The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability (DVS)
November 27, 2024 updated by: Technical University of Dortmund
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability Across the Lifespan. An Interdisciplinary, Cross-sectional and Longitudinal Study
The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular system, immune system, and mental performance over the lifespan with a focus on healthy working adults.
The Dortmund Vital Study is a multidisciplinary longitudinal study involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology of the Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo) in Dortmund, Germany, as well as several national and international cooperation partners.
Study Overview
Status
Status
Active, not recruiting
Conditions
Conditions
Detailed Description
The Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. About 600 subjects aged between 20 and 70 years will participate. A wide range of demographic, psychological, behavioral, sensory, cardiovascular, biochemical, immunological and biochemical data, a comprehensive EEG-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study. Specifically, parameters obtained by MRI and EEG-related measures can be evaluated as a function of polygenic scores, metabolic products, concentration of immune cells, immune age and infections, such as Toxoplasmosis or COVID-19 that are largely unexplored. The same is true for environmental and lifestyle factors that impact on brain activity and behavior.
The initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035).
The study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other.
Study Type
Study Type
Observational
Enrollment (Actual)
Enrollment
627
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Dortmund, Germany, 44139
- Technical University of Dortmund, Leibniz Research Centre for Working Environment and Human Factors
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Eligibility Criteria
Ages Eligible for Study
20 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Sampling Method
Non-Probability Sample
Study Population
Healthy individuals from the general population.
Description
Inclusion Criteria:
- Blood thinners
- Hormones
- Antihypertensives
- Cholesterol reducers
- Normal or corrected-to-normal vision and hearing
- Fulfill standard inclusion criteria for MRI measurements
- Sufficient language skills
Exclusion Criteria:
- Dementia
- Parkinsonism
- Stroke
- Cardiovascular diseases
- Bleeding tendency
- Oncological diseases
- Schizophrenia
- Obsessive-compulsive disorder
- Anxiety disorders
- Severe depression
- Head injuries
- Head surgery
- Head implants
- Eye diseases (cataract, glaucoma, blindness)
- Accidents that limit physical fitness and mobility
- Psychotropic drugs
- Neuroleptics
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Change in performance on global cognitive composite score assessed by neuropsychological tests
Time Frame: Baseline and 5, 10, 15 years
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Change in performance on global cognitive composite score based on measures from neuropsychological tests: Digit-Span forward and backward, semantic memory in written and spoken versions (Word-Fluency), selective attention and attentional endurance (D2-R), crystallized intelligence (Multiple Choice Vocabulary Test), general cognitive status (Mini-Mental-State-Examination; MMSE), different aspects of verbal memory like learning performance and retrieval (Verbal Learning and Memory Tests; VLMT), psychomotor performance and speed of processing (Digit-Symbol-Test), interference control and inhibition (Stroop Test), task switching (Trail-Making-Test; TMT-A and TMT-B), two subtests from the performance testing system measuring logical reasoning and spatial rotation, and fluid intelligence assessed by Raven's Progressive Matrices.
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Baseline and 5, 10, 15 years
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Change in attentional performance and perceptual control as assessed by a computerized Bar Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in attentional performance and perceptual control assessed by the Bar Task.
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Baseline and 5, 10, 15 years
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Change in vigilance control as assessed by a computerized Psychomotor Vigilance Test
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in a Psychomotor Vigilance Test.
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Baseline and 5, 10, 15 years
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Change in stimulus-response compatibility and conflict processing assessed by the computerized Simon Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Simon task.
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Baseline and 5, 10, 15 years
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Change in updating and strategy learning assessed by the computerized AX-CPT Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the AX-CPT task.
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Baseline and 5, 10, 15 years
|
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Change in speech understanding and auditory distractibility assessed by computerized Speech-In-Noise perception task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Speech-in-noise perception task.
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Baseline and 5, 10, 15 years
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Change in working memory assessed by the computerized N-back Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the N-back task.
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Baseline and 5, 10, 15 years
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Change in cue and memory-based task switching assessed by the computerized Task Switching Paradigm
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the cue- and memory based task switching.
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Baseline and 5, 10, 15 years
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Change in auditive attention and distractibility assessed by the computerized Auditory Distraction Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Auditory Distraction Task.
