ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack (ARTEMIS)

September 7, 2026 updated by: Novo Nordisk A/S

ARTEMIS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Patients With Acute Myocardial Infarction

The research study is being done to see if ziltivekimab can be used to treat people who were admitted to hospital because of a heart attack. Ziltivekimab might reduce development of heart disease, thereby preventing new heart attacks or strokes. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). Which treatment participants get is decided by chance. The chance of getting ziltivekimab or placebo is the same. The participant will need to inject the study medicine into a flat skin surface in there stomach, thigh, or upper arm once every month. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study will last for about 2 years.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Active, not recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
10000

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1181ACH
        • Hospital Italiano
      • Buenos Aires, Argentina, 1187
        • Sanatorio Finochietto
      • Buenos Aires, Argentina, C1221ADC
        • Cardiología Hospital J. M. Ramos Mejia
      • Corrientes, Argentina, W3400AMZ
        • Instituto de Cardiología de Corrientes
      • Córdoba, Argentina, 5000
        • Clínica Privada Vélez Sarsfield
      • Santa Fe, Argentina, 3000
        • Hospital Dr. Jose Maria Cullen
    • Buenos Aires
      • CABA, Buenos Aires, Argentina, C1428ART
        • Instituto Cardiovascular Buenos Aires
      • La Plata, Buenos Aires, Argentina, B 1900AXI
        • Hospital Italiano de La Plata
      • Pilar, Buenos Aires, Argentina, 1663
        • Hospital Universitario Austral
      • Pilar, Buenos Aires, Argentina, 1663
        • Hospital Universitario Austral - Instituto de Cardiologia
      • Quilmes, Buenos Aires, Argentina, 1878
        • Sanatorio Modelo Quilmes
      • San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900ACF
        • Fundación Nuestra Señora del Rosario - Estudios Clínicos los Arroyos
    • Buenos Aires, Argentina
      • CABA, Buenos Aires, Argentina, Argentina, C1093AAS
        • Fundacion Favaloro
    • City of Buenos Aires
      • CABA, City of Buenos Aires, Argentina, C1180AAX
        • Sanatorio Güemes
    • Mendoza Province
      • Godoy Cruz, Mendoza, Mendoza Province, Argentina, 5501
        • Hospital Español de Mendoza
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Sanatorio Parque
      • Rosario, Santa Fe, Santa Fe Province, Argentina, S2002KDT
        • Hospital del Centenario
    • Tucumán Province
      • San Miguel de Tucuimán, Tucumán Province, Argentina, 4000
        • Centro Privado de Cardiología
      • San Miguel de Tucumán, Tucumán Province, Argentina, T4000DPX
        • Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio
  • Australia
    • New South Wales
      • Concord, New South Wales, Australia, 2139
        • Concord Repatriation General Hospital - Cardiology Department
      • Kingswood, New South Wales, Australia, 2747
        • Nepean Hospital
      • Liverpool, New South Wales, Australia, 2170
        • Liverpool Hospital
      • Randwick, New South Wales, Australia, 2031
        • Prince of Wales Hospital - Sydney
      • Wollongong, New South Wales, Australia, 2500
        • Illawarra Heart Health Centre
    • Queensland
      • Birtinya, Queensland, Australia, 4575
        • Sunshine Coast University Hospital - Clinical Research Unit
      • Brisbane, Queensland, Australia, 4029
        • Royal Brisbane and Women's Hospital
      • Brisbane, Queensland, Australia, 4032
        • The Prince Charles Hospital
      • Cairns, Queensland, Australia, 4870
        • Cairns Base Hospital
      • Chermside, Queensland, Australia, 4032
        • The Prince Charles Hospital - Cardiology Clinical Research Centre
      • Douglas, Queensland, Australia, 4814
        • Townsville University Hospital
      • Southport, Queensland, Australia, 4215
        • Gold Coast University Hosptial
      • Southport, Queensland, Australia, 4215
        • Gold Coast University Hospital - Cardiology Department
      • Woolloongabba, Queensland, Australia, 4102
        • Princess Alexandra Hospital
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital Cardiovascular Clinical Trials
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital - Cardiology Department
      • Bedford Park, South Australia, Australia, 5042
        • Flinders Medical Centre
      • Elizabeth Vale, South Australia, Australia, 5112
        • Lyell McEwin Hospital
    • Victoria
      • Epping, Victoria, Australia, 3076
        • Northern Health
      • Frankston, Victoria, Australia, 3199
        • Peninsula University Hospital - Cardiology Department
      • Geelong, Victoria, Australia, 3220
        • Adrian Costa Clinical Trials Centre
      • Heidelberg, Victoria, Australia, 3084
        • Austin Hospital
      • South Yarra, Victoria, Australia, 3004
        • The Alfred - Endocrinology & Diabetes Department
      • St Albans, Victoria, Australia, 3021
        • Sunshine Hospital - Western Centre for Health Research and Education
    • Western Australia
      • Perth, Western Australia, Australia, 6000
        • Royal Perth Hospital
  • Brazil
      • Aracaju, Brazil, 49055-530
        • jmf Clinica do Coracao ltda
      • Porto Alegre/RS, Brazil, 90840-440
        • Hospital Mãe de Deus - Porto Alegre
    • Federal District
      • Brasília, Federal District, Brazil, 70390-700
        • Hospital do Coração do Brasil - Rede Do'r
    • Goiás
      • Goiânia, Goiás, Brazil, 74453200
        • Hospital Ruy Azeredo Ltda
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30220-140
        • NUPEC Cardio
      • Passos, Minas Gerais, Brazil, 37904-020
        • Irmandade Santa Casa de Misericórdia de Passos
      • Poços de Caldas, Minas Gerais, Brazil, 37706-106
        • Hospital Maternidade e Pronto Socorro Santa Lucia
      • Uberaba, Minas Gerais, Brazil, 38025-350
        • Hospital das Clínicas da Universidade Federal do Triangulo Mineiro
      • Uberlândia, Minas Gerais, Brazil, 38405-325
        • Centro de Pesquisa Clínica do Hospital de Clínicas da Universidade Federal de Uberlândia
    • Pernambuco
      • Recife, Pernambuco, Brazil, 52051-380
        • Hospital Agamenon Magalhães
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90050-170
        • Irmandade da Santa Casa de Misericórdia de Porto Alegre
      • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
        • Hospital São Lucas - PUC/RS
    • São Paulo
      • Bragança Paulista, São Paulo, Brazil, 12916-542
        • Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
      • Campinas, São Paulo, Brazil, 13060-080
        • Instituto de Pesquisa Clínica de Campinas
      • Campinas, São Paulo, Brazil, 13060-803
        • PUCCAMP - Hospital e Maternidade Celso Pierro
      • Cidade Nova Votuporanga, São Paulo, Brazil, 15501-405
        • Integral Pesquisa e Ensino
      • Marília, São Paulo, Brazil, 17515-900
        • Irmandade da Santa Casa de Misericórdia de Marília
      • Morumbi, São Paulo, Brazil, 05651-901
        • Hospital israelita Albert Einstein
      • Presidente Prudente, São Paulo, Brazil, 19050-680
        • ASSOCIAÇÃO LAR SÃO FRANCISCO DE ASSIS NA PROVIDÊNCIA DE DEUS - Hospital Regional de Presidente Prudente
      • São José do Rio Preto, São Paulo, Brazil, 15090-000
        • CIP Centro Integrado de Pesquisas do Hospital de Base
      • São Paulo, São Paulo, Brazil, 04012-909
        • Instituto Dante Pazzanese de Cardiologia
      • Votuporanga, São Paulo, Brazil, 15500-269
        • Integral Pesquisa e Ensino
  • Bulgaria
      • Blagoevgrad, Bulgaria, 2700
        • MHAT Puls AD, Cardiology Department
      • Burgas, Bulgaria, 8000
        • MHAT Heart and Brain EAD - Burgas, Cardiology
      • Burgas, Bulgaria, 8000
        • UMHAT - Burgas AD
      • Burgas, Bulgaria, 8127
        • UMHAT Deva Maria EOOD
      • Gabrovo, Bulgaria, 5300
        • MHAT Dr. Tota Venkova AD
      • Gabrovo, Bulgaria, 5300
        • Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD
      • Gotse Delchev, Bulgaria, 2900
        • MHAT - Ivan Skenderov EOOD
      • Haskovo, Bulgaria, 6300
        • MHAT Haskovo AD
      • Kardzhali, Bulgaria, 6600
        • MHAT - Dr. Atanas Dafovski AD, Cardiology department
      • Lovech, Bulgaria, 5500
        • MHAT - Cardiolife OOD - Lovech
      • Montana, Bulgaria, 3400
        • MHAT - City Clinic - Sveti Georgi EOOD
      • Pazardzhik, Bulgaria, 4401
        • MHAT - Pazardzhik AD
      • Pleven, Bulgaria, 5804
        • MHAT Heart and Brain EAD - Pleven, Cardiology
      • Plovdiv, Bulgaria, 4003
        • MHAT MC-Sv Ivan Rilski EOOD
      • Plovdiv, Bulgaria, 4002
        • UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
      • Plovdiv, Bulgaria, 4004
        • MHAT Sveta Karidad EAD
      • Plovdiv, Bulgaria, 4002
        • UMHAT Pulmed OOD - Plovdiv, Department of Cardiology
      • Rousse, Bulgaria, 7013
        • SHATC - Medica Kor EAD
      • Sandanski, Bulgaria, 2800
        • MHAT Southwest Hospital OOD, Cardiology Department
      • Sliven, Bulgaria, 8800
        • MHAT Hadzhi Dimitar OOD
      • Smolyan, Bulgaria, 4700
        • MHAT "Dr. Bratan Shukerov"
      • Smolyan, Bulgaria, 4700
        • MHAT Dr. Bratan Shukerov
      • Sofia, Bulgaria, 1309
        • MHAT National Cardiology Hospital EAD
      • Sofia, Bulgaria, 1750
        • "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
      • Sofia, Bulgaria, 1797
        • UMHAT Sofiamed EAD
      • Sofia, Bulgaria, 1415
        • Acibadem City Clinic UMHAT EOOD, Cardiology
      • Sofia, Bulgaria, 1431
        • UMHAT Aleksandrovska EAD, Clinic of Cardiology
      • Sofia, Bulgaria, 1750
        • MHAT Sveta Anna Sofia AD, Clinic of Cardiology
      • Sofia, Bulgaria, 1606
        • UMHATEM N.I. Pirogov EAD
      • Sofia, Bulgaria, 1407
        • Acibadem City Clinic UMHAT Tokuda EAD, Cardiology
      • Sofia, Bulgaria, 1431
        • UMHAT Sveta Ekaterina EAD
      • Varna, Bulgaria, 9009
        • Specialized Hospital For Active Cardiology Treatement Cardiolife OOD
      • Varna, Bulgaria, 9010
        • UMHAT Sveta Marina EAD, Second Clinic of Cardiology
      • Varna, Bulgaria, 9009
        • SHATC - Cardiolife OOD - Varna
      • Varna, Bulgaria, 910
        • UMHAT "Sveta Marina" EAD
      • Yambol, Bulgaria, 8600
        • SHATC - Yambol EAD
  • Canada
      • Québec, Canada, G1R 2J6
        • CHU de Quebec-Universite-Laval,HDQ
      • Québec, Canada, G1V 4G5
        • Ins Uni de Cardi et de PNA de
    • Alberta
      • Calgary, Alberta, Canada, T2N 4Z6
        • Heritage Medical Research Clinic
      • Edmonton, Alberta, Canada, T5H 3V9
        • Royal Alexandra Hospital
      • Edmonton, Alberta, Canada, T6G 2B7
        • Grey Nuns Community Hospital
      • Edmonton, Alberta, Canada, T6G 2B7
        • Univ of Alberta Hosp Edmonton
    • British Columbia
      • Kelowna, British Columbia, Canada, V1Y 1T2
        • Kelowna Cardiology Res. Ltd.
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Vancouver General Hospital
      • Vancouver, British Columbia, Canada, V6Z 1Y6
        • Saint Paul's Hospital
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2H 2A6
