- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02958735
Exercise and Cognition Trials (EXACT)
Human Performance: Role of Acute Exercise in Enhancing Cognitive Function
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This is a randomized experiment consisting of three visits for each participant. Participants are determined to be eligible beforehand during a phone screening, in which the various study inclusions and exclusions are determined and the Physical Activity Readiness Questionnaire for Everyone 2015 (PARQ) is administered.
In the first visit, various anthropometric data are collected from participants, such as height, weight, and waist and hip circumference. The participants' blood pressure is also checked for hypertension. The participants are given Dual Energy X-Ray Absorptiometry (DEXA) scans to determine total body composition (bone, fat, and fat-free mass) If the participant is female, a urine analysis to determine pregnancy is required during the visit before the DEXA to ensure safety. Participants are given the Rapid Assessment of Physical Activity (RAPA) questionnaire to assess habitual activity levels. The participants' muscle strength is also measured using the Biodex System 3, an isokinetic dynamometer. The participants then undergo a maximal stress test on a treadmill integrated with a Cardinal Health Metabolic/ECG cart using a modified Balke protocol, beginning at 3 mph, 0% grade, and increasing 2.5% grade every 3 minutes. The ECG component of the metabolic cart will be used for continuous heart rate monitoring as part of the fitness assessment. Cardiorespiratory parameters (VO2, ventilation, respiratory rate) will also be measured throughout the test. Blood pressure is measured during the last 30 seconds of each exercise stage and the rating of perceived exertion (RPE) using the Borg 6 to 20 scale is obtained during each stage. Subjects are urged to give a maximal effort and are pushed until volitional fatigue.
In the second visit, participants are first given a series of cognitive tests designed to quantify such cognitive faculties as visual short-term memory, selective attention, processing speed, and verbal fluency. These tests consist of seeing simple images on a computer screen, such as a series of colored shapes, and responding using a keypad. A blood sample is also collected from the participants to serve as a baseline. The subject is then randomized to one of three groups: the first group rests for 30 minutes; the second group walks on the treadmill at a mild intensity, defined as maintaining 60% of the heart rate observed during the max VO2 from the first visit; the last group walks on the treadmill at a hard intensity, defined as maintaining 80% of the heart rate observed during the max VO2 from the first visit. The subjects then undergo a second blood draw after cooling down, followed immediately by another round of the same cognitive tests. An hour after finishing the exercise intervention, the same procedure of blood draw followed by cognitive tests is repeated, and an hour after that it is repeated again.
The third visit must be about 24 hours after the previous visit. Participants have blood drawn and one final round of cognitive tests.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Maryland
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Baltimore, Maryland, United States, 21224
- Johns Hopkins Bayview Medical Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Body mass index (BMI) of between 18.5 and 35 kg/m2
- Normal or corrected-to-normal vision
- No contraindications to participation in moderate to hard intensity physical activity
Exclusion Criteria:
- Self-report of alcohol or substance abuse in the past year or current treatment
- Women who are pregnant or nursing
- BMI of < 18.5 or > 35 kg/m2
- Diabetes mellitus. Subjects will be excluded for diabetes even if controlled by medications
- Cigarette smoking in the previous 12 weeks
- Elevated blood pressure (BP) defined as systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg
- Self-report of cardiovascular disease, cancer, renal disease, and other serious conditions that could be exacerbated by moderate intensity physical activity.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: Rest
Participants randomly assigned to this arm rest quietly for thirty minutes instead of participating in the exercise challenge.
|
|
Experimental: Mild Exercise
Participants randomly assigned to this arm are made to maintain a heart rate equivalent to 60% of the heart rate observed when VO2 max was achieved in the maximal stress test from the first visit.
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Participants randomized to an exercise condition will perform treadmill exercise for 30 minutes.
Participants will self-select a comfortable walking speed.
The treadmill grade will be adjusted to elicit and maintain the target heart rate.
|
Experimental: Hard Exercise
Participants randomly assigned to this arm are made to maintain a heart rate equivalent to 80% of the heart rate observed when VO2 max was achieved in the maximal stress test from the first visit.
|
Participants randomized to an exercise condition will perform treadmill exercise for 30 minutes.
Participants will self-select a comfortable walking speed.
