Connect™ CLL: The Chronic Lymphocytic Leukemia Disease Registry

May 8, 2020 updated by: Celgene

The purpose of the Connect™ Chronic Lymphocytic Leukemia (CLL) Disease Registry is to explore the history and real world management of patients diagnosed with CLL, provide insight into the management of CLL, and evaluate the effectiveness of first, second and subsequent therapeutic strategies employed in both the community and academic settings.

Study Overview

Status

Completed

Conditions

Chronic Lymphocytic Leukemia

Study Type

Observational

Enrollment (Actual)

1494

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

United States
- California
  - Pomona, California, United States, 91767
    - New Hope Cancer & Research Institute
- Florida
  - Atlantis, Florida, United States, 33462
    - Medical Specialists of the Palm Beaches
  - Boynton Beach, Florida, United States, 33426
    - University Cancer Institute
  - Boynton Beach, Florida, United States, 33435
    - Thomas Niederman, MD
  - New Port Richey, Florida, United States, 34652
    - Pasco Hernando Oncology Associates (Kumar)
- Georgia
  - Albany, Georgia, United States, 31701
    - Phoebe Putney Memorial Hospital
  - Atlanta, Georgia, United States, 30318
    - Peachtree Hematology-Oncology Consultants
  - Atlanta, Georgia, United States, 30331
    - Georgia Cancer Specialists
  - Dublin, Georgia, United States, 31021
    - US Oncology - Dublin Hematology & Oncology
- Hawaii
  - Honolulu, Hawaii, United States, 96816
    - Straub Clinic and Hospital
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Arlington
  - Chicago, Illinois, United States, 60612
    - Rush University Medical Center
  - Chicago, Illinois, United States, 60612
    - John H. Stroger, Jr., Hospital of Cook County
  - Harvey, Illinois, United States, 60426
    - Ingalls Cancer Research Center
  - Lombard, Illinois, United States, 60148
    - Elmhurst Memorial Hospital
  - Niles, Illinois, United States, 60714
    - Oncology Specialists, S.C.
  - Niles, Illinois, United States, 60714
    - US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Niles
  - Peoria, Illinois, United States, 61615
    - Illinois Cancer Care
  - Skokie, Illinois, United States, 60076
    - Orchard Research
  - Urbana, Illinois, United States, 61801
    - Carle Cancer Center
  - Winfield, Illinois, United States, 60190
    - US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Winfield
- Indiana
  - Beech Grove, Indiana, United States, 46107
    - St. Francis Cancer Research
  - Goshen, Indiana, United States, 46526
    - Center for Cancer Care @ Goshen Health Systems
  - Indianapolis, Indiana, United States, 46202
    - Indiana University Cancer Center Clinical Research Office
  - Mishawaka, Indiana, United States, 46545
    - Cancer Care Partners, LLC
  - New Albany, Indiana, United States, 47150
    - Cancer Care Center, Inc.
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic
  - Bettendorf, Iowa, United States, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Cedar Rapids, Iowa, United States, 52402
    - Iowa Blood and Cancer Care of PCI
  - Waterloo, Iowa, United States, 50702
    - Covenant Clinic
- Kansas
  - Wichita, Kansas, United States, 67214
    - Cancer Center of Kansas, PA
- Louisiana
  - Baton Rouge, Louisiana, United States, 70809
    - Mary Bird Perkins Cancer Center
- Maryland
  - Cumberland, Maryland, United States, 21502
    - Western Maryland Health System, Inc.
  - Westminster, Maryland, United States, 21157
    - Alliance Hematology Oncology, PA
- Massachusetts
  - Hyannis, Massachusetts, United States, 02601
    - Capecod Hospital / Davenport Mugar Cancer Center
  - Worcester, Massachusetts, United States, 01608
    - Fallon Clinic
- Michigan
  - Flint, Michigan, United States, 48532
    - Michigan State University / McLaren Regional Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - Cancer and Hematology Centers of Western Michigan
  - Kalamazoo, Michigan, United States, 49007
    - West Michigan Cancer Center
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - Duluth Clinic Cancer Center
  - Saint Louis Park, Minnesota, United States, 55416
    - Park Nicollet Institute Metro - MN CCOP
  - Saint Louis Park, Minnesota, United States, 55426
    - Park Nicollet Institute - Louisiana Ave.
- Mississippi
  - Southaven, Mississippi, United States, 38671
    - US Oncology - University of Tennessee Cancer Institute - Southaven
- Missouri
  - Columbia, Missouri, United States, 65201
    - US Oncology - Missouri Cancer Associates
  - Jefferson City, Missouri, United States, 65109
    - Capitol Comprehensive Cancer Care Clinic
  - Saint Joseph, Missouri, United States, 64507
    - St. Joseph Oncology, Inc.
  - Saint Louis, Missouri, United States, 63136
    - Hematology Oncology Consultants, Inc.
  - Springfield, Missouri, United States, 65807
    - St. John's Medical Research Institute
- Montana
  - Missoula, Montana, United States, 59802
    - Montana Cancer Institute Foundation
- Nebraska
  - Lincoln, Nebraska, United States, 68510
    - Southeast Nebraska Hematology & Oncology Consultants, PC
  - Lincoln, Nebraska, United States, 68506
    - Nebraska Hematology Oncology, PC
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - Southern Nevada Cancer Research Foundation
  - Reno, Nevada, United States, 89502
    - VA Sierra Nevada Healthcare System
- New Jersey
  - Cherry Hill, New Jersey, United States, 08003
