- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04037410
Environmental Temperature and White Adipose Tissue in Cancer Patients
Effects of Environmental Temperature on White Adipose Tissue Thermogenic Capacity of Cancer Patients
Study Overview
Status
Conditions
Detailed Description
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk for disease. For this reason, previous research focused on the thermogenic capacity of white adipocytes in response to cold exposure. Cold exposure represents a main stimulus for increased thermogenic capacity in human white adipocytes, which may have an impact on body weight loss and subsequently on obesity phenomenon.
In a cohort of 202 cancer patients (male=126), who undertook a Positron Emission Tomography (PET/CT), we retrospectively investigated the association between Tenv and thermogenic capacity of subcutaneous WAT (dorsolumbar region near vertebrae L3 and abdominal region). These patients undertook a PET/CT examination in order to define their disease status. They were given instructions in advance to refrain from smoking, exercise and excessive muscle stressors 24-hour prior to their examination. On the day of the measurements they advised to transport themselves by car to the PET/CT Laboratory between 08:00 am to 12 pm, following at least a 6-hour fasting. Patients were first injected an appropriate dose of 18F-FDG (based on their body weight) and then they were remained in a sitting relaxed position within a quiet room of 22-24°C for 60 minutes. Following this period, patients undertook the PET/CT examination, which included on average eight bed positions, while four minutes scanning per bed position was used.
PET/CT imaging analysis for WAT activity (dorsolumbar region near vertebrae L3 and abdominal region) was performed by two independent trained physicians, using previous methodology.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Thessaly
-
Tríkala, Thessaly, Greece, 42100
- Petros Dinas
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Cancer patients who undertook a PET/CT examination independently of their disease status
Exclusion Criteria:
- Examinations prior to 2016
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assessment of thermogenic capacity of white adipocytes
Time Frame: The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.
|
Thermogenic capacity of white adipocytes was measured via Positron Emission Tomography/computed tomography (PET/CT) device, unit of measurement: Standardized Uptake Value (SUV)
|
The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.
|
Environmental temperature
Time Frame: The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019
|
The daily environmental temperature was obtained in degrees Celsius for the period 1-1-2016 to 30-4-2019.
|
The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 2. Tenv & cancer patient
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Cancer Patients
-
Memorial Sloan Kettering Cancer CenterColumbia University; NYU Langone Health; Roswell Park Cancer Institute; Jacobi... and other collaboratorsRecruiting
-
KTO Karatay UniversityCompleted
-
University Hospital, Basel, SwitzerlandCompletedCancer PatientsSwitzerland
-
Jiandong ZhangRecruiting
-
Institute of Liver and Biliary Sciences, IndiaCompleted
-
Canon Medical Systems, USACompleted
-
Milton S. Hershey Medical CenterCompleted
-
Thomas SeufferleinUnknown
-
Hospices Civils de LyonCompleted
-
National Taiwan University HospitalRecruiting