Whole Body Vibration Exercise for Elderly With Cognitive Impairments

The Effects of Whole Body Vibration Exercise Training on Physical Functioning and Falls in Community-dwelling Elderly With Cognitive Impairments

The whole body vibration exercise group will have significantly more improvement in mobility, muscle strength, balance, balance confidence, and cognitive function with a lower fall rate than the control group.

Study Overview

• Status: Unknown
• Conditions: Dementia
• Intervention / Treatment: Device: Whole body vibration exercise; Behavioral: Conventional exercise

• Study Type: Interventional
• Enrollment (Anticipated): 66
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Hong Kong
  • New Territories
    • Shatin, New Territories, Hong Kong
      • Recruiting
      • Jockey Club Centre for Positive Ageing
      • Contact: Timothy Kwok, MD; Phone Number: 852-2636-6323; Email: tkwok@cuhk.edu.hk
      • Principal Investigator: Timothy Kwok, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• a diagnosis of mild or moderate dementia, with a Clinical Dementia Rating (CDR) of 1 to 2, and a Cantonese Mini-mental State Examination (CMMSE) score at 10 or above but below the local cutoff for dementia (18-22, depending on education level)
• able to stand for at least 1 minute with or without hand support
• living in the community
• having an informed consent (from the primary caregiver)

Exclusion Criteria:

• significant musculoskeletal conditions (e.g. amputations)
• metal implants in the lower extremity
• recent fracture in the lower extremity
• vestibular disorders
• peripheral vascular disease
• other serious illnesses or contraindications to exercise.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Whole body vibration exercise; The experimental group will receive 2 sessions of whole body vibration exercise training and conventional exercise per week for a period of 9 weeks. The total duration of vibration exposure per session will range from 4 to 6 minutes. The vibration frequency and amplitude used will be 30 Hz and 1 mm, respectively.	Device: Whole body vibration exercise; The whole body vibration will be delivered by a platform that can generate vibration signals (Powerplate). The total duration of vibration exposure per session will range from 4 to 6 minutes. The vibration bouts (30-45 seconds per bout) will be interspersed with a 1 to 2 minutes of rest period. While standing on the vibration platform, subjects will be instructed to repeat two exercises: (1) static semi-squats, and (2) dynamic semi-squats.; Behavioral: Conventional exercise; The conventional exercise training will involve a combination of upper limb and lower limb stretching and strengthening exercises, balance training, and gait re-education.
Active Comparator: Conventional exercise; This group will receive 2 sessions of conventional exercise training per week for a period of 9 weeks.	Behavioral: Conventional exercise; The conventional exercise training will involve a combination of upper limb and lower limb stretching and strengthening exercises, balance training, and gait re-education.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Timed-up-and-go test	A measure of functional mobility	week 0
Timed-up-and-go test		week 9
Timed-up-and-go test		week 21

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Berg balance scale		week 0
Activities-specific balance confidence scale		week 0
Berg balance scale		week 9
Berg balance scale		week 21
Activities-specific balance confidence scale		week 9
Activities-specific balance confidence scale		week 21
five times sit-to-stand test		week 0
five times sit-to-stand test		week 9
five times sit-to-stand test		week 21
Mini-Mental State Examination		week 0
Mini-Mental State Examination		week 9
Mini-Mental State Examination		week 21
Quality of Life in Alzheimer's disease		week 0
Quality of Life in Alzheimer's disease		week 9
Quality of Life in Alzheimer's disease		week 21
incidence of falls	Incidence of falls will be recorded by using fall diaries.	daily starting from week 0 to week 33

Collaborators and Investigators

• Sponsor: The Hong Kong Polytechnic University
• Collaborators: Chinese University of Hong Kong
• Investigators: Principal Investigator: Marco Pang, PhD, Hong Kong Polytechnic University

Publications and helpful links

General Publications

• Bautmans I, Van Hees E, Lemper JC, Mets T. The feasibility of Whole Body Vibration in institutionalised elderly persons and its influence on muscle performance, balance and mobility: a randomised controlled trial [ISRCTN62535013]. BMC Geriatr. 2005 Dec 22;5:17. doi: 10.1186/1471-2318-5-17.
• Bruyere O, Wuidart MA, Di Palma E, Gourlay M, Ethgen O, Richy F, Reginster JY. Controlled whole body vibration to decrease fall risk and improve health-related quality of life of nursing home residents. Arch Phys Med Rehabil. 2005 Feb;86(2):303-7. doi: 10.1016/j.apmr.2004.05.019.

Study record dates

Study Major Dates

• Study Start: November 1, 2012
• Primary Completion (Anticipated): January 1, 2015
• Study Completion (Anticipated): July 1, 2015

Study Registration Dates

• First Submitted: November 21, 2012
• First Submitted That Met QC Criteria: November 26, 2012
• First Posted (Estimate): November 27, 2012

Study Record Updates

• Last Update Posted (Estimate): November 27, 2012
• Last Update Submitted That Met QC Criteria: November 26, 2012
• Last Verified: November 1, 2012

More Information

Terms related to this study

• Keywords: exercise; rehabilitation; cognition; muscle; mobility; vibration; fall
• Additional Relevant MeSH Terms: Mental Disorders; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction
• Other Study ID Numbers: HSEARS20120929006