The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists

Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.

Study Overview

• Status: Not yet recruiting
• Conditions: The Focus of the Study is to Investigate the Effects of Phosphatidylserine Supplementation on Exercise Physiology and Cycling Time-trial Performance
• Intervention / Treatment: Dietary supplement: Phosphatidylserine

• Study Type: Interventional
• Enrollment (Anticipated): 20
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Mark Glaister, PhD; Phone Number: 02082404012; Email: mark.glaister@stmarys.ac.uk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Cyclists
• Maximum oxygen uptake of at least 55 mL/kg/min

Exclusion Criteria:

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Phosphatidylserine, 800 mg per day, 10 days	Dietary supplement: Phosphatidylserine; 800 mg per day for 10 days
Placebo Comparator: Maltodextrin, 800 mg per day, 10 days	Dietary supplement: Phosphatidylserine; 800 mg per day for 10 days

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer	Mean power output	From baseline to 11 days post supplementation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using an online breath-by-breath gas analyser	From baseline to 11 days post supplementation
Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using an online breath-by-breath gas analyser	From baseline to 11 days post supplementation
Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using an online breath-by-breath gas analyser	From baseline to 11 days post supplementation
Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using an online breath-by-breath gas analyser	From baseline to 11 days post supplementation
Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Obtained via capillary puncture and analysed using an automated analyser	From baseline to 11 days post supplementation
Blood glucose concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Obtained via capillary puncture and analysed using an automated analyser	From baseline to 11 days post supplementation
Rating of perceived exertion at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using a 15-point (6-20) scale	From baseline to 11 days post supplementation
Heart rate at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	Evaluated using a heart rate monitor	From baseline to 11 days post supplementation

Collaborators and Investigators

• Sponsor: Mark Glaister

Study record dates

Study Major Dates

• Study Start (Anticipated): July 15, 2021
• Primary Completion (Anticipated): September 22, 2021
• Study Completion (Anticipated): September 22, 2021

Study Registration Dates

• First Submitted: June 11, 2021
• First Submitted That Met QC Criteria: July 8, 2021
• First Posted (Actual): July 19, 2021

Study Record Updates

• Last Update Posted (Actual): July 19, 2021
• Last Update Submitted That Met QC Criteria: July 8, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Other Study ID Numbers: StMarysUC

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No