        • St. Boniface Hospital
    • New Brunswick
      • Saint John, New Brunswick, Canada, E2L 4L2
        • New Brunswick Heart Centre
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • QE II Health Sciences Centre
    • Ontario
      • Barrie, Ontario, Canada, L4M 6M2
        • Royal Victoria Regional Health Centre
      • Brampton, Ontario, Canada, L6R 3J7
        • William Osler Hel Bra Civic Hs
      • Greater Sudbury, Ontario, Canada, P3E 5J1
        • Health Sciences North Rsrch Inst
      • Hamilton, Ontario, Canada, L8L 2X2
        • Hamilton Health Sciences Corp, Ontario
      • Kingston, Ontario, Canada, K7L 2V7
        • Kingston General Hospital
      • London, Ontario, Canada, N6A 5A5
        • London Health Sciences Center Ontario
      • Newmarket, Ontario, Canada, L3Y 2R2
        • Southlake Regional Hlth Centre
      • Ottawa, Ontario, Canada, K1Y 4W7
        • University of Ottawa Heart Institute (UOHI)
      • St. Catharines, Ontario, Canada, L2S 0A9
        • Niagara Health System
      • Toronto, Ontario, Canada, M4N 3M5
        • Sunnybrook Health Sciences Centre
      • Toronto, Ontario, Canada, M5B 1W8
        • St. Michael's Hospital
      • Toronto, Ontario, Canada, M5G 2C4
        • UHN-Toronto General Hospital
    • Quebec
      • Chicoutimi, Quebec, Canada, G7H 5H6
        • CIUSS Hopit de Chicoutimi
      • Montreal, Quebec, Canada, H4J 1C5
        • Hôpital Sacré-Coeur de Montréal
      • Montreal, Quebec, Canada, H2X 0C1
        • CHUM Centre de Recherch Hotel-Dieu
      • Saint-Charles-Borromée, Quebec, Canada, J6E 6J2
        • CISSS de Lanaudiere - Centre hospitalier De Lanaudiere
      • Terrebonne, Quebec, Canada, J6V 2H2
        • CISSSL Hôsp Pierre-Le Gardeur
      • Trois-Rivières, Quebec, Canada, G8Z 3R9
        • Centre hosp affilié univ rég
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4P 0W5
        • Regina General Hospital
      • Saskatoon, Saskatchewan, Canada, S7N 0W8
        • Royal University Hospital
  • China
      • Guangzhou, China, 510515
        • Nanfang Hospital, Southern Medical University
      • Hangzhou, China, 310009
        • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
      • Hangzhou, China, 310030
        • Zhejiang Hospital, Zhejiang University School of Medicine
      • Harbin, China, 150001
        • The First Affiliated Hospital of Harbin Medical University
      • Nanjing, China, 210009
        • Zhongda Hospital, Southeast University
      • Shenyang, China, 110136
        • Shengjing Hospital of China Medical University
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100191
        • Peking University Third Hospital
      • Beijing, Beijing Municipality, China, 100029
        • China-Japan Friendship Hospital
      • Beijing, Beijing Municipality, China, 100029
        • Beijing AnZhen Hospital, Capital Medical University
      • Beijing, Beijing Municipality, China, 100034
        • Peking University First Hospital-Cardiology
      • Beijing, Beijing Municipality, China, 100037
        • Chinese Academy of Medical Sciences Fuwai Hospital
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400060
        • The Second Affiliated Hospital of Chongqing Medical University
    • Fujian
      • Fuzhou, Fujian, China, 350005
        • The First Affiliated Hospital of Fujian Medical University
    • Guangdong
      • Guangzhou, Guangdong, China, 510515
        • Nanfang Hospital, Southern Medical University
      • Guangzhou, Guangdong, China, 510080
        • Guangdong Provincial People's Hospital
    • Guangxi
      • Nanning, Guangxi, China, 530021
        • The People's Hospital of Guangxi Zhuang Autonomous Region
    • Hebei
      • Cangzhou, Hebei, China, 061001
        • Cangzhou Central Hospital
      • Shijiazhuang, Hebei, China, 050051
        • Hebei General Hospital
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150001
        • The First Affiliated Hospital of Harbin Medical University
    • Hubei
      • Wuhan, Hubei, China, 430060
        • Renmin Hospital of Wuhan University-Cardiology
      • Wuhan, Hubei, China, 430022
        • Union Hospital Tongji Medical College Huazhong University of Science and Technology-Cardiology
    • Hunan
      • Changsha, Hunan, China, 410008
        • Xiangya Hospital Central-South University
      • Changsha, Hunan, China, 410011
        • The Second Xiangya Hospital of Central South University
    • Jiangsu
      • Nanjing, Jiangsu, China, 210008
        • Nanjing Drum Tower Hospital
      • Nanjing, Jiangsu, China, 210009
        • Zhongda Hospital Southeast University
      • Nanjing, Jiangsu, China, 210011
        • The Second Affiliated Hospital of Nanjing Medical University
    • Jilin
      • Changchun, Jilin, China, 130033
        • China-Japan Union Hospital of Jilin University
      • Changchun, Jilin, China, 130033
        • China-Japan Union Hospital of Jilin University-Cardiology
    • Liaoning
      • Shenyang, Liaoning, China, 110016
        • The People's Hospital of Liaoning Province
      • Shenyang, Liaoning, China, 110136
        • Shengjing Hospital of China Medical University-Cardiology
      • Shenyang, Liaoning, China, 110016
        • The People's Hospital of Liaoning Province-Cardiology
    • Shaanxi
      • Xi'an, Shaanxi, China, 710061
        • The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
    • Shandong
      • Jinan, Shandong, China, 250013
        • Jinan Central Hospital
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200040
        • Huashan Hospital Fudan University
      • Shanghai, Shanghai Municipality, China, 200032
        • Zhongshan Hospital, Fudan University-Cardiology
    • Sichuan
      • Chengdu, Sichuan, China, 610044
        • West China Hospital Sichuan University-Cardiology
      • Chengdu, Sichuan, China, 610072
        • Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital; Affiliated Hospital of UESTC-Cardiology
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300122
        • Tianjin People's Hospital
      • Tianjin, Tianjin Municipality, China, 300457
        • Teda International Cardiovascular Hospital
      • Tianjin, Tianjin Municipality, China, 300052
        • Tianjin Medical University General Hospital-Endocrinology
      • Tianjin, Tianjin Municipality, China, 300457
        • TEDA International Cardiovascular Hospital-Cardiovascular
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
      • Hangzhou, Zhejiang, China, 310030
        • Zhejiang Hospital-Cardiology
      • Wenzhou, Zhejiang, China, 325000
        • The First Affiliated Hospital of WMU-Cardiology
      • Wenzhou, Zhejiang, China, 325000
        • The 1st Affiliated Hospital of WMU-Cardiology
  • Czechia
      • Brno, Czechia, 625 00
        • Fakultni nemocnice Brno
      • Brno, Czechia, 656 91
        • FN u Sv. Anny
      • Olomouc, Czechia, 779 00
        • Fakultni Nemocnice Olomouc
      • Pardubice, Czechia, 53203
        • Nemocnice Pardubickeho kraje a.s.
      • Plzen - Lochotín, Czechia, 323 00
        • Fakultni nemocnice Plzen - Lochotin
      • Prague, Czechia, 150 30
        • Nemocnice na Homolce
      • Prague, Czechia, 140 21
        • IKEM
      • Prague, Czechia, 100 00
        • Fakultni nemocnice Kralovske Vinohrady
      • Prague, Czechia, 128 08
        • II. interni klinika VFN - Kardiologie a angiologie
      • Třinec, Czechia, 739 61
        • Nemocnice AGEL Třinec-Podlesí a.s.
      • Zlín, Czechia, 762 75
        • Krajská nemocnice T.Bati a.s.
      • České Budějovice, Czechia, 370 01
        • Nemocnice Ceske Budejovice a.s.
    • Czech Republic
      • Liberec, Czech Republic, Czechia, 460 01
        • Krajská nemocice Liberec, a.s
    • Czechia
      • Ústní Nad Labem, Czechia, Czechia, 400 11
        • Krajská zdravotní, a.s. - Masarykova nemocnice v Ústí nad Labem, o.z.
  • Denmark
      • Aalborg, Denmark, 9000
        • Aalborg Universitetshospital Kardiologisk Afdeling
      • Aarhus N, Denmark, 8200
        • Aarhus Universitetshospital, Hjertesygdomme
      • Gistrup, Denmark, 9260
        • Aalborg Universitetshospital Hjertemedicinsk Afdeling
      • Hillerød, Denmark, 3400
        • Nordsjællands hospital - Kardiologisk Forskning
      • København Ø, Denmark, 2100
        • Rigshospitalet - Kardiologisk Forskningsenhed
      • Odense C, Denmark, 5000
        • Odense Universitetshospital, Kardiologisk afd.
      • Svendborg, Denmark, 5700
        • Svendborg Sygehus - Kardiologisk
    • Capital Region
      • Hellerup, Capital Region, Denmark, 2900
        • Herlev og Gentofte Hospital
  • France
      • Besançon, France, 25030
        • Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz
      • Bron, France, 69500
        • Hospices Civils de Lyon- Hopital Louis Pradel
      • Caen, France, 14033
        • Centre Hospitalier Universitaire de Caen Normandie- Cote de Nacre
      • Chambray-lès-Tours, France, 37170
        • Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau
      • Corbeil-Essonnes, France, 91100
        • Centre Hospitalier Sud Francilien
      • Grenoble, France, 38043
        • Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon
      • Le Coudray, France, 28630
        • Les Hopitaux de Chartres-Hopital Louis Pasteur
      • Lille, France, 59000
        • Centre Hospitalier Universitaire de Lille-Institut Coeur Poumon
      • Lyon, France, 69007
        • Centre Hospitalier Saint Joseph Saint Luc
      • Marseille, France, 13005
        • Assistance Publique Hopitaux de Marseille-Hopital de La Timone
      • Nice, France, 06000
        • Centre Hospitalier Universitaire de Nice-Hopital Pasteur
      • Paris, France, 75015
        • Ap-Hp-Hopital Europeen Georges Pompidou
      • Paris, France, 75877
        • Ap-Hp-Hopital Bichat-Claude Bernard
      • Paris, France, 75013
        • Aphp-Hopital La Pitie Salpetriere
      • Pessac, France, 33600
        • Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque
      • Poitiers, France, 86000
        • Centre Hospitalier Universitaire de Poitiers
      • Toulouse, France, 31059
        • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil
      • Toulouse, France, 31059
        • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1
      • Vandœuvre-lès-Nancy, France, 54500
        • Chru de Nancy - Hopital Brabois
  • Germany
      • Bad Berka, Germany, 99437
        • Rhön-Klinikum AG - Zentralklinik Bad Berka - Kardiologie
      • Berlin, Germany, 12203
        • Charité - Campus Benjamin Franklin - Klinik für Kardiologie
      • Berlin, Germany, 12683
        • BG Klinikum Unfallkrankenhaus Berlin GmbH - Klinik für Kardiologie
      • Bielefeld, Germany, 33604
        • Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin
      • Bremen, Germany, 28277
        • Bremer Institut für Herz- und Kreislaufforschung (BIHKF)
      • Cologne, Germany, 50733
        • Cellitinnen-Krankenhaus St. Vinzenz Köln - Kardiologie
      • Dachau, Germany, 85221
        • Amper Kliniken AG - Helios Amper-Klinikum Dachau - Kardiologie
      • Dortmund, Germany, 44137
        • Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie
      • Dresden, Germany, 01307
        • Uniklinik TU Dresden - Herzzentrum Dresden GmbH
      • Dresden, Germany, 01067
        • Städt. Klinikum Dresden - 2. Medizinische Klinik
