- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00541437
Type 2 Diabetes Patients Switched From Sulfonylurea With Metformin to Glyburide/Metformin Combination Tablet
October 9, 2007 updated by: Genovate Biotechnology Co., Ltd.,
An Open-Label Study to Investigate the Efficacy and Safety of Type 2 Diabetes Patients Switched From Sulfonylurea With Metformin to Glyburide/Metformin Combination Tablet
To evaluate the efficacy and safety of type 2 diabetes patients switched from sulfonylurea co-administered with metformin to glyburide/metformin combination tablet.
It is expected that safety and efficacy of GlucoMet® is not inferior to co-administration of sulfonylurea and metformin.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
12
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan
- National Taiwan University Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Male or female age between 20 to 75 years and were diagnosed with type-2 DM for a minimum of 4 months before baseline.
- Maintain stable dose of sulfonylurea and metformin co-administered 4 months before baseline.
- Consider suitable to switch from current therapeutic dose to one of the eight testing regimens.
- FPG of 80-200mg/dl at screening visit
- 6.5% ≦ HbA1c ≦ 9% at screening visit, and change of HbA1c ≦ 1% within 12 weeks before screening visit.
- The body index must be between 18.5 and 35 Kg/m2 at screening visit.
- Sign and date the Informed Consent Form
Exclusion Criteria:
- Renal disease or renal dysfunction (e.g. serum creatinine > 1.5mg/dl)
- Currently significant GI disorder (such as peptic ulcer or diarrhea requiring chronic medical treatment) or which may interfere with absorption of the study drugs.
- History or concurrent liver disease or hepatic impairment (total bilirubin above upper normal limit, ALT or AST above 2.5 times of upper normal limit at screening visit.)
- Acute or chronic metabolic acidosis, including lactic acidosis, diabetic ketoacidosis, with or without coma.
- History of cardiovascular collapse (shock) or congestive heart failure (function class III to IV).
- History of stroke, myocardial infarction, coronary revascularization, or arrhythmia that requires medical treatment, within past 6 months.
- Having proliferative retinopathy.
- Current acute infection, including systemic infection with fever and/or sepsis, or pulmonary infection, cellulitis, etc.
- Having been treated with insulin during past 6 months, or treated with acarbose or glitazones with change of daily dose past 4 months.
- Seriously dehydrated.
- History of alcoholism (all the time or short-term heavy drinking) or drug abuse, or taking other investigational drug.
- Pregnant or breast feeding women or planning a pregnancy.
- Having a surgery within 4 weeks prior to entering the study or a history of cancer within five years.
- Known hypersensitive to glyburide or metformin hydrochloride.
- Any clinical condition or significant concurrent disease judged by the investigator to complicate the evaluation of the study treatment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Tien-Shang Huang, M.D, National Taiwan University Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2006
Study Completion (Actual)
February 1, 2007
Study Registration Dates
First Submitted
October 8, 2007
First Submitted That Met QC Criteria
October 9, 2007
First Posted (Estimate)
October 10, 2007
Study Record Updates
Last Update Posted (Estimate)
October 10, 2007
Last Update Submitted That Met QC Criteria
October 9, 2007
Last Verified
October 1, 2007
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- GBL L-13
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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