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Baseline and 5, 10, 15 years
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Change in susceptibility to interference and the capacity to inhibit irrelevant stimuli assessed by the computerized Stroop Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Stroop Task.
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Baseline and 5, 10, 15 years
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Change in inhibitory control of prepotent responses assessed by the computerized Go/NoGo Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Go/NoGo Task.
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Baseline and 5, 10, 15 years
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Change in spatial selective attention assessed by the computerized Visual Search Task
Time Frame: Baseline and 5, 10, 15 years
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Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Visual Search Task.
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Baseline and 5, 10, 15 years
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Change in Work Ability Index
Time Frame: Baseline and 5, 10, 15 years
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Change in work ability assessed by Work Ability Index (WAI).
WAI assess physical and psychological risks to avoid work-related disabilities and early retirement.
The index is determined by the employees' answers related to work demands, individual health status and physical and psychological capacities.
The total score of WAI is calculated by summing up scores of seven dimensions.
The work ability ranged between 7 (insufficient) and 49 points (best work ability).
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Baseline and 5, 10, 15 years
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Secondary Outcome Measures
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Change in resting state EEG activity
Time Frame: baseline and 5, 10, 15 years
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Change in resting state EEG activity measured for 2 minutes with eyes open, and 2 minutes with eyes closed.
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baseline and 5, 10, 15 years
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Change in brain function MRI
Time Frame: 5, 10, 15 years
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Changes in functional magnetic resonance imaging assessed by resting state MRI.
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5, 10, 15 years
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Change in brain structure MRI
Time Frame: 5, 10, 15 years
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Changes in structural resonance imaging assessed by multi-shell diffusion-weighted imaging (DWI).
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5, 10, 15 years
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Change in Depressive Symptoms
Time Frame: Baseline and 5, 10, 15 years
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Change in total score using the Becks Depression Inventory (BDI).
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Baseline and 5, 10, 15 years
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Change in Psychosocial Stress Symptoms
Time Frame: Baseline and 5, 10, 15 years
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Change in total score using the Psychosocial Stress Questionnaire (PSQ-20).
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Baseline and 5, 10, 15 years
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Change in Chronic Stress Symptoms
Time Frame: Baseline and 5, 10, 15 years
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Change in chronic stress symptoms assessed by the Trier Inventory of Chronic Stress (TICS), consisting of several dimensions: Work Overload, Social Overload, Pressure to Perform, Work Discontent, Demands from work, Lack of Social Recognition, Social Tensions, Social Isolation, Chronic Worrying, and a 12 Item Screening-Scale (SSCS) that provides a score for general stress.
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Baseline and 5, 10, 15 years
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Change in Psychosocial Work Demands
Time Frame: 5, 10, 15 years
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Change in total score in the Copenhagen Psychosocial Questionnaire (COPSOQ III) that consists of several dimensions: cognitive and physical demands at work, job control, influence at work, developmental possibilities, interpersonal relations, leadership, and strain.
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5, 10, 15 years
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Change in Self-Control at work
Time Frame: Baseline and 5, 10, 15 years
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Change of the psychosocial demands at work assessed by the scale Self-Control at Work.
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Baseline and 5, 10, 15 years
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Change in Cognitive Failures in the Daily Life
Time Frame: Baseline and 5, 10, 15 years
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Change in cognitive failures in daily life assessed by the Cognitive Failure Questionnaire (CFQ).
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Baseline and 5, 10, 15 years
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Change in Positive and Negative Affect
Time Frame: Baseline and 5, 10, 15 years
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Change in scores of positive and negative affect.
The Positive and Negative Affect Schedule (PANAS) is a self-report questionnaire that consists of two 10-item scales to measure both positive and negative affect.
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Baseline and 5, 10, 15 years
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Change in Quality of Life
Time Frame: Baseline and 5, 10, 15 years
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Change in total score of the quality of life questionnaire (WHOQoL-BREF), consisting of dimensions: physical, psychological, social, environmental, and global quality of life.
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Baseline and 5, 10, 15 years
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Change in sociodemographic parameters
Time Frame: Baseline and 5, 10, 15 years
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Change in different sociodemographic aspects like marital status, occupational status, nutrition, leisure activities, alcohol drinking, frequency of social contacts, using of electronic media etc. Qualitative data will be categorized.