      • Düsseldorf, Germany, 40225
        • Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie
      • Erfurt, Germany, 99089
        • Helios Klinikum Erfurt GmbH - 3. Med. Klinik - Kardiologie
      • Frankfurt, Germany, 60389
        • MVZ CCB Frankfurt und Main-Taunus GbR
      • Frankfurt am Main, Germany, 60596
        • Universitätsklinikum Frankfurt aM - Kardiologie
      • Freiburg im Breisgau, Germany, 79106
        • Universitätsklinikum Freiburg - Medical Center
      • Friedrichshafen, Germany, 88048
        • Klinikum Friedrichshafen GmbH - Klinik für Kardiologie, Angiologie, Pneumologie und internistische Intensivmedizin
      • Fulda, Germany, 36043
        • Klinikum Fulda gAG - Med. Klinik I
      • Hamburg, Germany, 20246
        • Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf
      • Hanover, Germany, 30625
        • Medizinische Hochschule Hannover - Kardiologie und Angiologie
      • Heidelberg, Germany, 69120
        • UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie
      • Langen, Germany, 63225
        • Asklepios Klinik Langen - Medizinische Klinik I
      • Leipzig, Germany, 04103
        • Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie
      • Leverkusen, Germany, 51375
        • Klinikum Leverkusen gGmbH - Med. Klinik 1
      • Mannheim, Germany, 68167
        • Universitätsklinikum Mannheim - 1. Medizinische Klinik
      • München, Germany, 80636
        • Deutsches Herzzentrum TU München - Klinik für Herz- und Kreislauferkrankungen
      • Regensburg, Germany, 93053
        • Uniklinik Regensburg - Innere Medizin II
      • Stuttgart, Germany, 70376
        • Robert-Bosch-Krankenhaus GmbH Stuttgart
      • Tübingen, Germany, 72076
        • Uniklinik Tübingen - Innere Med. III Kardiologie und Angiologie
  • Greece
      • Ampelokipoi/Athens, Greece, 11522
        • General Hospital of Athens "Elpis" - Cardiology Department
      • Athens, Greece, 11526
        • Henry Dunant Hospital Center
      • Athens, Greece, 11528
        • Alexandra General Hospital, Therapeutic Clinic
      • Athens, Greece, 10676
        • Evangelismos Hospital
      • Athens, Greece, 11527
        • Hippokration Hospital
      • Athens, Greece, 10676
        • G.H. of Athens "Evaggelismos"
      • Athens, Greece, 11527
        • "Sotiria" Thoracic Diseases Hospital of Athens
      • Athens, Greece, 11527
        • 'G. Gennimatas' General Hospital of Athens
      • Athens, Greece, 14233
        • Konstantopouleio G.H. of Athens, "Agia Olga"
      • Athens, Greece, 15123
        • "Hygeia" General Hospital of Athens
      • Athens, Greece, 11527
        • Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
      • Athens, Greece, 11527
        • 'G. Gennimatas' General Hospital of Athens - Cardiology Department
      • Athens, Greece, 15562
        • Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic
      • Athens, Greece, 115 21
        • NIMTS Army Share Fund Hospital
      • Athens, Greece, 11521
        • Group Euroclinic - Athens Euroclinic - Cardiology Department
      • Athens/Voula, Greece, 16673
        • Asklepieion General Hospital - Cardiology Clinic
      • Chaidari, Athens, Greece, 12462
        • U.G.H of Athens "Attikon"
      • Chios, Greece, 82100
        • General Hospital of Chios "Skilitsio" - Cardiology Clinic
      • Eleusina, Greece, 19018
        • General Hospital Of Eleusina Thriasio - Cardiology Clinic
      • Goudi/Athens, Greece, 115 27
        • General Hospital of Athens "Laiko"
      • Ioannina, Greece, GR-455 00
        • University General Hospital of Ioannina,Internal Medicine
      • Ioannina, Greece, 455 00
        • University General Hospital of Ioannina,Internal Medicine
      • Kifissia, Greece, 14561
        • Kat Attica General Hospital - Cardiology Department
      • Marousi, Greece, 151 26
        • Sismanogleio General Hospital - Cardiology Department
      • Piraeus, Greece, 18536
        • Geniko Nosokomeio Peiraia Tzaneio - Cardiology department
      • Pátrai, Greece, 265 00
        • General Hospital Of Patras Agios Andreas - Cardiology Department
      • Thessaloniki, Greece, 54636
        • "AHEPA" University General Hospital of Thessaloniki
      • Thessaloniki, Greece, 546 39
        • Interbalkan Medical Center of Thessaloniki
      • Thessaloniki, Greece, 57010
        • Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt
      • Tripoli, Greece, 22100
        • Pan-Arcadian General Hospital of Tripoli Evangelistria - Cardiology Department
      • Véroia, Greece, 59132
        • General Hospital of Imathia Monada Veria - Cardiology Department
      • Véroia, Greece, 59132
        • General Hospital of Imathia Monada Veria
    • Greece
      • Larissa/Thessaly, Greece, Greece, 41110
        • Univ Gen Hospital Larisa, Cardiology Medicine Clinic
    • Thessaloniki
      • Nea Efkarpia, Thessaloniki, Greece, 56429
        • General Hospital Of Thessaloniki Papageorgiou
  • India
      • Chandigarh, India, 160012
        • Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
      • New Delhi, India, 110075
        • Aakash Healthcare Super Speciality Hospital
    • Andhra Pradesh
      • Guntur, Andhra Pradesh, India, 522001
        • Lalitha PVS Institute of Medical Sciences
      • Visakhapatnam, Andhra Pradesh, India, 530002
        • King George Hospital
      • Visakhapatnam, Andhra Pradesh, India, 530017
        • Medicover Hospitals, Visakhapatnam MVP
    • Chhattisgarh
      • Raipur, Chhattisgarh, India, 492007
        • SMC Heart Institute and IVF Research Centre
    • Gujarat
      • Ahmedabad, Gujarat, India, 380006
        • Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
      • Ahmedabad, Gujarat, India, 380060
        • Marengo CIMS Hospital
      • Surat, Gujarat, India, 395001
        • Shri B. D. Mehta Mahavir Heart Institute
      • Vadodara, Gujarat, India, 390022
        • Rhythm Heart Institute
      • Vadodara, Gujarat, India, 390 007
        • Sterling Hospitals, Race Course Road
    • Karnataka
      • Bengaluru, Karnataka, India, 560054
        • Ramaiah Memorial Hospital
      • Bengaluru, Karnataka, India, 560069
        • Sri Jayadeva Institute of Cardiovascular Sciences & Research
      • Mangaluru, Karnataka, India, 575018
        • Justice K S Hegde Charitable Hospital
      • Udupi, Karnataka, India, 576104
        • Kasturba Medical College and Hospital, Manipal
    • Kerala
      • Kochi, Kerala, India, 682018
        • Lisie Hospital
      • Palakkad, Kerala, India, 678013
        • Lakshmi Hospital
    • Maharashtra
      • Mumbai, Maharashtra, India, 400012
        • Seth GS Medical College & KEM Hospital
      • Nagpur, Maharashtra, India, 440012
        • Shri Krishna Hrudayalaya & Critical Care Centre
      • Nagpur, Maharashtra, India, 440010
        • Arneja Heart & Multispeciality Hospital
      • Nagpur, Maharashtra, India, 440015
        • Central India Cardiology Hospital and Research Institute
      • Nagpur, Maharashtra, India, 441108
        • All India Institute of Medical Sciences (AIIMS), Nagpur
      • Nashik, Maharashtra, India, 422005
        • Vijan Hospital & Research Centre
      • Nashik, Maharashtra, India, 422005
        • Chopda Medicare and Research Centre Pvt. Ltd.
      • Pune, Maharashtra, India, 411004
        • Deenanath Mangeshkar Hospital & Research Centre
      • Pune, Maharashtra, India, 411004
        • Sahyadri Super Speciality Hospital
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110017
        • Max Super Speciality Hospital, Saket
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • All India Institute of Medical Sciences (AIIMS)
      • New Delhi, National Capital Territory of Delhi, India, 110060
        • Sir Ganga Ram Hospital
      • New Delhi, National Capital Territory of Delhi, India, 110002
        • G B Pant Institute of Postgraduate Medical Education and Research
      • New Delhi, National Capital Territory of Delhi, India, 110062
        • Batra Hospital and Medical Research Center
      • New Delhi, National Capital Territory of Delhi, India, 110025
        • Fortis Escorts Heart Institute, New Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Vardhaman Mahavir Medical College & Safdarjung Hospital
      • New Delhi, National Capital Territory of Delhi, India, 110001
        • Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
      • New Delhi, National Capital Territory of Delhi, India, 110076
        • Indraprastha Apollo Hospital, New Delhi
    • Odisha
      • Bhubaneswar, Odisha, India, 751019
        • All India Institute of Medical Sciences (AIIMS), Bhubaneswar
      • Cuttack, Odisha, India, 753007
        • SCB Medical College and Hospital
    • Punjab
      • Ludhiana, Punjab, India, 141001
        • Dayanand Medical College & Hospital
      • Mohali, Punjab, India, 160062
        • Fortis Hospital, Mohali
    • Rajasthan
      • Bikaner, Rajasthan, India, 334003
        • S.P. Medical College & Associated Group of Hospitals
      • Jaipur, Rajasthan, India, 302004
        • SMS Medical College & Attached Hospitals
    • Tamil Nadu
      • Chennai, Tamil Nadu, India, 600037
        • The Madras Medical Mission
      • Chennai, Tamil Nadu, India, 600116
        • Sri Ramachandra Medical Centre
      • Coimbatore, Tamil Nadu, India, 641037
        • G. Kuppuswamy Naidu Memorial Hospital
      • Puducherry, Tamil Nadu, India, 605006
        • Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
    • Telangana
      • Hyderabad, Telangana, India, 500012
        • Osmania General Hospital
      • Hyderabad, Telangana, India, 500038
        • ESIC Medical College and Hospital, Hyderabad
      • Hyderabad, Telangana, India, 500055
        • Malla Reddy Narayana Multispeciality Hospital
    • Uttar Pradesh
      • Aligarh, Uttar Pradesh, India, 202002
        • Jawaharlal Nehru Medical College and Hospital
      • Kanpur, Uttar Pradesh, India, 208002
        • Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College
      • Lucknow, Uttar Pradesh, India, 226014
        • Sanjay Gandhi Postgraduate Institute of Medical Sciences
      • Lucknow, Uttar Pradesh, India, 226003
        • King George's Medical University (KGMU)
      • Lucknow, Uttar Pradesh, India, 226010
        • Dr. Ram Manohar Lohia Institute of Medical Sciences
    • Uttarakhand
      • Dehradun, Uttarakhand, India, 248001
        • Shri Mahant Indiresh Hospital
    • West
      • Kolkata, West, India, 700014
        • Nil Ratan Sircar Medical College and Hospital
    • West Bengal
      • Kolkata, West Bengal, India, 700073
        • Medical College & Hospital, Kolkata
      • Kolkata, West Bengal, India, 700054
        • Apollo Multispeciality Hospital, Kolkata
      • Kolkata, West Bengal, India, 700027
        • B M Birla Heart Research Centre
  • Israel
      • Beer Yaakov, Israel, 7033001
        • Shamir MC - Cardiology Department
      • Hadera, Israel, 3810101
        • Hillel Yaffe MC - Cardiology Department
      • Haifa, Israel, 3109601
        • Rambam MC - Cardiac Intensive Care Unit
      • Holon, Israel, 58100
        • Wolfson MC - The Heart Institute
      • Jerusalem, Israel, 91120
        • Hadassah Ein Karam MC - Cardio Department
      • Jerusalem, Israel, 9765422
        • Hadassah Mount Scorpus MC - Cardiology department
