- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01419782
Effects of Unilateral WBV on Muscleactivity of Contralateral Hip Adductor (WBV-BM)
The Effects Of Femur On The Resting Myoelectrical Activity Of Contralateral Adductor Muscle During Unilateral Lower Extremity Vibration: Bone Myoregulation Reflex
The aim of this study is to investigate effects of femur exposed to unilateral vibration on the rest muscle electrical activity of contralateral hip adductors and contralateral soleus H-reflex in young adult men.
This study hypothesize that femur exposed to unilateral vibration may affect the rest muscle electrical activity of contralateral hip adductors. Vibration can effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. It has been showed that bone has an effect on the increase in muscle EMG activity caused by vibration in healthy young adults in a study. In this study, it was reported that vibrations-induced increases in muscle electrical activity of flexor carpi radialis (FCR) was related to ultradistal radius bone mineral content (BMC) and the FCR H-reflex was suppressed or depressed during vibration. This findings were reported to support the assumption that the bone exposed to cyclic mechanical loading may neuronally regulate muscle activity.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
A total of 20 voluntaries are planned to include in this study.
Vibration will be applied the right lower extremity by whole-body vibration (PowerPlate Pro). Cases will stand on vibration plate. WBV will be applied at a frequency of 40 Hz and amplitude of 2 mm for 60 seconds. WBV will be applied one session only.
The rest muscle electrical activity of ipsilateral and contralateral hip adductor muscles at rest will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.The rest-EMGrms will be measured at before and during vibration. We also evaluate a change in contralateral soleus H reflex during vibration.
Effects of bone on the rest muscle electrical activity will be assessed by hip bone mineral density, bone mineral content and serum sclerostin level. The right hip bone mineral density (BMD) and BMC will be evaluated by bone densitometer (Norland). Plasma sclerostin level will be measured by using Human Sclerostin ELISA kıt before and after vibration.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
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Istanbul, Turkey
- Bagcilar Training & Research Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age: 20-40 yrs
- Gender: Male
- Volunteer
- Healthy status: Patients having hypoesthesia in his leg and Healthy subjects
- Dominant hand:Right-handed
Exclusion Criteria:
- Bone diseases (osteoporosis, osteomalacia, paget's disease, neoplasm, etc),
- Systemic diseases (cardiovascular, endocrine, infections etc),
- Myopathy-tendinopathy
- Lower limb joint disease
- Vertigo
- Obesity (BMI >30 kg/m2)
- Professional sportsman
- Male doing regular sports activities
- Skin disease in lower limb
- Non-cooperative subject
- Hemolysis of blood sample
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Whole-body vibration
whole body vibration will be applied the right lower limb.
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Frequency: 40 Hz, vibration amplitude: 2 mm, duration: 60 sec
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Vibration-induced contralateral muscle electrical activity
Time Frame: 3 month
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3 month
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Collaborators and Investigators
Investigators
- Principal Investigator: ILHAN KARACAN, MD, Bagcilar Training & Research Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- BEAH FTR-5
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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