Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

May 17, 2009 updated by: National Taiwan University Hospital

The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the cardiac computed tomography angiography (cardiac CTA) may induce a higher level of ROS in the peripheral blood.

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease (CAD). In total, twenty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families after the arrangement of cardiac CTA. It then will be retrieved just before the performance of cardiac CTA.

For each enrolled case, peripheral blood will be sampled three times (once before and twice after the performance of cardiac CTA). Totally 60 blood samples will be collected from 20 study subjects within 3 months (January 1 ~ March 31, 2009). ROS level in the collected blood samples will be then measured, compared, and analyzed.

Study Overview

Status

Status

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Withdrawn

Conditions

Conditions

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Study Type

Study Type

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Observational

Enrollment (Anticipated)

Enrollment

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20

Contacts and Locations

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Study Locations

  • Taiwan
      • Taipei, Taiwan, 10002
        • NTUH

Participation Criteria

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Eligibility Criteria

Eligibility Criteria

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Ages Eligible for Study

20 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Description

Inclusion Criteria:

  • subjects who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Exclusion Criteria:

  • none

Study Plan

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How is the study designed?

Design Details

Collaborators and Investigators

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Sponsor

Sponsor

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National Taiwan University Hospital

Study record dates

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Study Major Dates

Study Start

Study Start

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January 1, 2009

Study Completion (Anticipated)

Study Completion

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March 1, 2009

Study Registration Dates

First Submitted

First Submitted

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December 25, 2008

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

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December 25, 2008

First Posted (Estimate)

First Posted

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December 29, 2008

Study Record Updates

Last Update Posted (Estimate)

Last Update Posted

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May 19, 2009

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
May 17, 2009

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
December 1, 2008

More Information

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Keywords

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Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • 200812057R

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