      • Kfar Saba, Israel, 4428164
        • Meir MC - Cardiology department
      • Petah Tikva, Israel, 4941492
        • Rabin MC -Beilinson - Cardiac intensive unit
      • Rehovot, Israel, 7661041
        • Kaplan MC - Cardiac Intensive Care
      • Tel Aviv, Israel, 6423906
        • Sourasky MC - Cardio Vascular Research Center
      • Tel Litwinsky, Israel, 5265601
        • Sheba MC - Cardiology Clinical Research Unit
  • Italy
      • Acquaviva delle Fonti, Italy, 70021
        • Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC
      • Alessandria, Italy, 15121
        • Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo
      • Bologna, Italy, 40133
        • Ospedale Maggiore Carlo Alberto Pizzardi
      • Catanzaro, Italy, 88100
        • Azienda Ospedaliero-Universitaria Renato Dulbecco
      • Cosenza, Italy, 87100
        • Ospedale Civile dell'Annunziata
      • Florence, Italy, 50134
        • Azienda Ospedaliera Universitaria Careggi
      • Genova, Italy, 16132
        • Ospedale Policlinico San Martino
      • Grosseto, Italy, 58100
        • AUSL Toscana Sud Est - Ospedale Misericordia Grosseto
      • La Spezia, Italy, 19124
        • Ospedale Sant'Andrea - UOC Cardiologia
      • Latina, Italy, 04100
        • ICOT Istituto Marco Pasquali - UOC Cardiologia
      • Milan, Italy, 20162
        • Grande Ospedale Metropolitano Niguarda
      • Monza, Italy, 20900
        • Fondazione IRCCS San Gerardo dei Tintori
      • Naples, Italy, 80131
        • Azienda Ospedaliera Universitaria Federico II di Napoli
      • Naples, Italy, 80131
        • Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
      • Novara, Italy, 28100
        • Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara
      • Novara, Italy, 28100
        • AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia
      • Parma, Italy, 43126
        • Azienda Ospedaliera di Parma
      • Pavia, Italy, 27100
        • Fondazione IRCCS Policlinico San Matteo
      • Piacenza, Italy, 29121
        • Azienda Unità Sanitaria Locale Di Piacenza - Cardiologia
      • Reggio Emilia, Italy, 42123
        • Arcispedale S Maria Nuova Azienda ULSS-IRCCS
      • Rimini, Italy, 47923
        • AUSL Romagna - Distretto Rimini - Ospedale Infermi
      • Rome, Italy, 00168
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
      • Rome, Italy, 00189
        • Azienda ospedaliero - Universitaria Sant'Andrea
      • Rome, Italy, 00168
        • Fondazione Policlinico Universitario Agostino Gemelli IRCS
      • Rome, Italy, 00157
        • Ospedale Sandro Pertini - UOC Cardiologia
      • Rome, Italy, 00169
        • Policlinico Casilino - Cardiologia e UTIC
      • Rome, Italy, 00186
        • Ospedale Isola Tiberina Gemelli Isola
      • Torino, Italy, 10126
        • A.O.U Città della Salute e della Scienza di Torino
      • Verona, Italy, 37126
        • AOUI Verona
    • Abruzzo
      • Chieti, Abruzzo, Italy, 66100
        • Ss. Annunziata
    • Ce
      • Caserta, Ce, Italy, 81100
        • AORN "Sant'Anna e San Sebastiano"
    • Fe
      • Cona (Ferrara), Fe, Italy, 44124
        • A.O.U. Ferrara, Sant'Anna
    • Lazio
      • Latina, Lazio, Italy, 04100
        • ICOT Istituto Marco Pasquali - UOC Cardiologia
    • Lombardy
      • Bergamo, Lombardy, Italy, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
    • MI
      • San Donato Milanese, MI, Italy, 20097
        • IRCCS Policlinico San Donato
    • PN
      • Pordenone, PN, Italy, 33170
        • Azienda Ospedaliera Santa Maria Degli Angeli
      • Pordenone, PN, Italy, 33170
        • Azienda Sanitaria Friuli Occidentale - Azienda Ospedaliera Santa Maria Degli Angeli - SC Cardiologia Pordenone
    • Piedmont
      • Turin, Piedmont, Italy, 10126
        • A.O.U Città della Salute e della Scienza di Torino
    • To
      • Rivoli, To, Italy, 10098
        • Presidio Ospedaliero di Rivoli
      • Torino, To, Italy, 10128
        • Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia
  • Japan
      • Aichi, Japan, 470-1192
        • Fujita Health University Hospital_Cardiology
      • Chiba, Japan, 289-2511
        • Asahi General Hospital_Cardiology
      • Chiba, Japan, 285-8741
        • Toho University Sakura Medical Center_Cardiology
      • Ehime, Japan, 790-8524
        • Matsuyama Red Cross Hospital_Department of Cardiovascular Medicine
      • Ehime, Japan, 790-0024
        • Ehime Prefectural Central Hosp
      • Fukuoka, Japan, 815-8555
        • Japanese Red Cross Fukuoka Hospital_Cardiology
      • Fukuoka, Japan, 830-8543
        • St.Mary's Hospital_Cardiology & Cardiovascular Disease Management
      • Fukuoka-shi, Fukuoka, Japan, 814-0133
        • Fukuoka University Hospital_Cardiology
      • Himeji-shi, Hyogo, Japan, 670-8560
        • Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
      • Hokkaido, Japan, 062-0003
        • Hanaoka Seishu Memorial Hospital
      • Hokkaido, Japan, 062-0003
        • Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine
      • Hyōgo, Japan, 662-0911
        • Nishinomiya Watanabe Cardiovascular Cerebral Center_Cardiovascular Medicine
      • Hyōgo, Japan, 663-8501
        • Hyogo Medical University Hospital_Cardiovascular Medicine
      • Ibaraki, Japan, 300-0028
        • Tsuchiura Kyodo General Hospital_Internal Medicine
      • Ibaraki, Japan, 311-4198
        • Mito Saiseikai General Hospital_Cardiology
      • Ishikawa, Japan, 920-8530
        • Ishikawa Prefectural Central Hospital_Cardiology
      • Kanagawa, Japan, 236-0004
        • Yokohama City University Hospital
      • Kanagawa, Japan, 211-8510
        • Kanto Rosai Hospital_Cardiology
      • Kanagawa, Japan, 221-0855
        • Yokohama Municipal Citizen's Hospital_Cardiology
      • Kanagawa, Japan, 230-8765
        • Saiseikai Yokohamashi Tobu Hospital_Cardiology
      • Kanagawa, Japan, 232-0024
        • Yokohama City University Medical Center_Cardiovascular Center
      • Kanagawa, Japan, 259-1193
        • Tokai University Hospital_Cardiology
      • Kumamoto, Japan, 860-0008
        • National Hospital Organization Kumamoto Medical Center_Cardiology
      • Kure-shi, Hiroshima, Japan, 737-0023
        • NHO Kure Medical Center and Chugoku Cancer Center
      • Kure-shi, Hiroshima, Japan, 737-0023
        • NHO Kure Medical Center and Chugoku Cancer Center_Cardiology
      • Okayama, Japan, 700-0804
        • The Sakakibara Heart Institute of Okayama_Department of Cardiovascular Medicine
      • Osaka, Japan, 558-8558
        • Osaka General Medical Center_Cardiology
      • Osaka, Japan, 579-8026
        • Ishikiriseiki Hospital_Circulatory Medicine
      • Sendai-shi, Miyagi, Japan, 980-8574
        • Tohoku University Hospital, Cardiovascular
      • Shiga, Japan, 520-2192
        • Shiga University of Medical Science Hospital_Cardiology
      • Shizuoka, Japan, 410-2295
        • Juntendo University Shizuoka Hospital
      • Shizuoka, Japan, 410-2295
        • Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology
      • Takamatsu-shi, Kagawa, Japan, 760-8557
        • Kagawa Prefectural Central Hospital_Cardiovascular Medicine
      • Tokushima, Japan, 770-8539
        • Tokushima Prefectural Central Hospital_Cardiology
      • Tokyo, Japan, 173-8606
        • Teikyo University Hospital_Cardiology
      • Tsukuba-shi, Ibaraki, Japan, 305-8558
        • Tsukuba Medical Center Hospital_Department of Cardiology
      • Yokohama-shi, Kanagawa, Japan, 234-0054
        • Saiseikai Yokohamashi Nanbu Hospital_Cardiology
    • Miyazaki
      • Miyazaki, Miyazaki, Japan, 880-2102
        • Miyazaki Medical Association Hospital
      • Miyazaki, Miyazaki, Japan, 880-2102
        • Miyazaki Medical Association Hospital_Cardiology
  • Malaysia
      • Kota Bharu, Kelantan, Malaysia, 16150
        • Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan
      • Kuala Lumpur, Malaysia, 56000
        • Hospital Universiti Kebangsaan Malaysia
      • Kuala Lumpur, Malaysia, 50400
        • National Heart Institute
      • Sabak Bernam, Malaysia, 88300
        • Hospital Queen Elizabeth II
    • Johor
      • Johor Bahru, Johor, Malaysia, 80100
        • Hospital Sultanah Aminah
    • Kedah
      • Alor Star, Kedah, Malaysia, 05460
        • Hospital Sultanah Bahiyah
    • Kelantan
      • Kota Bharu, Kelantan, Malaysia, 15586
        • Hospital Raja Perempuan Zainab II
    • Kuala Lumpur
      • Cheras, Kuala Lumpur, Malaysia, 56000
        • Hospital Canselor Tuanku Muhriz UKM
      • Lembah Pantai, Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
    • Pahang
      • Kuantan, Pahang, Malaysia, 25100
        • Hospital Tengku Ampuan Afzan
      • Kuantan, Pahang, Malaysia, 25200
        • Sultan Ahmad Shah Medical Centre @IIUM
    • Perak
      • Ipoh, Perak, Malaysia, 30450
        • Hospital Raja Permaisuri Bainun Ipoh
    • Pulau Pinang
      • George Town, Pulau Pinang, Malaysia, 10990
        • Hospital Pulau Pinang
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Sarawak Heart Centre
    • Selangor
      • Kajang, Selangor, Malaysia, 43000
        • Hospital Serdang
      • Sungai Buloh, Selangor, Malaysia, 47000
        • Universiti Teknologi MARA, Sungai Buloh Campus
  • Mexico
      • Ciudad de México, D.F., Mexico, 07760
        • Hospital Juarez de Mexico
      • Mexico City, Mexico, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
      • Mexico City, Mexico, 06720
        • Centro Médico Nacional Siglo XXI
      • Querétaro, Mexico, 76000
        • Centro de Estudios Clínicos de Querétaro S.C.
      • San Luis Potosí City, Mexico, 44340
        • Centro de Atención e Investigación Cardiovascular del Potosi (CICAP)
      • San Luis Potosí City, Mexico, 44340
        • Centro de atención e investigación cardiovascular del Potosí
      • San Nicolás de los Garza, Mexico, 66450
        • Servicios Integrales Nova de Monterrey
    • Aguascalientes
      • Aguascalientes, Aguascalientes, Mexico, 20230
        • Hospital Cardiologica Aguascalientes
    • Coahuila
      • Torreón, Coahuila, Mexico, 27000
        • Unidad Medica de Alta Especialidad No. 71 IMSS
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44280
        • Hospital Civil de Guadalajara Fray Antonio Alcalde
      • Guadalajara, Jalisco, Mexico, 44340
        • Nuevo Hospital Civil "Dr. Juan I. Menchaca"
    • La Magdalena Contreras
      • México, La Magdalena Contreras, Mexico, 10700
        • Centro de Imagen y Tecnologia en Intervención Cardiovascular
    • Mexico City
      • Tlalpan, Mexico City, Mexico, 14080
        • Instituto Nacional de Ciencias Médicas y Nutrición
    • México, D.F.
      • Cuauhtémoc, México, D.F., Mexico, 06720
        • Hospital General de México (HGM)
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64460
        • Hospital Universitario Dr. Jose Eleuterio González
      • Monterrey, Nuevo León, Mexico, 64360
        • UMAE Hospital IMSS
    • Sinaloa
      • Culiacán, Sinaloa, Mexico, 80020
        • Hospital Angeles de Culiacan
    • Sonora
      • Hermosillo, Sonora, Mexico, 83280
        • Hermosillo Heart Team
    • State of Mexico
      • México, State of Mexico, Mexico, 52763
        • Hospital Angeles de las Lomas
    • Veracruz
      • Xalapa, Veracruz, Mexico, 91193
        • Hospital Angeles de Xalapa
  • Netherlands