    - The Center for Cancer and Hematologic Disease
  - Englewood, New Jersey, United States, 07432
    - Drs. Forte, Schleider, Attas & Condemi, PA
  - Morristown, New Jersey, United States, 07962
    - Charles Farber, MD
  - Morristown, New Jersey, United States, 07962
    - Hematology Oncology of Northern New Jersey
  - Somerville, New Jersey, United States, 08876
    - Steeplechase Cancer Center
- New York
  - Albany, New York, United States, 12208
    - Samuel S Stratton VAMC
  - Bay Shore, New York, United States, 11706
    - Hematology Oncology Associates of Western Suffolk
  - Bronx, New York, United States, 10469
    - Eastchester Center for Cancer Care
  - Bronx, New York, United States, 10467
    - Bronx River Medical Associates
  - Bronxville, New York, United States, 10708
    - Eduardo Saponara, MD
  - Buffalo, New York, United States, 14215
    - Jonah Cancer Care Center & ECMC
  - Johnson City, New York, United States, 13790
    - Broome Oncology
  - Syracuse, New York, United States, 14222
    - SUNY Upstate Medical University - Adult Program
- North Carolina
  - Cary, North Carolina, United States, 27518
    - US Oncology - Cancer Centers of North Carolina - Cary
  - Raleigh, North Carolina, United States, 27607
    - US Oncology - Cancer Centers of North Carolina - Macon
  - Raleigh, North Carolina, United States, 27614
    - US Oncology - Cancer Centers of North Carolina - Falls
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Legacy Pharma Research
  - Fargo, North Dakota, United States, 58122
    - Roger Maris Cancer Center
- Ohio
  - Akron, Ohio, United States, 44304
    - Summa Health System - Cancer Research Office
  - Canton, Ohio, United States, 44718
    - Gabrail Cancer Center Research
  - Columbus, Ohio, United States, 43219
    - Mid Ohio Oncology / Hematology, Inc.
  - Elyria, Ohio, United States, 44035
    - Hematology Oncology Center, Inc.
- Oregon
  - Eugene, Oregon, United States, 97401-8122
    - US Oncology - Willamette Valley Cancer Institute - Eugene
  - Portland, Oregon, United States, 97213-2996
    - US Oncology - Northwest Cancer Specialists, PC - Portland - Hoyt
  - Portland, Oregon, United States, 97225
    - US Oncology - Northwest Cancer Specialists, PC - Portland - Barnes
  - Portland, Oregon, United States, 97227
    - US Oncology - Northwest Cancer Specialists, PC - Portland - Broadway
  - Springfield, Oregon, United States, 97477
    - US Oncology - Willamette Valley Cancer Institute - Springfield
  - Tualatin, Oregon, United States, 97062
    - US Oncology - Northwest Cancer Specialists, PC - Tualatin
- Pennsylvania
  - Bethlehem, Pennsylvania, United States, 18015
    - Oncology Hematology of Lehigh Valley
  - Drexel Hill, Pennsylvania, United States, 19026
    - Consultants in Medical Oncology and Hematology, PC
  - Gettysburg, Pennsylvania, United States, 17325
    - Gettysburg Cancer Center
  - Harrisburg, Pennsylvania, United States, 17111
    - Andrews and Patel Associates
  - Kingston, Pennsylvania, United States, 18704
    - US Oncology - Medical Oncology Associates (Nahar)
  - Lancaster, Pennsylvania, United States, 17605
    - Lancaster Cancer Center
  - Reading, Pennsylvania, United States, 19612
    - Berks Hematology Oncology Associates
- Rhode Island
  - Cranston, Rhode Island, United States, 02920
    - Hematology & Oncology Associates of Rhode Island
- South Carolina
  - Charleston, South Carolina, United States, 29403
    - Charleston Hematology Oncology Associates, PA
  - Columbia, South Carolina, United States, 29210
    - South Carolina Oncololgy Associates, PA
  - Easley, South Carolina, United States, 29640
    - US Oncology - Cancer Centers of the Carolinas - Easley
  - Greenville, South Carolina, United States, 29605
    - US Oncology - Cancer Centers of the Carolinas - Butternut
  - Greenville, South Carolina, United States, 29605
    - US Oncology - Cancer Centers of the Carolinas - West Faris
  - Greenville, South Carolina, United States, 29615
    - US Oncology - Cancer Centers of the Carlinas - Eastside
  - Seneca, South Carolina, United States, 29672
    - US Oncology - Cancer Centers of the Carolinas - Seneca
  - Spartanburg, South Carolina, United States, 29307
    - US Oncology - Cancer Centers of the Carolinas - Spartanburg
- South Dakota
  - Sioux Falls, South Dakota, United States, 57104
    - Sanford Clinic
- Tennessee
  - Bartlett, Tennessee, United States, 38133
    - US Oncology - University of Tennessee Cancer Institute - Bartlett
  - Collierville, Tennessee, United States, 38017
    - Family Cancer Center, PLLC
  - Germantown, Tennessee, United States, 38138
    - US Oncology - University of Tennessee Cancer Institute - Germantown
  - Memphis, Tennessee, United States, 38104
    - US Oncology - University of Tennessee Cancer Institute - Memphis
  - Nashville, Tennessee, United States, 37203
    - SCRI
- Texas
  - Abilene, Texas, United States, 79606
    - US Oncology - Texas Cancer Center - Abilene (South)
  - Amarillo, Texas, United States, 79106
    - US Oncology - Texas Oncology, PA - Amarillo
  - Arlington, Texas, United States, 76014
    - US Oncology - Texas Oncology - Arlington South
  - Bedford, Texas, United States, 76022
    - US Oncology - Texas Oncology, PA - Bedford
  - Bryan, Texas, United States, 77802
    - St. Joseph Regional Cancer Center
  - College Station, Texas, United States, 77802
    - Scott & White Clinic
  - Corpus Christi, Texas, United States, 78405
