- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00613912
Advanced MRI in Major Depression
Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression
Depression is the most common psychiatric disorder.
- 3-5% of a given population has major depression.
- Less than 50% of the depressed in Denmark are diagnosed with major depression.
- 25-50% of the depressed have a relative with major depression-underlying brain pathology?
The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.
MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Jutland
-
Aalborg, Jutland, Denmark, 9000
- Aalborg Hospital / Aarhus University Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18
Exclusion Criteria:
- If the patient has pacemaker or other magnetic devices
- Pregnancy
- Has had an operation in the brain
- bipolar disorder
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
A
Ambulant patients with major depression
|
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Differences in morphological and functional cerebral MRI findings in patients suffering from major depression
Time Frame: 6 months from first MRI in each patient
|
6 months from first MRI in each patient
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Elna-Marie B Larsson, Professor, Uppsala University Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AUFF-2005-740-004
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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