- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01527266
Carbohydrate Mouth-rinse (CHO rinse)
The Impact of a Sucrose Mouth-rinse in the Fasted and Fed-state on Time Trial Performance
Study Overview
Status
Intervention / Treatment
Detailed Description
It has been well established that carbohydrate (CHO) ingestion during prolonged, moderate- to high-intensity endurance-type exercise can delay the onset of fatigue and enhance exercise performance. Interestingly, several studies have reported that CHO ingestion can also improve performance during more intense exercise of short duration-less than 45-60 min. However, there is no apparent metabolic explanation for this improvement, because endogenous CHO stores should not limit exercise performance during short duration exercise tasks. To examine exogenous and endogenous glucose kinetics during high-intensity cycling exercise, Carter and colleagues tested 6 endurance athletes for 1 h at 75% Wmax while infusing either 20% glucose or 0.9% saline. Despite greater plasma glucose availability in the glucose-infusion trial, total CHO oxidation rates did not differ between treatments. Moreover, no performance benefits were observed after intravenous glucose administration. Consequently, the authors suggested that CHO ingestion during high-intensity exercise of short duration might exert its ergogenic effect by acting through the central nervous system, possibly mediated by glucose receptors in the mouth or gastrointestinal tract.
To test this hypothesis, Carter and colleagues investigated the impact of a carbohydrate mouth-rinse solution on 1-h time trial performance. The use of a mouth-rinse treatment, in which a CHO solution is spat out without swallowing, was chosen to remove any influence of the gut or exogenous CHO oxidation on performance. Participants were reported to cycle faster after a mouth rinse with a 6.4% maltodextrin solution at every 12.5% of the trial completed compared with a placebo rinse. The authors concluded that CHO mouth rinsing improves time trial performance and that the mechanism responsible might be an increase in central drive or motivation mediated by glucose receptors in the mouth. However in the former study, subjects were tested in a fasted state, which is impractical compared to how athletes normally prepare for training and competition.
In follow-up to the former study, we tested the performance effect of a carbohydrate mouth rinse 2 h after subjects ingested a CHO rich meal. From an evolutionary viewpoint, it can be speculated that the potential stimulating effect of glucose in the mouth might be of considerable impact under conditions when liver glycogen stores might be compromised. In agreement with this theory, there was no performance improvement with a CHO mouth rinse during time trial performance 2 h following the ingestion of a CHO -rich meal. However, as there are now studies demonstrating results both for and against any ergogenic effect of a CHO mouth rinse during short duration time trials it remains to be determined whether CHO mouth rinse improves performance during a 1 h time trial in the fasted state only. Therefore, the present study aims to investigate any potential ergogenic effect of a CHO mouth rinse during a 1 h time trial performance in both the fasted and fed state.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Naomi Cermak, Ph.D.
- Phone Number: 31433881393
- Email: naomi.cermak@maastrichtuniversity.nl
Study Locations
-
-
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Maastricht, Netherlands
- Recruiting
- Maastricht University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Healthy
- Male
- 18 - 35 years of age
- Endurance cycling trained (≥ 3 sessions of endurance exercise per week)
- VO2 max ≥ 50 ml/kg/min
- Training history of more than one year of ≥ 3 sessions of endurance cycling exercise per week
- BMI < 25 kg/m2
Exclusion Criteria:
- Use of medication
- Smoking
Study Plan
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: carbohydrate mouth rinse fasted
sucrose mouth rinse in the fasted state
|
sucrose beverage
|
Experimental: carbohydrate mouth rinse fed
sucrose mouth rinse fed state
|
sucrose beverage
|
Placebo Comparator: Placebo mouth rinse fed
placebo (non-caloric sweetened drink) in the fed state
|
placebo; non-caloric sweetened beverage for use as a mouth rinse
|
Placebo Comparator: Placebo mouth rinse fasted
placebo (non-caloric sweetened drink) in the fasted condition
|
placebo; non-caloric sweetened beverage for use as a mouth rinse
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Time to complete a set amount of work (time-trial performance)
Time Frame: laboratory visit 2
|
Time to complete the set amount of work measured in minutes.
To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.
|
laboratory visit 2
|
Time to complete a set amount of work (time trial performance)
Time Frame: laboratory visit 3
|
Time to complete the set amount of work measured in minutes.
To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.
|
laboratory visit 3
|
Time to complete a set amount of work (time-trial performance)
Time Frame: laboratory visit 4
|
Time to complete the set amount of work measured in minutes.
To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.
|
laboratory visit 4
|
Time to complete a set amount of work (time-trial performance)
Time Frame: laboratory visit 5
|
Time to complete the set amount of work measured in minutes.
To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.
|
laboratory visit 5
|
Collaborators and Investigators
Investigators
- Study Director: Luc van Loon, Ph.D., Maastricht University
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 11-3-068
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