Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function

Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function After Total Knee Arthroplasty: A Prospective, Consecutive, Trial

Aim of the present study is twofold.

• First we want to evaluate the effect of mobilization on acute postoperative pain
• Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty

Study Overview

• Status: Completed
• Conditions: Pain, Postoperative; Pain Sensitivity, Postoperative
• Intervention / Treatment: Other: Mobilization (walking)

Detailed Description

Little is known about the effect of mobilization on acute postoperative pain and mobilization induced pain, and if altered pain sensitivity occur under these circumstances.

• First we want to evaluate the effect of mobilization on acute postoperative pain using the visual analog scale (VAS)
• Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty, using two simple tools, the Pain Matcher and a Pressure Algometer.

• Study Type: Observational
• Enrollment (Actual): 26

Contacts and Locations

Study Locations

• Denmark
  • Hvidovre
    • Copenhagen, Hvidovre, Denmark
      • Hvidovre University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients operated with TKA

Description

Inclusion Criteria:

• Patients scheduled for total unilateral knee arthroplasty

Exclusion Criteria:

• Cognitive dysfunction or peripheral / central neurological dysfunction inconsistent with protocol completing
• Alcohol and medical abuse (as defined by the National Health Service of Denmark
• Daily use of opioids or glucocorticoids

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain score on the visual analog scale (difference before and after two mobilisation seances)	pain at rest (supine) 5 min after exercise(after the 2nd walk)	up to 24 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain score on the visual analog scale (difference before and after two mobilisation seances)	pain at rest (supine) 20 min after the 2nd walk, pain during passive hip flexion and pain during passive knee flexion 5 and 20 min after the 2nd walk, as well as pain during the 2nd walk after 6 and 25 m	up to 24 hours
Pain sensitivity measured with pressure algometry and with pain matcher (difference before and after two mobilisation seances and difference before and after surgery)	Nociceptive function before and after postoperative exercise	up to 24 hours

Collaborators and Investigators

• Sponsor: Hvidovre University Hospital
• Collaborators: Lundbeck Foundation
• Investigators: Principal Investigator: Troels Haxholdt Lunn, MD, Hvidovre University Hospital

Study record dates

Study Major Dates

• Study Start: December 1, 2009
• Primary Completion (ACTUAL): June 1, 2010
• Study Completion (ACTUAL): June 1, 2010

Study Registration Dates

• First Submitted: November 20, 2009
• First Submitted That Met QC Criteria: November 20, 2009
• First Posted (ESTIMATE): November 23, 2009

Study Record Updates

• Last Update Posted (ESTIMATE): April 20, 2012
• Last Update Submitted That Met QC Criteria: April 19, 2012
• Last Verified: April 1, 2012

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications; Pain; Neurologic Manifestations; Pain, Postoperative
• Other Study ID Numbers: H-1-2009-115; 2009-41-4004