Environmental Temperature and White Adipose Tissue in Cancer Patients
Effects of Environmental Temperature on White Adipose Tissue Thermogenic Capacity of Cancer Patients
研究概览
地位
条件
详细说明
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk for disease. For this reason, previous research focused on the thermogenic capacity of white adipocytes in response to cold exposure. Cold exposure represents a main stimulus for increased thermogenic capacity in human white adipocytes, which may have an impact on body weight loss and subsequently on obesity phenomenon.
In a cohort of 202 cancer patients (male=126), who undertook a Positron Emission Tomography (PET/CT), we retrospectively investigated the association between Tenv and thermogenic capacity of subcutaneous WAT (dorsolumbar region near vertebrae L3 and abdominal region). These patients undertook a PET/CT examination in order to define their disease status. They were given instructions in advance to refrain from smoking, exercise and excessive muscle stressors 24-hour prior to their examination. On the day of the measurements they advised to transport themselves by car to the PET/CT Laboratory between 08:00 am to 12 pm, following at least a 6-hour fasting. Patients were first injected an appropriate dose of 18F-FDG (based on their body weight) and then they were remained in a sitting relaxed position within a quiet room of 22-24°C for 60 minutes. Following this period, patients undertook the PET/CT examination, which included on average eight bed positions, while four minutes scanning per bed position was used.
PET/CT imaging analysis for WAT activity (dorsolumbar region near vertebrae L3 and abdominal region) was performed by two independent trained physicians, using previous methodology.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Thessaly
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Tríkala、Thessaly、希腊、42100
- Petros Dinas
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Cancer patients who undertook a PET/CT examination independently of their disease status
Exclusion Criteria:
- Examinations prior to 2016
学习计划
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设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Assessment of thermogenic capacity of white adipocytes
大体时间:The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.
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Thermogenic capacity of white adipocytes was measured via Positron Emission Tomography/computed tomography (PET/CT) device, unit of measurement: Standardized Uptake Value (SUV)
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The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.
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Environmental temperature
大体时间:The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019
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The daily environmental temperature was obtained in degrees Celsius for the period 1-1-2016 to 30-4-2019.
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The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019
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合作者和调查者
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研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2. Tenv & cancer patient
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研究美国 FDA 监管的设备产品
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