      • 's-Hertogenbosch, Netherlands, 5223 GZ
        • Jeroen Bosch Zkh
      • Alkmaar, Netherlands, 1815 JD
        • Noordwest Ziekenhuisgroep
      • Amersfoort, Netherlands, 3813 TZ
        • Meander MC
      • Amsterdam, Netherlands, 1091 AC
        • OLVG
      • Arnhem, Netherlands, 6815 AD
        • Rijnstate Ziekenhuis
      • Breda, Netherlands, 4818 CK
        • Amphia Ziekenhuis
      • Eindhoven, Netherlands, 5623 EJ
        • Catharina Zkh Eindhoven
      • Enschede, Netherlands, 7512 KZ
        • Medisch Spectrum Twente - Cardiologie
      • Gouda, Netherlands, 2803HH
        • Groene Hart Zkh Gouda
      • Groningen, Netherlands, 9713 GZ
        • UMC Groningen
      • Hilversum, Netherlands, 1212 VG
        • Tergooi, Hilversum
      • Nijmegen, Netherlands, 6525 GA
        • Radboudumc
      • Nijmegen, Netherlands, 6532 SZ
        • Canisius-Wilhelmina Ziekenhuis
      • Roosendaal, Netherlands, 4708 AE
        • Bravis Zkh Roosendaal
      • Rotterdam, Netherlands, 3083 AN
        • Ikazia Ziekenhuis
      • Rotterdam, Netherlands, 3079 DZ
        • Maasstad Ziekenhuis - Cardiologie
      • The Hague, Netherlands, 2512 VA
        • HMC, locatie Westeinde
      • Tilburg, Netherlands, 5042 AD
        • ETZ TweeSteden - Cardiologie
  • Poland
      • Bialystok, Poland, 15-276
        • Uniwersytecki Szpital Kliniczny w Bialymstoku
      • Biała Podlaska, Poland, 21-500
        • Wojewodzki Szpital Specjalistyczny w Bialej Podlaskiej
      • Bielsko-Biala, Poland, 43-316
        • American Heart of Poland S.A.
      • Bydgoszcz, Poland, 85-681
        • 10 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Bydgoszczy
      • Bydgoszcz, Poland, 85-168
        • Szpital Uniwersytecki Nr 2 im. Dr. Jana Biziela
      • Częstochowa, Poland, 42-202
        • Wojewodzki Szpital Specjalistyczny im. NMP w Czestochowie
      • Częstochowa, Poland, 42-217
        • SCANMED Spółka Akcyjna
      • Elblag, Poland, 82-300
        • Wojewodzki Szpital Zespolony W Elblagu samodzielny publiczny zakład opieki zdrowotnej
      • Gdansk, Poland, 80-214
        • Uniwersyteckie Centrum Kliniczne (Uck)
      • Gdansk, Poland, 80-462
        • COPERNICUS Podmiot Leczniczy Sp. z o.o.
      • Grodzisk Mazowiecki, Poland, 05-825
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
      • Kluczbork, Poland, 46-200
        • SCANMED Spółka Akcyjna
      • Konin, Poland, 62-504
        • Wojewodzki Szpital Zespolony im. dr. Romana Ostrzyckiego w Koninie
      • Krakow, Poland, 30-688
        • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
      • Krosno, Poland, 38-400
        • Intercard Spolka z ograniczona odpowiedzialnoscia
      • Kutno, Poland, 99-300
        • SCANMED Spółka Akcyjna
      • Kędzierzyn-Koźle, Poland, 47-200
        • American Heart of Poland S.A.
      • Lodz, Poland, 91-347
        • Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego,
      • Lodz, Poland, 90-549
        • Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi
      • Lodz, Poland, 90-549
        • Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Łodzi
      • Lubin, Poland, 59301
        • Miedziowe Centrum Zdrowia s.a.
      • Lublin, Poland, 20-049
        • 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
      • Nowy Targ, Poland, 34-400
        • Podhalanski Szpital Specjalistyczny
      • Opole, Poland, 45-401
        • Uniwersytecki Szpital Kliniczny w Opolu
      • Ostrów Mazowiecka, Poland, 07-300
        • Samodzielny Publiczny Zespół Zakładów Opieki Zdrowotnej w Ostrowi Mazowieckiej
      • Pińczów, Poland, 28400
        • Intercard Spolka z ograniczona odpowiedzialnoscia
      • Poznan, Poland, 61-848
        • Uniwersytecki Szpital Kliniczny W Poznaniu
      • Poznan, Poland, 60-335
        • Uniwersytecki Szpital Kliniczny W Poznaniu
      • Przemyśl, Poland, 37-700
        • Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
      • Swidnica, Poland, 58100
        • Samodzielny Publiczny Zespol Opieki Zdrowotnej w Swidnicy
      • Szczecin, Poland, 70-111
        • Uniwersytecki Szpital Kliniczny Nr 2 Pum W Szczecinie
      • Tarnów, Poland, 33-100
        • Specjalistyczny Szpital Im. E. Szczeklika W Tarnowie
      • Torun, Poland, 87-100
        • Specjalistyczny Szpital Miejski im. M.Kopernika w Toruniu
      • Warsaw, Poland, 04-628
        • Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
      • Warsaw, Poland, 00-685
        • Śródmiejskie Centrum Kliniczne,II Oddział Kardiologii MSB, Klinika Chorób Serca CMKP
      • Warsaw, Poland, 01-211
        • Szpital Wolski im. dr Anny Gostynskiej Sp. z o.o.
      • Warsaw, Poland, 02-097
        • Uniwersyteckie Centrum Kliniczne WUM
      • Warsaw, Poland, 04-073
        • Szpital Grochowski im. dr med. Rafala Masztaka Sp. z o.o.
      • Warsaw, Poland, 04-073
        • Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.
      • Wroclaw, Poland, 51-124
        • Wojewodzki Szpital Specjalistyczny We Wroclawiu
      • Wroclaw, Poland, 54-049
        • Dolnoslaski Szpital Specjalistyczny Im. T.Marciniaka-Centrum Medycyny Ratunkowej
      • Zgierz, Poland, 95100
        • American Heart of Poland S.A.
    • Greater Poland Voivodeship
      • Ostrów Wielkopolski, Greater Poland Voivodeship, Poland, 63-400
        • Zespol Zakladow Opieki Zdrowotnej w Ostrowie Wielkopolskim
      • Ostrów Wielkopolski, Greater Poland Voivodeship, Poland, 63-400
        • Zespół Zakładów Opieki Zdrowotnej w Ostrowie Wielkopolskim
    • Lesser Poland Voivodeship
      • Chrzanów, Lesser Poland Voivodeship, Poland, 32-500
        • American Heart of Poland S.A.
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 50-981
        • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
    • Lublin Voivodeship
      • Puławy, Lublin Voivodeship, Poland, 24-100
        • Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach
    • Podkarpackie Voivodeship
      • Rzeszów, Podkarpackie Voivodeship, Poland, 35-301
        • Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie
      • Rzeszów, Podkarpackie Voivodeship, Poland, 35-111
        • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie
    • Pomeranian Voivodeship
      • Gdynia, Pomeranian Voivodeship, Poland, 81-348
        • Szpitale Pomorskie Sp. z o.o.
    • Silesian Voivodeship
      • Dąbrowa Górnicza, Silesian Voivodeship, Poland, 41-300
        • American Heart of Poland S.A.
      • Gliwice, Silesian Voivodeship, Poland, 44-100
        • Szpital Miejski Nr 4 w Gliwicach Sp. z o.o., Oddzial Kardiologii
      • Tychy, Silesian Voivodeship, Poland, 43-100
        • American Heart of Poland S.A.
  • South Korea
      • Busan, South Korea, 48108
        • Inje University Haeundae Paik Hospital
      • Cheongju-si, South Korea, 28644
        • Chungbuk National University Hospital
      • Daegu, South Korea, 42601
        • Keimyung University Dongsan Hospital
      • Daegu, South Korea, 41944
        • Kyungpook National University Hospital
      • Daejeon, South Korea, 35015
        • Chungnam National University Hospital
      • Gangwon-do, South Korea, 26426
        • Wonju Severance Christian Hospital
      • Gwangju, South Korea, 61469
        • Chonnam National University Hospital
      • Incheon, South Korea, 21565
        • Gachon University Gil Medical Center
      • Incheon, South Korea, 22332
        • Inha University Hospital
      • Sejong-si, South Korea, 30099
        • Chungnam National University Sejong Hospital
      • Seoul, South Korea, 03080
        • Seoul National University Hospital
      • Seoul, South Korea, 05505
        • Asan Medical Center
      • Seoul, South Korea, 03722
        • Severance Hospital, Yonsei University Health System
      • Seoul, South Korea, 05278
        • Kyung Hee University Hospital at Gangdong
      • Seoul, South Korea, 06591
        • The Catholic University of Korea, Seoul St. Mary's Hospital
      • Seoul, South Korea, 02841
        • Korea University Anam Hospital
      • Seoul, South Korea, 08308
        • Korea University Guro Hospital
      • Seoul, South Korea, 04763
        • Hanyang University Seoul Hospital
      • Seoul, South Korea, 02447
        • Kyunghee University Medical Center
      • Seoul, South Korea, 07804
        • Ewha Womans University Seoul Hospital
      • Yangsan, South Korea, 50612
        • Pusan National University Yangsan Hospital
    • Gyeonggi-do
      • Bucheon-si, Gyeonggi-do, South Korea, 14647
        • The Catholic University of Korea, Bucheon St. Mary's Hospital
      • Goyang-si, Gyeonggi-do, South Korea, 10475
        • MyongJi Hospital
      • Seongnam-si, Gyeonggi-do, South Korea, 13620
        • Seoul National University Bundang Hospital
      • Suwon, Gyeonggi-do, South Korea, 16499
        • Ajou University Hospital
    • Gyeongsangnam-do
      • Yangsan, Gyeongsangnam-do, South Korea, 50612
        • Pusan National University Yangsan Hospital
  • Spain
      • A Coruña, Spain, 15006
        • Complejo Hospitalario Universitario A Coruña
      • Alicante, Spain, 03010
        • Hospital General Universitario Dr. Balmis
      • Alicante, Spain, 03010
        • Hospital Gral Alicante Dr. Balmis
      • Badalona, Spain, 08907
        • Bellvitge Universitary Hospital
      • Barcelona, Spain, 08003
        • Hospital Del Mar
      • Barcelona, Spain, 08036
        • Hospital Clinic I Provincial
      • Barcelona, Spain, 08041
        • Hospital de La Santa Creu i Sant Pau
      • Lleida, Spain, 25198
        • Hospital de Lleida "Arnau de Vilanova"
      • Madrid, Spain, 28009
        • Hospital Gregorio Marañón
      • Madrid, Spain, 28040
        • Hospital Clinico San Carlos
      • Madrid, Spain, 28046
        • Hospital Universitario La Paz
      • Madrid, Spain, 28006
        • Hospital Universitario de La Princesa
      • Madrid, Spain, 28034
        • Hospital Ramon y Cajal
      • Santander, Spain, 39008
        • Hospital Universitario Marqués de Valdecilla
      • Santiago de Compostela, Spain, 15706
        • Hospital Clínico de Santiago
      • Seville, Spain, 41013
        • Hospital Universitario Virgen del Rocío
      • Tarragona, Spain, 43005
        • Hospital Universitari Joan XXIII
      • Valencia, Spain, 46010
        • Hospital Clínico Universitario de Valencia
      • Valladolid, Spain, 47003
        • Hospital Clínico Universitario de Valladolid
      • Vigo, Spain, 36312
        • Hospital Álvaro Cunqueiro de Vigo
    • Barcelona
      • Badalona, Barcelona, Spain, 08916
        • Hospital Germans Trías i Pujol
    • Malaga
      • Málaga, Malaga, Spain, 29010
        • H. Clinico Univ. Virgen de la Victoria
    • Murcia
      • El Palmar, Murcia, Spain, 30120
        • Hospital Virgen de la Arrixaca
      • El Palmar, Murcia, Spain, 30120
        • Hospital Univ. Virgen de la Arrixaca
  • Turkey (Türkiye)
      • Afyonkarahisar, Turkey (Türkiye), 03200
        • Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Bilkent Şehir Hastanesi-Kardiyoloji
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Sehir Hastanesi Cardiology
      • Antalya, Turkey (Türkiye), 07059
        • Akdeniz Üniversitesi Hastanesi-Kardiyoloji
      • Bursa, Turkey (Türkiye), 16310
        • Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji
      • Bursa, Turkey (Türkiye), 16110
        • Bursa Şehir Hastanesi- Kardiyoloji
