- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01395368
Cognitive Speed as an Objective Measure of Tinnitus (COMeT)
July 18, 2012 updated by: Jay F. Piccirillo, MD, Washington University School of Medicine
Tinnitus, commonly referred to as "ringing in the ears", affects 50 million people in the United States and is recognized as a major public health concern.
Tinnitus is the most frequent cause of service-connected disability claims among war veterans.
Tinnitus remains a subjectively diagnosed entity.
There is no standardized objective method of diagnosing tinnitus or describing the functional impact of the condition.
Currently, physicians have to rely on patient-based self reports.
Without an objective method of diagnosing tinnitus and describing the functional implications, adequate treatment delivery is also hampered since there is no way to objectively stratify patients into severity groups and assess response to treatment.
Because tinnitus is known to negatively affect cognition through the ventral attention networks and the prefrontal cortex, measuring cognitive processing speed is a possible way to objectively measure tinnitus.
This study builds on previous work the investigators have done that utilized a quick, easily accessible measure of auditory processing speed.
That earlier study showed a correlation between that measure and self reported measures of tinnitus severity, and this study attempts determine a more precise estimate of that correlation.
It also better validates those results by including a traditional neurocognitive measuring cognitive speed and by controlling for the presence of depression and somatoform disorders.
Study Overview
Status
Completed
Conditions
Detailed Description
This was a cross-sectional study designed to investigate the relationship that self-reported tinnitus severity has with cognitive processing speed and psychiatric factors
Study Type
Observational
Enrollment (Actual)
108
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Missouri
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St. Louis, Missouri, United States, 63110
- Washington University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
The study population will include men and women between the ages of 18-80 years who have subjective, unilateral or bilateral, non-pulsatile tinnitus of 6 month's duration or longer.
Description
Inclusion Criteria:
- Participants must be between the ages of 18 and 80.
- Participants must have subjective, unilateral or bilateral, non-pulsatile tinnitus of 6 month's duration or longer.
- Participants must be able to read, write and speak using the English language.
- Participants must be able to read and follow the instructions for both computerized tests, "The Brain Speed Test" and "The 60 Second Brain Game."
- Participants must be able to provide written informed consent.
Exclusion Criteria:
- Participants with tinnitus related to Workman's Compensation Claim or other litigation-related situations.
- Participants with active diagnoses of any acute or chronic brain-related neurological conditions that alter normal brain anatomy or function including Parkinson's disease, Multiple Sclerosis, Alzheimer's Disease, cerebral infarcts, traumatic brain injury, history of brain tumor(s), epilepsy, or dementia.
- Participants with tinnitus related to retrocochlear lesions, cochlear implants, or other known anatomic/structural lesions of the brain, skull-base, temporal bone or ear.
- Participants who have a hearing threshold above 90 dB on any of the tested frequencies during audiometry.
- Participants unable to hear the highest volume of the computer-based objective assessments.
- Participants taking any medications that may affect or alter cognition including but not limited to sedatives, hypnotics, narcotics, or opiates.
- Participants with any medical condition the PI determines would compromise the safety of the participant or complicate the interpretation of the study results.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Brain Speed Test
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Brain Speed Test
Time Frame: Participants completed brain speed test on the same day as enrollment. No follow-up required.
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Standardized Z-scores of the Brain Speed Test (BST-Z scores) calculated based on age group-matched normal population data were used for analysis in order to control for the impact of age on test scores.
Age-standardized Z-scores, which reflect the distance from the mean in standard deviation values, allow for the comparison of scores across age groups.
A z-score of 0 indicates a value of the average, while absolute z-score values above 2 indicate observations significantly different from normal populations.
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Participants completed brain speed test on the same day as enrollment. No follow-up required.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Jay F Piccirillo, Washington University School of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
June 1, 2011
Primary Completion (Actual)
October 1, 2011
Study Completion (Actual)
October 1, 2011
Study Registration Dates
First Submitted
July 13, 2011
First Submitted That Met QC Criteria
July 14, 2011
First Posted (Estimate)
July 15, 2011
Study Record Updates
Last Update Posted (Estimate)
August 23, 2012
Last Update Submitted That Met QC Criteria
July 18, 2012
Last Verified
July 1, 2012
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 201103191
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Tinnitus
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State University of New York at BuffaloUniversity at BuffaloCompletedTinnitus, Subjective | Tinnitus | Noise Induced Tinnitus | Tinnitus, Objective | Tinnitus Aggravated | Tinnitus, Pulsatile | Tinnitus, Spontaneous Oto-Acoustic Emission | Tinnitus, Clicking | Tinnitus, Tensor Tympani InducedUnited States
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Mohab MohammedNot yet recruitingPulsatile Tinnitus (Diagnosis)
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University of GuadalajaraHospital Civil de Guadalajara; Institute of Experimental and Clinical TherapeuticsRecruitingOxidative Stress | Tinnitus, Subjective | Tinnitus, Bilateral | Antioxidant Therapy | Psychiatric Drugs | Inflammatory Cytokines | SSRIMexico
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University Hospital, BordeauxNot yet recruiting
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Cairo UniversityRecruiting
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University of ZurichRecruitingTinnitus, Subjective | TinnitusSwitzerland
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Eye & ENT Hospital of Fudan UniversityNot yet recruiting
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University of Illinois at Urbana-ChampaignGN Hearing A/SActive, not recruitingTinnitus, SubjectiveUnited States
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University of ZurichCompletedTinnitus, SubjectiveGermany, Switzerland