Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

September 10, 2012 updated by: Javier Gonzalez, Northumbria University
The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Tyne on Wear
      • Newcastle upon Tyne, Tyne on Wear, United Kingdom, NE1 8ST
        • Northumbria University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • ADULT
  • OLDER_ADULT
  • CHILD

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • recreationally active
  • male

Exclusion Criteria:

  • food intolerances/allergies

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: DOUBLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Breakfast consisting of milk-based porridge with a normal calcium content.
Experimental: High-Calcium
As control, but with a high-calcium content.
Dietary supplement: Calcium
Milk-calcium supplement

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Subjective appetite ratings
Time Frame: 3 hour
Subjective ratings of appetite assessed by visual analogue scales.
3 hour

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Serum insulin concentration
Time Frame: 2 hour
2 hour area under the curve for serum insulin following breakfast consumption
2 hour
Plasma glucose-dependent insulinotropic peptide concentration
Time Frame: 2 hour
2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption
2 hour
Plasma glucagon-like peptide-1 concentration
Time Frame: 2 hour
2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption
2 hour

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total fat oxidised during 60 min of exercise (g)
Time Frame: 1 hour
Assessed by indirect calorimetry
1 hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northumbria University

Investigators

  • Principal Investigator: Javier T Gonzalez, MRes, Northumbria University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2012

Primary Completion (Actual)

August 1, 2012

Study Completion (Actual)

August 1, 2012

Study Registration Dates

First Submitted

September 6, 2012

First Submitted That Met QC Criteria

September 6, 2012

First Posted (Estimate)

September 10, 2012

Study Record Updates

Last Update Posted (Estimate)

September 11, 2012

Last Update Submitted That Met QC Criteria

September 10, 2012

Last Verified

September 1, 2012

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 32AN2

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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