Aggressive Prostate Cancers in Elderly Patients

May 18, 2011 updated by: Seoul National University Hospital

Patients Aged More Than 70 Had More Aggressive Prostate Cancers and Higher Risk of Biochemical Recurrence in Korea

Patients aged 70 years or older had a higher possibility of high risk cancer than younger patients.

Study Overview

Status

Completed

Conditions

Detailed Description

Patients aged 70 years or older had a higher risk of advanced prostate cancer and shorter BCR-free survival than younger ones. Definite treatment of clinically localized prostate cancer should be actively considered in well-selected healthy patients older than 70 years.

Study Type

Observational

Enrollment (Actual)

1333

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Sampling Method

Non-Probability Sample

Study Population

Men who underwent radical prostatectomy for the treatment of clinically localized prostate cancer

Description

Inclusion Criteria:

  • clinically localized prostate cancer
  • good health status
  • follow-up period more than 12 months

Exclusion Criteria:

  • insufficient clinical data
  • poor health status
  • clinically advanced prostate cancer

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
patients older than 70 years
patients 70 years or younger

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
biochemical recurrences (BCR)
Time Frame: 5 year-BCR
BCR was defined as two consecutive increasing PSA values of more than 0.2 ng/mL
5 year-BCR

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
pathologic outcomes
Time Frame: postoperative 1 week
biopsy or pathologic Gleason scores, mean percent of positive cores and tumor volume percent, Extracapsular extension and seminal vesicle invasion
postoperative 1 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Hospital

Investigators

  • Principal Investigator: Sung Yong Cho, M.D., Seoul National University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2010

Primary Completion (Actual)

October 1, 2010

Study Completion (Actual)

October 1, 2010

Study Registration Dates

First Submitted

April 29, 2011

First Submitted That Met QC Criteria

May 3, 2011

First Posted (Estimate)

May 4, 2011

Study Record Updates

Last Update Posted (Estimate)

May 19, 2011

Last Update Submitted That Met QC Criteria

May 18, 2011

Last Verified

May 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • old age prostate
  • elderly pts with high risk CaP

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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