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Baseline and 5, 10, 15 years
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Change in self-reported physical activity
Time Frame: Baseline and 5, 10, 15 years
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Change of the self-reported physical activity (Lüdenscheid Physical Activity Questionnaire) in minutes per week.
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Baseline and 5, 10, 15 years
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Change in lateralization and motor functions
Time Frame: Baseline and 5, 10, 15 years
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Change in total score of the Perdue Pegboard Test, assessing lateralization and motor functions.
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Baseline and 5, 10, 15 years
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Change of cytokines concentration in serum
Time Frame: Baseline and 5, 10, 15 years
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Change of concentration of cytokines in serum (pg/ml): (IL-1b, IFN-alpha, IFN-gamma, TNF-alpha, MCP-1, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33).
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Baseline and 5, 10, 15 years
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Change of functional activiy of T cells and Natural Killer cells
Time Frame: Baseline and 5, 10, 15 years
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Change of functional activities of T cells and natural killer cells in %.
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Baseline and 5, 10, 15 years
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Change of peripheral blood mononuclear cells concentration
Time Frame: Baseline and 5, 10, 15 years
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Change of peripheral blood mononuclear cells concentration (pg/ml): (PBMC; CD14 positive monocytes).
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Baseline and 5, 10, 15 years
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Change in physical performance
Time Frame: Baseline and 5, 10, 15 years
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Change of physical fitness assessed by bicycle ergometer and a physical work capacity cycle test (PWC-130) to predict the absolute power output (in Watt) at a projected heart rate of 130 beats per minute.
A relative power output is calculated by the power-to-weight ratio (Watt/kg).
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Baseline and 5, 10, 15 years
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Change in cardiovascular parameters
Time Frame: Baseline and 5, 10, 15 years
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Diastolic and systolic blood pressure (mm/Hg) and pulse (bpm) measured during rest and during cycle ergometry.
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Baseline and 5, 10, 15 years
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Change in electrocardiography
Time Frame: Baseline and 5, 10, 15 years
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Change in electrocardiogram (ECG) measured during rest and during cycle ergometry.
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Baseline and 5, 10, 15 years
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Change in antibody concentrations of Toxoplasma gondii in serum
Time Frame: Baseline and 5, 10, 15 years
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Change of concentration of Toxoplasma gondii IgG antibodies (pg/ml) in serum to assess the severity of latent toxoplasmosis infection.
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Baseline and 5, 10, 15 years
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Change in antibody concentrations of COVID-19 in serum
Time Frame: 5, 10, 15 years
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Concentration of COVID-19 antibodies (pg/ml) in serum to assess the intensity of immunological response to potential SARC-CoV-2 infection or response to vaccination.
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5, 10, 15 years
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Change in metabolic parameters in blood
Time Frame: Baseline and 5, 10, 15 years
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Change in metabolic parameters in serum (pg/ml): concentration of ammonia, leucocytes, erythrocytes, hematocrit, monocytes, creatinine, lymphocytes, cell volume, thrombocytes, triglycerides, cholesterol, high- and low-density lipoprotein cholesterol, glycosylated hemoglobin, glucose, C-reactive protein and creatinine are measured in venous blood.
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Baseline and 5, 10, 15 years
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Change of metabolic parameters in urine
Time Frame: Baseline and 5, 10, 15 years
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Change in metabolic parameters in urine (pg/ml): concentartion of creatinine and calcium oxalate.
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Baseline and 5, 10, 15 years
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Change of endocrine parameter
Time Frame: Baseline and 5, 10, 15 years
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Change of hair cortisol concentration (pg/mg) as an index of long-term stress.
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Baseline and 5, 10, 15 years
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Change in Burnout Symptoms
Time Frame: Baseline and 5, 10, 15 years
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Change in total score using the Maslach Burnout Inventory (MBI-D) with 6-point Likert-type scale ranging from 1 (never) to 6 (always), total scores: 14 - 84.
Higher scores indicate more severe symptoms.
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Baseline and 5, 10, 15 years
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Change in Burnout Symptoms
Time Frame: Baseline and 5, 10, 15 years
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Change in total score using the Oldenburg Burnout Inventory (OLBI).
4-point Likert-type scale ranging from 1 (strongly agree) to 4 (strongly disagree), total scores: 8 - 32.