The treadmill grade will be adjusted to elicit and maintain the target heart rate.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
visual short-term memory questionnaire
Time Frame: baseline
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
|
baseline
|
visual short-term memory questionnaire
Time Frame: up to 5 minutes post intervention
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
|
up to 5 minutes post intervention
|
visual short-term memory questionnaire
Time Frame: 1 hour after intervention
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
|
1 hour after intervention
|
visual short-term memory questionnaire
Time Frame: 2 hours after intervention
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
|
2 hours after intervention
|
visual short-term memory questionnaire
Time Frame: 24 hours after baseline
|
participants are shown sets of colored squares briefly and must pick out the square that changed color after a delay, scored on accuracy (0-100%)
|
24 hours after baseline
|
visual long-term memory questionnaire
Time Frame: 24 hours after baseline
|
participants encode images in a cover task at baseline, scored on accuracy (0-100%)
|
24 hours after baseline
|
verbal fluency
Time Frame: baseline
|
participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
|
baseline
|
verbal fluency
Time Frame: up to 5 minutes post intervention
|
participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
|
up to 5 minutes post intervention
|
verbal fluency
Time Frame: 1 hour after intervention
|
participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
|
1 hour after intervention
|
verbal fluency
Time Frame: 2 hours after intervention
|
participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
|
2 hours after intervention
|
verbal fluency
Time Frame: 24 hours after baseline
|
participants are asked to name as many words as they can that begin with a certain letter within 1 minute, scored on number of appropriate words
|
24 hours after baseline
|
cortisol in circulation
Time Frame: baseline
|
in nanograms per milliliter (ng/ml)
|
baseline
|
cortisol in circulation
Time Frame: up to 5 minutes post intervention
|
in nanograms per milliliter (ng/ml)
|
up to 5 minutes post intervention
|
cortisol in circulation
Time Frame: 1 hour after intervention
|
in nanograms per milliliter (ng/ml)
|
1 hour after intervention
|
cortisol in circulation
Time Frame: 2 hours after intervention
|
in nanograms per milliliter (ng/ml)
|
2 hours after intervention
|
cortisol in circulation
Time Frame: 24 hours after baseline
|
in nanograms per milliliter (ng/ml)
|
24 hours after baseline
|
igf-1 in circulation
Time Frame: baseline
|
insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
baseline
|
igf-1 in circulation
Time Frame: up to 5 minutes post intervention
|
insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
up to 5 minutes post intervention
|
igf-1 in circulation
Time Frame: 1 hour after intervention
|
insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
1 hour after intervention
|
igf-1 in circulation
Time Frame: 2 hours after intervention
|
insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
2 hours after intervention
|
igf-1 in circulation
Time Frame: 24 hours after baseline
|
insulin-like growth factor 1 in nanograms per milliliter (ng/ml)
|
24 hours after baseline
|
bdnf in circulation
Time Frame: baseline
|
brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
baseline
|
bdnf in circulation
Time Frame: up to 5 minutes post intervention
|
brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
up to 5 minutes post intervention
|
bdnf in circulation
Time Frame: 1 hour after intervention
|
brain derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
1 hour after intervention
|
bdnf in circulation
Time Frame: 2 hours after intervention
|
brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
2 hours after intervention
|
bdnf in circulation
Time Frame: 24 hours after baseline
|
brain-derived neurotrophic factor in nanograms per milliliter (ng/ml)
|
24 hours after baseline
|
general executive functioning as assessed by the stroop test questionnaire
Time Frame: baseline
|
participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
baseline
|
general executive functioning as assessed by the stroop test questionnaire
Time Frame: up to 5 minutes post intervention
|
participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
up to 5 minutes post intervention
|
general executive functioning as assessed by the stroop test questionnaire
Time Frame: 1 hour after intervention
|
participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
1 hour after intervention
|
general executive functioning as assessed by the stroop test questionnaire
Time Frame: 2 hours after intervention
|
participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
2 hours after intervention
|
general executive functioning as assessed by the stroop test questionnaire
Time Frame: 24 hours after baseline
|
participants must identify the color of various words on the screen irrespective of their meaning, scored based on accuracy (0-100%) and reaction time in milliseconds
|
24 hours after baseline
|
general executive functioning as assessed by the flanker task questionnaire
Time Frame: baseline
|
participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
baseline
|
general executive functioning as assessed by the flanker task questionnaire
Time Frame: up to 5 minutes post intervention
|
participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
up to 5 minutes post intervention
|
general executive functioning as assessed by the flanker task questionnaire
Time Frame: 1 hour after intervention
|
participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
1 hour after intervention
|
general executive functioning as assessed by the flanker task questionnaire
Time Frame: 2 hours after intervention
|
participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
2 hours after intervention
|
general executive functioning as assessed by the flanker task questionnaire
Time Frame: 24 hours after baseline
|
participants must identify the orientation of a central arrow while ignoring those of other arrows on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
24 hours after baseline
|
general executive functioning as assessed by the irrelevant capture task questionnaire
Time Frame: baseline
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
baseline
|
general executive functioning as assessed by the irrelevant capture task questionnaire
Time Frame: up to 5 minutes post intervention
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
up to 5 minutes post intervention
|
general executive functioning as assessed by the irrelevant capture task questionnaire
Time Frame: 1 hour after intervention
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
1 hour after intervention
|
general executive functioning as assessed by the irrelevant capture task questionnaire
Time Frame: 2 hours after intervention
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
2 hours after intervention
|
general executive functioning as assessed by the irrelevant capture task questionnaire
Time Frame: 24 hours after baseline
|
participants must identify a set of symbols as either letters or numbers while ignoring distracting images that flash on the screen, scored based on accuracy (0-100%) and reaction time in milliseconds
|
24 hours after baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
total and regional bone mass
Time Frame: baseline
|
as assessed by dual-energy x-ray absorptiometry (DEXA) scan, in grams per square centimeter (g/cm2)
|
baseline
|
total and regional fat and fat-free mass
Time Frame: baseline
|
as assessed by dual-energy x-ray absorptiometry (DEXA) scan in grams per square centimeter (g/cm2)
|
baseline
|
habitual activity levels
Time Frame: baseline
|
as assessed by Rapid Assessment of Physical Activity questionnaire, possible scores are: Active, Under Active Regular, Under Active Regular- Light Activities, Under Active, Sedentary
|
baseline
|
muscle strength
Time Frame: baseline
|
as measured by isokinetic testing using the Biodex System 3
|
baseline
|
cardiorespiratory endurance
Time Frame: baseline
|
as assessed by maximal stress test, represented by heart rate at maximal oxygen uptake
|
baseline
|
body mass index (BMI)
Time Frame: baseline
|
measured in kilograms per square meter (kg/m2)
|
baseline
|
waist-to-hip ratio
Time Frame: baseline
|
baseline
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Peter Searson, PhD, Johns Hopkins University
- Principal Investigator: Kerry Stewart, EdD, Johns Hopkins University
- Principal Investigator: Howard Egeth, PhD, Johns Hopkins University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- IRB00076336
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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