Non Invasive and Non-Contact Imaging Of Tissue Oxygenation and Vascular Reactivity

Non Invasive and Non-Contact Dual-modal Imaging Of Tissue Oxygenation and Vascular Reactivity Dynamic Imaging Of Tissue Metabolism and Vascular Function.

1. Quantitative validation of non-contact oxygenation imaging by the CWC imaging system
2. Quantitative validation of non-contact vascular function imaging by the CWC imaging system
3. Evaluation of the clinical usability of the CWC imaging system for further technology development and engineering improvement

Study Overview

• Status: Withdrawn
• Conditions: Quantitative Validation of Imaging System

Detailed Description

The hyperspectral imaging technique estimates cutaneous tissue oxygenation by illuminating tissue and detecting tissue reflectance at different wavelengths. One major advantage of hyperspectral imaging is non-invasive and non-contact detection of tissue functional properties. The dual-mode imaging system integrates hyperspectral and thermal imaging modalities for simultaneous assessment of cutaneous tissue oxygenation and vascular function. This clinical protocol is defined to validate the CWC system on healthy human subjects

• Study Type: Observational

Contacts and Locations

Study Locations

• United States
  • Ohio
    • Columbus, Ohio, United States, 43210
      • The Ohio State University.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Interested healthy volunteers

Description

Inclusion Criteria:

• Adult 18 years and older
• No history of diabetes.
• No history of vascular disease

Exclusion Criteria:

• Under 18 years of age
• Unable to provide informed consent
• Prisoners
• Current smoker

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
1; Healthy participants.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Non-Contact Oxygenation Imagiing	Quantitative validation of non-contact oxygenation imaging by the CWC imaging system	1 year
Non-Contact Vascular Function Imaging	Quantitative validation of non-contact vascular function imaging by the CWC imaging system	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical usability for Comprehensive Wound Centers	Evaluation of the clinical usability of the CWC imaging system for further technology development and engineering improvement.	1 year

Collaborators and Investigators

• Sponsor: Chandan K Sen
• Investigators: Principal Investigator: Chandan K Sen, Ph.D., Ohio State University

Publications and helpful links

General Publications

• Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen. 2009 Jan-Feb;17(1):1-18. doi: 10.1111/j.1524-475X.2008.00436.x.
• Xu RX, Huang K, Qin R, Huang J, Xu JS, Ding L, Gnyawali US, Gordillo GM, Gnyawali SC, Sen CK. Dual-mode imaging of cutaneous tissue oxygenation and vascular function. J Vis Exp. 2010 Dec 8;(46):2095. doi: 10.3791/2095.
• Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999 Sep 2;341(10):738-46. doi: 10.1056/NEJM199909023411006. No abstract available.
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• Broughton G 2nd, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):1e-S-32e-S. doi: 10.1097/01.prs.0000222562.60260.f9.
• Leach RM, Treacher DF. Oxygen transport-2. Tissue hypoxia. BMJ. 1998 Nov 14;317(7169):1370-3. doi: 10.1136/bmj.317.7169.1370. No abstract available.
• Treacher DF, Leach RM. Oxygen transport-1. Basic principles. BMJ. 1998 Nov 7;317(7168):1302-6. doi: 10.1136/bmj.317.7168.1302. No abstract available.
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• Scheffler A, Rieger H. Clinical information content of transcutaneous oxymetry (tcpO2) in peripheral arterial occlusive disease (a review of the methodological and clinical literature with a special reference to critical limb ischaemia). Vasa. 1992;21(2):111-26.
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• Shah SA, Bachrach N, Spear SJ, Letbetter DS, Stone RA, Dhir R, Prichard JW, Brown HG, LaFramboise WA. Cutaneous wound analysis using hyperspectral imaging. Biotechniques. 2003 Feb;34(2):408-13. doi: 10.2144/03342pf01.
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• Whiston R. Wound care. Principles of Doppler. Nurs Times. 1996 May 15-21;92(20):66-70. No abstract available.
• Luypaert R, Boujraf S, Sourbron S, Osteaux M. Diffusion and perfusion MRI: basic physics. Eur J Radiol. 2001 Apr;38(1):19-27. doi: 10.1016/s0720-048x(01)00286-8.
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Study record dates

Study Registration Dates

• First Submitted: April 5, 2012
• First Submitted That Met QC Criteria: April 5, 2012
• First Posted (Estimate): April 9, 2012

Study Record Updates

• Last Update Posted (Actual): April 28, 2022
• Last Update Submitted That Met QC Criteria: April 20, 2022
• Last Verified: April 1, 2022

More Information

Terms related to this study

• Keywords: Non-invasive; hyperspectral; tissue-oxygenation; CWC imaging system
• Other Study ID Numbers: 2010H0017