Higher scores indicate more severe symptoms.
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Baseline and 5, 10, 15 years
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Other Outcome Measures
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Genetic parameters (Single Nucleotide Polymorphisms; SNP)
Time Frame: Baseline
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A number of genetic polymorphisms coding common homozygotes, heterozygotes and rare homozygotes variants were selected which are potentially related to structure and function of the central nervous system.
Blood samples were used for the DNA-genotyping of: Apo-E2, E3, E4 (rs7412, rs429358), BDNF Val66Met (rs6265), COMT-1 (rs4633), COMT-2 Val158Met (rs4680), DRD2 (rs6277, DRD1-48A/G (rs4532), CHRNA6-1 (rs1072003), CHRNA6-3 (rs2304297), CHRNB3-1 (rs13280604), CHRNB3-2 (rs4950), GPCPD1 (EDI3) (rs)6116869), GRIN2A (rs1969060), GRIN2A (rs8057394), GRIN2B (rs890), IL-1beta (rs16944), IL-6 (rs1800795), IL-12A (rs568408), TNF-alpha (rs1800629).
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Baseline
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Change in visual acuity
Time Frame: Baseline and 5, 10, 15 years
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Change in visual acuity assessed by Vistec's Optovist according to DIN 58220-3 "Visual acuity testing - Part 3: Test for use in expertise" for far vision with the right and left eye separately (monocular) and with both eyes together (binocular), and if available with correction for distance (glasses for far vision).
The "inclined optometer" is used to determine the zones of sufficient vision binocular at horizontal gaze inclination.
For this, the near and far points are obtained, if available with distance correction (glasses for far vision).
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Baseline and 5, 10, 15 years
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Change in auditory acuity
Time Frame: Baseline and 5, 10, 15 years
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Change in auditory acuity evaluated by audiometry.
Audiometric thresholds are tested for ten pure-tone frequencies (125, 250, 500, 750, 1000, 2000, 3000, 4000, 6000, 8000 Hz) for the left and right ears separately.
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Baseline and 5, 10, 15 years
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Change in Body Mass Index
Time Frame: Baseline and 5, 10, 15 years
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Height (m) and weight (kg) are measured to compute the Body Mass Index (BMI in kg/m^2).
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Baseline and 5, 10, 15 years
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Change in Waist-To-Hip ratio
Time Frame: Baseline and 5, 10, 15 years
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Waist- and hip measurements (cm) are measured to compute the waist-to-hip ratio.
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Baseline and 5, 10, 15 years
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Personality traits
Time Frame: Baseline
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Personality traits are evaluated by the Big-Five-Factor inventory (NEO-FFI), assessing the personality dimensions: neuroticism, extraversion, openness, agreeableness, and conscientiousness.
Grit personality trait are assessed by the GRID scale and the self-control by the general self-control scale.
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Baseline
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Stress reactivity
Time Frame: Baseline
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Subjective stress reactivity are assessed by the Perceived Stress Reactivity Scale (PSRS).
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Baseline
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Chronotype
Time Frame: Baseline
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The chronotype assessing the morning or evening type is evaluated by (D-MEQ).
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Baseline
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Handedness
Time Frame: Baseline
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Handedness is evaluated by Handedness Edinburgh Inventory.
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Baseline
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Traumatic Experiences During Childhood
Time Frame: Baseline
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Traumatic experiences during childhood are assessed to evaluate stress reactivity in the adult life.
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Baseline
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Sociodemographic characteristics
Time Frame: Baseline
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Sociodemographic characteristics like education, history of physical activity, marital status, children etc. were obtained.
Qualitative data are categorized.
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Baseline
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Experiences with COVID-19 pandemic
Time Frame: 5, 10, 15 years
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Questionnaire addressing COVID-19-specific experience with the pandemic and the consequences of a COVID-19 infection (if applicable).
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5, 10, 15 years
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Sponsor
Investigators
Investigators
- Study Director: Edmund Wascher, PhD, Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo)
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Gajewski PD, Getzmann S, Brode P, Burke M, Cadenas C, Capellino S, Claus M, Genc E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study. JMIR Res Protoc. 2022 Mar 14;11(3):e32352. doi: 10.2196/32352.
