Genomic Analysis of Pediatric Bone Tumors

Genomic Analysis of Pediatric Bone Tumors (Other Title: Pediatric Bone Tumor Biology Study)

To determine whether gene expression analysis of primary tumor samples before and after chemotherapy are predictive of long-term survival in pediatric patients with bone sarcomas (Ewings sarcoma (ES) and Osteosarcoma(OS)).

Study Overview

• Status: Completed
• Conditions: Bone Cancer

• Study Type: Observational
• Enrollment (Actual): 163

Contacts and Locations

Study Locations

• United States
  • California
    • Stanford, California, United States, 94305
      • Stanford University School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients with bone x-rays suggestive of a malignant bone tumor

Description

Inclusion Criteria:All patients with bone x-rays suggestive of a malignant bone tumor Exclusion Criteria:Patients with a known diagnosis of cancer.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
% necrosis post chemotherapy	his is measured at the time of sample collection since we are looking for % necrosis in the sample we are collecting
overall survival and event free survival	This is measured at the time the patient dies, or at the time when patient relapses from their disease. There is no set time since this outcome is individually assessed.

Collaborators and Investigators

• Sponsor: Stanford University
• Investigators: Principal Investigator: Arun A Rangaswami, Stanford University

Study record dates

Study Major Dates

• Study Start: August 1, 2007
• Primary Completion (Actual): June 1, 2018
• Study Completion (Actual): December 1, 2019

Study Registration Dates

• First Submitted: January 11, 2010
• First Submitted That Met QC Criteria: January 12, 2010
• First Posted (Estimate): January 13, 2010

Study Record Updates

• Last Update Posted (Actual): July 28, 2020
• Last Update Submitted That Met QC Criteria: July 24, 2020
• Last Verified: July 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms; Neoplasms by Site; Musculoskeletal Diseases; Bone Diseases; Bone Neoplasms
• Other Study ID Numbers: PEDSSARC0001; 97630 (Other Identifier: Stanford University Alternate IRB Approval Number); SU-12082009-4522 (Other Identifier: Stanford University)