TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants (IMAP-TMS)
April 15, 2026 updated by: Institut National de la Santé Et de la Recherche Médicale, France
Transcranial Magnetic Stimulation-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants
The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection.
This project is based on four sequences.
For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test.
The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training.
For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process.
The secondary objective will be to examine the corticospinal changes (i.e.
amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation.
For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training.
More specifically, the investigators will study the links between brain plasticity and motor learning through mental training.
The secondary objective will be to examine the corticospinal changes (i.e.
amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period.
For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training.
The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning.
The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery.
The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.
Study Overview
Status
Status
Recruiting
Conditions
Conditions
Intervention / Treatment
Intervention / Treatment
Study Type
Study Type
Interventional
Enrollment (Estimated)
Enrollment
556
Phase
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
Study Contact
- Name: Florent Lebon, PhD
- Phone Number: +33 3 80 39 67 49
- Email: Florent.Lebon@u-bourgogne.fr
Study Locations
-
-
-
Dijon, France
- Recruiting
- INSERM - U1093 Cognition, Action, and Sensorimotor Plasticity
-
Contact:
- Florent Lebon, PhD
- Phone Number: +33 3 80 39 67 49
- Email: Florent.Lebon@u-bourgogne.fr
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Eligibility Criteria
Ages Eligible for Study
18 years to 60 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Male or female between 18 and 60 years old
- Having given written informed consent
- Affiliated to a social security scheme
Exclusion Criteria:
- History of psychiatric illness (declarative)
- Person under guardianship, curatorship, safeguard of justice
- Neurological problem that could bias the results of the study (declarative)
- Personal or family history of epilepsy
- Person deprived of liberty by judicial or administrative decision
- Person hospitalized without consent and not subject to legal protection, and person admitted to a health or social institution for purposes other than that of the research
- Person subject to an exclusion period for another research
- Pregnant women or women of childbearing age not using known contraception
- Breastfeeding women
- Person on medication that could influence neurophysiological measures (neuroleptics, anxiolytics, antidepressants)
- Person carrying :
- pacemaker or other device that could interfere with the magnetic field
- Implants (mechanical or electronic: cochlear implants, neural or cardiac pacemakers, infusion pumps, magnetic aneurysm clips, etc.)
- Metallic foreign bodies in the eye or nervous system
- Metallic objects (tattoos, piercings, etc.)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
Number of Arms
28
Arms and Interventions
Participant Group / ArmParticipant Group / Arm |
Intervention / TreatmentIntervention / Treatment |
|---|---|
|
Active Comparator: Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Combined magnetic and electric stimulation of cortex and nerve, respectively
Other Names:
Electric stimulation of the muscle
|
|
Sham Comparator: Sequence 4 - Control
Transcranial magnetic stimulation Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with same task - Long follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with same task - Short follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with different tasks - Long follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with different tasks - Short follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with muscle contractions - Long follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 1 - Training with muscle contractions - Short follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
|
Magnetic stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Active Comparator: Sequence 1 - Control
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training
|
Magnetic stimulation of the cortex
Other Names:
|
|
Active Comparator: Sequence 2 - Physical training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by actually doing the task
|
|
Active Comparator: Sequence 2 - Physical training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by actually doing the task
|
|
Active Comparator: Sequence 2 - Physical training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by actually doing the task
|
|
Active Comparator: Sequence 2 - Physical training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by actually doing the task
|
|
Experimental: Sequence 2 - Mental training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 2 - Mental training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 2 - Mental training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 2 - Mental training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
|
Magnetic stimulation of the cortex
Other Names:
External perturbation of force field induced by robotic arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Combined magnetic and electric stimulation of cortex and nerve, respectively
Other Names:
Training to perform the task by imaging doing the task
Electric stimulation of the muscle
|
|
Experimental: Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Combined magnetic and electric stimulation of cortex and nerve, respectively
Other Names:
Training to perform the task by imaging doing the task
Electric stimulation of the muscle
|
|
Experimental: Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Combined magnetic and electric stimulation of cortex and nerve, respectively
Other Names:
Training to perform the task by imaging doing the task
Electric stimulation of the muscle
|
|
Experimental: Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Combined magnetic and electric stimulation of cortex and nerve, respectively
Other Names:
Training to perform the task by imaging doing the task
Electric stimulation of the muscle
|
|
Active Comparator: Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the nerves
Training to perform the task by imaging doing the task
Electric stimulation of the muscle
|
|
Experimental: Sequence 4 - Immobilization - Short follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Short-term immobilization of the arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 4 - Immobilization - Long follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Short-term immobilization of the arm
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 4 - Cathodal - Short follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 4 - Cathodal - Long follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 4 - Anodal - Short follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
|
Experimental: Sequence 4 - Anodal - Long follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
|
Magnetic stimulation of the cortex
Other Names:
Electric stimulation of the cortex
Other Names:
Training to perform the task by imaging doing the task
|
What is the study measuring?