    - South Texas Institute of Cancer
  - Corpus Christi, Texas, United States, 78463
    - Coastal Bend Cancer Center
  - Dallas, Texas, United States, 75231
    - US Oncology - Texas Oncology, PA - Dallas
  - El Paso, Texas, United States, 79902
    - US Oncology - El Paso Cancer Treatment Center - West
  - El Paso, Texas, United States, 79902
    - US Oncology - El Paso Cancer Treatment Center
  - Fort Worth, Texas, United States, 76104
    - US Oncology - Texas Oncology, PA - Fort Worth
  - Fort Worth, Texas, United States, 76132
    - US Oncology - Southwest Fort Worth Cancer Center
  - Grapevine, Texas, United States, 76051
    - US Oncology - Texas Oncology - Grapevine
  - Houston, Texas, United States, 77030
    - MD Anderson Cancer Center
  - Houston, Texas, United States, 77024
    - Oncology Consultants
  - Kerrville, Texas, United States, 78028
    - US Oncology - San Antonio Tumor & Blood Clinic - Kerrville
  - Lackland Air Force Base, Texas, United States, 78236
    - Wilford Hall Medical Center
  - Longview, Texas, United States, 75601
    - US Oncology - Longview Cancer Center
  - Lubbock, Texas, United States, 79410
    - Joe Arrington Cancer Research and Treatment Center
  - McAllen, Texas, United States, 78503
    - US Oncology - Texas Oncology - McAllen
  - Mesquite, Texas, United States, 75150
    - US Oncology - Texas Oncology - Mesquite
  - Midland, Texas, United States, 79701
    - US Oncology - Allison Cancer Center
  - Paris, Texas, United States, 75460-5004
    - US Oncology - Texas Oncology - Paris
  - San Antonio, Texas, United States, 78217
    - US Oncology - Cancer Care Centers of South Texas
  - San Antonio, Texas, United States, 78258-3912
    - US Oncology - San Antonio Tumor & Blood Clinic - M. Oak
  - Sherman, Texas, United States, 75090-0504
    - US Oncology - Texas Oncology - Sherman
  - Temple, Texas, United States, 76508
    - Scott & White Healthcare Department of Research
  - Tyler, Texas, United States, 75701
    - ETMC dba Blood and Cancer Center - East Texas
  - Tyler, Texas, United States, 75701
    - ETMC dba Tyler Hematology Oncology
  - Tyler, Texas, United States, 75702
    - US Oncology - Texas Oncology - Tyler
  - Waco, Texas, United States, 76712
    - US Oncology - Texas Oncology Cancer Care and Research Center
  - Weslaco, Texas, United States, 78596
    - US Oncology - Texas Oncology - Weslaco
  - Wichita Falls, Texas, United States, 76310
    - US Oncology - Texoma Cancer Center
- Utah
  - American Fork, Utah, United States, 84003
    - Central Utah Clinic
  - Ogden, Utah, United States, 84403
    - Northern Utah Associates
- Virginia
  - Arlington, Virginia, United States, 22205
    - US Oncology - Arlington Fairfax Hematology Oncology
  - Christiansburg, Virginia, United States, 24073
    - US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Christiansburg
  - Fairfax, Virginia, United States, 22031
    - US Oncology - Fairfax Northern VA Hem-Onc PC
  - Gainesville, Virginia, United States, 20155
    - US Oncology - Fairfax - Northern Virginia Hematology-Oncology, PC - Gainesville
  - Leesburg, Virginia, United States, 20176
    - US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Leesburg
  - Low Moor, Virginia, United States, 24457
    - US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Low Moor
  - Roanoke, Virginia, United States, 24014
    - US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Roanoke
  - Salem, Virginia, United States, 24153
    - US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Salem
  - Winchester, Virginia, United States, 22601
    - US Oncology - Shenandoah Oncology - Winchester
  - Woodbridge, Virginia, United States, 22191
    - US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Woodbridge
  - Wytheville, Virginia, United States, 24382
    - US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Wytheville
- Washington
  - Bellingham, Washington, United States, 98226
    - Peace Health Medical Group
  - Edmonds, Washington, United States, 98133
    - US Oncology - Puget Sound Cancer Center - Edmonds
  - Everett, Washington, United States, 98201
    - Providence Everett Medical Center
  - Kennewick, Washington, United States, 99337
    - Columbia Basin Hematology and Oncology
  - Seattle, Washington, United States, 98133
    - US Oncology - Puget Sound Cancer Center - Seattle
  - Spokane, Washington, United States, 99208
    - Medical Oncology Associates PS
  - Spokane, Washington, United States, 99202
    - US Oncology - Cancer Care Northwest - Sherman
  - Spokane, Washington, United States, 99218
    - US Oncology - Cancer Care Northwest - Holland
  - Spokane, Washington, United States, 99218
    - US Oncology - Cancer Care Northwest - Mission
  - Vancouver, Washington, United States, 98684
    - US Oncology - Northwest Cancer Specialists, PC - Vancouver - 136th St.
  - Vancouver, Washington, United States, 98686
    - US Oncology - Northwest Cancer Specialists, PC - Vancouver - 134th St
  - Walla Walla, Washington, United States, 99362
    - Providence St. Mary Regional Cancer Center
  - Yakima, Washington, United States, 98902
    - US Oncology - Yakima Valley Memorial Hospital/North Star Lodge (Boyd)
- Wisconsin
  - Green Bay, Wisconsin, United States, 54301
    - St. Vincent Hospital/Green Bay Oncology
  - Waukesha, Wisconsin, United States, 53188
    - Waukesha Memorial Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

