- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00295568
Interaction of Right and Left Brain Hemispheres in Learning Precision Hand Movements
Contribution of Interhemispheric Inhibition to Motor Learning
This study will examine how the two sides of the brain interact when learning precision hand movements. Both sides of the brain are active when a person performs an accurate hand movement. This study will look at the extent to which the two brain hemispheres interact when learning accurate hand movements.
Healthy, right-handed normal volunteers 18 - 40 years of age may be eligible for this study. Candidates are screened with a clinical and neurological examination.
Participants are randomly assigned to one of two groups - precision or non-precision hand movements. All participants undergo the following procedures:
- Force precision task: Subjects are press a small device between the thumb and index finger. The force produced with the fingertips is translated onto a computer screen. Subjects track a white line passing on the screen with their fingertips.
- Paired-pulse transcranial magnetic stimulation (TMS): A wire coil is held to the subject's scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. During the stimulation, the subject may be asked to tense certain muscles slightly or perform other simple actions. The stimulation may cause a twitch in muscles of the face, arm, or leg, and the subject may hear a click and feel a pulling sensation on the skin under the coil. The effect of paired-pulse TMS on the muscles is detected with electrodes taped to the skin on the arms or legs.
- Surface electromyography (EMG): This test measures the electrical activity of muscles. For this test, electrodes are filled with a gel and taped to the skin over the muscle to be tested.
The study involves six sessions. Sessions 1-5 are on consecutive days; session 6 is one week after session 5.
- Session 1: Familiarization with the motor task and baseline measurements, including error rate, EMG, and paired-pulse TMS
- Session 2: Training in the motor task and repeat measurements as in session 1
- Session 3: Training and measurements as in session 2
- Session 4: Training and measurements as in session 2
- Session 5: Training and measurements as in session 2
- Session 6: Measurements only
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment
Contacts and Locations
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20892
- National Institutes of Health Clinical Center, 9000 Rockville Pike
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
- INCLUSION CRITERIA
Healthy volunteers will be eligible for the study if they are:
- are between the ages of 18-40 years;
- are right-handed;
- are able to perform tasks required by the study;
- are willing and able to give consent
EXCLUSION CRITERIA
Healthy volunteers will not be eligible for the study if they:
- are unable to perform the tasks;
- are left-handed;
- have a history of neurological and psychiatric illness, or of alcohol or drug abuse or severe language disturbances or serious cognitive deficits;
- have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus, have severe tactile deficits (defined by Frey filaments exerting a force of 4 N to the distal pad of the finger);
- have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium, with the exception of dental braces.
Study Plan
How is the study designed?
Collaborators and Investigators
Publications and helpful links
General Publications
- Kim SG, Ashe J, Hendrich K, Ellermann JM, Merkle H, Ugurbil K, Georgopoulos AP. Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science. 1993 Jul 30;261(5121):615-7. doi: 10.1126/science.8342027.
- Beltramello A, Cerini R, Puppini G, El-Dalati G, Viola S, Martone E, Cordopatri D, Manfredi M, Aglioti S, Tassinari G. Motor representation of the hand in the human cortex: an f-MRI study with a conventional 1.5 T clinical unit. Ital J Neurol Sci. 1998 Oct;19(5):277-84. doi: 10.1007/BF00713853.
- Roland PE, Skinhoj E, Lassen NA, Larsen B. Different cortical areas in man in organization of voluntary movements in extrapersonal space. J Neurophysiol. 1980 Jan;43(1):137-50. doi: 10.1152/jn.1980.43.1.137.
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 060095
- 06-N-0095
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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