Primary Outcome Measures
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Evolution of movement speed - Sequence 1
Time Frame: Each day in Sequence 1 (Sequence 1 is 11 days)
|
The duration of performed movement sequences
|
Each day in Sequence 1 (Sequence 1 is 11 days)
|
|
Evolution of movement accuracy - Sequence 1
Time Frame: Each day in Sequence 1 (Sequence 1 is 11 days)
|
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
|
Each day in Sequence 1 (Sequence 1 is 11 days)
|
|
Evolution of trajectory error - Sequence 2
Time Frame: Each day in Sequence 2 (Sequence 1 is 10 days)
|
The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target.
|
Each day in Sequence 2 (Sequence 1 is 10 days)
|
|
Evolution of maximal deviation - Sequence 2
Time Frame: Each day in Sequence 2 (Sequence 1 is 10 days)
|
The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target
|
Each day in Sequence 2 (Sequence 1 is 10 days)
|
|
Evolution of final error - Sequence 2
Time Frame: Each day in Sequence 2 (Sequence 1 is 10 days)
|
The distance between the final position of the hand and the position of the final target.
|
Each day in Sequence 2 (Sequence 1 is 10 days)
|
|
Evolution of movement speed - Sequence 3
Time Frame: Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
|
The duration of performed movement sequences
|
Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
|
|
Evolution of movement accuracy - Sequence 3
Time Frame: Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
|
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
|
Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
|
|
Evolution of movement speed - Sequence 4
Time Frame: Each day in Sequence 4 (Sequence 4 is 6 days)
|
The duration of performed movement sequences
|
Each day in Sequence 4 (Sequence 4 is 6 days)
|
|
Evolution of movement accuracy - Sequence 4
Time Frame: Each day in Sequence 4 (Sequence 4 is 6 days)
|
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
|
Each day in Sequence 4 (Sequence 4 is 6 days)
|
Secondary Outcome Measures
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Evolution of motor evoked potentials amplitude - Sequence 2
Time Frame: Each day in Sequence 2 (Sequence 2 is 10 days)
|
Peak-to-peak amplitude of motor evoked potentials
|
Each day in Sequence 2 (Sequence 2 is 10 days)
|
|
Evolution of motor evoked potentials amplitude - Sequence 3
Time Frame: Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days)
|
Peak-to-peak amplitude of motor evoked potentials
|
Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days)
|
|
Evolution of motor evoked potentials amplitude - Sequence 4
Time Frame: Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days)
|
Peak-to-peak amplitude of motor evoked potentials
|
Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days)
|
|
Evolution of motor evoked potentials amplitude - Sequence 1
Time Frame: Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days).
|
Peak-to-peak amplitude of motor evoked potentials
|
Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days).
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Sponsor
Investigators
Investigators
- Principal Investigator: Florent Lebon, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
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- Doyon J, Bellec P, Amsel R, Penhune V, Monchi O, Carrier J, Lehericy S, Benali H. Contributions of the basal ganglia and functionally related brain structures to motor learning. Behav Brain Res. 2009 Apr 12;199(1):61-75. doi: 10.1016/j.bbr.2008.11.012. Epub 2008 Nov 17.
- Malouin F, Jackson PL, Richards CL. Towards the integration of mental practice in rehabilitation programs. A critical review. Front Hum Neurosci. 2013 Sep 19;7:576. doi: 10.3389/fnhum.2013.00576.
- Jeannerod M. Neural simulation of action: a unifying mechanism for motor cognition. Neuroimage. 2001 Jul;14(1 Pt 2):S103-9. doi: 10.1006/nimg.2001.0832.
- Decety J. The neurophysiological basis of motor imagery. Behav Brain Res. 1996 May;77(1-2):45-52. doi: 10.1016/0166-4328(95)00225-1.
- Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature. 1995 Sep 14;377(6545):155-8. doi: 10.1038/377155a0.
- Guillot A, Moschberger K, Collet C. Coupling movement with imagery as a new perspective for motor imagery practice. Behav Brain Funct. 2013 Feb 20;9:8. doi: 10.1186/1744-9081-9-8.
