Retinal Venous Pressure and ET-1 in Patients With Diabetes Mellitus
Measurement of Retinal Venous Pressure and Endothelin-1 in Patients With Diabetes Mellitus
研究概览
地位
条件
详细说明
Diabetic retinopathy and maculopathy are the main causes of visual loss. Hyperglycemia as the main risk factor of diabetic retinopathy induced damage to retinal capillaries. These in turn lead to hypoxia in the tissue and promote the release of VEGF (vascular endothelial growth factor) , which in turn increases the vascular pathology. Simultaneously, there is an increased expression of endothelin (ET-1). Endothelin increases vascular tone and regulates the micro-and macro-vascular remodeling.
In ocular blood flow perfusion pressure plays an important role. While in healthy eyes a spontaneous retinal venous pulsation is frequently observed, this is significantly less frequent in diseased eyes. An increased venous pressure lowers the ocular perfusion pressure, and increases the transmural pressure. A measurement of the retinal venous pressure and the hormone ET-1 in the blood will give us a better knowledge of the circulatory changes and their relationship to diabetes.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Basel、瑞士、4031
- University of Basel, Dept. of Ophthalmology
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- diabetes mellitus type I or II
- no diabetic retinopathy
Exclusion Criteria:
- known diabetic retinopathy
- acute or chronic inflammation of the eyes
- narrow angle glaucoma
- minority
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Diabetes patients
Patients with diabetes mellitus type I + II, without diabetic retinopathy
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Quantification of retinal venous pressure (RVP)
大体时间:30 minutes
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30 minutes
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次要结果测量
结果测量 |
大体时间 |
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Quantification of ET-1 in correlation with RVP
大体时间:30 minutes
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30 minutes
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合作者和调查者
调查人员
- 研究主任:Josef Flammer, MD、University of Basel, Dept. of Ophthalmology
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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