- Rieker JA, Gajewski PD, Reales JM, Ballesteros S, Golka K, Hengstler JG, Wascher E, Getzmann S. The impact of physical fitness, social life, and cognitive functions on work ability in middle-aged and older adults. Int Arch Occup Environ Health. 2023 May;96(4):507-520. doi: 10.1007/s00420-022-01943-8. Epub 2022 Dec 16.
- Akan O, Bierbrauer A, Kunz L, Gajewski PD, Getzmann S, Hengstler JG, Wascher E, Axmacher N, Wolf OT. Chronic stress is associated with specific path integration deficits. Behav Brain Res. 2023 Mar 28;442:114305. doi: 10.1016/j.bbr.2023.114305. Epub 2023 Jan 20.
- Getzmann S, Arnau S, Gajewski PD, Wascher E. When long appears short: Effects of auditory distraction on event-related potential correlates of time perception. Eur J Neurosci. 2022 Jan;55(1):121-137. doi: 10.1111/ejn.15553. Epub 2021 Dec 14.
- Getzmann S, Schneider D, Wascher E. Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age. Neurobiol Aging. 2023 Jun;126:1-13. doi: 10.1016/j.neurobiolaging.2023.02.003. Epub 2023 Feb 14.
- Wascher E, Sharifian F, Gutberlet M, Schneider D, Getzmann S, Arnau S. Mental chronometry in big noisy data. PLoS One. 2022 Jun 8;17(6):e0268916. doi: 10.1371/journal.pone.0268916. eCollection 2022.
- Sharifian F, Schneider D, Arnau S, Wascher E. Decoding of cognitive processes involved in the continuous performance task. Int J Psychophysiol. 2021 Sep;167:57-68. doi: 10.1016/j.ijpsycho.2021.06.012. Epub 2021 Jul 1.
- Getzmann S, Digutsch J, Kleinsorge T. COVID-19 Pandemic and Personality: Agreeable People Are More Stressed by the Feeling of Missing. Int J Environ Res Public Health. 2021 Oct 13;18(20):10759. doi: 10.3390/ijerph182010759.
- Metzen D, Genc E, Getzmann S, Larra MF, Wascher E, Ocklenburg S. Frontal and parietal EEG alpha asymmetry: a large-scale investigation of short-term reliability on distinct EEG systems. Brain Struct Funct. 2022 Mar;227(2):725-740. doi: 10.1007/s00429-021-02399-1. Epub 2021 Oct 21.
- Bierbrauer A, Kunz L, Gomes CA, Luhmann M, Deuker L, Getzmann S, Wascher E, Gajewski PD, Hengstler JG, Fernandez-Alvarez M, Atienza M, Cammisuli DM, Bonatti F, Pruneti C, Percesepe A, Bellaali Y, Hanseeuw B, Strange BA, Cantero JL, Axmacher N. Unmasking selective path integration deficits in Alzheimer's disease risk carriers. Sci Adv. 2020 Aug 28;6(35):eaba1394. doi: 10.1126/sciadv.aba1394. eCollection 2020 Aug.
- Gajewski PD, Hanisch E, Falkenstein M, Thones S, Wascher E. What Does the n-Back Task Measure as We Get Older? Relations Between Working-Memory Measures and Other Cognitive Functions Across the Lifespan. Front Psychol. 2018 Nov 26;9:2208. doi: 10.3389/fpsyg.2018.02208. eCollection 2018.
- Brode P, Claus M, Gajewski PD, Getzmann S, Golka K, Hengstler JG, Wascher E, Watzl C. Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness. Biology (Basel). 2022 Oct 27;11(11):1576. doi: 10.3390/biology11111576.
- Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Ocklenburg S. Stress exposure, hand preference, and hand skill: A deep phenotyping approach. Laterality. 2023 Mar-May;28(2-3):209-237. doi: 10.1080/1357650X.2023.2204551. Epub 2023 Apr 26.
- Gajewski PD, Rieker JA, Athanassiou G, Brode P, Claus M, Golka K, Hengstler JG, Kleinsorge T, Nitsche MA, Reinders J, Tisch A, Watzl C, Wascher E, Getzmann S. A Systematic Analysis of Biological, Sociodemographic, Psychosocial, and Lifestyle Factors Contributing to Work Ability Across the Working Life Span: Cross-sectional Study. JMIR Form Res. 2023 May 19;7:e40818. doi: 10.2196/40818.