- Classen J, Liepert J, Wise SP, Hallett M, Cohen LG. Rapid plasticity of human cortical movement representation induced by practice. J Neurophysiol. 1998 Feb;79(2):1117-23. doi: 10.1152/jn.1998.79.2.1117.
- Abraham WC. Metaplasticity: tuning synapses and networks for plasticity. Nat Rev Neurosci. 2008 May;9(5):387. doi: 10.1038/nrn2356.
- Anwar MN, Khan SH. Trial-by-trial adaptation of movements during mental practice under force field. Comput Math Methods Med. 2013;2013:109497. doi: 10.1155/2013/109497. Epub 2013 May 7.
- Allami N, Paulignan Y, Brovelli A, Boussaoud D. Visuo-motor learning with combination of different rates of motor imagery and physical practice. Exp Brain Res. 2008 Jan;184(1):105-13. doi: 10.1007/s00221-007-1086-x. Epub 2007 Sep 12.
- Arora S, Aggarwal R, Sevdalis N, Moran A, Sirimanna P, Kneebone R, Darzi A. Development and validation of mental practice as a training strategy for laparoscopic surgery. Surg Endosc. 2010 Jan;24(1):179-87. doi: 10.1007/s00464-009-0624-y. Epub 2009 Jul 25.
- Avanzino L, Giannini A, Tacchino A, Pelosin E, Ruggeri P, Bove M. Motor imagery influences the execution of repetitive finger opposition movements. Neurosci Lett. 2009 Nov 27;466(1):11-5. doi: 10.1016/j.neulet.2009.09.036. Epub 2009 Sep 20.
- Bienenstock EL, Cooper LN, Munro PW. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J Neurosci. 1982 Jan;2(1):32-48. doi: 10.1523/JNEUROSCI.02-01-00032.1982.
- Burianova H, Marstaller L, Sowman P, Tesan G, Rich AN, Williams M, Savage G, Johnson BW. Multimodal functional imaging of motor imagery using a novel paradigm. Neuroimage. 2013 May 1;71:50-8. doi: 10.1016/j.neuroimage.2013.01.001. Epub 2013 Jan 12.
- Cantarero G, Tang B, O'Malley R, Salas R, Celnik P. Motor learning interference is proportional to occlusion of LTP-like plasticity. J Neurosci. 2013 Mar 13;33(11):4634-41. doi: 10.1523/JNEUROSCI.4706-12.2013.
- Cumming J, Hall C. Deliberate imagery practice: the development of imagery skills in competitive athletes. J Sports Sci. 2002 Feb;20(2):137-45. doi: 10.1080/026404102317200846.
- Doyon J, Benali H. Reorganization and plasticity in the adult brain during learning of motor skills. Curr Opin Neurobiol. 2005 Apr;15(2):161-7. doi: 10.1016/j.conb.2005.03.004.
- Gentili R, Han CE, Schweighofer N, Papaxanthis C. Motor learning without doing: trial-by-trial improvement in motor performance during mental training. J Neurophysiol. 2010 Aug;104(2):774-83. doi: 10.1152/jn.00257.2010. Epub 2010 Jun 10.
- Gentili R, Papaxanthis C, Pozzo T. Improvement and generalization of arm motor performance through motor imagery practice. Neuroscience. 2006 Feb;137(3):761-72. doi: 10.1016/j.neuroscience.2005.10.013. Epub 2005 Dec 9.
- Grush R. The emulation theory of representation: motor control, imagery, and perception. Behav Brain Sci. 2004 Jun;27(3):377-96; discussion 396-442. doi: 10.1017/s0140525x04000093.
- Halsband U, Lange RK. Motor learning in man: a review of functional and clinical studies. J Physiol Paris. 2006 Jun;99(4-6):414-24. doi: 10.1016/j.jphysparis.2006.03.007. Epub 2006 May 26.
- Izawa J, Shadmehr R. Learning from sensory and reward prediction errors during motor adaptation. PLoS Comput Biol. 2011 Mar;7(3):e1002012. doi: 10.1371/journal.pcbi.1002012. Epub 2011 Mar 10.
- Keller PE. Mental imagery in music performance: underlying mechanisms and potential benefits. Ann N Y Acad Sci. 2012 Apr;1252:206-13. doi: 10.1111/j.1749-6632.2011.06439.x.
- Lebon F, Lotze M, Stinear CM, Byblow WD. Task-dependent interaction between parietal and contralateral primary motor cortex during explicit versus implicit motor imagery. PLoS One. 2012;7(5):e37850. doi: 10.1371/journal.pone.0037850. Epub 2012 May 31.
