- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00343655
Evaluation of Atorvastatin Treatment on Carotid Plaque.
February 17, 2021 updated by: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
A Randomized Clinical Trial Of Atorvastatin 10 Mg And 80 Mg In The Reversal Of Or Stabilization Of Carotid Atheroma Lipid Pool
The purpose of the study is to evaluate the effect of 18 months treatment with atorvastatin 80mg or atorvastatin 10mg on the carotid vessel plaque morphology, in particular, the effect on evident necrotic lipid rich core of the plaque in patients.
Study Overview
Study Type
Interventional
Enrollment
160
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Massachusetts
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Boston, Massachusetts, United States, 02114
- Pfizer Investigational Site
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Subjects with measurable carotid plaque with lipid and are eligible for statin therapy.
Exclusion Criteria:
- Subjects at higher risk for cardiovascular disease with a screen LDL-cholesterol greater than 120 mg/dL,
- Subjects currently on high dose statin, and
- Subjects with contraindications for MRI or statin therapy.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Change in lipid pool volume from baseline to 18 months in response to atorvastatin 80mg.
|
Comparison of effect of atorvastatin 80mg versus 10mg
|
Secondary Outcome Measures
Outcome Measure |
---|
Correlation of MRI measure of carotid morphology with cIMT measured by B-mode US.
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Correlation of MRI measure of carotid morphology with DS-CT measure of coronary morphology.
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Correlation of biomarkers to carotid changes.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2007
Study Completion (Actual)
August 1, 2007
Study Registration Dates
First Submitted
June 20, 2006
First Submitted That Met QC Criteria
June 20, 2006
First Posted (Estimate)
June 23, 2006
Study Record Updates
Last Update Posted (Actual)
February 18, 2021
Last Update Submitted That Met QC Criteria
February 17, 2021
Last Verified
February 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- A2581152
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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