Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study (DOSI)

Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry

The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.

Study Overview

• Status: Completed
• Conditions: Hypoxia-Ischemia, Brain; Signs and Symptoms
• Intervention / Treatment: Device: Diffuse optical spectroscopy

Detailed Description

The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity.

Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.

• Study Type: Observational
• Enrollment (Actual): 78

Contacts and Locations

Study Locations

• United States
  • California
    • Irvine, California, United States, 92612
      • UCI Beckman Laser Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Elective surgery

Description

Inclusion Criteria:

1. Male or Female 20 years of age and older
2. Female non-pregnant
3. Subject scheduled for elective surgery under general anesthesia with intubation.
4. Subject who is able to give informed consent.

Exclusion Criteria:

1. Less than 20 years old of age
2. Pregnant woman
3. Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Diagnostic tool; Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity	Device: Diffuse optical spectroscopy; Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity; Other Names: Diffuse Optical Spectroscopy Imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain blood flow	Optical Imaging assess of Brain blood flow during surgical procedure	6 hours

Collaborators and Investigators

• Sponsor: University of California, Irvine
• Collaborators: Beckman Laser Institute University of California Irvine
• Investigators: Principal Investigator: Lingzhong Meng, M.D, Anesthesiology Perioperative Care

Study record dates

Study Major Dates

• Study Start: December 1, 2011
• Primary Completion (ACTUAL): December 1, 2011
• Study Completion (ACTUAL): December 1, 2011

Study Registration Dates

• First Submitted: August 2, 2011
• First Submitted That Met QC Criteria: November 30, 2011
• First Posted (ESTIMATE): December 1, 2011

Study Record Updates

• Last Update Posted (ACTUAL): November 1, 2022
• Last Update Submitted That Met QC Criteria: October 28, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Signs and Symptoms, Respiratory; Hypoxia, Brain; Brain Ischemia; Ischemia; Hypoxia; Hypoxia-Ischemia, Brain
• Other Study ID Numbers: 20107521