      • Edirne, Turkey (Türkiye), 22030
        • Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
      • Istanbul, Turkey (Türkiye), 34098
        • Cerrahpaşa Kardiyoloji Enstitüsü
      • Istanbul, Turkey (Türkiye), 34668
        • Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
      • Istanbul, Turkey (Türkiye), 34854
        • Marmara University Medical Faculty
      • Istanbul, Turkey (Türkiye), 34098
        • İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
      • Istanbul, Turkey (Türkiye), 34854
        • Marmara Üniversitesi Pendik EAH- Kardiyoloji
      • Istanbul, Turkey (Türkiye), 34335
        • Adana Şehir Eğitim ve Araştırma Hastanesi
      • Istanbul, Turkey (Türkiye), 34718
        • Kartal Kosuyolu Yuksek Ihtisas EAH
      • Istanbul, Turkey (Türkiye), 34718
        • Koşuyolu Yüksek İhtisas EAH- Kardiyoloji
      • Kayseri, Turkey (Türkiye), 38080
        • Kayseri City Hospital
      • Kayseri, Turkey (Türkiye), 38039
        • Erciyes University Cardiology
      • Kayseri, Turkey (Türkiye), 38039
        • Erciyes Üniversitesi Hastanesi- Kardiyoloji
      • Kayseri, Turkey (Türkiye), 38080
        • Kayseri Şehir Hastanesi-Kardiyoloji
      • Kocaeli, Turkey (Türkiye), 41380
        • Kocaeli Üniversitesi Hastanesi- Kardiyoloji
      • Konya, Turkey (Türkiye), 42090
        • Necmettin Erbakan University Hospital
      • Konya, Turkey (Türkiye), 42090
        • Necmettin Erbakan Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
      • Kütahya, Turkey (Türkiye), 43100
        • Kütahya Şehir Hastanesi-Kardiyoloji
      • Merkez/Kütahya, Turkey (Türkiye), 43040
        • Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi EAH- Kardiyoloji
      • Mersin, Turkey (Türkiye), 33343
        • Mersin Üniversitesi Hastanesi- Kardiyoloji
      • Mersin, Turkey (Türkiye), 33240
        • Mersin Şehir Eğitim Araştırma Hastanesi- Kardiyoloji
      • Muratpasa/ Antalya, Turkey (Türkiye), 07100
        • Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji
      • Odunpazarı /Eskişehir, Turkey (Türkiye), 26080
        • Eskişehir Şehir Hastanesi- Kardiyoloji
      • Samsun, Turkey (Türkiye), 55100
        • Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji
      • Tokat Province, Turkey (Türkiye), 60000
        • Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
    • Altindag
      • Ankara, Altindag, Turkey (Türkiye), 06230
        • Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesi- Kardiyoloji
    • Bakirkoy
      • Istanbul, Bakirkoy, Turkey (Türkiye), 34153
        • Istanbul University Cerrahpasa Medical Faculty
      • Istanbul, Bakirkoy, Turkey (Türkiye), 34153
        • İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Prof. Dr. Murat Dilmener Yerleşkesi
    • Odunpazari
      • Eskişehir, Odunpazari, Turkey (Türkiye), 26040
        • Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
  • United Kingdom
      • Edinburgh, United Kingdom, EH16 4SA
        • Royal Infirmary of Edinburgh - Cardiology
      • Glasgow, United Kingdom, G81 4SA
        • Golden Jubilee University National Hospital
      • Kettering, United Kingdom, NN16 8UZ
        • Kettering General Hospital
      • Leicester, United Kingdom, LE3 9QP
        • Glenfield Hospital
      • Lincoln, United Kingdom, LN2 5QY
        • Lincoln County Hospital
      • Liverpool, United Kingdom, L14 3PE
        • Liverpool Heart & Chest Hospital
      • London, United Kingdom, SE5 9RS
        • Kings College Hospital
      • London, United Kingdom, EC1A 7BE
        • Barts Heart Centre
      • London, United Kingdom, EC1A 7BE
        • St Bartholomew's Hospital - Barts Heart Centre
      • London, United Kingdom, SE5 9RS
        • King's College Hospital - Cardiology
      • Middlesbrough, United Kingdom, TS4 3BW
        • The James Cook University Hospital - Cardiology
      • Newcastle upon Tyne, United Kingdom, NE7 7DN
        • Freeman Hospital, Newcastle
      • Plymouth, United Kingdom, PL6 5FP
        • Derriford Hospital - Plymouth
      • Portsmouth, United Kingdom, PO6 3LY
        • Queen Alexandra Hospital
      • Portsmouth, United Kingdom, PO6 3LY
        • Queen Alexandra Hospital - Cardiology
      • Sheffield, United Kingdom, S5 7AU
        • Northern General Hospital
      • Stevenage, United Kingdom, SG1 4AB
        • Lister Hospital
      • Swansea, United Kingdom, SA6 6NL
        • Morriston Hospital
      • Taunton, United Kingdom, TA1 5DA
        • Musgrove Park Hospital
      • Wolverhampton, United Kingdom, WV10 0QP
        • New Cross Hospital
    • Cornwall
      • Truro, Cornwall, United Kingdom, TR1 3HD
        • Royal Cornwall Hospital (Treliske)
    • Devon
      • Torquay, Devon, United Kingdom, TQ2 7AA
        • Torbay Hospital - Cardiology
    • Dorset
      • Bournemouth, Dorset, United Kingdom, BH7 6JH
        • Royal Bournemouth Hospital - Cardiology
    • Kent
      • Ashford, Kent, United Kingdom, TN24 0LZ
        • William Harvey Hospital
    • Lancashire
      • Blackpool, Lancashire, United Kingdom, FY3 8NR
        • Blackpool Victoria Hospital
    • Middlesex
      • Harefield, Middlesex, United Kingdom, UB9 6JH
        • Harefield Hospital
      • Harefield, Middlesex, United Kingdom, UB9 6JH
        • Royal Brompton and Harefield Hospitals
  • United States
    • Alabama
      • Alexander City, Alabama, United States, 35010
        • Advanced Cardiovascular, LLC
      • Birmingham, Alabama, United States, 35243
        • Grandview Medical Center
      • Birmingham, Alabama, United States, 35233
        • Birmingham VA Medical Center
      • Fairhope, Alabama, United States, 36532
        • Eastern Shore Rsrch Inst, LLC
      • Huntsville, Alabama, United States, 35801
        • Heart Center Rsrch_Hunstville
      • Mobile, Alabama, United States, 36606
        • Mobile Heart USA Health Cardiology Clinic
    • Arizona
      • Gilbert, Arizona, United States, 85297
        • Mercy Gilbert Medical Center
      • Phoenix, Arizona, United States, 85054
        • Mayo Clinic Arizona
      • Scottsdale, Arizona, United States, 85258
        • Honor Health
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • Central Arkansas Veteran's Healthcare System
      • Little Rock, Arkansas, United States, 72205
        • Arkansas Cardiology Clinic
    • California
      • Covina, California, United States, 91723
        • Valley Clinical Trials
      • La Jolla, California, United States, 92037
        • UCSD Medical Center
      • Loma Linda, California, United States, 92354
        • Loma Linda University Faculty Medical Clinics
      • Los Angeles, California, United States, 90095
        • University of Californ LA-UCLA
      • Los Angeles, California, United States, 90073
        • VAGrtrLosAngelesHlthcareSystem
      • Orange, California, United States, 92868-3201
        • University of California Irvine
      • San Diego, California, United States, 92123
        • San Diego Cardiac Center
      • San Diego, California, United States, 92123
        • Kaiser Permanente Viewridge Medical Offices
      • San Francisco, California, United States, 94121
        • San Francisco V.A. Medical Center
      • Torrance, California, United States, 90505
        • Torrance Memorial Medical Center
      • Torrance, California, United States, 90502
        • LA BioMed Harbor UCLA Med Cenr
      • West Hills, California, United States, 91307
        • Interventional Cardiology Medical Group
    • Colorado
      • Aurora, Colorado, United States, 80045
        • University of CO - Division of Cardiology
      • Denver, Colorado, United States, 80204
        • Denver Health Medical Center
      • Golden, Colorado, United States, 80401
        • Colorado Heart and Vascular PC
      • Littleton, Colorado, United States, 80120
        • S Denver Cardiology Associates
      • Thornton, Colorado, United States, 80023
        • Advanced Heart & Vein Center
    • Connecticut
      • Bridgeport, Connecticut, United States, 06610
        • Bridgeport Hospital
      • Danbury, Connecticut, United States, 06810
        • Danbury Hospital - Cardiology Department
      • New Haven, Connecticut, United States, 06519
        • Yale Ctr for Clin Invest
      • Stamford, Connecticut, United States, 06905
        • Cardiology Associates of Fairfield County
    • Delaware
      • Newark, Delaware, United States, 19718
        • Christiana Care Health Services, Inc.
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20010
        • MedStar Hlth Res Institute
    • Florida
      • Fort Lauderdale, Florida, United States, 33308
        • Holy Cross Hospital
      • Gainesville, Florida, United States, 32608
        • University of Florida
      • Hollywood, Florida, United States, 33021
        • Memorial Healthcare
      • Jacksonville, Florida, United States, 32224
        • Mayo Clinic Jacksonville
      • Jacksonville, Florida, United States, 32258
        • Baptist Heart Specialists
      • Jacksonville, Florida, United States, 32209
        • UF Hlth Jacksonville
      • Pensacola, Florida, United States, 32504
        • Ascension Sacred Heart
      • Pensacola, Florida, United States, 32503
        • Baptist Hospital Cardiology
      • Sarasota, Florida, United States, 34232
        • Intercoastal Medical Group
      • Winter Haven, Florida, United States, 33881
        • Winter Haven Hospital
    • Georgia
      • Atlanta, Georgia, United States, 30322-1059
        • Emory University Hospital
      • Augusta, Georgia, United States, 30912
        • Augusta University
      • Decatur, Georgia, United States, 30033
        • Atlanta VAMC
      • Gainesville, Georgia, United States, 30501
        • Northeast Georgia Medical Ctr
      • Thomasville, Georgia, United States, 31792
        • Cardio. Consult. of S. GA
    • Idaho
      • Meridian, Idaho, United States, 83642
        • St. Luke's Idaho Cardiology Associates
    • Illinois
      • Evanston, Illinois, United States, 60201
        • Endeavor Health Glenbook Hosp
      • Rockford, Illinois, United States, 61107
        • OSF HealthCare_Cardiovasc Inst
      • Springfield, Illinois, United States, 62701
        • Prairie Cardiovascular Consultants, Ltd.
    • Indiana
      • Elkhart, Indiana, United States, 46514
        • Midwest Cardiovascu Rsrch Foundation
      • Indianapolis, Indiana, United States, 46202
        • Indiana University Health Methodist Hospital
      • Richmond, Indiana, United States, 47374
        • Reid Physician Associates
    • Iowa
      • Waterloo, Iowa, United States, 50702
        • MercyOne NE Iowa Fam Med & Res
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • University of Kansas Hospital
      • Overland Park, Kansas, United States, 66211
        • Midwest Heart and Vascular Specialists
    • Kentucky
      • Edgewood, Kentucky, United States, 41017
        • Saint Elizabeth Medical Center
      • Louisville, Kentucky, United States, 40202
        • University of Louisville
    • Louisiana
      • New Orleans, Louisiana, United States, 70112
        • University Medical Center New Orleans
      • Shreveport, Louisiana, United States, 71101-4295
        • Overton Brooks V.A. Medical Center
    • Maine
      • Bangor, Maine, United States, 04401
        • Northern Light Eastern Maine Medical Center
