <10.0 g/dL)
- liver disease (ALT >2 UNL)
- hypoalbuminemia (albumin <3.5 g/dL)
- serum creatinine >2 mg/dL
- acute or chronic renal tubulointerstitial disease
- severe medical illness
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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postprandial hyperglycemia
大体时间:3days
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3days
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glucose variability
大体时间:3 days
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3 days
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合作者和调查者
调查人员
- 研究主任:Jeong-taek Woo, MD, PhD、Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
研究记录日期
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研究完成 (实际的)
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首次发布 (估计)
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