The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery

February 23, 2026 updated by: Kerem Erkalp, MD, Prof, Istanbul University - Cerrahpasa

The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery: Risk Assessment With Fuzzy Logic

Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Determination of perioperative risk factors and creating protocols to take precautions accordingly may reduce mortality in patients.

In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose, various scoring systems have been developed.

Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.

The records of patients who underwent CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be examined.

Preoperative major risk factors diabetes, pulmonary, neurological, kidney and liver disease with preoperative minor risk factors age, weight and smoking will be recorded. Perioperative risk factors; duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG surgery. Secondly we aimed to investigate the effect of perioperative risk factors on postoperative complications

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities such as diabetes mellitus and renal diseases. Tehese risk factors affect morbidity and mortality rates. Even in developed countries mortality rate in CABG patients is between 1.9-5.3%. Identifying perioperative risk factors and taking precautions by creating protocols can decrease mortality in patients. Experienced surgical and anesthesia teams, evidence-based practices, and advances in pharmacology and technology can increase survival.

Risk assessment is important in determining the treatment plans of patients who will be operated on, providing patient education for the postoperative period, providing insight into prognosis, and determining health care quality standards.

In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose low and high risk studies have been conducted and various scoring systems have been developed. European System for Cardiac Operative Risk Evaluation-II (EUROSCORE-II) is a scoring system that was created specifically for cardiac surgery patients and is widely used all over the world, predicting mortality through preoperative evaluation. EUROSCORE-II scoring may be low in older patients (over 70 years of age). A scoring system with higher predictive power is aimed by making modifications to EUROSCORE-II or comparisons with other scoring systems.

In 1965, Zadeh first introduced Fuzzy, which is the basis of the fuzzy logic procedure Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.

The records of patients who underwent isolated CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be included.

Diabetes mellitus, pulmonary, neurological, kidney and liver disease will be recorded as preoperative major risk factors. Age, weight and smoking will be recorded as preoperative minor risk factors. Duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded as perioperative risk factors.

The effect of preoperative risk factors on mortality has been investigated in many studies. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in isolated CABG surgery.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
485

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Contact Backup

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Over 18 year of age, all isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital

Description

Inclusion Criteria:

  • All isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital

Exclusion Criteria:

  • All surgical procedures other than isolated coronary artery bypass surgery and patients under the age of 18 were excluded

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
coronary artery bypass surgery group
All patients over the age of 18 who underwent isolated coronary artery bypass surgery at the IUC Cardiology Institute hospital between January 1, 2020 and July 31, 2024 will be included in the study.
Other: There is no intervention in this study.
This study is planned as a retrospective cross sectional study. Only the information of the patients will be used.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Risk assessment with fuzzy logic
Time Frame: 4 months
Create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG operations.
4 months

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Perioperative risk factors
Time Frame: 4 months
Investigate the effects of artificial circulation time, number of bypassed vessels, and how many bags of blood products were used as perioperative risk factors on postoperative complications.
4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Istanbul University - Cerrahpasa

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Chair: Kerem Erkalp, Istanbul University - Cerrahpasa

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
December 15, 2024

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 15, 2025

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 15, 2025

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
February 2, 2025

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 2, 2025

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
February 6, 2025

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
February 24, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 23, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
January 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • 112

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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