      • Portland, Maine, United States, 04102
        • Maine Medical Center Bramhall
    • Maryland
      • Clinton, Maryland, United States, 20735
        • MedStar Hlth Res Institute
      • Rockville, Maryland, United States, 20850
        • Adventist HealthCare Shady Grove Medical Center
      • Silver Spring, Maryland, United States, 20904
        • Jadestone Clinical Research, LLC
    • Massachusetts
      • Boston, Massachusetts, United States, 02115
        • Brigham & Women's Hospital
    • Michigan
      • Bay City, Michigan, United States, 48708
        • McLaren Bay Region
      • Detroit, Michigan, United States, 48201
        • Wayne State University/University Health Center
      • Kalamazoo, Michigan, United States, 49008
        • WMU Homer Stryker MD School of Medicine
      • Lansing, Michigan, United States, 48910
        • McLaren Greater Lansing
      • Midland, Michigan, United States, 48670
        • MidMic Medical Cntr - Midland
      • Mount Clemens, Michigan, United States, 48043
        • McLaren Macomb Health Care
      • Petoskey, Michigan, United States, 49770
        • McLaren Northern MI Hosp
      • Pontiac, Michigan, United States, 48341
        • Trinity Health Oakland Hospital
      • Royal Oak, Michigan, United States, 48073
        • Corewell Health
      • Southfield, Michigan, United States, 48075
        • Ascension St. Mary's Research Institute - Michigan
      • Ypsilanti, Michigan, United States, 48197
        • Trinity Health Michigan Heart
    • Minnesota
      • Duluth, Minnesota, United States, 55805
        • Essentia Health
      • Maplewood, Minnesota, United States, 55109
        • Fairview Health Services
      • Minneapolis, Minnesota, United States, 55407
        • Abbott Northwestern Hospital
      • Minneapolis, Minnesota, United States, 55417
        • VA Medical Center_Minneapolis
      • Saint Paul, Minnesota, United States, 55101
        • Regions Hospital
    • Mississippi
      • Jackson, Mississippi, United States, 39216
        • Jackson Heart Clinic
      • Jackson, Mississippi, United States, 39216
        • Univ of Mississippi Med Center
      • Tupelo, Mississippi, United States, 38801
        • North Mississippi Medical Center
      • Tupelo, Mississippi, United States, 38801
        • Cardiolg Assoc Rsch LLC_Tupelo
    • Missouri
      • Columbia, Missouri, United States, 65201
        • Missouri Cardiovascular Specialist
      • North Kansas City, Missouri, United States, 64116
        • North Kansas City Hospital
      • Springfield, Missouri, United States, 65804
        • Mercy Research
      • St Louis, Missouri, United States, 63110
        • Washington University School of Medicine_St. Louis
    • Nebraska
      • Omaha, Nebraska, United States, 681114
        • Methodist Physicians Clinic
    • Nevada
      • Las Vegas, Nevada, United States, 89102
        • UMC of Southern Nevada
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03766
        • Dartmouth-Hitchcock Med Ctr
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807-3064
        • Advanced Heart Care LLC
      • Camden, New Jersey, United States, 08103
        • Virtua Health
      • Hackensack, New Jersey, United States, 07601
        • Hackensack Meridian Health - Cardiovascular
      • Haddon Heights, New Jersey, United States, 08035
        • The Heart House Haddon Heights
      • Jersey City, New Jersey, United States, 07302
        • Jersey City Medical Center
      • Mullica Hill, New Jersey, United States, 08062
        • Inspira Health - Cardiology
      • Pomona, New Jersey, United States, 08240
        • AtlantiCare Regional Medical Center
      • Teaneck, New Jersey, United States, 07666
        • Holy Name Medical Center
      • Vineland, New Jersey, United States, 08360
        • Heart House - Vineland
    • New York
      • Brooklyn, New York, United States, 11215
        • The New York Hospital
      • Buffalo, New York, United States, 14220
        • Trinity Medical WNY, PC
      • Liverpool, New York, United States, 13088
        • Saint Joseph's Hospital Health Center
      • New York, New York, United States, 10025
        • Mount Sinai Morningside
      • New York, New York, United States, 10016
        • NYU Grossman School of Med
      • Rochester, New York, United States, 14642
        • University of Rochester
      • Roslyn, New York, United States, 11576
        • St Francis Hospital Lindner Research Center
      • Stony Brook, New York, United States, 11794
        • Stony Brook University Hospital
      • The Bronx, New York, United States, 10461
        • Jacobi Medical Center
      • Valhalla, New York, United States, 10595
        • Westchester Medical Center
    • North Carolina
      • Asheville, North Carolina, United States, 28803
        • Cardiology Associates_Asheville
      • Chapel Hill, North Carolina, United States, 27599-7075
        • UNC Hospital HVC_Meadowmont
      • Charlotte, North Carolina, United States, 28204
        • Novant Hlth Vasc Ins Charlotte
      • Durham, North Carolina, United States, 27710
        • Duke University Medical Center
      • Greensboro, North Carolina, United States, 27401
        • Moses H. Cone Mem Hosp
      • High Point, North Carolina, United States, 27262
        • Wake Forest Uni Hlth Sciences
      • Raleigh, North Carolina, United States, 27697
        • NC Heart and Vascular Research
      • Winston-Salem, North Carolina, United States, 27103
        • Novant Hlth Cardio - Kimel Park
    • North Dakota
      • Fargo, North Dakota, United States, 58102
        • Sanford Health - Fargo
      • Minot, North Dakota, United States, 58701
        • Trinity Medical Group
    • Ohio
      • Canton, Ohio, United States, 44710
        • Aultman Hospital
      • Cincinnati, Ohio, United States, 45241
        • University of Cincinnati/UC Health
      • Cincinnati, Ohio, United States, 45219
        • Lindner Center,Christ Hospital
      • Cleveland, Ohio, United States, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, United States, 44195
        • Cleveland Clinic_Cleveland
      • Cleveland, Ohio, United States, 44106
        • Louis Stokes Clvlnd VA Med Ctr
      • Elyria, Ohio, United States, 44035
        • University Hospitals Of Cleveland Medical Center
      • Fairborn, Ohio, United States, 45324
        • Wright State University
      • Kettering, Ohio, United States, 45429
        • Kettering Medical Center
      • Toledo, Ohio, United States, 43608
        • Mercy Health - St. Vincent Medical Center
      • Toledo, Ohio, United States, 43614
        • University of Toledo
      • Toledo, Ohio, United States, 43606
        • ProMedica
      • Zanesville, Ohio, United States, 43701
        • Genesis Health Care System
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73135
        • South Oklahoma Heart Research, LLC
    • Pennsylvania
      • Camp Hill, Pennsylvania, United States, 17011
        • Penn State Hlth Holy Spirit Med Ctr
      • Chambersburg, Pennsylvania, United States, 17201
        • Chambersburg Hospital
      • Danville, Pennsylvania, United States, 17822
        • Geisinger Medical Center
      • Hershey, Pennsylvania, United States, 17033
        • Penn State Hershey Medical Center
      • Sayre, Pennsylvania, United States, 18840
        • Robert Packer Hospital
      • West Reading, Pennsylvania, United States, 19611
        • Reading Hospital
    • Rhode Island
      • Providence, Rhode Island, United States, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, United States, 29621
        • AnMed Health Clinical Research
      • Greenville, South Carolina, United States, 29605
        • Prism Hlth Carolina Card Cons
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Monument Health Clinical Rsrch
      • Sioux Falls, South Dakota, United States, 57105
        • Sanford Research
    • Tennessee
      • Chattanooga, Tennessee, United States, 37404
        • Chattanooga Heart Institute
      • Knoxville, Tennessee, United States, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, United States, 37934
        • Tennova HC Turkey Creek MC
      • Memphis, Tennessee, United States, 38120
        • Baptist Clin Res Institute
      • Nashville, Tennessee, United States, 37232
        • Vanderbilt University Medical Center
      • Nashville, Tennessee, United States, 37205
        • Saint Thomas Hospital
      • Oak Ridge, Tennessee, United States, 37830
        • Parkway Cardiology Associates, PC
      • Powell, Tennessee, United States, 37849
        • CV Research of Knoxville
    • Texas
      • Amarillo, Texas, United States, 79106
        • PharmaTex Research, LLC
      • Austin, Texas, United States, 78705
        • Austin Heart
      • Dallas, Texas, United States, 75216
        • Dallas VA Medical Center
      • Dallas, Texas, United States, 75203
        • Liver Ins@ Mthdist DTX Med Cen
      • Dallas, Texas, United States, 75390-9302
        • University of Texas Southwestern Medical Center
      • Galveston, Texas, United States, 77555
        • University of Texas Medical Branch
      • Houston, Texas, United States, 77030
        • Houston Methodist Hospital
      • Houston, Texas, United States, 77030
        • Texas Heart Inst Medical Ctr
      • Houston, Texas, United States, 77030
        • UT Health University of Texas
      • Houston, Texas, United States, 77054
        • Prolato Clinical Research Cntr
      • Houston, Texas, United States, 77004
        • Houston Medical Center
      • McAllen, Texas, United States, 78503-1299
        • HCA Research Institute
      • Mount Pleasant, Texas, United States, 75455
        • Heart & Vascular Inst._Titus
      • Plano, Texas, United States, 75093
        • Baylor Scott & White Res Inst
      • San Antonio, Texas, United States, 78229
        • Methodist Healthcare System of San Antonio
      • Tyler, Texas, United States, 75701
        • Christus Heart and Vascular Institute
    • Utah
      • Murray, Utah, United States, 84107-5701
        • Intermountain Medical Center
    • Virginia
      • Charlottesville, Virginia, United States, 22908
        • University of Virginia
      • Falls Church, Virginia, United States, 22042
        • Inova Fairfax Medical Campus
      • Norfolk, Virginia, United States, 23507
        • Sentara Bayside Hospital
      • Richmond, Virginia, United States, 23249
        • McGuire VA Medical Center
      • Richmond, Virginia, United States, 23225
        • Chippenham Medical Center
      • Richmond, Virginia, United States, 23298
        • Virginia Commonwealth University Health System
      • Richmond, Virginia, United States, 23226
        • Bon Secours St. Mary's Hospital of Richmond, LLC
      • Salem, Virginia, United States, 24153-6404
        • VA Medical Center_Salem
      • Winchester, Virginia, United States, 22601
        • Valley Health Link
    • Washington
      • Seattle, Washington, United States, 98122-5789
        • Swedish Medical Center_Seattle
      • Seattle, Washington, United States, 98195
        • University Of Washington_Seattle
      • Tacoma, Washington, United States, 98405
        • MultiCare Health System
    • Wisconsin
      • Milwaukee, Wisconsin, United States, 53215
        • Aurora St. Luke's Medi Ctr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Key inclusion:

