- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00182923
Forearm Vascular Relaxation
August 28, 2008 updated by: National Institute on Aging (NIA)
Determinants of Forearm Vascular Relaxation: Role of Genetic Polymorphisms
The purpose of this study is to learn the effect of inherited differences on forearm blood flow responses to hormones and drugs
Study Overview
Status
Completed
Conditions
Detailed Description
Differences in at least 4 genes are believed to have an important effect on responses to hormones and drugs.
For this study, healthy volunteers of normal body weight will be screened to find xxx individuals with the genes of interest.
Very small doses of hormones and drugs will be given so that changes in forearm blood flow can be measured, while not causing effects throughout the body.
A brachial artery line and venous line will be placed in the study arm so that blood samples may be withdrawn to compare amounts given into the artery and coming out of the vein after circulating through the arm.
Forearm blood flow is determined by the rate of swelling of the arm after a blood pressure cuff is inflated (above venous and below arterial blood pressure).
The hormones and drugs being studied include angiotensin I, angiotensin II, acetylcholine, sodium nitroprusside, enalaprilat, L-arginine, phenylephrine, endothelin-1, verapamil, and isoproterenol.
This procedure will last 4-6 hours.
The process will be repeated with the same participant over 2 weeks later.
Study Type
Observational
Enrollment
400
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Maryland
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Baltimore, Maryland, United States, 21225
- National Institute on Aging (NIA), Harbor Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
21 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Normal physical status without any medical interventions or agents which would alter the defined status of normal
Exclusion Criteria:
- Age less than 21 or greater than 45
- Unable to give informed consent
- BMI (Body Mass Index) less than 18 or greater than 25
- Clinically significant abnormal laboratory values
- Abnormal physical exam
- Abnormal EKG
- Pregnancy
- Smoking or drug usage (illicit or otherwise)
- Post-menopause
- Participation in another clinical trial in the past month
- Chronic Illness
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Darrell R. Abernethy, MD, PhD, National Institute on Aging, Laboratory of Clinical Investigation
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Abernethy DR, Laurie N, Andrawis NS. Local angiotensin-converting enzyme inhibition blunts endothelin-1-induced increase in forearm vascular resistance. Clin Pharmacol Ther. 1995 Sep;58(3):328-34. doi: 10.1016/0009-9236(95)90250-3.
- Abernethy DR, Winterbottom LM. Forearm vascular alpha 1-adrenergic blockade by verapamil. Clin Pharmacol Ther. 1990 Jun;47(6):755-9. doi: 10.1038/clpt.1990.104.
- Andrawis NS, Craft N, Abernethy DR. Calcium antagonists block angiotensin II-mediated vasoconstriction in humans: comparison with their effect on phenylephrine-induced vasoconstriction. J Pharmacol Exp Ther. 1992 Jun;261(3):879-84.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2003
Primary Completion (Actual)
December 1, 2006
Study Completion (Actual)
December 1, 2006
Study Registration Dates
First Submitted
September 12, 2005
First Submitted That Met QC Criteria
September 12, 2005
First Posted (Estimate)
September 16, 2005
Study Record Updates
Last Update Posted (Estimate)
August 29, 2008
Last Update Submitted That Met QC Criteria
August 28, 2008
Last Verified
August 1, 2008
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- AG0038
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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