- Kleinert T, Nash K, Koenig T, Wascher E. Correction: Normative Intercorrelations between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):270. doi: 10.1007/s10548-023-01012-4. No abstract available.
- Kleinert T, Nash K, Koenig T, Wascher E. Normative Intercorrelations Between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):265-269. doi: 10.1007/s10548-023-00988-3. Epub 2023 Jul 14. Erratum In: Brain Topogr. 2024 Mar;37(2):270. doi: 10.1007/s10548-023-01012-4.
- Kleinert T, Koenig T, Nash K, Wascher E. On the Reliability of the EEG Microstate Approach. Brain Topogr. 2024 Mar;37(2):271-286. doi: 10.1007/s10548-023-00982-9. Epub 2023 Jul 6.
- Getzmann S, Arnau S, Gajewski PD, Wascher E. Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study. Neurobiol Aging. 2024 Dec;144:114-126. doi: 10.1016/j.neurobiolaging.2024.09.012. Epub 2024 Sep 20.
- Getzmann S, Gajewski PD, Schneider D, Wascher E. Resting-state EEG data before and after cognitive activity across the adult lifespan and a 5-year follow-up. Sci Data. 2024 Sep 10;11(1):988. doi: 10.1038/s41597-024-03797-w.
- Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Genc E, Ocklenburg S. Phenotyping in clinical laterality research: a comparison of commonly used methods to determine mixed-handedness and ambidexterity. Laterality. 2024 May;29(3):331-349. doi: 10.1080/1357650X.2024.2370871. Epub 2024 Jul 5.
- Larra MF, Gajewski PD, Getzmann S, Wascher E, Metzler Y. Stress from early life to adulthood: Is there a protective role of cognitive control? Brain Cogn. 2024 Aug;178:106165. doi: 10.1016/j.bandc.2024.106165. Epub 2024 May 16.
- Getzmann S, Golka K, Brode P, Reinders J, Kadhum T, Hengstler JG, Wascher E, Gajewski PD. Chronic Toxoplasma gondii Infection Modulates Hearing Ability across the Adult Life Span. Life (Basel). 2024 Jan 29;14(2):194. doi: 10.3390/life14020194.
- Brode P, Claus M, Gajewski PD, Getzmann S, Wascher E, Watzl C. From Immunosenescence to Aging Types-Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation. Int J Mol Sci. 2023 Aug 24;24(17):13186. doi: 10.3390/ijms241713186.
- Gajewski PD, Golka K, Hengstler JG, Kadhum T, Digutsch J, Genc E, Wascher E, Getzmann S. Does physical fitness affect cognitive functions differently across adulthood? An advantage of being older. Front Psychol. 2023 Jun 16;14:1134770. doi: 10.3389/fpsyg.2023.1134770. eCollection 2023.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
Study Start
April 1, 2016
Primary Completion (Estimated)
Primary Completion
December 1, 2035
Study Completion (Estimated)
Study Completion
December 1, 2037
Study Registration Dates
First Submitted
First Submitted
November 16, 2021
First Submitted That Met QC Criteria
First Submitted That Met QC Criteria
December 2, 2021
First Posted (Actual)
First Posted
December 13, 2021
Study Record Updates
Last Update Posted (Actual)
Last Update Posted
December 3, 2024
Last Update Submitted That Met QC Criteria
Last Update Submitted That Met QC Criteria
November 27, 2024
Last Verified
Last Verified
November 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
Other Study ID Numbers
- A93-3
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
After primary analyses and publication of the main results the data and the scripts used for data analyses will be made available in repositories for secondary analyses.
The transfer agreement will be prepared by the coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit.
IPD Sharing Time Frame
After primary analyses and publication of the main results.
IPD Sharing Access Criteria
In order to access the data, scientists from IfADo, as well as external cooperation partners who plan to analyze data from the Dortmund Vital Study fill in a proposal form that includes a short description of the project and the respective hypotheses, the responsible persons, cooperation partners, data usage and analysis strategy.
The requested research data will be made available in an anonymized form after consultation with the scientists responsible for the data.
Responsible persons include project managers and coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit.
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- ANALYTIC_CODE
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
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