Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor
Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor
The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in patients with brain tumors is limited to supratentorial tumors. Due to their anatomic location, posterior fossa tumors result in obstruction of ventricular outflow, produce hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical positions themselves affect systemic hemodynamics which may influence cerebral blood flow; with presence of anesthetics further compromising the blood flow to the brain. Understanding the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of patients and maintenance of intraoperative hemodynamic.
The aim of this observational study was to evaluate CA and CO2R in patients with posterior fossa tumor prior to surgical decompression of the lesion.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Delhi
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New Delhi、Delhi、印度、110029
- All India Institute of Medical Sciences
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- All patients with posterior fossa tumor
- Scheduled for elective surgery
- History of recent ventriculoperitoneal shunt (within 24 hours)
Exclusion Criteria:
- previous craniotomy
- patients on ventilatory support
- history of cerebrovascular accident
- syncope or carotid artery disease
- anemia
- polycythemia
- patients on vasoactive medications
- those suffering from medical conditions such as diabetes mellitus and hypertension.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
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Posterior fossa tumor
Patients with posterior fossa tumor scheduled for elective surgery will be enrolled in the study.
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Transcranial Doppler will be used to assess the cerebral autoregulation and carbon dioxide reactivity of patients with posterior fossa tumor
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合作者和调查者
调查人员
- 首席研究员:Hemanshu Prabhakar, MD、All India Institute of Medical Sciences, New Delhi
研究记录日期
研究主要日期
学习开始
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
Monitoring的临床试验
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Royal Brompton & Harefield NHS Foundation TrustUniversity of Oxford; National Institute for Health Research, United Kingdom完全的
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University of AarhusOdense University Hospital; Aarhus University Hospital; Protac A/S; Innovation Fund Denmark招聘中