Exercise and Cognition Trials (EXACT)
Human Performance: Role of Acute Exercise in Enhancing Cognitive Function
研究概览
详细说明
This is a randomized experiment consisting of three visits for each participant. Participants are determined to be eligible beforehand during a phone screening, in which the various study inclusions and exclusions are determined and the Physical Activity Readiness Questionnaire for Everyone 2015 (PARQ) is administered.
In the first visit, various anthropometric data are collected from participants, such as height, weight, and waist and hip circumference. The participants' blood pressure is also checked for hypertension. The participants are given Dual Energy X-Ray Absorptiometry (DEXA) scans to determine total body composition (bone, fat, and fat-free mass) If the participant is female, a urine analysis to determine pregnancy is required during the visit before the DEXA to ensure safety. Participants are given the Rapid Assessment of Physical Activity (RAPA) questionnaire to assess habitual activity levels. The participants' muscle strength is also measured using the Biodex System 3, an isokinetic dynamometer. The participants then undergo a maximal stress test on a treadmill integrated with a Cardinal Health Metabolic/ECG cart using a modified Balke protocol, beginning at 3 mph, 0% grade, and increasing 2.5% grade every 3 minutes. The ECG component of the metabolic cart will be used for continuous heart rate monitoring as part of the fitness assessment. Cardiorespiratory parameters (VO2, ventilation, respiratory rate) will also be measured throughout the test. Blood pressure is measured during the last 30 seconds of each exercise stage and the rating of perceived exertion (RPE) using the Borg 6 to 20 scale is obtained during each stage. Subjects are urged to give a maximal effort and are pushed until volitional fatigue.
In the second visit, participants are first given a series of cognitive tests designed to quantify such cognitive faculties as visual short-term memory, selective attention, processing speed, and verbal fluency. These tests consist of seeing simple images on a computer screen, such as a series of colored shapes, and responding using a keypad. A blood sample is also collected from the participants to serve as a baseline. The subject is then randomized to one of three groups: the first group rests for 30 minutes; the second group walks on the treadmill at a mild intensity, defined as maintaining 60% of the heart rate observed during the max VO2 from the first visit; the last group walks on the treadmill at a hard intensity, defined as maintaining 80% of the heart rate observed during the max VO2 from the first visit. The subjects then undergo a second blood draw after cooling down, followed immediately by another round of the same cognitive tests. An hour after finishing the exercise intervention, the same procedure of blood draw followed by cognitive tests is repeated, and an hour after that it is repeated again.
The third visit must be about 24 hours after the previous visit. Participants have blood drawn and one final round of cognitive tests.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Maryland
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Baltimore、Maryland、美国、21224
- Johns Hopkins Bayview Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Body mass index (BMI) of between 18.5 and 35 kg/m2
- Normal or corrected-to-normal vision
- No contraindications to participation in moderate to hard intensity physical activity
Exclusion Criteria:
- Self-report of alcohol or substance abuse in the past year or current treatment
- Women who are pregnant or nursing
- BMI of < 18.5 or > 35 kg/m2
- Diabetes mellitus. Subjects will be excluded for diabetes even if controlled by medications
- Cigarette smoking in the previous 12 weeks
- Elevated blood pressure (BP) defined as systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg
- Self-report of cardiovascular disease, cancer, renal disease, and other serious conditions that could be exacerbated by moderate intensity physical activity.
学习计划
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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无干预:Rest
Participants randomly assigned to this arm rest quietly for thirty minutes instead of participating in the exercise challenge.
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实验性的:Mild Exercise
Participants randomly assigned to this arm are made to maintain a heart rate equivalent to 60% of the heart rate observed when VO2 max was achieved in the maximal stress test from the first visit.
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Participants randomized to an exercise condition will perform treadmill exercise for 30 minutes.
Participants will self-select a comfortable walking speed.
The treadmill grade will be adjusted to elicit and maintain the target heart rate.
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实验性的:Hard Exercise
Participants randomly assigned to this arm are made to maintain a heart rate equivalent to 80% of the heart rate observed when VO2 max was achieved in the maximal stress test from the first visit.
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Participants randomized to an exercise condition will perform treadmill exercise for 30 minutes.
Participants will self-select a comfortable walking speed.