An adult population (>=18 years old) of both men and women who have chronic lymphocytic leukemia treated in either community or academic medical centers.

Description

Inclusion Criteria:

Clinical diagnosis with CLL
Clinical decision made to initiate first-line therapy, second-line therapy or subsequent line of therapy prior to enrollment into the ConnectTM CLL registry, but within 2 months of enrollment
Age≥18 years
Willing and able to provide signed informed consent
Willing and able to complete patient assessment questionnaires either alone or with minimal assistance from caregivers and/or trained site personnel

Exclusion Criteria:

Participation in a clinical study in which study treatment is blinded
Patient condition is considered terminal (i.e.<6 months to live)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Identify and summarize patterns in therapeutic regimens and patient outcomes Time Frame: up to 8 years	The primary objective is to 1) describe practice patterns of first line therapy regimens and subsequent therapeutic strategies in patients initiated on therapy for CLL, as well as initiated on second line and subsequent therapies, in the community and academic setting (2) Provide insight into therapeutic regimens and therapy sequence in clinical practice as they relate to clinical outcomes in patients initiated on first-line, second-line or subsequent therapies for CLL.	up to 8 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Summarize Effectiveness of Treatment Regimens Time Frame: up to 8 years	Describe any differences in effectiveness associated with treatment regimens, including first-line regimens and subsequent therapeutic strategies in patients actively treated for CLL	up to 8 years
Health Related Quality of Life Measures Related to Therapeutic Regimens Time Frame: up to 8 years	Describe the health-related quality of life of patients actively treated for CLL, and to explore the association of HRQoL with therapeutic regimens, sequences and clinical outcomes.	up to 8 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Celgene

Investigators

Study Director: Kenneth Foon, MD, Celgene Corporation

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Related Info

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

March 19, 2010

Primary Completion (ACTUAL)

December 31, 2017

Study Completion (ACTUAL)

December 31, 2017

Study Registration Dates

First Submitted

March 4, 2010

First Submitted That Met QC Criteria