Comparison Between Dentine Autograft VS Platelet Rich Fibrin in Extraction Socket Bone Healing

August 27, 2026 updated by: Eman abdelbaki, Cairo University

Histomorphological Evaluation of Alveolar Bone Healing Using Dentin Autograft Mixed With Platelet-rich Fibrin in Extraction Socket vs Graftless Healing

The present study will be performed to:

evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

When teeth are extracted, a certain amount of bone loss or resorption occurs, usually about 30-60%. This loss is typically three-dimensional in nature, with width loss or horizontal deficiency developing to a greater extent than other types of deficiencies. An alveolar defect can be classified as the loss of labial or buccal cortical or medullary bone. In some cases, both exist. Although all alveolar defects present challenges when planning a dental implant procedure, if the defect is in the buccal cortex or cortical plate after tooth extraction, this can create significant difficulties in the reconstruction of a dental implant. Bone loss or bone augmentation techniques have been developed to counteract alveolar defects, such as guided bone regeneration, onlay block bone grafting, ridge/split bone grafting, and alveolar distraction osteogenesis. These procedures can help improve an alveolar defect and prepare the alveolar ridge for a successful dental implant.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
45

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypt, 11553
        • Faculty of Dentistry, Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • 1. Patients with hopeless non molar teeth that need extraction. 2. Age above 18 years. 3. Generally good state of health. 4. Agreement to participate in the study and also have to be able to attend postoperative clinical and radiological follow-up 6. Acquisition of informed consent.

Exclusion Criteria:

  • 1- Patients refuse to be enrolled in this study

    2- Patients with uncontrolled systemic disease.

    3- Previously diagnosed hematological and neurological conditions.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
No Intervention: Graftless Healing (Control)
Participants undergo atraumatic extraction of a hopeless non-molar tooth. The extraction socket is left to heal spontaneously without placement of any grafting material. The socket is sutured with 3-0 Vicryl to allow primary wound closure. Clinical, radiographic, and histomorphometric evaluations are performed according to the study follow-up schedule.
Experimental: Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP)
Participants undergo atraumatic extraction of a hopeless non-molar tooth followed by immediate socket preservation using an autogenous dentin graft prepared from the extracted tooth. The dentin particles are processed using the Smart Dentin Grinder system, disinfected, rinsed with phosphate-buffered saline, and mixed with autologous platelet-rich plasma (PRP) to produce a sticky dentin graft. The graft is placed into the extraction socket, and the surgical site is sutured with 3-0 Vicryl. Clinical, radiographic, and histomorphometric outcomes are evaluated throughout the follow-up period.
Procedure: DENTION AND PRF APPLICATION IN SOCKET
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
Experimental: Platelets rich fibrin applied in the socket
PRF from patient own blood is applied to the socket
Procedure: PLATETELT RICH FIBRIN IN EXTRACTION SOCKET
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Histomorphometric bone formation (%)
Time Frame: 3-6 months
a trephine bur is used to extract a sample from healed bone to be stained with H&E and analyzed under microscope
3-6 months

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Bone density (radiographic) Healing index
Time Frame: 3-6 months
type of bone is measerd on cbct scan after three months from healing of bone
3-6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
January 1, 2023

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
January 13, 2026

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
July 1, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
August 27, 2026

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 27, 2026

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
September 1, 2026

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
September 1, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 27, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
July 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • Dentine autograft vs PRF

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data (IPD) will not be shared because the study was not designed with participant-level data sharing. The collected data contain confidential information, and participants did not provide consent for public sharing of de-identified individual-level data. Only aggregate study results will be published.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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