The treadmill grade will be adjusted to elicit and maintain the target heart rate.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
visual short-term memory questionnaire
大体时间:baseline
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participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
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baseline
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visual short-term memory questionnaire
大体时间:up to 5 minutes post intervention
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participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
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up to 5 minutes post intervention
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visual short-term memory questionnaire
大体时间:1 hour after intervention
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participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
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1 hour after intervention
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visual short-term memory questionnaire
大体时间:2 hours after intervention
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participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
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2 hours after intervention
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visual short-term memory questionnaire
大体时间:24 hours after baseline
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
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24 hours after baseline
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visual long-term memory questionnaire
大体时间:24 hours after baseline
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participants encode images in a cover task at baseline, scored on accuracy (0-100%)
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24 hours after baseline
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verbal fluency
大体时间:baseline
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participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
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baseline
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verbal fluency
大体时间:up to 5 minutes post intervention
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participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
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up to 5 minutes post intervention
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verbal fluency
大体时间:1 hour after intervention
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participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
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1 hour after intervention
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verbal fluency
大体时间:2 hours after intervention
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participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
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2 hours after intervention
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verbal fluency
大体时间:24 hours after baseline
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participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
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24 hours after baseline
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cortisol in circulation
大体时间:baseline
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in nanograms per milliliter (ng/ml)
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baseline
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cortisol in circulation
大体时间:up to 5 minutes post intervention
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in nanograms per milliliter (ng/ml)
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up to 5 minutes post intervention
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cortisol in circulation
大体时间:1 hour after intervention
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in nanograms per milliliter (ng/ml)
|
1 hour after intervention
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cortisol in circulation
大体时间:2 hours after intervention
|
in nanograms per milliliter (ng/ml)
|
2 hours after intervention
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cortisol in circulation
大体时间:24 hours after baseline
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in nanograms per milliliter (ng/ml)
|
24 hours after baseline
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igf-1 in circulation
大体时间:baseline
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insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
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baseline
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igf-1 in circulation
大体时间:up to 5 minutes post intervention
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insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
up to 5 minutes post intervention
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igf-1 in circulation
大体时间:1 hour after intervention
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insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
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1 hour after intervention
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igf-1 in circulation
大体时间:2 hours after intervention
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insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
2 hours after intervention
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igf-1 in circulation
大体时间:24 hours after baseline
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insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
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24 hours after baseline
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bdnf in circulation
大体时间:baseline
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brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
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baseline
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bdnf in circulation
大体时间:up to 5 minutes post intervention
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brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
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up to 5 minutes post intervention
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bdnf in circulation
大体时间:1 hour after intervention
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brain derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
1 hour after intervention
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bdnf in circulation
大体时间:2 hours after intervention
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brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
2 hours after intervention
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bdnf in circulation
大体时间:24 hours after baseline
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brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
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24 hours after baseline
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general executive functioning as assessed by the stroop test questionnaire
大体时间:baseline
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participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
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baseline
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general executive functioning as assessed by the stroop test questionnaire
大体时间:up to 5 minutes post intervention
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participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
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up to 5 minutes post intervention
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general executive functioning as assessed by the stroop test questionnaire
大体时间:1 hour after intervention
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participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
1 hour after intervention
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general executive functioning as assessed by the stroop test questionnaire
大体时间:2 hours after intervention
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participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
2 hours after intervention
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general executive functioning as assessed by the stroop test questionnaire
大体时间:24 hours after baseline
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participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
24 hours after baseline
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general executive functioning as assessed by the flanker task questionnaire
大体时间:baseline
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participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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baseline
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general executive functioning as assessed by the flanker task questionnaire
大体时间:up to 5 minutes post intervention
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participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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up to 5 minutes post intervention
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general executive functioning as assessed by the flanker task questionnaire
大体时间:1 hour after intervention
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participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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1 hour after intervention
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general executive functioning as assessed by the flanker task questionnaire
大体时间:2 hours after intervention
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participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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2 hours after intervention
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general executive functioning as assessed by the flanker task questionnaire
大体时间:24 hours after baseline
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participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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24 hours after baseline
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general executive functioning as assessed by the irrelevant capture task questionnaire
大体时间:baseline
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participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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baseline
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general executive functioning as assessed by the irrelevant capture task questionnaire
大体时间:up to 5 minutes post intervention
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participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
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up to 5 minutes post intervention
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general executive functioning as assessed by the irrelevant capture task questionnaire
大体时间:1 hour after intervention
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participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
1 hour after intervention
|
general executive functioning as assessed by the irrelevant capture task questionnaire
大体时间:2 hours after intervention
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
2 hours after intervention
|
general executive functioning as assessed by the irrelevant capture task questionnaire
大体时间:24 hours after baseline
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
24 hours after baseline
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
total and regional bone mass
大体时间:baseline
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as assessed by dual-energy x-ray absorptiometry (DEXA) scan, in grams per square centimeter (g/cm2)
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baseline
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total and regional fat and fat-free mass
大体时间:baseline
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as assessed by dual-energy x-ray absorptiometry (DEXA) scan in grams per square centimeter (g/cm2)
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baseline
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habitual activity levels
大体时间:baseline
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as assessed by Rapid Assessment of Physical Activity questionnaire, possible scores are: Active, Under Active Regular, Under Active Regular- Light Activities, Under Active, Sedentary
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baseline
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muscle strength
大体时间:baseline
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as measured by isokinetic testing using the Biodex System 3
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baseline
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cardiorespiratory endurance
大体时间:baseline
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as assessed by maximal stress test, represented by heart rate at maximal oxygen uptake
|
baseline
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body mass index (BMI)
大体时间:baseline
|
measured in kilograms per square meter (kg/m2)
|
baseline
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waist-to-hip ratio
大体时间:baseline
|
baseline
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合作者和调查者
调查人员
- 首席研究员:Peter Searson, PhD、Johns Hopkins University
- 首席研究员:Kerry Stewart, EdD、Johns Hopkins University
- 首席研究员:Howard Egeth, PhD、Johns Hopkins University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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Exercise Challenge的临床试验
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University of Maryland, BaltimoreNational Institute on Aging (NIA)完全的