The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
2017年7月28日 更新者:tongjuan ZOU、West China Hospital
The Critical Care Ultrasound Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Shock is a common condition in critical care unit (ICU).
It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock.
However, several studies failed to demonstrate that the well used variables such as CVP and others could direct to a better treatment.
In recent years, critical care ultrasound (CCUS) has been respected as a reliable noninvasive tool and widely used in ICU practice.
With CCUS the investigators can accurately acquired the detailed information of the characteristic of the hemodynamics and lung pathology (the systole and diastole function, volume status, valve insufficiency, lung, edema, consolidation, and pleural effusion, etc.).
To the investigators knowledge, there is no study investigating the epidemic of such ultrasonic variables and its value to predict to outcome.
The aim of this study is to investigate the epidemic and the prognostic value of CCUS Based Characteristic of Hemodynamic and Lung pathology in Early Stage of Shock in patients admitted in ICU.
研究概览
地位
完全的
条件
详细说明
Adult patients who admitted to the intensive care unit of West China hospital of sichuan university with shock from April 2016 to April 2017 enrolled.
研究类型
观察性的
注册 (实际的)
181
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
-
Sichuan
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Chengde、Sichuan、中国、610041
- West China Hospital,Sichuan University
-
-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
取样方法
非概率样本
研究人群
Shock patients with 6 hours admitted in ICU in west china hospital of sichuan university.
描述
Inclusion Criteria:
- SBP<90 mm Hg or MAP <70 mm Hg or SBP decrease >40mmHg or need vasoactive drugs;
- Skin that is cold and clammy, capillary refill time >4.5s, urine output of <0.5ml/Kg.hr and lactate>2mmol/L;
- SHOCK presented within 6 hr.
Exclusion Criteria:
- <18 years old;
- Pregnancy;
- Patient or family member refuse to be enrolled.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 观测模型:其他
- 时间观点:预期
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
全因死亡率
大体时间:28天
|
28天
|
次要结果测量
结果测量 |
大体时间 |
---|---|
length of mechanical ventilation
大体时间:through study completion, an average of 28 days
|
through study completion, an average of 28 days
|
ICU length of stay
大体时间:through study completion, an average of 28 days
|
through study completion, an average of 28 days
|
hospital length of stay
大体时间:through study completion, an average of 28 days
|
through study completion, an average of 28 days
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 学习椅:Yan Kang, Doctor、West China hospital
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307.
- Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2014 Feb 6;370(6):583. doi: 10.1056/NEJMc1314999. No abstract available.
- Seif D, Perera P, Mailhot T, Riley D, Mandavia D. Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol. Crit Care Res Pract. 2012;2012:503254. doi: 10.1155/2012/503254. Epub 2012 Oct 24.
- Levitov A, Frankel HL, Blaivas M, Kirkpatrick AW, Su E, Evans D, Summerfield DT, Slonim A, Breitkreutz R, Price S, McLaughlin M, Marik PE, Elbarbary M. Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. Crit Care Med. 2016 Jun;44(6):1206-27. doi: 10.1097/CCM.0000000000001847.
- Guerin L, Vieillard-Baron A. The Use of Ultrasound in Caring for Patients with Sepsis. Clin Chest Med. 2016 Jun;37(2):299-307. doi: 10.1016/j.ccm.2016.01.005. Epub 2016 Mar 3.
- Wang H, Cui N, Su L, Long Y, Wang X, Zhou X, Chai W, Liu D. Prognostic value of extravascular lung water and its potential role in guiding fluid therapy in septic shock after initial resuscitation. J Crit Care. 2016 Jun;33:106-13. doi: 10.1016/j.jcrc.2016.02.011. Epub 2016 Feb 24.
- Zhou R, Zou T, Yin W, Wang X, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Functional mitral regurgitation combined with increased early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio is associated with a poor prognosis in patients with shock. Chin Med J (Engl). 2021 Sep 15;134(19):2299-2305. doi: 10.1097/CM9.0000000000001756.
- Zou T, Yin W, Li Y, Deng L, Zhou R, Wang X, Chao Y, Zhang L, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Hemodynamics in Shock Patients Assessed by Critical Care Ultrasound and Its Relationship to Outcome: A Prospective Study. Biomed Res Int. 2020 Sep 15;2020:5175393. doi: 10.1155/2020/5175393. eCollection 2020.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2016年4月5日
初级完成 (实际的)
2017年6月6日
研究完成 (实际的)
2017年6月6日
研究注册日期
首次提交
2017年3月3日
首先提交符合 QC 标准的
2017年3月11日
首次发布 (实际的)
2017年3月17日
研究记录更新
最后更新发布 (实际的)
2017年8月1日
上次提交的符合 QC 标准的更新
2017年7月28日
最后验证
2017年3月1日
更多信息
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