- Lehericy S, Benali H, Van de Moortele PF, Pelegrini-Issac M, Waechter T, Ugurbil K, Doyon J. Distinct basal ganglia territories are engaged in early and advanced motor sequence learning. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12566-71. doi: 10.1073/pnas.0502762102. Epub 2005 Aug 17.
- Minkova L, Peter J, Abdulkadir A, Schumacher LV, Kaller CP, Nissen C, Kloppel S, Lahr J. Determinants of Inter-Individual Variability in Corticomotor Excitability Induced by Paired Associative Stimulation. Front Neurosci. 2019 Aug 14;13:841. doi: 10.3389/fnins.2019.00841. eCollection 2019.
- Mulder T. Motor imagery and action observation: cognitive tools for rehabilitation. J Neural Transm (Vienna). 2007;114(10):1265-78. doi: 10.1007/s00702-007-0763-z. Epub 2007 Jun 20.
- Opie GM, Evans A, Ridding MC, Semmler JG. Short-term immobilization influences use-dependent cortical plasticity and fine motor performance. Neuroscience. 2016 Aug 25;330:247-56. doi: 10.1016/j.neuroscience.2016.06.002. Epub 2016 Jun 6.
- Palmiero M, Belardinelli MO, Nardo D, Sestieri C, Di Matteo R, D'Ausilio A, Romani GL. Mental imagery generation in different modalities activates sensory-motor areas. Cogn Process. 2009 Sep;10 Suppl 2:S268-71. doi: 10.1007/s10339-009-0324-5. No abstract available.
- Rozand V, Lebon F, Stapley PJ, Papaxanthis C, Lepers R. A prolonged motor imagery session alter imagined and actual movement durations: Potential implications for neurorehabilitation. Behav Brain Res. 2016 Jan 15;297:67-75. doi: 10.1016/j.bbr.2015.09.036. Epub 2015 Sep 30.
- Rosenkranz K, Seibel J, Kacar A, Rothwell J. Sensorimotor deprivation induces interdependent changes in excitability and plasticity of the human hand motor cortex. J Neurosci. 2014 May 21;34(21):7375-82. doi: 10.1523/JNEUROSCI.5139-13.2014.
- Ruffino C, Papaxanthis C, Lebon F. The influence of imagery capacity in motor performance improvement. Exp Brain Res. 2017 Oct;235(10):3049-3057. doi: 10.1007/s00221-017-5039-8. Epub 2017 Jul 21.
- Saimpont A, Mercier C, Malouin F, Guillot A, Collet C, Doyon J, Jackson PL. Anodal transcranial direct current stimulation enhances the effects of motor imagery training in a finger tapping task. Eur J Neurosci. 2016 Jan;43(1):113-9. doi: 10.1111/ejn.13122. Epub 2015 Dec 15.
- Rulleau T, Robin N, Abou-Dest A, Chesnet D, Toussaint L. Does the Improvement of Position Sense Following Motor Imagery Practice Vary as a Function of Age and Time of Day? Exp Aging Res. 2018 Oct-Dec;44(5):443-454. doi: 10.1080/0361073X.2018.1521496. Epub 2018 Oct 9.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
Study Start
April 8, 2024
Primary Completion (Estimated)
Primary Completion
April 1, 2027
Study Completion (Estimated)
Study Completion
April 1, 2029
Study Registration Dates
First Submitted
First Submitted
December 7, 2020
First Submitted That Met QC Criteria
First Submitted That Met QC Criteria
March 2, 2021
First Posted (Actual)
First Posted
March 5, 2021
Study Record Updates
Last Update Posted (Actual)
Last Update Posted
April 20, 2026
Last Update Submitted That Met QC Criteria
Last Update Submitted That Met QC Criteria
April 15, 2026
Last Verified
Last Verified
April 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Motor Activity
- Movement
- Musculoskeletal Physiological Phenomena
- Musculoskeletal and Neural Physiological Phenomena
- Therapeutics
- Behavioral Disciplines and Activities
- Magnetic Field Therapy
- Exercise
- Electric Stimulation Therapy
- Convulsive Therapy
- Psychiatric Somatic Therapies
- Electroshock
- Psychological Techniques
- Transcranial Magnetic Stimulation
- Transcranial Direct Current Stimulation
- Physical Conditioning, Human
Other Study ID Numbers
Other Study ID Numbers
- C19-19
- 2020-A00305-34 / 1 (Registry Identifier: IDRCB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.