Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity

September 7, 2007 updated by: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

In daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in different pathological situations ( surgery, trauma, tumors...). Dehydration can theorically concern extra-cellular or intracellular water, or both.

The relative proportion of those two components are not known, as well their kinetics.

Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but rather a non- gaussian one, more close to the reality ( q Space Imaging ).

Finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component.

Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component ?

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Unknown

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  • Belgium
      • Brussels, Belgium, 1200
        • Recruiting
        • Clinique Universitaire St LUC

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18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

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All

Description

Inclusion Criteria:

  • Systemic Lupus Erythematosus
  • normal neurological exam
  • informed consent
  • 18 yo or more

Exclusion Criteria:

  • abnormal neurological exam
  • younger than 18 years old

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Cliniques universitaires Saint-Luc- Université Catholique de Louvain

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Fonds National de la Recherche Scientifique

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  • Study Director: Thierry Duprez, MD, Université Catholique de Louvain
  • Principal Investigator: Denis Rommel, MD, Université Catholique de Louvain

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September 1, 2007

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September 1, 2007

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September 7, 2007

First Submitted That Met QC Criteria

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September 7, 2007

First Posted (Estimate)

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September 10, 2007

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September 10, 2007

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

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September 7, 2007

Last Verified

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September 1, 2007

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  • B40320072108

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