The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Sponsors

Lead sponsor: University of Alabama at Birmingham

Source University of Alabama at Birmingham
Brief Summary

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Detailed Description

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Overall Status Completed
Start Date April 2008
Completion Date July 2009
Primary Completion Date July 2009
Study Type Observational
Enrollment 36
Condition
Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Children between age 2-20

- Decrease in renal function by 25% or greater

- Renal function has returned to normal

Exclusion Criteria:

- History of chronic disease

- Cancer

- Congenital heart disease

- Organ Transplantation

- Liver disease

- Pulmonary disease

- Diabetes other primary metabolic condition

- Severe neurologic impairments

- Hypertension

- Auto-immune

- Infectious disease or renal disease

- Smokers

- Renal disease w/primary cause i.e. - HUS or Glomerulonephritis

- severe allergies including allergy to seafood and/or iodine

Gender: All

Minimum age: 2 Years

Maximum age: 20 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
David Askenazi, MD Principal Investigator UAB Pediatric Nephrology
Location
facility University Of Alabama
Location Countries

United States

Verification Date

May 2020

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: University of Alabama at Birmingham

Investigator full name: David Askenazi

Investigator title: Principal Investigator

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: a

Description: those with previous history of Acute kidney injury

Study Design Info

Observational model: Cohort

Time perspective: Cross-Sectional

Source: ClinicalTrials.gov