  • Age 18 years or above at the time of signing the informed consent.
  • Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.

  • ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.

    b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.

OR

  • Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
  • Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
  • Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)

Key exclusion:

  • Use of fibrinolytic therapy for treatment of the current AMI.
  • Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
  • Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
  • Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m^2. b) Chronic haemodialysis or peritoneal dialysis.
  • Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
  • Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
  • Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
  • Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
  • Known (acute or chronic) hepatitis B or hepatitis C.
  • History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Ziltivekimab
Participants will receive an initial loading dose of ziltivekimab Dose 1 subcutaneously (s.c.) as early as possible after invasive procedure, and latest within 36 hours of hospitalisation for ST-elevation myocardial infarction (STEMI) and within 48 hours of hospitalisation for non-ST-elevation myocardial infarction (NSTEMI), followed by ziltivekimab Dose 2 s.c. once-monthly during the treatment period (estimated up to 2 years) added to standard of care.
Drug: Ziltivekimab
Ziltivekimab will be adminsitered subcutaneously as an initial loading dose of Dose 1 followed by a maintenance dose of Dose 2 once- monthly.
Experimental: Placebo ziltivekimab
Participants will receive placebo matched to ziltivekimab at an initial loading dose subcutaneously (s.c.) as early as possible after invasive procedure, and latest within 36 hours of hospitalisation for STEMI and latest within 48 hours of hospitalisation for NSTEMI, followed by placebo matched to ziltivekimab s.c. once-monthly during the treatment period (estimated up to 2 years) added to standard of care.
Drug: Placebo
Placebo matched to ziltivekimab will be adminsitered subcutaneously as an initial loading dose followed by a maintenance dose once-monthly.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Time to first occurrence of a 3-component major adverse cardiovascular event (MACE) endpoint comprising: Cardiovascular (CV) death, Non-fatal myocardial infarction (MI), Non-fatal stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Number of cardiovascular hospitalisations
Time Frame: From randomisation (month 0) to 1 month/ 30 days
Measured as count of events.
From randomisation (month 0) to 1 month/ 30 days
Number of cardiovascular hospitalisations
Time Frame: From randomisation (month 0) to 12 months
Measured as count of events.
From randomisation (month 0) to 12 months
Change in high-sensitivity C-reactive protein (hs-CRP)
Time Frame: From randomisation (month 0) to 6 months
Measured as ratio to baseline.
From randomisation (month 0) to 6 months
Number of CV death, non-fatal MI, non-fatal stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a composite MACE endpoint consisting of: All-cause mortality, Non-fatal MI, Non-fatal stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of all-cause mortality, non-fatal MI, non-fatal stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of non-fatal MI
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of MI (fatal and non-fatal)
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of non-fatal stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of stroke (fatal and non-fatal)
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a 3-component coronary MACE endpoint comprising:CV death, Non-fatal MI, Ischaemia-driven coronary revascularisation
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a 5-component expanded MACE endpoint comprising: CV death, Non-fatal MI, Non-fatal stroke, Ischaemia-driven coronary revascularisation, Heart failure (HF) hospitalisation or urgent HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of CV death, non-fatal MI, non-fatal stroke, ischaemia-driven coronary revascularisation, or HF hospitalisation or urgent HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measired as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a 3-component HF endpoint comprising: CV death, HF hospitalisation or urgent HF visit, Outpatient HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of CV deaths, HF hospitalisation or urgent HF visits or outpatient HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a 2-component HF endpoint comprising: CV death, HF hospitalisation or urgent HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of CV deaths, HF hospitalisation or urgent HF visits
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of a 2-component expanded HF endpoint comprising: HF hospitalisation or urgent HF visit, Outpatient HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of HF hospitalisation or urgent HF visit or outpatient HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of outpatient HF visit
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to occurrence of CV death
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to occurrence of all-cause death
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as months.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of 6-component vascular event endpoint: CV death, Non-fatal MI, Non-fatal stroke, Ischaemia-driven coronary revascularisation, Non-coronary revascularisation procedure, Any other non-coronary ischaemic event excluding stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of CV death, non-fatal MI and non-fatal stroke, ischaemia-driven coronary revascularisation, non-coronary revascularisation procedure, or any other non-coronary ischaemic event excluding stroke
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of ischaemia-driven coronary revascularisation
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Time to first occurrence of ischaemia-driven coronary revascularisation or any non-coronary revascularisation
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured in months.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of ischaemia-driven coronary revascularisation or any non-coronary revascularisation
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)
Number of hospitalisations with infection as primary cause or death due to infection
Time Frame: From randomisation (month 0) to end-of-study (up to 25 months)
Measured as count of events.
From randomisation (month 0) to end-of-study (up to 25 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Novo Nordisk A/S

Collaborators

Collaborators

An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
Duke Clinical Research Institute

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Director: Clinical Transparency dept. 2834, Novo Nordisk A/S

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
June 25, 2024

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
January 29, 2027

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
January 29, 2027

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
October 31, 2023

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
October 31, 2023

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
November 7, 2023

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
September 9, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
September 7, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
September 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • EX6018-4979
  • 2023 (U.S. NIH Grant/Contract: GRAMMY Museum Foundation)
  • U1111-1294-3473 (Other Identifier: World Health Organization (WHO))
  • 2023-506876-28 (Other Identifier: European Medical Agency (EMA))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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