Temsirolimus and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia

A Phase I Study of CCI-779 in Combination With Imatinib Mesylate in Chronic Myelogenous Leukemia

This phase I trial is studying the side effects and best dose of temsirolimus when given with imatinib mesylate in treating patients with chronic myelogenous leukemia. Drugs used in chemotherapy, such as temsirolimus, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving temsirolimus with imatinib mesylate may kill more cancer cells

Study Overview

• Status: Terminated
• Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Relapsing Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Blastic Phase Chronic Myelogenous Leukemia
• Intervention / Treatment: Other: laboratory biomarker analysis; Drug: imatinib mesylate; Drug: temsirolimus

Detailed Description

OBJECTIVES:

I. Determine the safety and tolerability of temsirolimus when administered with imatinib mesylate in patients with chronic myelogenous leukemia.

II. Determine potential dose-limiting toxic effects of this regimen in these patients.

III. Determine, preliminarily, hematologic and cytogenetic response rates in patients treated with this regimen.

OUTLINE: This is a multicenter, dose-escalation study of temsirolimus.

Patients receive temsirolimus intravenously (IV) over 30 minutes once on days 1, 8, 15, and 22 and oral imatinib mesylate once daily on days 1-28. Courses repeat every 28 days in the absence of unacceptable toxicity or disease progression. Patients receive 2 additional courses beyond maximal response. Cohorts of 3-6 patients receive escalating doses of temsirolimus until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

Patients are followed for survival.

• Study Type: Interventional
• Enrollment (Actual): 21
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • California
    • Orange, California, United States, 92868
      • University of California Medical Center At Irvine-Orange Campus

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Histologically confirmed chronic myelogenous leukemia (CML)

  • Philadelphia chromosome-positive OR Bcr-Abl-positive disease, meeting 1 of the following criteria:

    • Accelerated phase, defined by at least 1 of the following:

      • 10-19% blasts in the peripheral blood or bone marrow
      • At least 20% basophils in peripheral blood or bone marrow
      • Platelet count < 100,000/mm^3 (unrelated to therapy)
      • Platelet count > 1,000,000/mm^3 (unresponsive to therapy)
      • Increasing splenomegaly AND increasing WBC count (unresponsive to therapy)
      • Clonal evolution

    • Blast phase, defined by 1 of the following:

      • At least 20% blasts in peripheral blood or bone marrow
      • Extramedullary disease

    • Chronic phase, defined by all of the following:

      • Less than 10% blasts in peripheral blood or bone marrow
      • Less than 20% basophils in peripheral blood or bone marrow
      • Platelet count > 100,000/mm^3
      • Absence of clonal evolution

• May have received and/or failed prior imatinib mesylate therapy

  • Patients not previously treated with imatinib mesylate receive oral imatinib mesylate once daily 14 days before beginning study drug

    • Must be able to tolerate 600 mg per day of imatinib mesylate before starting CCI-779

  • Patients with chronic phase disease must have failed prior imatinib mesylate at a dose ≥ 600 mg/day, as defined by 1 of the following:

    • Must not have achieved or must have lost hematologic response within 3 months after the start of imatinib mesylate
    • Must not have achieved or must have lost cytogenetic response after 6 months of treatment with imatinib mesylate
    • Must not have achieved or must have lost major cytogenetic response after 12 months of treatment with imatinib mesylate
    • Must have lost complete cytogenetic response
• Bone marrow aspirate and biopsy with cytogenetics and fluorescent in situ hybridization confirming t(9;22) completed within the past 28 days
• Performance status - SWOG 0-2
• More than 3 months
• See Disease Characteristics
• Bilirubin normal
• AST and ALT < 2.5 times upper limit of normal (ULN) (5 times ULN if suspected liver involvement with leukemia)
• Creatinine normal
• Creatinine clearance > 60 mL/min
• No symptomatic congestive heart failure
• No unstable angina pectoris
• No cardiac arrhythmia
• Ejection fraction ≥ 50% by echocardiogram or MUGA scan for patients with known positive cardiac history (e.g., heart failure, coronary artery disease, cardiomegaly on prior chest x-ray, or valvular heart disease)
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Fasting cholesterol ≤ 350 mg/dL
• Fasting triglycerides ≤ 400 mg/dL
• No history of allergic reaction attributed to compounds of similar chemical or biologic composition to temsirolimus or imatinib mesylate
• No active or ongoing infection
• No psychiatric illness or social situation that would preclude study compliance
• No other active malignancy except nonmelanoma skin cancer
• No other uncontrolled illness
• At least 48 hours since prior interferon alfa for CML
• At least 6 weeks since prior stem cell transplantation
• No concurrent biologic agents
• No concurrent prophylactic colony-stimulating factors
• At least 24 hours since prior hydroxyurea for CML
• At least 7 days since prior mercaptopurine or vinca alkaloids for CML
• At least 7 days since prior low-dose cytarabine (< 30 mg/m^2 every 12-24 hours) for CML
• At least 14 days since prior homoharringtonine for CML
• At least 14 days since prior moderate-dose cytarabine (100-200 mg/m^2 for 5-7 days) for CML
• At least 21 days since prior anthracyclines, mitoxantrone, cyclophosphamide, etoposide, or methotrexate for CML
• At least 28 days since prior high-dose cytarabine (1-3 g/m^2 every 12-24 hours for 6-12 doses) for CML
• At least 6 weeks since prior busulfan for CML
• No concurrent hydroxyurea
• No other concurrent chemotherapy
• At least 7 days since prior steroids for CML
• No prior organ transplantation
• More than 2 weeks since prior major surgery (e.g., thoracotomy or intra-abdominal surgery)
• Recovered from all prior therapy
• Prior experimental therapy allowed provided completion of treatment corresponds to a duration > 5 half-lives of the experimental drug or any known active metabolite before study
• No concurrent cyclosporine
• No concurrent anagrelide
• No concurrent oral anticoagulants, including warfarin
• No concurrent CYP3A4 inducers or inhibitors
• No concurrent tacrolimus
• No concurrent plasmapheresis
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No other concurrent investigational agents
• No other concurrent anticancer therapies

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Treatment (imatinib mesylate, temsirolimus); Patients receive temsirolimus IV over 30 minutes once on days 1, 8, 15, and 22 and oral imatinib mesylate once daily on days 1-28. Courses repeat every 28 days in the absence of unacceptable toxicity or disease progression	Other: laboratory biomarker analysis; Correlative studies; Drug: imatinib mesylate; Given orally; Other Names: Gleevec; CGP 57148; Glivec; Drug: temsirolimus; Given IV; Other Names: Torisel; CCI-779; cell cycle inhibitor 779

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Unacceptable toxicity graded according to the NCI CTCAE version 3.0	Up to 5 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Disease progression		Up to 5 years
Survival		Up to 5 years
Duration of response	Presented using descriptive statistics.	Up to 5 years

Collaborators and Investigators

• Sponsor: National Cancer Institute (NCI)
• Investigators: Principal Investigator: Tiong Ong, University of California Medical Center At Irvine-Orange Campus

Study record dates

Study Major Dates

• Study Start: April 1, 2005
• Primary Completion (Actual): June 1, 2010

Study Registration Dates

• First Submitted: January 7, 2005
• First Submitted That Met QC Criteria: January 7, 2005
• First Posted (Estimate): January 10, 2005

Study Record Updates

• Last Update Posted (Estimate): January 14, 2013
• Last Update Submitted That Met QC Criteria: January 11, 2013
• Last Verified: January 1, 2013

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms by Histologic Type; Neoplasms; Bone Marrow Diseases; Hematologic Diseases; Myeloproliferative Disorders; Neoplastic Processes; Cell Transformation, Neoplastic; Carcinogenesis; Leukemia; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Chronic-Phase; Blast Crisis; Leukemia, Myeloid, Accelerated Phase; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents; Enzyme Inhibitors; Antineoplastic Agents; Immunosuppressive Agents; Immunologic Factors; Anti-Bacterial Agents; Protein Kinase Inhibitors; Antibiotics, Antineoplastic; Antifungal Agents; Imatinib Mesylate; Sirolimus
• Other Study ID Numbers: NCI-2009-00073; UCI-04-04; R21CA112936 (U.S. NIH Grant/Contract)