Radiocontrast Media Induced Hyponatremia

Radiocontrast Media Induced Hyponatremia After Percutaneous Coronary Intervention: Observational Study

Osmolality of contrast media can be resulted in translocational hyponatremia after percutaneous coronary intervention.

Study Overview

• Status: Unknown
• Conditions: Percutaneous Coronary Intervention

Detailed Description

Radiocontrast media after percutaneous coronary interventioncan lead to increased osmolaliry of plasma, which results in translocational hyponatremia.

The investigator will exam the incidence of hyponatremia after percutaneous coronary intervention, and will evaluate the underlying mechanism related to hyponatremia including translocational hyponatremia, or osmotic natriuresis.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• Korea, Republic of
  • Incheon, Korea, Republic of
    • Recruiting
    • Gachon University Gil Hospital
    • Contact: Wookyung Chung, MD, PhD; Phone Number: +82-32-460-3431

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients who receive contrast media during percutaneous coronary intervention

Description

Inclusion Criteria:

• Patients who receive contrast media during percutaneous coronary intervention

Exclusion Criteria:

• Patients who have sensitivity to contrast media.
• Liver cirrhosis
• Hypothyroidism
• SIADH
• Patients who receive IVIG or mannitol.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
GFR >= 60; MDRD eGFR 60 or more
GFR <60; Under MDRD eGFR 60

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of contrast media induced translocational hyponatremia	The will investigator evaluate how often translocational hyponatremia may develop after percutaneous coronary intervention.	01/10/2010-28/02/2011

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Renal function is affected by the incidence of translocational hyponatremia.	Reduced renal function and urine output contribute the development of contrast media induced translocational hyponatremia.	01/10/2010-28/02/2011

Collaborators and Investigators

• Sponsor: Gachon University Gil Medical Center
• Investigators: Principal Investigator: Sejoong Kim, MD, PhD, Gachon University Gil Medical Center

Publications and helpful links

General Publications

• Aronson D, Dragu RE, Nakhoul F, Hir J, Miller A, Boulos M, Zinder O, Green J, Mittleman MA, Markiewicz W. Hyponatremia as a complication of cardiac catheterization: a prospective study. Am J Kidney Dis. 2002 Nov;40(5):940-6. doi: 10.1053/ajkd.2002.36324.

Study record dates

Study Major Dates

• Study Start: October 1, 2010
• Primary Completion (Anticipated): February 1, 2011
• Study Completion (Anticipated): June 1, 2011

Study Registration Dates

• First Submitted: October 12, 2010
• First Submitted That Met QC Criteria: October 12, 2010
• First Posted (Estimate): October 13, 2010

Study Record Updates

• Last Update Posted (Estimate): October 14, 2010
• Last Update Submitted That Met QC Criteria: October 13, 2010
• Last Verified: October 1, 2010

More Information

Terms related to this study

• Keywords: hyponatremia; Radiocontrast media,
• Additional Relevant MeSH Terms: Metabolic Diseases; Water-Electrolyte Imbalance; Hyponatremia
• Other Study ID Numbers: Hyponatremia-GUGH